Precautions
Mucomyst is usually administered as fine nebulae and the nebulizer used should be capable of providing optimal quantities of a suitable range of particle sizes. Commercially available nebulizers will produce nebulae of Mucomyst satisfactory for retention in the respiratory tract.
What is mucomyst and how is it administered?
Precautions 1 General. With the administration of Mucomyst, the patient may observe initially a slight disagreeable odor that is soon not noticeable. 2 Drug Interactions. ... 3 CARCINOGENESIS, MUTAGENESIS, IMPAIRMENT OF FERTILITY. ... 4 Pregnancy: Teratogenic Effects: Pregnancy Category B. ... 5 Nursing Mothers. ...
What are the precautions to be taken when taking mucomyst?
Reproduction studies of Mucomyst with isoproterenol have been performed in rats and of acetylcysteine alone in rabbits at doses up to 2.6 times the human dose. These have revealed no evidence of impaired fertility or harm to the fetus due to acetylcysteine. There are, however, no adequate and well-controlled studies in pregnant women.
Is mucomyst safe during pregnancy?
Can acetylcysteine be given IV?
N-acetylcysteine should be administered by intravenous infusion preferably using Glucose 5% as the infusion fluid. Sodium Chloride 0.9% solution may be used if Glucose 5% is not suitable. Doses should be administered using an appropriate infusion pump.
What is acetylcysteine IV used for?
Summary: I.V. acetylcysteine is most often used as an antidote for acetaminophen overdose due to its ability to increase levels of glutathione; however, it is also used to treat NAI-ALF and severe alcoholic hepatitis and to prevent CIN.
How is mucomyst administered?
MUCOMYST may be introduced directly into a particular segment of the bronchopulmonary tree by inserting (under local anesthesia and direct vision) a small plastic catheter into the trachea. Two to 5 mL of the 20% solution may then be instilled by means of a syringe connected to the catheter.
How do you administer acetylcysteine?
The medicine is inhaled through a face mask, mouthpiece, or tracheostomy. The 10 or 20% solution may be used for inhalation as a heavy mist in a tent or croupette. Sometimes the 10 or 20% solution is placed directly into the trachea or through a catheter into the trachea for certain conditions.
What is mucomyst the antidote for?
Mucomyst® (acetylcysteine solution, USP) As An Antidote for Acetaminophen Overdose.
Is acetylcysteine compatible with normal saline?
Additional comments: Acetylcysteine is hyperosmolar (2600 mOsm/L) and is compatible with 5% Dextrose (D5W), ½ Normal Saline (0.45% Sodium Chloride Injection, ½ NS), and Water for Injection (WFI).
How do you give Mucomix injection?
Mucomix Injection is given as an injection under the supervision of a doctor. It must be injected within 8 hours of paracetamol overdose. It can be given up to 24 hours, but medicine effective slow down when given after 24 hours of dosage overdose.
Why is Mucomyst given orally?
Acetylcysteine, administered orally, is indicated as an antidote to prevent or lessen hepatic injury which may occur following the ingestion of a potentially hepatotoxic quantity of acetaminophen.
Is acetylcysteine the same as Mucomyst?
Acetylcysteine is available under the following different brand names: N-acetylcysteine, and Mucomyst.
How are mucolytics administered?
Most mucolytics are administered as an oral medication, although they can also be administered as an intravenous or nebulizer formulation. For example, N-acetylcysteine, carbocisteine, and erdosteine are given as oral doses for respiratory diseases.
Is Mucomyst a bronchodilator?
Is acetylcysteine a bronchodilator? Acetylcysteine is not a bronchodilator because it does not relax your airway. Most people who take acetylcysteine will also be need to take a bronchodilator like albuterol or ipratropium.
Can you mix albuterol and Mucomyst?
No interactions were found between albuterol and Mucomyst.
How to give mucomyst?
MUCOMYST may also be given through a percutaneous intratracheal catheter. One to 2 mL of the 20% or 2 to 4 mL of the 10% solution every 1 to 4 hours may then be given by a syringe attached to the catheter. DIAGNOSTIC BRONCHOGRAMS.
How many ml of mucomyst?
MUCOMYST is available in rubber stoppered glass vials containing 4, 10, or 30 mL. The 20% solution may be diluted to a lesser concentration with either Sodium Chloride for Injection, Sodium Chloride for Inhalation, Sterile Water for Injection, or Sterile Water for Inhalation. The 10% solution may be used undiluted.
How much ipecac should I take for emesis?
Syrup of ipecac should be given in a dose of 15 mL for children up to age 12 and 30 mL for adolescents and adults followed immediately by drinking copious quantities of water.
How much mucomyst should I use for a tent?
If a tent or Croupette must be used, the recommended dose is the volume of MUCOMYST (using 10% or 20%) that will maintain a very heavy mist in the tent or Croupette for the desired period. Administration for intermittent or continuous prolonged periods, including overnight, may be desirable. DIRECT INSTILLATION.
Can you put mucomyst in a hot pot?
MUCOMYST should not be placed directly into the chamber of a heated (hot pot) nebulizer. A heated nebulizer may be part of the nebulization assembly to provide a warm saturated atmosphere if the MUCOMYST aerosol is introduced by means of a separate unheated nebulizer.
Can MUCOMYST be mixed with antibiotics?
