Precautions
How do you give nicardipine IV push?
Nicardipine hydrochloride injection is administered by slow continuous infusion at a CONCENTRATION OF 0.1 MG/ML. Each vial (25 mg) should be diluted with 240 mL of compatible intravenous fluid (see below), resulting in 250 mL of solution at a concentration of 0.1 mg/mL.
How is cardene administered?
Administer Cardene I.V. by a central line or through a large peripheral vein. Change the infusion site every 12 hours if administered via peripheral vein [see Intravenous Infusion Site].
How fast do you push nicardipine?
Initial dose: Treatment should start with the continuous administration of nicardipine at a rate of 3-5 mg/h for 15 minutes. Rates can be increased by increments of 0.5 or 1 mg every 15 minutes. The infusion rate should not exceed 15 mg/h.
How do you IV cardene titrate?
Initiate therapy at 5 mg/hour as a continuous IV infusion. The initial infusion rate of 5mg/hr IV may be increased by 2.5 mg/hr every 5 minutes to a maximum of 15 mg/hr, to maintain a SBP less than 220 mm Hg and DBP <110 mm Hg. In general, aim for a 10-15% reduction in SBP.
Can cardene go through peripheral IV?
Administer CARDENE I.V. by a central line or through a large peripheral vein. Change the infusion site every 12 hours if administered via peripheral vein [see Warnings and Precautions (5.5)]. CARDENE I.V. is available as a single-dose, ready-to-use, iso-osmotic solution for intravenous administration.
Can you bolus nicardipine?
Nicardipine administered as an IV bolus was found to be effective for acutely decreasing arterial pressure in a heterogeneous group of patients undergoing cardiac operations.
What is the difference between Cardene and Cardizem?
Cardene is a dihydropyridine calcium channel blocker and Cardizem is a benzothiazepine calcium channel blocker.
Does nicardipine slow heart rate?
By slowing calcium influx into cardiac muscle cells, calcium channel blockers tend to reduce the force of cardiac contraction, thus reducing cardiac work and the vigor of the heart beat.
Why is nicardipine used in stroke?
Nicardipine is recommended for elevated blood pressure after acute ischemic stroke or intracerebral haemorrhage and is effective in prevention of stroke. More recent investigations were focused on the treatment of cognitive deterioration of vascular origin.
Does nicardipine cause tachycardia?
Nicardipine-induced tachycardia is generally attributed to the involvement of the baroreflex. The effects of nicardipine on blood pressure (BP) and heart rate (HR) as well as on plasma catecholamine levels were studied in six conscious dogs made hypertensive by sinoaortic denervation.
How do you transition off nicardipine drip?
[ ] NiCARdipine drip: 40mg/200ml, IV, Routine, T;N, Titrate, Comment: Start at 5 mg/hr and increase by 2.5 mg/hr as often as every 15 minutes to achieve MAP goal. Maximum dose is 15 mg/hr. Begin to wean continuous infusion 6-12 hours after beginning oral medications.
How long does it take for nicardipine to work?
The onset of action is 1 to 2 minutes and the half-life is approximately 40 minutes. Nicardipine is metabolized in the liver. Nicardipine can be started at a dose of 0.5 to 1 mcg/kg per minute and titrated to a maximum infusion rate of 3 mcg/kg per minute.
What is the difference between Cardene and Cardizem?
Cardene is a dihydropyridine calcium channel blocker and Cardizem is a benzothiazepine calcium channel blocker.
When do you use a cardene drip?
Intravenous (IV) nicardipine (Cardene IV), which demonstrates a relatively rapid onset/offset of action, is used in situations requiring the rapid control of blood pressure (BP). IV nicardipine was as effective as IV nitroprusside in the short-term reduction of BP in patients with severe or postoperative hypertension.
What is a cardene drip?
Cardene I.V. (nicardipine hydrochloride) Premixed Injection is a calcium channel blocker indicated for the short-term treatment of hypertension when oral therapy is not feasible or not desirable. For prolonged control of blood pressure, transfer patients to oral medication as soon as their clinical condition permits.
What is nicardipine drip used for?
Nicardipine is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly.