Can statins make you cough?
Within the considered period, about 9 years, we found 977 spontaneous reports of cough associated with the use of statins.
Should I stop taking statins?
Why you may want to come off statins
- Side effects. Statins can cause several side effects. ...
- Cost. Many types of statins are available today, and most are covered by health insurance plans. ...
- Reduced need. Lowering your cholesterol levels through diet, exercise, or weight loss could eliminate your need to take statins or other cholesterol medications.
Is it dangerous to stop statins?
This is because it can be dangerous to stop taking statins. These drugs are highly effective in preventing heart problems such as heart attack and stroke. In fact, according to the American Heart...
What are the side effects of statins?
The medical director shared these myopathy signs to look out for:
- Severe weak muscles (especially on the shoulders, arms, legs, and thighs)
- Intense muscle cramps
- Feeling generally weak and exhausted at all times
- Muscle spasms.
Why do statins make me cough?
In conclusion, the possible mechanisms by which statins stimulate cough are linked to increased induction of COX-2 and NOS expression followed by increased nitric oxide and prostaglandins production, which in turn enhance cough reflex sensitivity.
Can cholesterol medication cause coughing?
Fernandez and colleagues have shown that for every 10,000 reports of a statin-associated adverse event, approximately 1–40 reports were for statin- induced ILD [Fernandez et al. 2008]. This shows that statin-induced ILD is a newly recognized side effect of statin therapy which can present as a cough.
Can Atorvastatin cause cough?
If you feel short of breath or develop an unexplained cough. This is because (in very rare cases), atorvastatin may cause a disease called interstitial lung disease. If you develop any allergic-type reactions, such as swelling around your mouth or face, or a skin rash.
What medications can cause a persistent cough?
Drug-induced chronic cough, a rare cause of chronic cough, refers to a chronic cough caused by certain drugs. In addition to angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), there are cases reporting that some drugs such as omeprazole and leflumide that can cause cough.
What are the two most common adverse effects of statins?
What are statin side effects?Muscle pain and damage. One of the most common complaints of people taking statins is muscle pain. ... Liver damage. Occasionally, statin use could cause an increase in the level of enzymes that signal liver inflammation. ... Increased blood sugar or type 2 diabetes. ... Neurological side effects.
What are the most common side effects of statins is?
Side effects can vary between different statins, but common side effects include:headache.dizziness.feeling sick.feeling unusually tired or physically weak.digestive system problems, such as constipation, diarrhoea, indigestion or farting.muscle pain.sleep problems.low blood platelet count.
What are the worst side effects of atorvastatin?
Serious allergic reactionyou get a skin rash that may include itchy, red, swollen, blistered or peeling skin.you're wheezing.you get tightness in the chest or throat.you have trouble breathing or talking.your mouth, face, lips, tongue or throat start swelling.
Can statins affect your lungs?
Statin-induced lung injury (SILI) is an uncommon but serious complication of statins. The clinical features and outcome of patients with SILI vary widely.
Can statins affect your throat?
The most frequent vocal tract symptom in patients on statins was dryness followed by tightness and lump sensation. The difference in the mean of the total score and in the mean frequency of any vocal tract symptom was not significant between patients taking statins and controls.
What medication causes nagging cough?
Sometimes medications can cause a persistent dry cough. A classic example of this is with a class of medication called angiotensin-converting enzyme (ACE) inhibitors. These medications are commonly prescribed for people who have high blood pressure, heart disease, and diabetes.
Why do I have a chronic cough that won't go away?
Dozens of conditions can cause a recurrent, lingering cough, but the lion's share are caused by just five: postnasal drip, asthma, gastroesophageal reflux disease (GERD), chronic bronchitis, and treatment with ACE inhibitors, used for high blood pressure and heart failure.
What is a persistent cough an indication of?
A persistent cough may be a sign of postnasal drip, acid reflux, asthma or an infection like the common cold, the flu, bronchitis or pneumonia. A cough is considered chronic or persistent when it lasts longer than eight weeks in adults or four weeks in children.
Are there side effects from taking cholesterol medication?
Common side effects of cholesterol drugs include: Diarrhea. Constipation. Nausea.
Is coughing a side effect of high blood pressure medicine?
These high blood pressure medications block formation of a hormone that causes blood vessels to narrow, so vessels relax. ACE inhibitors may cause these side effects: A dry, hacking cough that doesn't go away. If you have this side effect, the doctor may prescribe another type of medication.
Is coughing a side effect of ezetimibe?
Common side effects of ezetimibe include: cough. diarrhea. fatigue.
What heart medication causes dry cough?
A dry, tickly and often bothersome cough is the most common adverse effect of ACE inhibitors. Recent studies indicate that cough may develop in around 10% of the patients treated with ACE inhibitors. In half of these patients, the ACE inhibitor has to be discontinued.
How to get rid of coughing from statin?
Use a humidifier in the house or at work. Statin coughs are normally dry coughs. A humidifier puts moisture in the air, allowing lubrication to the nose and throat and decreasing the risk of coughing. Mix a teaspoon of honey with an herbal tea. Honey lubricates the throat, and herbal tea suppresses the cough.
What are the side effects of statins?
Statin drugs are used to lower cholesterol levels in the body. Statins may cause side effects such as muscle pain, digestive upset and coughing. There are several ways to reduce coughs brought on by statin drugs.
What to avoid when you cough?
Foods to Avoid With a Cough. Learn More. Suck on cough lozenges 1. Cough lozenges sooth and lubricate the throat and heal the throat aggravated by coughing spells. Drink plenty of fluids throughout the day. Moisture decreases the tickling effect in the throat that causes you to cough.
Can cough medicine lower cholesterol?
Talk to your doctor about taking cough medicines. Cough medicines may interact with your statin drugs, affecting their ability to lower cholesterol levels. Ask your doctor what kind of cough medicines are safe to take or whether he has other solutions for your statin cough.
How long did it take for cough to appear after taking atorvastatin?
A 71 years old man in whom the cough appeared four days after he began the treatment with atorvastatin (10 mg/day) for hypercholesterolemia. The patient was also in therapy with losartan and hydrochlorothiazide, notoriously associated to possible cough onset.
What are statins involved in?
Statins are involved in the production of prostacyclin (PGI2) and prostaglandins (PG) and in the upregulation of enzyme cyclooxygenase-2 (COX-2). Birbaum and colleagues showed that atorvastatin cardioprotective effects are mediated by the induction of PG synthetase activity, following A2 cytosolic phospholipase (cPLA2) and COX-2 upregulation, PGI2 synthetase and, to a small extent, PGE2 synthetase. 2 Similarly, Degraeve et al. documented COX-2 induction and higher PGI2 production in human aortic smooth muscle cells following metavastatin and lovastatin administration. 3#N#Prostanoids like PGD2, PGE2, PGF2alpha and PGI2 mediate a wide range of physiological effects by means of five receptor classes named: DP, EP, FP, IP and TP.#N#In particular, inhaled PGE2 can induce cough as a result of an important increase of cough reflex sensitivity itself, by binding to specific receptor molecules. 4,5#N#A second hypothesised mechanism, probably involved in the potentiation of the prostaglandin-mediated action, is correlated to the effect caused by these drugs on the transmission way of nitric oxide (NO).#N#The activation of this way mediates protective effects against vascular damages; statins’ beneficial role in atherosclerotic vascular diseases is in fact well known.#N#In particular, statins stabilise messenger RNA in endothelial nitric oxide synthase (eNOS) leading to increased enzyme expression and NO production. 6,7#N#Besides, increased inducible nitric oxide synthase (iNOS) expression, associated to stabilisation and potentiation of statin-mediated COX-2 activity, promotes significant cardioprotective effects.8 Recent results indicates that NO produced by NOS is an important stimulator in the normal cough reflex circuit, determining increased sensitivity of this reflex.#N#In conclusion, the possible mechanisms by which statins stimulate cough are linked to increased induction of COX-2 and NOS expression followed by increased nitric oxide and prostaglandins production, which in turn enhance cough reflex sensitivity. 9
How long does coughing last with atorvastatin?
