How much detomidine is in a dormosedan IV?
How long should a horse be sedated before administering Dormosedan?
How much detomidine is safe for horses?
Is Dormosedan a sedative?
Is Dormosedan a narcotic?
Does detomidine affect heart rate?
Can detomidine be used in horses?
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Can injectable Dormosedan be given orally?
HUMAN SAFETY INFORMATION: Care should be taken to assure that detomidine hydrochloride is not inadvertently ingested as safety studies have indicated that the drug is well absorbed when administered orally.
How do you administer Dormosedan?
DOSAGE AND ADMINISTRATION DORMOSEDAN GEL produces sedation when administered sublingually at 0.018 mg/lb (0.040 mg/kg). DORMOSEDAN GEL must be placed beneath the tongue of the horse and is not meant to be swallowed. The dosing syringe delivers the product in 0.25 mL increments.
Can horses eat on DORMOSEDAN GEL?
The gel is perfectly fine to use on any healthy horse or pony as long as they are not running a fever. You should not use Dormosedan Gel on any horse with cardiovascular disease, severe debilitation, liver or kidney disease, stress from extreme heat, cold, or in high altitude. Can the gel cause harm to humans?
How do you sedate a horse orally?
The 2 options for oral sedatives are ACP (Oralject Sedazine) or Dormosedan Gel (Detomidine Hcl). ACP is fairly mild and it has a ceiling of effect (4- 10ml/ 450kg bodyweight). This means that if 10ml doesn't work, 20ml won't do any more but you will get more side effects.
What happens if a horse swallows DORMOSEDAN GEL?
Dormosedan Gel must be placed beneath the tongue of the horse. Unlike most oral veterinary products, this product is not meant to be swallowed. Swallowing could result in ineffectiveness.
How much Dormosedan do you give a horse?
Donecker reports that the full label dosage for Dormosedan – critical for achieving optimum levels of sedation and analgesia – is 20 to 40 micro- grams per kilogram of body weight; or 1 to 2 ml IV or IM to a 1,100 lb. horse.
Can a horse eat after dorm gel?
For the best results, allow adequate time (a minimum of 40 minutes) between administration of DORMOSEDAN GEL and beginning the procedure. In general, horses show sedative effects lasting approximately 90-180 minutes. Withhold food and water until the sedative effects of the product wear off.
What happens if a horse eats while sedated?
A stall is the safest place for a sedated horse to recover. But eating while sedated can lead to choke, so remove all hay and grain. Also take out any hanging hay nets and any feed tubs set on the floor that the horse might trip over. A sedated horse can safely drink, so it's fine to leave water buckets in place.
How long after dorm gel can horses eat?
It may take up to 3–4 hours for the horse to recover from sedation. Withhold food and water until the horse has recovered.
How long does it take for Dormosedan to work?
For best results, allow adequate time (a minimum of 40 minutes) between the administration of DORMOSEDAN GEL and beginning the procedure. In general, horses show sedative effects lasting approximately 90 to 180 minutes.
What do farriers use to sedate horses?
Xylazine is a common equine sedative. It can be given iv, im or (less commonly) sq and acts on alpha 2 receptors. It also provides analgesia and is synergistic with opioids for both sedation and analgesia. Doses range from 100-200 mg iv (1-2cc of 100mg/ml) for most horses.
What is the best horse sedative?
Probably the most famous is Acepromazine or “Ace”. Acepromazine is a phenothiazine derivative antipsychotic drug. It was first used in humans in the 1950's. Acepromazine is frequently used in horses as a sedative.
How long does it take Dormosedan to work?
For best results, allow adequate time (a minimum of 40 minutes) between the administration of DORMOSEDAN GEL and beginning the procedure. In general, horses show sedative effects lasting approximately 90 to 180 minutes.
How do you give a horse a sedative?
For those who haven't seen it before, a sedated horse doesn't lie down, but their head gets lower and lower, and they may require something to lean on to help them balance....There are three routes by which we normally give sedation: By syringe or in feed. ... By injection into the muscle. ... By intravenous injection.
How long does it take for Domosedan to wear off?
