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can myoclonus be caused by stress

by Mr. Tommie Schuster Published 3 years ago Updated 2 years ago
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Anxiety really can create an increase in brief muscle spasms. It's not entirely clear why. Anxiety does pump adrenaline in the body, which likely causes the muscles to react unusually. It also affects neurotransmitters and hormones, both of which send responses to the nerves.

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Unfortunately, myoclonus is also a symptom of some very serious neurological diseases with other similar symptoms to anxiety, and that can cause people to experience considerable distress over whether or not their symptoms are something more.

Is myoclonus something more than anxiety?

Myoclonus may be just one of many symptoms. There are a plethora of causes, including: Nervous system conditions such as head or spinal cord injury, epilepsy (myoclonic seizure), stroke, brain tumor, Alzheimer’s disease, Parkinson’s disease, cerebral palsy, Creutzfeldt-Jakob disease, and many other rare neurological disorders.

What causes myoclonic myoclonus?

Essential myoclonus. Essential myoclonus occurs on its own, usually without other symptoms and without being related to any underlying illness. The cause of essential myoclonus is often unexplained (idiopathic) or, in some cases, hereditary.

Can essential myoclonus occur without any other symptoms?

Myoclonus is a movement disorder, which presents itself with sudden, brief, shock-like jerks. Most myoclonic jerks are due to a brief burst of muscular activity, resulting in positive myoclonus [Shibasaki and Hallett, 2005]. When jerks result from brief cessation of ongoing muscular activity, they are called negative myoclonus (NM).

What is negative myoclonus?

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What is the most common cause of myoclonus?

Myoclonus may be caused: most commonly by a disturbance of the brain or spinal cord (the central nervous system, or CNS), or. more rarely by an injury to the peripheral nerves (the nerves outside the CNS that connect to sensory organs and muscles, and relay information from/to the CNS).

Should I worry about myoclonus?

Hiccups are a mild type of myoclonus, a muscle twitch followed by relaxation. These types of myoclonus are rarely harmful. However, some forms of myoclonus can cause recurring, shock-like spasms that can interfere with a person's ability to eat, talk, and walk.

How does myoclonus develop?

Myoclonus is caused by an abrupt and brief discharge of motor neurons to affected muscles. In most cases, this results from a disturbance in the central nervous system, although it is believed that in rare cases may be caused by an injury to the nerves outside the central nervous system (peripheral nerves).

Can stress cause body jerks?

What causes muscle twitching? Stress – Anxiety and stress can cause twitching by releasing neurotransmitters from the nerves supplying the muscles. Also, anxiety can make you hyperventilate, or breathe faster, which changes the ions concentration and pH in your body, and predisposes you to muscle twitching.

Can stress and anxiety cause myoclonus?

The truth is that myoclonus occurs in nearly everyone, not just those with anxiety, and so it may not even be anxiety related at all. Some people twitch when they start to fall asleep at night. Others twitch after exercise.

What kind of doctor treats myoclonus?

You'll probably first discuss your concerns with your primary care doctor, who may then refer you to a doctor trained in nervous system conditions (neurologist).

Does myoclonus show up on EEG?

In cortical myoclonus, the EEG usually shows multifocal or generalized spike-and-wave or multiple spike-and-wave discharges with or without associated myoclonus (Fig.

How long can myoclonic jerks last?

Usually they don't last more than a second or two. There can be just one, but sometimes many will occur within a short time. Even people without epilepsy can experience myoclonus in hiccups or in a sudden jerk that may wake you up as you're just falling asleep.

Does myoclonus go away on its own?

It usually goes away on its own anywhere between six months and five years after it starts. Progressive myoclonus epilepsy. This is a very severe type of epilepsy that worsens over time. It usually involves brain deterioration or damage that also affects memory, muscle control, thinking ability and more.

How do you stop anxiety jolts?

To help stop anxiety twitching:Eat a healthy diet. ... Get 7 to 8 hours of sleep per night.Avoid energy drinks or caffeine. ... Get regular exercise. ... Drink water. ... Reduce stress as much as possible.Avoid drugs and alcohol.Try relaxation methods like progressive muscle relaxation.More items...

Why does my body keep twitching and jerking?