MUCOMYST should not be mixed with certain antibiotics. For example, the antibiotics tetracycline hydrochloride, oxytetracycline hydrochloride, and erythromycin lactobionate were found to be incompatible when mixed in the same solution.
Can you use mucomyst undiluted?
The 10% solution may be used undiluted. MUCOMYST does not contain an antimicrobial agent, and care must be taken to minimize contamination of the sterile solution. If only a portion of the solution in a vial is used, store the remainder in a refrigerator and use for inhalation only within 96 hours. NEBULIZATION—FACE MASK, MOUTH PIECE, TRACHEOSTOMY. ...
How to get rid of acetylcysteine stickiness?
Wash your face with water to remove the stickiness. Do not mix acetylcysteine with other inhaled medications unless directed by the doctor or pharmacist. If you are taking this medication by mouth, take it as directed by your doctor.
What happens if you take a syringe by mouth?
Tell your doctor if your condition does not improve or if it worsens. Side Effects. Nausea and vomiting may occur. Mouth sores and runny nose may also occur if you are inhaling this medication by mouth. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
What are the side effects of mucomyst?
The most common side effects of Mucomyst include: difficulty breathing, coughing, shortness of breath, wheezing, calmness, tightness in your chest, foul odor,
What materials can be used to make acetyl l-cysteine?
Where materials may come into contact with acetylcysteine solution (n-acetyl-l-cysteine) , parts made of the following acceptable materials should be used: glass, plastic, aluminum, anodized aluminum, chromed metal, tantalum, sterling silver, or stainless steel.
Can a nebulizer be inhaled?
The nebulized solution may be inhaled directly from the nebulizer. Nebulizers may also be attached to plastic face masks or plastic mouthpieces. Suitable nebulizers may also be fitted for use with the various intermittent positive pressure breathing (IPPB) machines. The nebulizing equipment should be cleaned immediately after use because the residues may clog the smaller orifices or corrode metal parts.
Can you use 10% acetylcysteine?
The 10% solution may be used undiluted. Acetylcysteine does not contain an antimicrobial agent, and care must be taken to minimize contamination of the sterile solution. If only a portion of the solution in a vial is used, store the remainder in a refrigerator and use for inhalation only within 96 hours.
Is acetylcysteine an antidote?
Acetylcysteine, administered orally, is indicated as an antidote to prevent or lessen hepatic injury which may occur following the ingestion of a potentially hepatotoxic quantity of acetaminophen. It is essential to initiate treatment as soon as possible after the overdose and, in any case, within 24 hours of ingestion.
Is mucomyst safe for children?
Mucomyst belongs to a class of drugs called Pulmonary, Other. It is not known if Mucomyst is safe and effective in children younger than 1 month of age.
Does mucomyst cause nausea?
vomiting. Tell the doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Mucomyst.
Mucomyst Description
When inhaled by mouth, acetylcysteine is used to help thin and loosen mucus in the airways due to certain lung diseases (such as emphysema, bronchitis, cystic fibrosis, pneumonia).
Status: Discontinued
May Treat: Acetaminophen overdose · Amyloidosis · Atelectasis due to mucous obstruction · Bronchiectasis · Contrast media-induced nephrotoxicity and more
Drug Class: Amino Acids, Single Ingredient, Oral (non-injectable) · Antidote - Acetaminophen Poisoning · Dietary Product - Dietary Supplements · Mucolytics
Availability: Prescription sometimes needed
Pregnancy: Consult a doctor before using
Status: Discontinued
May Treat: Acetaminophen overdose · Amyloidosis · Atelectasis due to mucous obstruction · Bronchiectasis · Contrast media-induced nephrotoxicity and more
Drug Class: Amino Acids, Single Ingredient, Oral (non-injectable) · Antidote - Acetaminophen Poisoning · Dietary Product - Dietary Supplements · Mucolytics
Availability: Prescription sometimes needed
Pregnancy: Consult a doctor before using
Lactation: Does not adversely affect lactation
Alcohol: Limit intake while taking this medication
Driving: May cause drowsiness or dizziness. Use caution
- Can inhale or swallow the drug. Use as directed.
- May cause nausea and vomiting
- If vomiting occurs within 1 hour of dose, call MD
- Can inhale or swallow the drug. Use as directed.
- May cause nausea and vomiting
- If vomiting occurs within 1 hour of dose, call MD
- Medicine may smell like rotten eggs.
- Be alert for signs of stomach pain or bleeding
- Report hives, itching, breathing problems to MD.
- Lab tests may be ordered to monitor therapy
- Refrigerate for up to 4 days after vial opened.
Mucomyst - Clinical Pharmacology
Indications and Usage For Mucomyst
Warnings
Precautions
Adverse Reactions
Mucomyst Dosage and Administration
Indications
How Is Mucomyst Supplied
- General
Mucomyst is available in rubber stoppered glass vials containing 4, 10, or 30 mL. The 20% solution may be diluted to a lesser concentration with either Sodium Chloride for Injection, Sodium Chloride for Inhalation, Sterile Water for Injection, or Sterile Water for Inhalation. The 10… - Administration of Aerosol
MATERIALS Mucomyst may be administered using conventional nebulizers made of plastic or glass. Certain materials used in nebulization equipment react with acetylcysteine. The most reactive of these are certain metals (notably iron and copper) and rubber. Where materials may …
References