Is Benzisothiazolinone a skin sensitiser?
Benzisothiazolinone is a skin sensitiser in animal models with potency similar to methylisothiazolinone. Methylisothiazolinone, at 100 ppm (0.01%) in cosmetic products is causing contact allergy and allergic contact dermatitis in the consumer. Benzisothiazolinone is known to be a sensitiser in man and has induced sensitisation...
Is Methylisothiazolinone a sensitiser?
Methylisothiazolinone, at 100 ppm (0.01%) in cosmetic products is causing contact allergy and allergic contact dermatitis in the consumer. Benzisothiazolinone is known to be a sensitiser in man and has induced sensitisation at circa 20 ppm in gloves.".
Does Methylisothiazolinone cause contact dermatitis?
Methylisothiazolinone, at 100 ppm (0.01%) in cosmetic products is causing contact allergy and allergic contact dermatitis in the consumer. Benzisothiazolinone is known to be a sensitiser in man and has induced sensitisation at circa 20 ppm in gloves." [10]
Is Methylisothiazolinone a biocide?
The researchers stated, “a brief exposure to methylisothiazolinone, a widely used industrial and household biocide, is highly toxic to cultured neurons….” The scientists went on to state that these toxic effects had been reported previously, and because of their widespread use, the consequences of chronic human exposure need to be evaluated.
What are other names for methylisothiazolinone?
Trade names for MCI/MI include Kathon®, Kathon CG®, Kathon 886®Euxyl K100, Acticide, Algucid, Algucid CH 50, Amerstat 250, GR 856,Groton TK2, Metatin GT, Mitco CC, Mx 323 Parmetol.
What is methylisothiazolinone Benzisothiazolinone?
Benzisothiazolinone (BIT), like its better known 'siblings' methylisothiazolinone (MI) and methylchloroisothiazolinone (MCI), is a member of the 'isothiazolinone' group of highly effective preservatives, which between them have contributed towards a worldwide epidemic of allergic contact dermatitis in recent decades.
Can you be allergic to Benzisothiazolinone?
A significant increase was noted in the prevalence of contact allergy to benzisothiazolinone (BIT) from 0.26% in 2014 to 3.42% in 2019. The most common dermatitis distribution was generalized. Household cleaning products, including laundry detergent, were identified as the culprit in 45% of these BIT-positive cases.
What products contain Benzisothiazolinone?
Benzisothiazolinone can be an important cause of allergic contact dermatitis from paints....It may be present in:Water based paints, varnishes, stains, and printing inks.Adhesives, plasters, and sealant.Household cleaning products, laundry detergents, and fabric softener.Cooling fluids, industrial processes.
Is benzisothiazolinone harmful to humans?
Benzisothiazolinone is classified as hazardous with the hazard category 'Acute Toxicity Category 4' and the hazard statement 'Harmful if swallowed' (H302) in HCIS (Safe Work Australia).
What is benzisothiazolinone made from?
The 2-halogenothiobenzoyl halide is typically made by cleaving the disulphide bond of 2,2′-dithio-bis-benzoic acid with halogen and simultaneously or sequentially converting the carboxylic acid groups to acid halides.
Does all free and clear contain methylisothiazolinone?
Allergy to Isothiazolinone, Methylisothiazolinone and Benzisothiazolinone. **USA Update: Looks like All has continued to make changes to their formulation and are now including benzisothiazolinone in all sizes of their new "All Stainlifter Free & Clear" detergent.
What is methylisothiazolinone allergy?
Methylisothiazolinone (MI) is a preservative used in baby wipes and other personal products, which is currently causing an appreciable number of cases of allergic contact dermatitis, an itchy skin rash. Preservatives like MI are needed in moist wipes to prevent bacterial contamination. Where is MI found?
Is Benzisothiazolinone a benzene?
Benzisothiazolinone (BIT) is an organic compound with the formula C6H4SN(H)CO. A white solid, it is structurally related to isothiazole, and is part of a class of molecules called isothiazolinones. BIT is widely used as a preservative and antimicrobial....Benzisothiazolinone.NamesCompTox Dashboard ( EPA )DTXSID503252332 more rows
Does Aveeno have MI?
Aveeno products are mixed: some of their shampoos are reported to contain MI, but this line of Eczema Therapy treatments are reported to work well for us. X's is most controlled by prescribed homeopathic sulphur (took it for a while, during which his skin got worse and then almost completely clear up).
What products have methylisothiazolinone in them?
Specifically methlisothiazolinone can be found in cleansers such as liquid dish soap, liquid laundry soap, all purpose spray cleaners and window cleaning solutions. This substance can also be found in products labeled "natural".
Is methylisothiazolinone found in food?
Is there methylisothiazolinone in food? This synthetic preservative has not been approved for food preservation, and neither have any of its relatives, such as methylchloroisothiazolinone. There should not be, nor should there ever have been, any MI in any products for human oral consumption.
Is methylisothiazolinone harmful?
Methylisothiazolinone is moderately to highly acutely toxic in oral, dermal, eye irritation, dermal irritation, and inhalation acute toxicity studies. The use of methylisothiazolinone in the manufacture of paper, paperboard, and adhesives which may contact food is regulated by FDA.
Is methylisothiazolinone safe for skin?
Takeaway. Methylchloroisothiazolinone (MCI), especially when paired with methylisothiazolinone (MI), is an effective preservative. In high concentrations it can be a skin irritant and even cause chemical burns.
Is methylisothiazolinone safe for hair?
MI, MCI and your health Used in the proper amounts in rinse-off products like shampoo and conditioner, they are safe and effective, and they help protect you by keeping your shampoo and conditioner free from microbial contamination.
What is methylisothiazolinone used for?
Methylisothiazolinone, along with other isothiazolinones, is a biocide widely used as a preservative in personal care products. It is also used in many industrial processes, such as paint and paper manufacturing, metalworking, mining, and sanitizing.
Why are isothiazolinones used as a preservative?
Home cleaning and other care products that are high in water are easily contaminated by microorganisms, so isothiazolinones are often used as a preservatives in these products because they are good at combatting a broad array of bacteria, fungi, and yeasts.
Who published the Directory of Microbicides for the Protection of Materials and Processes?
Wilfried Paulus: Directory of Microbicides for the Protection of Materials and Processes. Springer Netherland, Berlin 2006, ISBN 1-4020-4861-0.
Is benzisothiazolinone safe for cosmetics?
The opinion further states: "There is no information on what may be safe levels of exposure to benziso thiazolinone in cosmetic products from the point of view of sensitisation. Until safe levels of exposure have been established, the use of benziso thiazolinone in cosmetic products as a preservative or for other functions cannot be considered safe in relation to sensitisation."
Is benzisothiazolinone a microbicide?
Benzisothiazolinone has a microbicide and a fungicide mode of action. It is widely used as a preservative, for example in: industrial settings, for example in textile spin-finish solutions, leather processing solutions, preservation of fresh animal hides and skins. gas and oil drilling in muds and packer fluids preservation.
What Does Benzisothiazolinone Do in Our products?
Benzisothiazolinone is a preservative, but it is also a disinfectant used in the film, fiber, leather, masonry, metalworking, and embalming industries. [1] However, it is also found in liquid hand soap and sunscreen. [2] It dissolves in water and is used in water-based solutions, such as pastes, paints, and oils. [3]
Why is benzisothiazolinone used in puracy?
We use benzisothiazolinone in several of our products as a biodegradable preservative that is a better alternative to formaldehyde, methylisothiazolinone, and medium-chain triglycerides.
What is the cyclization method of 2-halogenothiobenzamide?
A second method involves cyclising 2-halogenothiobenzamide in the presence of acid or alkali. The 2-halogenothiobenzamide typically comes from converting 2,2'-dithio-bis- benzoic acid to bisamide and then cleaving the disulphide bond with halogen.
How is 2-halogenothiobenzoyl halide made?
The 2-halogenothiobenzoyl halide is typically made by cleaving the disulphide bond of 2,2'-dithio-bis-benzoic acid with halogen and simultaneously or sequentially converting the carboxylic acid groups to acid halides. A second method involves cyclising 2-halogenothiobenzamide in the presence of acid or alkali.
Applications
Methylisothiazolinone is used for controlling microbial growth in water-containing solutions. It is typically used in a formulation with 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT), in a 3:1 mixture (CMIT:MIT) sold commercially as Kathon. Kathon is supplied to manufacturers as a concentrated stock solution containing from 1.5–15% of CMIT/MIT.
Hazards
MIT is allergenic and cytotoxic, and this has led to some concern over its use. A report released by the European Scientific Committee on Cosmetic Products and Non-food Products Intended for Consumers (SCCNFP) in 2003 also concluded that insufficient information was available to allow for an adequate risk assessment analysis of MIT.
