How much B12 should a diabetic take?
Sep 29, 2021 · Mellitus Diabetic patients can easily develop a B12 deficiency as they are at a higher risk. It is because diabetics mostly take metformin, which is a well-known treatment of Type-2 diabetes. You don’t have to take Vitamins supplements if you are facing a minor B12 deficiency. You can obtain it through meat, poultry, fish, and dairy products.
What does it mean when your blood test shows high B12 levels?
Dec 09, 2021 · How much B12 should a diabetic take? In the US, it is currently believed that adults with type 2 diabetes that are over 50 should take 2.4 µg of synthetic vitamin B12 daily either in supplement form or in fortified food.
What does high B12 blood levels really mean?
Jun 05, 2018 · For example, having diabetes mellitus can increase your risk of having a B-12 deficiency because it may be a side effect of metformin, a common treatment for type 2 diabetes mellitus. A 2009 study...
What are the warning signs of a B12 deficiency?
May 07, 2013 · Vitamin B12 replacement has been shown to cause symptomatic improvement among patients with severe diabetic neuropathy. One meta-analysis showed that if used either alone or in combination with vitamin B complex, there was a significant improvement in the somatic symptoms like pain and paraesthesias.
How much Vit B12 should a diabetic take?
In the US, it is currently believed that adults with type 2 diabetes that are over 50 should take 2.4 µg of synthetic vitamin B12 daily either in supplement form or in fortified food.Dec 20, 2011
Can B12 affect diabetes?
There are other ways to develop a deficiency. For example, having diabetes mellitus can increase your risk of having a B-12 deficiency because it may be a side effect of metformin, a common treatment for type 2 diabetes mellitus. A 2009 study found that 22 percent of people with type 2 diabetes were low in B-12.
Can I take B12 with metformin?
Frequently Asked Questions. Does metformin affect the absorption of vitamin B12? Yes, metformin appears to inhibit intestinal absorption of vitamin B12, which can lead to anemia and neuropathy due to B12 deficiency.Jan 5, 2022
How much B12 should a diabetic on metformin take?
The fact that the symptoms of diabetic neuropathy resemble metformin-induced neuropathy will add to the confusion. Thus, annual injections of vit B12 (in a dose of 1 mg) given to every patient on long-term metformin therapy will be a more practical and cost-effective method.
What vitamins can diabetics take?
What are the best vitamins for people with diabetes?Thiamin (b1) Those with type 1 or type 2 diabetes are more likely to have lower blood levels of thiamin and usually suffer a higher risk of thiamin deficiency than people who don't have diabetes. ... Vitamin B12. ... Vitamin D. ... Magnesium. ... Vitamin E. ... Vitamin C.Apr 8, 2021
Is vitamin B12 good for diabetic neuropathy?
It's unclear whether taking vitamin B-12 supplements can help treat diabetic neuropathy. Some small studies have shown a lessening of pain and other abnormal sensations. However, for people who don't have a vitamin B-12 deficiency, taking B-12 supplements for diabetic neuropathy hasn't been shown to help.
Why is vitamin B12 important for diabetics?
Vitamin B12 replacement has been shown to cause symptomatic improvement among patients with severe diabetic neuropathy. One meta-analysis showed that if used either alone or in combination with vitamin B complex, there was a significant improvement in the somatic symptoms like pain and paraesthesias.May 7, 2013
Is 5000 mcg of vitamin B12 too much to take?
Is 5000 mcg of B12 too much? A dosage of 5000 mcg of Vitamin B12 has been deemed a safe dosing amount. In fact, it is often recommended for those who have a health condition that affects their B12 absorption. Consultation with a qualified health professional is always recommended.
How much B12 should I take with metformin daily?
All individuals age 14 or higher need 2.4 mcg B12 daily. Women who are pregnant or nursing will need slightly more. Mandatory supplementation with B12 has now been proposed for those taking metformin. Taking a daily multivitamin containing 100% of the daily value (DV) for vitamin B12 will do the trick.
Is it OK to take 1000 mcg of B12 a day?
The recommended dose for treating vitamin B12 deficiency is 1000 mcg daily. The recommended dose for preventing vitamin B12 deficiency is 1500 mg or 2500 mcg (sublingual tablets) daily. The dose for treating hyperhomocysteinemia is 400 mg daily in combination with folic acid.
What is the role of vitamin B12 in the conversion of methylmalonyl coenzyme A to
In another essential enzymatic pathway, vitamin B12 as a co-factor mediates the conversion of methylmalonyl coenzyme A (CoA) to succinyl-CoA.
What is the role of vitamin B12 in the salivary gland?
After the release, dietary vitamin B12 binds to the R-protein secreted by the salivary glands. In the duodenum, in the presence of an alkaline medium and pancreatic proteases, the R- protein is hydrolysed to release vitamin B12 which later binds with the intrinsic factor (IF) secreted by the gastric parietal cells.
What is the role of B12 in DNA synthesis?
Vitamin B12 or cobalamin is a water soluble vitamin that plays a very fundamental role in DNA synthesis, optimal haemopoesis and neurological function. The clinical picture of vitamin B12 deficiency hence, is predominantly of features of haematological and neuro-cognitive dysfunction [1].
What is the importance of vitamin B12?
Vitamin B12 is an essential micronutrient required for optimal hemopoetic, neuro-cognitive and cardiovascular function. Biochemical and clinical vitamin B12 deficiency has been demonstrated to be highly prevalent among patients with type 1 and type 2 diabetes mellitus.
What is type 1 diabetes?
Type 1 DM (T1DM) is an auto immune condition that results from auto immune destruction of insulin secreting beta cells of the pancreas. It is invariably associated with other organ and non organ specific auto immune and endocrine conditions leading to development of autoimmune polyglandular syndromes [30].
How much vitamin B12 should a diabetic take?
In the US, it is currently believed that adults with type 2 diabetes that are over 50 should take 2.4 µg of synthetic vitamin B12 daily either in supplement form or in fortified food.
Does B12 help with diabetes?
Worsening of diabetic neuropathy is also noted among patients with co-existing vitamin B12 deficiency [49]. Vitamin B12 replacement has been shown to cause symptomatic improvement among patients with severe diabetic neuropathy.
Can you take B12 with metformin?
No interactions were found between metformin and Vitamin B12. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
How much B12 should a diabetic on metformin take?
The fact that the symptoms of diabetic neuropathy resemble metformin-induced neuropathy will add to the confusion. Thus, annual injections of vit B 12 ( in a dose of 1 mg ) given to every patient on long-term metformin therapy will be a more practical and cost-effective method.
Is it OK to take 1000 mcg of B12 a day?
The recommended dose for treating vitamin B12 deficiency is 1000 mcg daily. The recommended dose for preventing vitamin B12 deficiency is 1500 mg or 2500 mcg (sublingual tablets) daily. The dose for treating hyperhomocysteinemia is 400 mg daily in combination with folic acid.
Can Vitamin B12 affect blood pressure?
We found that a higher intake of vitamin B12 was associated with lower systolic and diastolic blood pressure and a higher intake of folic acid was associated with lower systolic blood pressure in children.
How often should I take vitamin B12?
ADULTS: BY MOUTH: The typical general supplemental dose of vitamin B12 is 1-25 mcg per day: The recommended dietary allowances (RDAs) of vitamin B12 are: 1.8 mcg; older children and adults, 2.4 mcg; pregnant women, 2.6 mcg; and breast-feeding women, 2.8 mcg.
Why is Vitamin B12 important?
Vitamin B12 s critical to ensure that your blood reaches even the smallest capillaries. A deficiency of Vitamin B12 can lead to tingling or numbness in your hands and legs, memory loss, mood swings, etc. Diabetic retinopathy or damage caused to eyes by diabetes is the other big diabetic complication that can be addressed by Vitamin B12.
How many people are deficient in B12?
A study found that as many as 22% of diabetics are deficient in vitamin B12. Another study that tracked 785 women after delivery found that low vitamin B12 levels during pregnancy contributed to their risk of gestational diabetes and later full blown diabetes.
What are the symptoms of vitamin B12 deficiency?
A severe health complication of vitamin B12 deficiency is pernicious anemia, the inability of the body to produce healthy red cells. Without sufficient red cells, the body does not get enough oxygen ...
What is the B complex?
Vitamin B Complex is a combination of eight B vitamins – B1, B2, B3, B5, B6, B7, B9 and B12. The B family of vitamins plays a variety of critical roles in our body, including converting the food we eat into energy. Health researchers and experts have found a deep connection, especially between Vitamin b12 and diabetes.
What is the best vitamin for diabetics?
Vitamin B9 or Folate (along with B12) Helps to reduce the arterial irritant homocysteine that can cause nerve damage in diabetics. It also helps prevent diabetes-induced blindness and leg pains from hardening of veins.
What foods contain B vitamins?
However, we’ve picked some of the foods that have a high balance of all the Vitamins B. Beef, beef liver, oats, tuna, turkey breast, eggs, bananas (green only, for diabetics), avocado, kidney beans, summer squash, ...
Does vitamin B12 cause diabetes?
Health researchers and experts have found a deep connection, especially between Vitamin b12 and diabetes. In addition to this, research has shown that several drugs commonly prescribed by doctors to diabetics begin to cause depletion of the Vitamin B family from the human body. This process is called ‘drug induced nutrient depletion’ ...
How to get B12?
Vitamin B12 is necessary for a healthy nervous system and healthy blood cells. The best way to get vitamin B12 is through your diet. This important vitamin is found in meat, fish, poultry, and dairy products. If you don’t eat enough of these foods, it could leave you with a deficiency. Consuming enough vitamin B12 isn’t the only problem. Your body also needs to be able to absorb it efficiently. Some medications like Pepcid AC, Prevacid, Prilosec, and Zantac, as well as others used to treat acid reflux, peptic ulcer disease, and infection, may make it harder for your body to absorb B12. Another medication that may interfere with B12 absorption is metformin, a common type 2 diabetes treatment. Simply having diabetes may make you more prone to B12 deficiency. A 2009 study found that 22 percent of people with type 2 diabetes were low in B12. Read on to learn the symptoms of B12 deficiency, what it could mean for your overall health, and what you can do about it. Symptoms of vitamin B12 deficiency may be mild at first, and not always obvious. If you’re slightly low on B12, you may not have any symptoms at all. Some of the more common early symptoms are: tiredness weakness loss of appetite weight loss constipation It may be easy to dismiss these as minor complaints, but over time, insufficient B12 can lead to bigger problems. Very low levels of B12 can result in serious complications. One of these is called pernicious anemia. Anemia means you don’t have enough healthy red blood cells. This deprives your cells of much-needed oxygen. According to a study in the Journal of Oral Pathology Medicine, less than 20 percent of those with a B12 deficiency experience pernicious anemia. Symptoms of anemia include: fatigue pale skin chest pain dizziness headache You may even lose Continue reading >>
What is the role of vitamin B12 in the body?
Go to: Introduction Vitamin B12 or cobalamin is a water soluble vitamin that plays a very fundamental role in DNA synthesis, optimal haemopoesis and neurological function. The clinical picture of vitamin B12 deficiency hence, is predominantly of features of haematological and neuro-cognitive dysfunction [1]. This review will mainly discuss the physiological roles of vitamin B12, the varied pathophysiological mechanisms of vitamin B12 deficiency among patients with type 1 and 2 diabetes mellitus (DM) and perspectives on screening for vitamin B12 deficiency and supplementation of vitamin B12 among diabetic patients. Absorption of vitamin B12 The principal source of vitamin B12 is animal proteins. The preliminary step in the metabolism of vitamin B12 involves its release from animal sources, a process mediated by the action of pepsin and gastric acid. After the release, dietary vitamin B12 binds to the R-protein secreted by the salivary glands. In the duodenum, in the presence of an alkaline medium and pancreatic proteases, the R- protein is hydrolysed to release vitamin B12 which later binds with the intrinsic factor (IF) secreted by the gastric parietal cells. The vitamin B12 –IF complex is highly resistant to proteolytic degradation. The complex attaches at its specific receptors on the mucosa of the terminal ileum, a site where its absorption occurs. This stage of vitamin B12 absorption is calcium mediated. The intracellular vitamin B12 is released following IF degradation. This free vitamin B12 attaches to another protein carrier, transcobalamin –II (TC-II) and is later released into the circulation. This vitamin B12 – TC-II complex, also referred to as holo TC-II is then actively taken up by the liver, bone marrow and other vital body cells. The liver serves as Continue reading >>
Can vitamin B12 cause neuropathy?
Vitamin B12 deficiency linked to heart condition in people with type 2 diabetes Vitamin B12 deficiency linked to heart condition in people with type 2 diabetes Psoriasis patients have similar risk of heart disease to those with type 2 diabetes, says study 01 September 2016 Adults with type 2 diabetes and low levels of vitamin B12 could be more likely to experience cardiovascular autonomic neuropathy ( CAN), according to new findings. CAN occurs when nerve damage affects the heart , which can be caused by prolonged hyperglycemia over several years in people with diabetes . The Steno Diabetes Centre in Denmark sought to investigate the association of vitamin B12 deficiency and CAN in type 2 diabetes patients, so they analysed data from 469 patents, all of whom were screened for CAN between June 2013 and December 2014. Participants also provided blood samples for serum vitamin B12 measurements, with researchers analysing associations between deficiency and measures of neuropathy . Those who were treated with metformin and/or proton pump inhibitors (PPIs) were more likely to have significantly lower levels of vitamin B12 compared to participants who were not on treatment . Additionally, vitamin B12 levels were linked to a lower diagnosis rate of CAN in models adjusted for sex, age, alcohol consumption and diabetes duration. The scientists also noted that a 25 pmol/L higher level of vitamin B12 was associated with a 21 per cent increase in the cardiovascular autonomic reflex test for deep breathing and a decrease in five-minute resting heart rate. These findings remained after excluding patients that had received B12 supplements and following adjustment for confounding factors such as HbA1c , total cholesterol, smoking status and triglyceride levels. "The present study prese Continue reading >>
Should diabetics take B12?
Research claims that diabetics should take more vitamin B12 daily A new study has argued that people who have developed type 2 diabetes and are taking the oral drug metformin to treat it should take more than the recommended daily allowance of vitamin B12 . The research, which was published in Diabetes Care, assessed data from the National Health and Nutritional Examination Survey (NHANES) in the United States between 1999 and 2006. The NHANES data showed that the prevalence of biochemical B12 deficiency was greatest for people with type 2 diabetes taking metformin compared with those with type 2 diabetes but not taking metformin and those without diabetes. Biochemical B12 deficiency was revealed in 5.8 per cent of patients with diabetes that took metformin as compared to 2.4 per cent of those who did not take metformin and 3.3 per cent of people that did not have diabetes. In the US, it is currently believed that adults with type 2 diabetes that are over 50 should take 2.4 g of synthetic vitamin B12 daily either in supplement form or in fortified food. Researcher Godfrey Oakley commented "It is important to conduct further research to learn how much B12 is needed to correct the deficiency and to determine whether or not raising serum B12 levels improves the clinical picture for persons taking metformin who have low serum B12 concentrations." Continue reading >>
Why do you need a blood test for B12?
Since diabetes puts you at risk for a deficiency of vitamin B12, you also need regular blood tests to monitor your B12 blood level. If you are deficient, your doctor might recommend certain steps to increase your B12 levels because maintenance of proper B12 levels is vital to your health.
What is the role of B12 in the body?
Vitamin B12 is important for the proper functioning of nerve cells and blood cells. It also plays an integral part in the synthesis of DNA and promotes the ability of your digestive system to maintain steady glucose blood levels.
What to do if you have a vitamin B12 deficiency?
Correcting B12 Deficiency. If you have diabetes and develop a vitamin B12 deficiency, your doctor might recommend an oral B12 supplement. If that is not effective because of a medical condition or because of a medication you are taking, your doctor could administer a B12 injection.
How does B12 affect the body?
Vitamin B12 taken orally must form a complex with a stomach protein called intrinsic factor before it can enter the bloodstream, where it exerts its beneficial biological effects. The B12-intrinsic factor complex enters the bloodstream from the small intestine. If you have type 1 diabetes, you may have a B12 deficiency called pernicious anemia, because your immune system attacks the intrinsic factor protein. If you have type 2 diabetes and are taking metformin, the most widely prescribed type 2 drug, you may experience B12 deficiency at some point. This is because metformin interferes with the absorption of the B12-intrinsic factor complex from the small intestine.
What is the hallmark symptom of diabetes?
By Robert DiPardo Updated December 09, 2018. The hallmark symptom of diabetes is chronically high glucose levels in the blood. If you have diabetes, you must control and constantly monitor your glucose levels.
What happens if you are deficient in B12?
Effects of Deficiency. If you are deficient in vitamin B12, you may experience fatigue, weakness, constipation, loss of weight, loss of appetite or megaloblastic anemia, a condition characterized by enlarged red blood cells. You also might incur nerve damage that shows as numbness or tingling in your hands and feet.
Can B12 deficiency cause numbness?
You also might incur nerve damage that shows as numbness or tingling in your hands and feet. This damage may become permanent if you don't address the B12 deficiency. Other deficiency symptoms include memory lapses, depression, confusion, difficulty balancing and a sore mouth or tongue.