In general, horses show sedative effects lasting approximately 90-180 minutes. Withhold food and water until the sedative effects of the product wear off. CONTRAINDICATIONS: DORMOSEDAN GEL is contraindicated in horses with known hypersensitivity to detomidine.
How do you wake up a sedated horse?
0:213:51How do you wake up a horse safely? - YouTubeYouTubeStart of suggested clipEnd of suggested clipAnd then we give a dose of a couple of different drugs call induction drugs which are given fairlyMoreAnd then we give a dose of a couple of different drugs call induction drugs which are given fairly rapidly intravenously the horse is then not rendered unconscious and slumps to the ground.
Dormosedan Gel - Better Sedation for Horses - EquiMed
Flossie Sellers - 06/08/2013 Products. Dormosedan Gel - Better Sedation for Horses. Newsdate: Wed, 21 Jul 2010 - 01:01 pm Location: NEW YORK, New York Some horses require sedating for clipping, dental treatment or shoeing, but calling a veterinarian each time is rather costly.
Dormosedan Gel 3ml - Dog.com
Dormosedan Gel 3ml . For Sedation: Administer Dormosedan ® IV or IM at the rates of 20 or 40 mcg detomidine hydrochloride per kg of body weight (0.2 or 0.4 mL of Dormosedan ® per 100 kg or 220 lb), depending on the depth and duration of sedation required. Onset of sedative effects should be reached within 2-4 minutes after IV administration and 3-5 minutes after IM administration.
#29 – Fear Aggressive Dogs in the Veterinary Clinic
Make it Simple & Easy for Everybody. Dormosedan: Owner-administered oral transmucosal (OTM) sedation. There are a few dogs who will bite anybody, including their owners.
Accidental human poisoning with a veterinary tranquilliser
Detomidine is an alpha-2 adrenoceptor agonist drug, which is used in veterinary medicine for sedation of large animals.1–4 It is highly potent and has sedative and analgesic properties.1,2 This paper reports a case of accidental human poisoning with this drug. A 35 year old farmer was preparing to sedate a bull in order to pare its hooves. No vet was present. The farmer had 5 ml of Domosedan ...
What is a dormosedon?
DORMOSEDAN ® is indicated for use as a sedative and analgesic to facilitate minor surgical and diagnostic procedures in mature horses and yearlings. It has been used successfully for the following: to calm fractious horses; to provide relief from abdominal pain; and to facilitate bronchoscopy, bronchoalveolar lavage, nasogastric intubation, nonreproductive rectal palpations, suturing of skin lacerations, and castrations. Additionally, an approved local infiltration anesthetic is indicated for castration.
Who owns Dormosedan?
DORMOSEDAN is trademark owned by Orion Corporation Orion Pharma Animal Health.
What is the best sedative for horses?
With 30 years of use, DORMOSEDAN ® Sterile Solution ( detomidine hydrochloride) provides veterinarians with safe and reliable sedation and analgesia 1 that is rated highest of all equine sedatives for efficacy, safety and reliability. 1,2
Can you use sulfonamide in horses?
Intra venous potentiated sulfonamides should not be used in anesthetized or sedated horses. Careful consideration should be given to horses approaching or in endotoxic or traumatic shock, to horses with advanced liver or kidney disease, or to horses under stress from extreme heat, cold, fatigue, or high altitude.
Is Dormosedan a narcotic?
DORMOSEDAN ® is a synthetic alpha 2 adrenoceptor agonist with sedative and analgesic properties. DORMOSEDAN is a non-narcotic sedative and analgesic that can be used in horses for a variety of minor surgical and diagnostic procedures. The greater a 2 selectivity of DORMOSEDAN allows it to bind specifically to a 2 adrenoceptors to produce predictable, reliable and effective sedation and analgesia.
How successful is Dormosedan gel?
The following success rates with DORMOSEDAN GEL were recorded for electric clipping of hair (48%), cleaning the prepuce (81%), manual floating of teeth (89%), hoof trimming or shoeing (86%), passage of a nasogastric tube or endoscope (80%), or radiography (74%). At 40 minutes post dosing, 94% of DORMOSEDAN GEL-treated horses showed minimal, moderate or marked sedation compared with 14% of the horses treated with placebo. All DORMOSEDAN GEL-treated horses had recovered from sedation by 240 minutes post treatment.
How many horses were sedated with DORMOSEDAN gel?
In a US field study of 270 horses sedated to facilitate completion of various veterinary and husbandry procedures, the following adverse reactions were reported in 202 horses treated with DORMOSEDAN GEL and 68 horses treated with placebo:
What is the first pass effect of detomidine?
First pass effect results in a very small portion of drug reaching the systemic circulation if it is swallowed. Sedation achieved with the DORMOSEDAN GEL is attributable to sublingual drug absorption. Peak concentrations occur approximately 1.83 hours after sublingual administration of DORMOSEDAN GEL. The peak concentrations observed after administration of DORMOSEDAN GEL are approximately 40% of those observed after intramuscular injection of detomidine solution. The absolute bioavailability of detomidine in DORMOSEDAN GEL is 22%.
What is a doromosedon gel?
DORMOSEDAN GEL is indicated for sedation and restraint in horses.
How long does it take to get a dormosedone out of a horse's mouth?
Remove gloves for disposal. For the best results, allow adequate time (a minimum of 40 minutes) between administration of DORMOSEDAN GEL and beginning the procedure.
Why not use with other sedatives?
Do not use with other sedative drugs because the effects may be additive.
Can you use Dormosedan gel on your face?
DORMOSEDAN GEL can be absorbed following direct exposure to skin, eyes, or mouth, and may cause irritation. Skin and mucosal contact with the product should be avoided. Use impermeable gloves at all times.
What is Dormosedan used for?
Dormosedan® is indicated for use as a sedative and analgesic to facilitate minor surgical and diagnostic procedures in mature horses and yearlings. It has been used successfully for the following: to calm fractious horses, to provide relief from abdominal pain, to facilitate bronchoscopy, bronchoalveolar lavage, nasogastric intubation, nonreproductive rectal palpations, suturing of skin lacerations, and castrations. Additionally, an approved, local infiltration anesthetic is indicated for castration.
How much detomidine is in a dormosedan IV?
Administer Dormosedan® IV or IM at the rates of 20 or 40 mcg detomidine hydrochloride per kg of body weight (0.2 or 0.4 mL of Dormosedan® per 100 kg or 220 lb), depending on the depth and duration of sedation required. Onset of sedative effects should be reached within 2–4 minutes after IV administration and 3–5 minutes after IM administration. Twenty mcg/kg will provide 30–90 minutes of sedation and 40 mcg/kg will provide approximately 90 minutes to 2 hours of sedation.
How much detomidine is safe for horses?
In safety studies in horses, detomidine hydrochloride at 400 mcg/kg of body weight administered daily for 3 consecutive days produced microscopic foci of myocardial necrosis in 1 of 8 horses.
How long does it take for a sedative to work after IV?
Onset of sedative effects should be reached within 2–4 minutes after IV administration and 3–5 minutes after IM administration. Twenty mcg/kg will provide 30–90 minutes of sedation and 40 mcg/kg will provide approximately 90 minutes to 2 hours of sedation.
How long should a horse be sedated before a dormosedan?
Allowing the horse to stand quietly for 5 minutes before administration and for 10–15 minutes after injection may improve the response to Dormosedan®.
Does detomidine affect heart rate?
Sensitivity to touch is little affected and in some cases may actually be enhanced. With detomidine administration, heart rate is markedly decreased, blood pressure is initially elevated, and then a steady decline to normal is seen.
Can detomidine be used in horses?
Information on the possible effects of detomidine hydrochloride in breeding horses is limited to uncontrolled clinical reports ; therefore, this drug is not recommended for use in breeding animals.
How much detomidine is in a dormosedan IV?
For Sedation: Administer Dormosedan ® IV or IM at the rates of 20 or 40 mcg detomidine hydrochloride per kg of body weight (0.2 or 0.4 mL of Dormosedan ® per 100 kg or 220 lb), depending on the depth and duration of sedation required. Onset of sedative effects should be reached within 2-4 minutes after IV administration and 3-5 minutes after IM administration. Twenty mcg/kg will provide 30-90 minutes of sedation and 40 mcg/kg will provide approximately 90 minutes to 2 hours of sedation.
How long should a horse be sedated before administering Dormosedan?
Routine safety measures should be employed to protect practitioners and handlers. Allowing the horse to stand quietly for 5 minutes before administration and for 10-15 minutes after injection may improve the response to Dormosedan ® .
How much detomidine is safe for horses?
In safety studies in horses, detomidine hydrochloride at 400 mcg/kg of body weight administered daily for 3 consecutive days produced microscopic foci of myocardial necrosis in 1 of 8 horses.
Is Dormosedan a sedative?
Dormosedan ® is indicated for use as a sedative and analgesic to facilitate minor surgical and diagnostic procedures in mature horses and yearlings. It has been used successfully for the following: to calm fractious horses, to provide relief from abdominal pain, to facilitate bronchoscopy, bronchoalveolar lavage, nasogastric intubation, nonreproductive rectal palpations, suturing of skin lacerations, and castrations. Additionally, an approved, local infiltration anesthetic is indicated for castration.
Is Dormosedan a narcotic?
Dormosedan ®, a non-narcotic sedative and analgesic, is a potent α 2 -adrenoreceptor agonist which produces sedation and superficial and visceral analgesia which is dose dependent in its depth and duration.
Does detomidine affect heart rate?
Sensitivity to touch is little affected and in some cases may actually be enhanced. With detomidine administration, heart rate is markedly decreased, blood pressure is initially elevated, and then a steady decline to normal is seen.
Can detomidine be used in horses?
Information on the possible effects of detomidine hydrochloride in breeding horses is limited to uncontrolled clinical reports; therefore, this drug is not recommended for use in breeding animals. WARNINGS: Do not use in horses intended for human consumption. Not for human use. Keep out of reach of children.
Contraindications
Warnings
- For sublingual use in horses only. Do not use in horses intended for human consumption. HUMAN WARNINGS: Not for human use. Keep out of the reach of children. Use impermeable gloves during drug administration and during procedures that require contact with the horse’s mouth.Following sublingual administration of detomidine oromucosal gel, drug concentrations up to 0.072 mg/m…
Precautions
- DORMOSEDAN GEL must be placed beneath the tongue of the horse. Unlike most oral veterinary products, this product is not meant to be swallowed. Swallowing could result in ineffectiveness. DORMOSEDAN GEL does not provide analgesia. Do not use for painful procedures. Do not use with other sedative drugs because the effects may be additive. Repeat dos...
Adverse Reactions
- Clinical field study: In a US field study of 270 horses sedated to facilitate completion of various veterinary and husbandry procedures, the following adverse reactions were reported in 202 horses treated with DORMOSEDAN GEL and 68 horses treated with placebo: Table 2: Adverse reactions (number of horses) during the clinical field study In a laboratory study, transient erythema of the …
Clinical Pharmacology
- Detomidine is a potent non-narcotic alpha2-adrenoceptor agonist which produces sedation with a central effect inhibiting the transmission of noradrenalin-mediated nervous impulses. Blood pressure is initially increased due to peripheral vasoconstriction, subsequently dropping to normal or slightly below normal levels. Vasoconstriction may cause mucous membranes to appear pal…
Effectiveness
- A prospective, randomized, masked, multi-center study was conducted to evaluate under field conditions, whether DORMOSEDAN GEL provided sufficient sedation and restraint in horses to successfully conduct procedures requiring administration of a sedative. Two hundred and seventy client-owned horses of any breed or sex were sedated to facilitate grooming (including cleaning …
How Supplied
- 3.0 mL graduated oral dosing syringe, 7.6 mg/mL detomidine hydrochloride. DORMOSEDAN®is a trademark of Orion Corporation. Approved by FDA under NADA # 141-306 Mfd by: ORION PHARMA,Orion Corporation, Turku, Finland Distributed by: Zoetis Inc., Kalamazoo, MI 49007 Revised: March 2022 128717-3 CPN:3690256.3