A disturbance to the central nervous system (brain and spinal cord) most likely causes these involuntary muscle twitches. For unknown reasons, the central nervous system sends an electrical impulse to muscles. Rarely, myoclonus occurs after an injury to the peripheral nerves outside the central nervous system.

Why do I get jolts in my body?

Body jolt and body jolts are common symptoms of anxiety disorder, including generalized anxiety disorder, social anxiety disorder, panic disorder, and others. Many people experience body jolt symptoms when they are anxious and stressed.

Does myoclonus go away on its own?

It usually goes away on its own anywhere between six months and five years after it starts. Progressive myoclonus epilepsy. This is a very severe type of epilepsy that worsens over time. It usually involves brain deterioration or damage that also affects memory, muscle control, thinking ability and more.

When should I worry about muscle twitching?

If muscle twitching is new and you're experiencing additional symptoms, however, Dr. Ondo says this is when muscle twitching becomes more concerning. "We start to worry about fasciculations when they're of relatively sudden onset and there's accompanying weakness, loss of tone and shrinkage in the muscle," says Dr.

Can myoclonus lead to seizures?

Myoclonic and other types of seizures are associated with the disorder. Deliberate breath-holding often may bring on seizures. Dravet Syndrome is a severe disorder that causes multiple seizure types, including myoclonic seizures. It begins in early childhood, with seizures often following a history of fever.

Why does my body randomly jerk sometimes?

A disturbance to the central nervous system (brain and spinal cord) most likely causes these involuntary muscle twitches. For unknown reasons, the central nervous system sends an electrical impulse to muscles. Rarely, myoclonus occurs after an injury to the peripheral nerves outside the central nervous system.

What is myoclonus muscle spasm?

What is myoclonus? Myoclonus is a sudden muscle spasm. The movement is involuntary and can’t be stopped or controlled. It may involve one muscle or a group of muscles. The movements may occur in a pattern or randomly. Myoclonus is usually a symptom of an underlying disorder rather than a condition itself.

Why does myoclonus cause muscle jerking?

The muscular jerking is made worse by attempts at controlled, voluntary movement. It’s often caused by a lack of oxygen or blood flow to the brain. Cortical reflex myoclonus originates in the outer layer of the brain tissue. It’s thought to be a form of epilepsy.

How do you know if you have myoclonus?

One region of the body or all muscle groups can be affected. The nature of the symptoms will depend on the underlying condition. Typically, signs of myoclonus include jerks or spasms that are: unpredictable. sudden.

Why does my ear make a clicking sound?

Some people hear a clicking sound in the ear as the muscles contract. Physiological myoclonus occurs in healthy individuals. It usually doesn’t need treatment. This type includes hiccups, sleep starts, spasms related to anxiety or exercise, and infant muscle twitching while asleep.

What is reflex myoclonus?

Reticular reflex myoclonus is a form of epilepsy that starts in the brain stem. Spasms usually affect the whole body, causing reactions with muscles on both sides. In some, intense jerks may affect all of the muscles in only one part of the body. A voluntary movement or an external stimulus can trigger spasms.

What are the different types of myoclonus?

The following are some of the most common types: Action myoclonus is the most severe form. It may affect the arms, legs, face, and voice.

What causes myoclonus and dementia?

Cerebral storage diseases usually cause myoclonus, visual problems, and dementia. They can also cause dystonia, continued muscle contractions that cause twisting movements and irregular posture.

What diseases are linked to myoclonus?

Most people with anxiety - especially those with panic disorder or health anxiety that are prone to Googling symptoms - often fear that they have some of the diseases linked to myoclonus, including: Multiple Sclerosis. Parkin son's Disease. Lupus. Huntington's Disease.

What is the rapid twitching of a muscle somewhere on the body?

Myoclonus is the rapid, instant twitching of a muscle somewhere on the body, where the muscle immediately contracts and stops in moments. In those without anxiety, a myoclonus is usually ignored and forgotten. But in those with anxiety, these muscle twitches become cause for concern, often leading people to self-diagnose terrible diseases.

What is the term for the rapid twitching of a muscle somewhere on the body, where the muscle immediately?

One of the biggest issues that prevents those with anxiety from curing themselves is the way the symptoms create more anxiety. Myoclonus is a prime anxiety. Myoclonus is the rapid, instant twitching of a muscle somewhere on the body, where the muscle immediately contracts and stops in moments.

How to stop muscle twitching?

