Precautions
Skipping doses can increase your risk of infection that is resistant to medication. Imipenem and cilastatin will not treat a viral infection such as the flu or a common cold. Store unmixed medicine at room temperature, away from moisture and heat. After mixing imipenem and cilastatin, you must use it within 4 hours.
What happens if you skip a dose of imipenem?
Imipenem and cilastatin combination is used to treat infections in many different parts of the body. It is sometimes given with other antibiotics. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms:
What is im imipenem and cilastatin?
How to use Imipenem-Cilastatin Suspension For Reconstitution. This medication is given by injection into a muscle or vein, usually every 6 to 8 hours or as directed by your doctor. The dosage is based on your medical condition and response to treatment.
How do you give imipenem suspension for reconstitution?
Store unmixed medicine at room temperature, away from moisture and heat. After mixing imipenem and cilastatin, you must use it within 4 hours. You may also store mixed medicine in the refrigerator for up to 24 hours.
What is the best way to store imipenem?
How is imipenem administered?
Imipenem and cilastatin injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle). When imipenem and cilastatin is injected intravenously, it is usually infused (injected slowly) over a period of 20 minutes to 1 hour every 6 or 8 hours.
Can Primaxin IV be given IM?
PRIMAXIN I.M. is for intramuscular use only. Patients with lower respiratory tract infections, skin and skin structure infections, and gynecologic infections of mild to moderate severity may be treated with 500 mg or 750 mg administered every 12 hours depending on the severity of the infection.
How is imipenem cilastatin administered?
How to use Imipenem-Cilastatin SODIUM Vial. This medication is given by injection into a muscle or vein, usually every 6 to 8 hours or as directed by your doctor. The dosage is based on your medical condition and response to treatment.
Is imipenem given IV?
For Intravenous Injection Only The dosage recommendations for PRIMAXIN represent the quantity of imipenem to be administered. An equivalent amount of cilastatin is also present in the solution. These doses should be used for patients with creatinine clearance of greater than or equal to 90 mL/min.
What is the difference between imipenem and meropenem?
Imipenem, the first carbapenem, was first marketed in 1987; meropenem was introduced to the market in 1996. In general, imipenem is more active against Gram-positive cocci while meropenem is more active against Gram-negative bacilli. The agents display similar pharmacokinetics.
Why is cilastatin added to imipenem?
Because imipenem is rapidly inactivated by renal dehydropeptidase I (DHP-1), it is given in combination with cilastatin, a DHP-I inhibitor which increases half-life and tissue penetration of imipenem.
Who should not take imipenem?
chronic kidney disease stage 3B (moderate) chronic kidney disease stage 4 (severe) chronic kidney disease stage 5 (failure) kidney disease with likely reduction in kidney function.
What is another name for imipenem?
Primaxin (imipenem/cilastatin) dosing, indications, interactions, adverse effects, and more.
What kind of drug is imipenem?
Imipenem is a carbapenem antibiotic normally administered with cilastatin to treat a variety of infections. Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.
Does imipenem cover MRSA?
Imipenem appears to be an effective antistaphylococcal agent against both MRSA and MSSA infections.
Does imipenem cross blood brain barrier?
By using an in situ brain perfusion technique, we found that imipenem was transported through the blood-brain barrier principally via passive diffusion with a permeability-surface area product comparable to that of mannitol.
How do you mix imipenem?
Reconstitution and Dilution Reconstitute single-dose vials containing 250 mg of imipenem and 250 mg of cilastatin or single-dose vials containing 500 mg of imipenem and 500 mg of cilastatin by adding approximately 10 mL of compatible IV solution to provide a suspension and shake well.
How is PRIMAXIN given?
PRIMAXIN is to be reconstituted and further diluted (see sections 6.2, 6.3 and 6.6) prior to administration. Each dose of ≤500 mg/500 mg should be given by intravenous infusion over 20 to 30 minutes. Each dose >500 mg/500 mg should be infused over 40 to 60 minutes.
How is meropenem administered?
Meropenem is usually given by intravenous infusion over approximately 15 to 30 minutes (see section 6.2, 6.3 and 6.6). Alternatively, doses up to 1 g can be given as an intravenous bolus injection over approximately 5 minutes.
What is the dilution of imipenem cilastatin PRIMAXIN?
Reconstitution and Dilution Reconstitute single-dose vials containing 250 mg of imipenem and 250 mg of cilastatin or single-dose vials containing 500 mg of imipenem and 500 mg of cilastatin by adding approximately 10 mL of compatible IV solution to provide a suspension and shake well.
What should you assess before giving PRIMAXIN?
Before initiating therapy with PRIMAXIN, careful inquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins, other beta-lactams and other allergens. If an allergic reaction to PRIMAXIN occurs, discontinue the drug immediately.
Commonly Used Brand Name
This medication is used to treat a wide variety of bacterial infections.
May Treat: Lower respiratory infection · Skin and skin structure infection · Peritonitis · Klebsiella pneumonia · Enterobacter pneumonia and more
Brand Names: Primaxin IM · Primaxin IV
Drug Class: Carbapenem Antibiotic Combinations
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
- Tell your pharmacist & Dr if you have allergies
- Read directions carefully before start of therapy
- For intravenous injection dilute prior to use.
- Tell your pharmacist & Dr if you have allergies
- Read directions carefully before start of therapy
- For intravenous injection dilute prior to use.
- Prepare carefully as you have been shown
- Don't use if solution has particles or color change
- Success is dependent on completing therapy course
- Call DR if rash or severe diarrhea occur.
- Follow directions on best place to keep drug supply
Uses For Imipenem and Cilastatin
Before Using Imipenem and Cilastatin
Proper Use of Imipenem and Cilastatin
Precautions While Using Imipenem and Cilastatin
Imipenem and Cilastatin Side Effects
- Imipenem and cilastatin combination is used in the treatment of infections caused by bacteria. It works by killing bacteria or preventing their growth. Imipenem and cilastatin will not work for colds, flu, or other virus infections. Imipenem and cilastatin combination is used to treat infections in many different parts of the body. It is sometimes given with other antibiotics. Imipe…
Further Information
- In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For imipenem and cilastatin, the following should be considered: