Protonix or any drug of it's type (PPI's) reduces the effectiveness of Plavix. There are a lot of drugs that interact negatively with Plavix, but a lot of interactions are minor.
Will you have alcohol interaction with Plavix?
Talk with your doc: There is not an "interaction" between alcohol and plavix (clopidogrel). Moderation may be prudent. Drinking enough to fall down and strike your head c...
Does Plavix interact with other medications?
Plavix can interact negatively with several prescription and over-the-counter medications, chiefly blood thinners. Before going on Plavix, be sure to inform your doctor if you are taking any other medication that may thin the blood or prevent clotting.
What are the side affects of Protonix?
What are the long term side effects of Protonix?
- headache, dizziness;
- stomach pain, gas, nausea, vomiting, diarrhea;
- joint pain; or.
- fever, rash, or cold symptoms (most common in children).
Does omeprazole interfere with Plavix?
While all of them carry this warning, the interaction with Plavix is worse with some PPIs than others. Omeprazole (Prilosec) and esomeprazole (Nexium) block more CYP2C19 than others in this medication class, meaning they would be the most likely to stop Plavix from working.
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Can you take pantoprazole and Plavix at the same time?
clopidogrel pantoprazole Combining these medications may reduce the effectiveness of clopidogrel in preventing heart attack or stroke. The interaction is most likely to occur if you are using a higher dosage of pantoprazole than recommended or if you are using it too frequently.
Does Protonix interfere with blood thinners?
Results of a study presented Monday at the American Heart Association's annual meeting in Orlando, Fla., also found that people taking the acid reflux drugs Prilosec or Protonix in combination with blood thinners such as Plavix had a higher risk for death after angioplasty than people who didn't take the two popular ...
What acid reflux medicine is safe with Plavix?
The FDA advises that if you are experiencing heartburn or acid reflux while taking Plavix, you should try using antacids ( Maalox, Mylanta, Rolaids, Tums and generics) and most H2 blockers such as famotidine (Pepcid), nizatidine (Axid) and ranitidine (Zantac), but not cimetidine (Tagamet, Tagamet HB, and generics).
Which PPI to avoid with Plavix?
FDA is recommending that the co-administration of clopidogrel (Plavix), a drug used to prevent blood clot formation, and omeprazole (Prilosec/Prilosec OTC), a proton pump inhibitor (PPI) used to reduce stomach acid, be avoided because omeprazole reduces the effectiveness of clopidogrel.
What meds Cannot be taken with Plavix?
These drugs are:Tagamet (generic name: cimetidine)Prozac, Sarafem, and Symbyax (generic name: fluoxetine)Luvox (generic name: fluvoxamine)Ticlid (generic name: ticlopidine)Diflucan (generic name: fluconazole)Nizoral (generic name: ketoconazole)VFEND (generic name: voriconazole)More items...•
What meds should not be taken with Protonix?
Pantoprazole decreases stomach acid, so it may change how well these products work. Some affected products include ampicillin, atazanavir, erlotinib, levoketoconazole, nelfinavir, pazopanib, rilpivirine, certain azole antifungals (itraconazole, ketoconazole, posaconazole), among others.
Does Plavix give you acid reflux?
Since blood thinners like Plavix can cause stomach problems including heartburn and ulcers, doctors also used to regularly give patients heartburn drugs.
Does Plavix cause stomach problems?
Stomach pain is not a common side effect of Plavix. However, if you have stomach pain or cramping while taking this drug, there's a small chance you could have bleeding in your stomach. (Serious bleeding is a possible side effect of Plavix.
What can I take for heartburn while on blood thinners?
Antacids, like Maalox, Mylanta, or Tums help neutralize stomach acid. H2 blockers, like Pepcid AC, Tagamet, and Zantac, reduce stomach acid production.
Should you take a PPI with clopidogrel?
Previous advice regarding an interaction In May 2009, the EU Committee for Medicinal products for Human Use (CHMP) concluded that concomitant use of any PPIs with clopidogrel should be avoided unless considered essential.
Do you need stomach protection with clopidogrel?
Is it safe to take it for a long time? Clopidogrel is generally safe to take for a long time. In fact, it works best if you take it for many months or even years. If you're at risk of getting a stomach ulcer, your doctor may prescribe a medicine to help protect your stomach while you're taking clopidogrel.
Can I take omeprazole and Plavix together?
Healthcare professionals are advised to avoid the concomitant use of clopidogrel with omeprazole and other CYP2C19 inhibitors e.g. esomeprazole, cimetidine, fluconazole, ketoconazole, viriconazole, etravirine, fluoxetine, and fluvoxamine.
Does Protonix interact with eliquis?
No interactions were found between Eliquis and pantoprazole.
Does Protonix interact with warfarin?
Increased INR and prothrombin time in patients receiving PPIs, including pantoprazole, and warfarin concomitantly. Increases in INR and prothrombin time may lead to abnormal bleeding and even death.
Can Protonix be taken with other meds?
Protonix is a prescription medicine used to treat the symptoms of esophagitis caused by stomach acid due to gastroesophageal reflux disease or GERD and Zollinger-Ellison syndrome or other conditions causing excess stomach acid. Protonix may be used alone or with other medications.
Does pantoprazole affect absorption of other medications?
May interact with some other medications including methotrexate, rilpivirine, and other antisecretory agents. Pantoprazole can also reduce the absorption of drugs that are dependent on a certain gastric pH for their absorption.
What can I take instead of a PPI?
If you are taking a PPI along with Plavix to prevent stomach bleeding , it’s best to discuss alternatives with your provider. PPIs are more effective than other types of medications at protecting your stomach.
Do all PPIs interact with Plavix?
There are six PPIs currently available in the U.S. While all of them carry this warning, the interaction with Plavix is worse with some PPIs than others. Omeprazole (Prilosec) and esomeprazole (Nexium) block more CYP2C19 than others in this medication class, meaning they would be the most likely to stop Plavix from working.
Do pharmacists cross index medications?
Hopefully, the patient is getting all their medications filled at the same pharmacy and they do cross index medications that a patient is taking. They have a record of all prescriptions filled by them for the patient. Doctors do make mistakes and it's the pharmacist job to catch it, they are more knowledgable when it comes to drug interactions! As for supplements, yes....
Does clopidogrel have an interaction with placebo?
Proper subgroup analyses from randomized trials, including CREDO, TRITON, PRINCIPLE, and preliminarily from PLATO and CURRENT, all indicate that no interaction exists... And then a preliminary analysis of data from the COGENT trial, a trial dedicated to specifically examining clopidogrel with a PPI vs placebo, fails to suggest even the slightest signal of a negative interaction. For the FDA to then strengthen the warning of a interaction is baffling, to say the least.
Does Zantac interfere with Plavix?
The FDA says there's no evidence that the acid reducers Zantac, Pepcid, or Axid interfere with Plavix.
Can you take Plavix with Nexium?
Nov. 17, 2009 - The FDA today warned patients not to combine Plavix with Nexium, Prilosec, and nine other drugs -- including Prozac and Tagamet. The drugs may make the anti-clotting drug Plavix dangerously less effective, the FDA says. They block an enzyme in the body that turns the drug into its active form.
Can you stop Plavix without a doctor?
Intelence (generic name: etravirine) Felbatol (generic name: felbamate) Patients taking Plavix should not stop taking any of these drugs -- including Nexium and Prilosec -- until speaking with a doctor. It's dangerous to stop taking any medication without medical advice. Patients taking Plavix should call their doctor as soon as possible ...
Does prilosec help with Plavix?
It's not the first time questions have been raised about the potent stomach -acid-reducing drug Prilosec blunting the benefit of Plavix. But data from more recent studies suggested that Prilosec -- and a similar drug called Nexium -- might actually help patients on Plavix.
Does Plavix cover Tagamet?
Patients taking Plavix should call their doctor as soon as possible to discuss all the other drugs and supplements they are taking, including over-the-counter medications. The FDA warning does not cover other acid-reducing drugs except for Tagamet, which inhibits CYP 2C19. The FDA is actively looking at data on other PPIs, ...
What are the interactions between Protonix and other drugs?
Other major interactions include drugs that rely on a certain stomach pH, like ampicillin.
How to take Protonix?
Although Protonix can be taken with most other medications, for optimal effect, most guidelines recommend Protonix to be taken as follows: 1 Take on an empty stomach, 30-60 minutes before meals. 2 Swallow whole. Do not chew, crush, or split the tablet.
How does Protonix work?
Protonix, like all proton pump inhibitors, works by suppressing gastric acid secretion by inhibiting the gastric (H+,K+)-ATPase enzyme pump. The antisecretory effects persist for more than 24 hours, which allows for once-daily dosing in most cases.
What is the PPI for pantoprazole?
Overview. Protonix ( pantoprazole) is a PPI (proton pump inhibitor) used to treat: Protonix, like all proton pump inhibitors, works by suppressing gastric acid secretion by inhibiting the gastric (H+,K+)-ATPase enzyme pump.
Can you take Protonix at the same time?
Therefore, it may be recommended to take Protonix at the same time as some of your other medication , which is safe in most situations.