Exercise is the solution. Exercise can contribute to further muscle twitching, but it also gives your brain an excuse for that twitching so that it doesn't assume it's disease related. It is possible to trick the brain, and by exercising often the muscle twitches you experience will not be as worrisome.

Is myoclonus a neurological disorder?

Unfortunately, myoclonus is also a symptom of some very serious neurological diseases with other similar symptoms to anxiety, and that can cause people to experience considerable distress over whether or not their symptoms are something more.

Can myoclonus cause anxiety?

It's possible it's simply evidence that your muscles have been drained of energy. The truth is that myoclonus occurs in nearly everyone, not just those with anxiety, and so it may not even be anxiety related at all.

Can anxiety and multiple sclerosis be the same?

Indeed, multiple sclerosis and anxiety can have near identical symptoms at first, and many people with anxiety fear that they have MS.

What causes myoclonus?

There are a plethora of causes, including: Nervous system conditions such as head or spinal cord injury, epilepsy (myoclonic seizure), stroke, brain tumor, Alzheimer’s disease, Parkinson’s disease, cerebral palsy, Creutzfeldt-Jakob disease, and many other rare neurological disorders.

Why is myoclonus a symptom?

There are many causes of this bizarre symptom. In most cases, myoclonus is physiological and innocent, occurring due to a temporary neurological disturbance.

What is progressive myoclonus?

Progressive myoclonus epilepsy (PME): Patients with PME suffer from a range of neurological symptoms including myoclonus and epilepsy, and they may have trouble walking or speaking. These disorders tend to be progressive, worsening over a period of a few months or years.

What is myoclonus jerking?

What is myoclonus? According to the National Institute of Neurological Disorders and Stroke, myoclonus “refers to sudden, involuntary jerking of a muscle or group of muscles.” It is a symptom, not a disease, affecting 8.6 people per 100,000 in its more serious presentations. A myoclonic twitch or a myoclonic jerk—when you’re literally twitching while sleeping —may range from hiccups (myoclonus of the diaphragm) to weird leg twitches as you drift into sleep, through to severe rapid-fire twitching of muscles in your leg or face.

How to treat myoclonus?

You may, however, benefit from tracking triggers, such as caffeine, nicotine, alcohol or antihistamines and then if you see a connection try cutting back on them. Many people also benefit from regular exercise ( walking and yoga are excellent), a leg massage or epsom salt bath before bed and a regular sleep schedule. It may also be worth asking your doctor if you would need a blood test, specifically to look for abnormalities in blood sugar, calcium, sodium, iron and magnesium. If levels are abnormal your doctor will recommend medication or supplements.

How many types of myoclonus are there?

There are two main types of myoclonus:

Can myoclonic twitches be localized?

Myoclonic twitches may be localized to one muscle or a group of muscles or they may occur all over the body. If you have myoclonus that is frequent, severe, or persistent, it’s time to seek a medical opinion to rule out an underlying medical problem.

How does myoclonus occur?

It typically occurs spontaneously, especially in recumbent position or may be provoked by tapping of the abdomen or by eliciting tendon reflexes.

What is cortical myoclonus?

Cortical myoclonus is the most common form of myoclonus, seen in both outpatient and inpatient clinical settings . Cortical myoclonus mainly affects the distal upper limbs and face, which reflects the largest cortical representations of these body areas [Caviness, 2009]. It is often focal, but may be multifocal, bilateral or generalized, as a consequence of intracortical and transcallosal spreading of abnormal activity [Brown et al.1996, 1991a]. It typically occurs on voluntary action and may affect speech and gait. Cortical myoclonic jerks are stimulus sensitive, typically to touch, but sensitivity to visual stimuli is also described [Shibasaki and Neshige, 1987]. Most patients with cortical myoclonus have both positive myoclonus and NM, occurring either independently or together as a complex of the two kinds of myoclonus [Shibasaki and Hallett, 2005]. If cortical myoclonus is prolonged and lasts for hours, days or weeks, it is called epilepsia partials continua and is considered to be a rare form of focal epileptic status [Bien and Elger, 2008]. Focal cortical myoclonus almost always points to an underlining lesion of the sensori-motor cortex, which produces hyperexcitability (e.g. vascular, inflammatory or neoplastic). Recently, Alvarez and Caviness reported a case series of seven patients aged over 65 with progressive cortical myoclonus, but no cause was identified after detailed investigations and they termed the condition as ‘primary progressive myoclonus of aging’ [Alvarez and Caviness, 2008]. Examples of multifocal cortical myoclonus include posthypoxic myoclonus (Lance–Adams syndrome), progressive myoclonic epilepsies (PMEs), progressive myoclonic ataxias (PMAs) and neurodegenerative diseases.