Persistent cough continued for 7 days during the therapy and disappeared only when the statin was withdrawn.
Do statins help with atherosclerotic vascular disease?
The activation of this way mediates protective effects against vascular damages; statins’ beneficial role in atherosclerotic vascular diseases is in fact well known. In particular, statins stabilise messenger RNA in endothelial nitric oxide synthase (eNOS) leading to increased enzyme expression and NO production. 6,7.
How to prevent statin side effects?
Try coenzyme Q10 supplements. Coenzyme Q10 supplements may help prevent statin side effects in some people, though more studies are needed to determine any benefits of taking it. Talk to your doctor first to make sure the supplement won't interact with any of your other medications.
What drugs interact with statins?
Some drugs that may interact with statins and increase your risk of side effects include: Amiodarone (Cordarone, Pacerone), a medication for irregular heart rhythms. Gemfibrozil (Lopid), another variety of cholesterol drug.
Can statins cause heart attacks?
Having too much cholesterol in your blood increases your risk of heart attacks and strokes. Statins block a substance your liver needs to make cholesterol. This causes your liver to remove cholesterol from your blood. If you think you're experiencing side effects from statins, don't just stop taking the pills.
Does statin help with heart attack?
Sign up now. Statin side effects: Weigh the benefits and risks. Statins are effective at lowering cholesterol and protecting against a heart attack and stroke, although they may lead to side effects for some people. By Mayo Clinic Staff.
Can statins cause liver damage?
While statins are highly effective and safe for most people, they have been linked to muscle pain, digestive problems and mental fuzziness in some people who take them and may rarely cause liver damage.
Do statins increase blood sugar?
Statins prevent heart attacks in people with diabetes, so the relevance of the mild increase in sugar values with statins observed in some people is unclear. The benefit of taking statins likely outweighs the small risk to have the blood sugar level go up. Talk to your doctor if you have concerns.
Can statins cause diabetes?
It's possible your blood sugar ( blood glucose) level may increase when you take a statin, which may lead to developing type 2 diabetes. The risk is small but important enough that the Food and Drug Administration (FDA) has issued a warning on statin labels regarding blood glucose levels and diabetes.
What are the side effects of statins?
The most commonly reported side effects of statins include: A headache. belching or excessive gas. constipation. croaky voice or hoarseness. difficulty sleeping. heartburn, indigestion, nausea, or stomach discomfort. lower back or side pain, tenderness around the eyes or cheekbones.
What are the symptoms of statin?
Examples of symptoms that might prompt you to see a doctor include: Excessive thirst or having to urinate frequently. Severe confusion or memory impairment. Unexplained significant joint or muscle pain, tenderness, or weakness.
Do statins cause muscle pain?
Statins and Muscle Pain. Statins do cause muscle pain, although the reported prevalence varies from 0.3 to 33% depending on the source. This variation may be due to the different ways muscle pain is described (such as muscle weakness, cramps, or muscle pain) and the fact patients are usually told to “ Watch out for muscle problems!
Do statins cause dementia?
Some large studies have shown no effect, and have implied that statins pose no threat and may, in fact, prevent dementia, whereas others found an association between statin use and memory loss and confusion, prompting the FDA to order labeling changes on all statins.
Can statins cause yellowing?
Unusual fatigue or weakness, loss of appetite, pain in your upper abdomen, dark-colored urine, or yellowing of your skin or eyes. Not everybody who takes a statin has side effects, but they tend to be more common in women, seniors, and people with liver or kidney disease.
Can statins cause diabetes?
Taking a statin may increase your blood gluco se (sugar) levels which can lead to the development of type 2 diabetes. People who take a statin are more likely to develop diabetes than people who don’t. However, in most cases, experts consider the benefits outweigh the risks.
Does grapefruit juice affect statins?
Grapefruit juice increases blood levels of atorvastatin, lovastatin, and simvastatin, which actually increases the effectiveness of these drugs, but may also increase the risk of side effects. The manufacturer’s advice is to avoid drinking grapefruit juice while taking statins.