Regulation
In 2014, the European Commission Scientific Committee on Consumer Safety further issued a voluntary ban on the MCI/MI mixture from leave-on products such as body creams. The measure applied for products placed on the market after 16 July 2015." Shortly thereafter, Canada moved to adopt similar measures in its Cosmetic Ingredients Hotlist.
How many chemicals are banned in other countries?
I am so disgusted with these companies that think they can get away with this. There are over 1,100 chemicals banned in other countries that we’re still using.
What is the name of the compound that MIT is made of?
MIT belongs to a group of similar compounds called “isothiazolinones,” which also include the following chemicals:
Is methylisothiazolinone a chemical?
Ingredient Watch List: Methylisothiazolinone, the Toxic Ingredient That Could Cause Nerve Damage. Also called MIT, this ingredient is often found in antibacterial products. Unlike some synthetic chemicals, however, this one isn't just a mild skin irritant. A recent study found the chemical may actually be linked to nerve damage, ...
Is MIT toxic to humans?
Another study found that exposure to MIT caused dermatitis, while a recent 2012 study found that brief exposure to MIT is toxic in low concentrations during neural development, increasing the risk of seizures and visual abnormalities.
Is MIT safe for cosmetics?
What did the cosmetic industry say about this? The Cosmetic, Toiletry, and Fragrance Association (CFTA) issued a response stating that MIT is safe as it is used in cosmetic formulas because the exposure is so low. Indeed, in 2004, the European Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers (SCCNFP) suggested that companies limit the maximum concentration of MIT to 0.01 percent, or 100 parts per million (ppm). U.S. companies, however, are not required to follow this guideline.
Is MIT a chemical?
Also called MIT, this ingredient is often found in antibacterial products. Unlike some synthetic chemicals, however, this one isn't just a mild skin irritant. A recent study found the chemical may actually be linked to nerve damage, and it's also known to be toxic in several other ways. Let's figure out how to avoid this one!
Is biocide a preservative?
That means it's a chemical substance that can control or kill harmful microorganisms. It works well as a preservative in products like shampoo and body care products, helping them to last a long time on the shelf and in your bathroom cabinets without becoming contamina ted with unwanted bugs, bacteria, and fungi.
What is METHYLISOTHIAZOLINONE?
WHAT ARE METHYLISOTHIAZOLINONE and METHYLCHLOROISOTHIAZOLINONE? Methylisothiazolinone (MIT) and Methylchloroisothiazolinone (CMIT) are widely used preservatives found in liquid cosmetic and personal care products. [3] [4] Both chemicals inhibit bacterial growth in cosmetic products on their own, but they are most commonly used as a mixture in products. [5]
Is MIT an allergen?
Allergies: Methylisothiazolinone (MIT) and Methylchloroisothiazolinone (CMIT) are two of the most predominant contact allergens found in cosmetic products. [9] . In a clinical study, researchers found that dermal irritation most commonly occurs in products with CMIT and MIT/CMIT mixtures, but is not as common in products with only MIT.
What is phenoxyethanol?
Phenoxyethanol is another name for ethylene glycol which is discussed in more detail below. A good guideline to use when shopping for cleaning products, is to make sure the ones that you buy are free from the aforementioned and following ingredients, all of which are known toxins or have known negative impacts on the environment.
What is the name of the toxins in dish soap?
For example, the company called Earth Friendly Products puts the known toxins phenoxyethanol and methylisothiazolinone in their Dishmate dish soap. Seventh Generation also has benzisothiazolinone and methylisothiazolinone in their dishwashing soaps and all purpose cleaner.
Can ethanolamines cause asthma?
Studies suggest that ethanolamines may contribute to the development of asthma, especially in children. They also cause allergic reactions in some pets, and they build up in the water supply after you wash them down the drain. Some types of ethanolamines are known carcinogens. Pine oil.
Is methylisothiazolinone a biocide?
Methylisothiazolinone is a biocide similar in chemical structure to Agent Orange and has been linked to nerve damage, allergies, immune disorders, and brain cell damage. Benzisothiazolinone is another type of biocide also linked to immune system toxicity, allergies, and cancer. Phenoxyethanol is another name for ethylene glycol which is discussed ...
Overview
Hazards
Given sufficient dose and duration, dermal exposure can produce skin sensitization and allergic contact dermatitis, and is classified as an irritant for skin and eyes. BIT's low molar mass allows for it to penetrate the epidermis and then react with the skin macromolecules, which causes the irritation. Benzisothiazolinone has also been linked with Systemic Contact Dermatitis via airborne contact.
Preparation
Applications
Regulation
External links