What is a myoclonic jerk?

Myoclonus is a movement disorder, which presents itself with sudden, brief, shock-like jerks. Most myoclonic jerks are due to a brief burst of muscular activity, resulting in positive myoclonus [Shibasaki and Hallett, 2005]. When jerks result from brief cessation of ongoing muscular activity, they are called negative myoclonus (NM). Positive myoclonus is generally more common, while NM frequently occurs in hospital settings, as a result of toxic–metabolic causes. A combination of both forms may be present in the same disease, as in posthypoxic myoclonus or progressive myoclonic epilepsies (PMEs).

What is myoclonus treatment?

Focal and segmental myoclonus, irrespective of its origin, may be treated with botulinum toxin injections, with variable success. Keywords: classification, clinical approach, myoclonus, treatment. Definition. Myoclonus is a movement disorder, which presents itself with sudden, brief, shock-like jerks.

How to classify myoclonus?

Myoclonus can be classified in a number of ways. By distribution, myoclonus is classified as focal, multifocal or generalized and by provoking factors as spontaneous and reflex. Myoclonus can also be divided in cortical, subcortical, spinal or peripheral, based on the presumed source of its generation. An alternative way of classifying myoclonus is based on the activity during which it occurs. It may occur at rest, when maintaining a posture or during action. A new category of ‘orthostatic myoclonus’ has recently been proposed by Glass and colleagues, who described a heterogeneous group of 15 patients in which myoclonic jerks occurred predominantly or exclusively on assuming an upright posture [Glass et al.2007]. Seven of these patients had neurodegenerative disease and two had a systemic illness that could cause myoclonus. Based on aetiology, myoclonus may be classified as physiological, essential, epileptic, symptomatic or psychogenic [Marsden et al.1982].

What is a sudden, brief, involuntary muscle jerk?

Myoclonus is a sudden, brief, involuntary muscle jerk. It is caused by abrupt muscle contraction, in the case of positive myoclonus , or by sudden cessation of ongoing muscular activity, in the case of negative myoclonus (NM). Myoclonus may be classified in a number of ways, although classification based on the underlying physiology is ...

What is the best treatment for myoclonus?

A single pharmacological agent rarely control myoclonus and therefore polytherapy with a combination of drugs, often in large dosages, is usually needed. Generally, antiepileptic drugs such as valproate, levetiracetam and piracetam are effective in cortical myoclonus, but less effective in other forms of myoclonus.

What is dystonia in the body?

Dystonia is involuntary, continued or repetitive muscle spasms that occur in a pattern. 2 Muscle contractions can occur in the form of twitching, squeezing, twisting and abnormal posture. Psychogenic dystonia can be divided into fixed or mobile dystonia. Fixed dystonia is at rest the affected body part is in an abnormal posture. Mobile dystonia is repetitive squeezing and twisting movements in the affected parts of the body. Fixed dystonia is more common and usually, an injury might have happened to that part of the body previously. One way to identify whether this is psychogenic is, patients don’t describe a way how to resolve the dystonia. The limbs are affected commonly than other parts of the body.

How do tremors occur?

Psychogenic tremor is the commonest psychogenic movement disorder. It usually occurs during rest and with action, starts in the hands then can gradually spread to the limbs and trunks. 1 Then the whole body can have a tremor at the same time. There can be changes in the direction the tremor moves, the way and distance it moves. The other key finding is this tremor is distractible. If the patient’s attention is focused on another activity then the tremor stops. The psychogenic tremor has an acute onset, remains only for a short period and spontaneously stops after sometime.

Can stress cause movement disorders?

Yes, stress can cause or worsens the movement disorders. The exact mechanism of how stress cause movement disorders are unknown. Movement disorders caused by genetic predisposition, neurodegenerative conditions, and due to metabolic changes can be increased by stress and anxiety. There is also a separate entity called psychogenic movement disorders where involuntary movements in the limbs, trunk, face, and neck; muscle spasms, tremors, difficulty in walking, swallowing difficulties and difficulty in speaking can occur due to stress and other psychological conditions. This includes psychogenic tremors, dystonia, dyskinesia, myoclonus, tics, gait disorders, and Parkinsonism.

Is dyskinesia a triggering factor?

Psychogenic dyskinesia occurs in episodes, the symptoms are only seen at times. A triggering factor is not found in many of the psychogenic dyskinesia patients and there were significant changes in the duration and the frequency of psychogenic dys kinesia.

What is myoclonic epilepsy?

Myoclonic epilepsy involves myoclonic seizures. They are characterized by myoclonic jerks—sudden, unintended muscle contractions. There are several types of myoclonic epilepsy, all of which usually begin during childhood, are typically caused by genetic factors, and may also cause cognitive and developmental problems.

When do myoclonic seizures occur?

Myoclonic seizures typically begin in early childhood, and they most commonly occur shortly before falling asleep or upon waking up , although they can occur at other times of the day.

How long does a myoclonic seizure last?

They are more common during childhood and young adulthood, and often improving during one's adult years. A myoclonic seizure typically lasts for a few seconds and looks like a sudden, repetitive jerking movement that can involve an arm, a leg, or the face.

Can a myoclonic seizure cause a complete loss of consciousness?

During a myoclonic seizure, you may have decreased voluntary movements of your body and a diminished level of consciousness. Myoclonic seizures don’t usually cause a complete loss of consciousness or severe shaking or jerking the way a generalized tonic-clonic seizure does.

Can a myoclonic seizure make you sleepy?

Myoclonic seizures can be preceded by an aura, or a sense that a seizure is going to happen. After a myoclonic seizure, you may feel tired or sleepy, but that is not always the case.

Which muscle is associated with peritubal myogenic tinnitus?

While tensor tympani movement may cause some cases of MEM tinnitus1,5,41and tensor veli palatini is widely cited as the primary muscle involved in EPT tinnitus,2,42,43movement of other palatal and pharyngeal muscles has also been associated with peritubal myogenic tinnitus.14,44It should be noted that peritubal muscle movement does not always induce tinnitus. For example, vigorous levator veli palatini activity in SPT is typically not associated with tinnitus.43Thus, peritubal myogenic tinnitus could be inappropriately diagnosed as MEM tinnitus due to similar symptomatology, unappreciated palatal movement, and non-specific positive impedance audiometry or tympanometry. When the pathogenic muscle is unclear, nasoendoscopic examination and electromyography (EMG) of the palate may be valuable.

Where is the tensor tympani located?

The tensor tympani is located largely outside the middle ear, is innervated by a terminal nerve originating in the mandibular branch of the trigeminal nerve (V3), and mediates several auditory-associated functions. Situated along the Eustachian tube (Figure 2), the approximately 20-mm-long tensor tympani is anchored to the sphenoid and the bony Eustachian tube and is also attached along the cartilaginous Eustachian tube.29Although the distal tensor tympani tendon inserts on the malleus in the middle ear,29the muscle location and major functions of the tensor tympani predominantly characterize a peritubal muscle. Repetitive contraction of the tensor tympani assists the tensor veli palatini and other peritubal muscles with opening and closing the tube during a variety of speech and swallowing activities.1Within the middle ear, contraction of tensor tympani pulls on the malleus to dampen TM vibrations. This action is primarily described in the context of preventing autophony associated with the palatal actions of chewing and swallowing and is considered less important during vocalization.1,12Although the tensor tympani and stapedius act in concert to mediate a variety of acoustic reflexes in other mammals, in humans the tensor tympani reflexively responds principally to external stimuli commonly associated with startle.12It may contract upon a puff of air to the cornea, tactile stimulation around the eye or ear, and eye closure.31Tensor tympani muscle spindles have also been described as having barometric properties, reflexively contracting in response to pressure changes.32Independent voluntary control of the striated tensor tympani has been described;1however, central nervous system networks specifically leading to tensor tympani activation are not well characterized.

What is MEM tinnitus?

MEM refers to a symptom of non-vascular, pulsatile tinnitus mediated through the middle ear. Tensor tympani or stapedius movement is the presumptive acoustogenic source; however, the etiology of MEM has not been well defined. Although the definitive treatment for MEM is considered middle ear muscle tendon lysis,1the variable benefit following surgical management highlights the uncertainty of MEM tinnitus pathogenesis. Since the movement phenomenology of MEM tinnitus is rarely described and clinical neurophysiologic studies of the tensor tympani and stapedius muscles are impractical, it is unclear whether or when the phenomenologic designation “myoclonus” is accurate. Analogous to the tinnitus of EPT, MEM tinnitus likely reflects a variety of causes. While tensor tympani or stapedius myoclonus may explain some cases of MEM tinnitus, middle ear muscle movement may also represent a final common pathway for a variety of acoustogenic processes. A systematic exploration of the anatomy, physiology, and phenomenology associated with myogenic tinnitus clarifies some of the confounding factors that muddle MEM tinnitus and related disorders.

What is MEM in ear?

Middle ear myoclonus (MEM) is a rare diagnosis of tinnitus that is presumed secondary to abnormal movement of the tensor tympani or stapedius muscles. This diagnosis has been primarily used in case reports in the otolaryngology literature,1where the phenomenology of the tinnitus, when described, is highly variable. MEM tinnitus is commonly characterized as clicking, suggested to be due the tensor tympani movement,2or buzzing, suggested to be due to stapedius movement;3however, it has also been described as throbbing, tapping, crackling like a grasshopper, bubbling, ticking, twitching, blowing, drum-like thumping, fluttering like a butterfly, whooshing or gushing.3–5MEM tinnitus is usually characterized as rhythmic, being regular or irregular, continuous or intermittent, and unilateral or bilateral.1The frequency, pitch, and intensity can vary within and among individuals.1MEM tinnitus is often objective, being perceptible also to the examiner, but can be subjective, being perceptible only to the patient. While objective tinnitus clearly identifies a somatic rather than sensorineural etiology, subjective tinnitus does not delineate an acoustogenic mechanism. There is variable response to middle ear muscle tendon lysis, the presumptive definitive treatment of MEM tinnitus.1

What is the MEM in the middle ear?

The term middle ear myoclonus (MEM) has been invoked to explain symptoms of tinnitus presumably caused by the dysfunctional movement of either of the two muscles that insert in the middle ear: tensor tympani and stapedius. MEM has been characterized through heterogeneous case reports in the otolaryngology literature, where clinical presentation is variable, phenomenology is scarcely described, the pathogenic muscle is usually not specified, natural history is unknown, and the presumptive definitive treatment, tensor tympani or stapedius tendon lysis, is inconsistently effective. It is not surprising that no unique acoustogenic mechanism or pathophysiologic process has been identified to explain MEM, one of several descriptive diagnoses associated with the complicated disorders of myogenic tinnitus.

Which muscles are involved in the opening and closing of the Eustachian tube?

The Eustachian tube directly connects the middle ear to the pharynx, where additional muscles that control Eustachian tube opening and closing play an integral role in three physiologic processes: equalizing middle ear and atmospheric pressure, promoting drainage of middle ear fluid, and decreasing autophony (Figure 2C). The tensor and levator veli palatini are innervated by V3 and a branch of the vagal nerve, respectively. Both muscles facilitate swallowing by elevating the palate. The salpingopharyngeus is innervated by a branch of the vagal nerve and assists swallowing by projecting food to the esophagus.

Does MEM tinnitus have a brainstem?

There is no imaging evidence of brainstem pathology to correlate with a source of segmental myoclonus in MEM tinnitus, and evoked potentials are not typically measured. Although it might be considered unusual for brainstem myoclonus to affect only one of the functionally related muscles supplied by the trigeminal or facial nerve nuclei, their topography supports this possibility. By analogy, it has been suggested that hemifacial spasm, which can be limited to individual muscles, may be mediated through aberrant facial nucleus activity.57,58MEM tinnitus associated with focal brainstem myoclonus might be considered similar to proprospinal myoclonus, another hyperkinetic disorder of unclear, likely mixed, etiology.

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1.Myoclonus - Symptoms and causes - Mayo Clinic

Url:https://www.mayoclinic.org/diseases-conditions/myoclonus/symptoms-causes/syc-20350459

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Url:https://www.ninds.nih.gov/myoclonus-fact-sheet

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Url:https://universityhealthnews.com/daily/sleep/myoclonus-innocent-twitch-serious-illness/

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