How many thrombocytopenia cases are associated with Topamax?
Thrombocytopenia(decrease of platelets in blood) is found to be associated with 3,613 drugs and 3,946 conditions by eHealthMe. Number of Topamax and Thrombocytopenia reports submitted per year:
What are the possible side effects of Topamax?
There are 9 disease interactions with Topamax (topiramate): Bone marrow depression/blood dyscrasias. Oligohidrosis/hyperthermia. Severe liver disease. Suicidal tendency. Renal dysfunction. Metabolic acidosis. Angle closure glaucoma.
What is Topamax (topiramate)?
Topamaxhas active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 52,407 Topamax users for its effectiveness, alternative drugs and more. What is Thrombocytopenia?
Can Topamax cause metabolic acidosis?
Metabolic Acidosis. Topamax® can cause hyperchloremic, non-anion gap, metabolic acidosis (i.e., decreased serum bicarbonate below the normal reference range in the absence of chronic respiratory alkalosis). This metabolic acidosis is caused by renal bicarbonate loss due to carbonic anhydrase inhibition by Topamax®.
How many drugs are associated with thrombocytopenia?
What is Thrombocytopenia?
Does Topamax cause thrombocytopenia?
Is Topamax good for migraines?
About this website
What medications cause low platelets?
Certain medications can reduce the number of platelets in your blood. Sometimes a drug confuses the immune system and causes it to destroy platelets. Examples include heparin, quinine, sulfa-containing antibiotics and anticonvulsants.
What are the serious side effects of Topamax?
Tell your doctor right away if you have any serious side effects, including: signs of kidney stones (such as severe back/side/abdominal/groin pain, fever, chills, painful/frequent urination, bloody/pink urine), rapid breathing, fast/slow/irregular heartbeat, bone pain, broken bones, loss of consciousness, unusual ...
Which drug would be the most common cause of drug induced thrombocytopenia?
A systematic review of individual patient data found that the most commonly reported drugs with a definite or probable causal relation to thrombocytopenia were quinine, quinidine, trimethoprim/sulfamethoxazole, vancomycin, penicillin, rifampin, carbamazepine, ceftriaxone, ibuprofen, mirtazapine, oxaliplatin, and ...
What does Topamax do to your blood?
Topiramate can increase the level of acid in your blood (metabolic acidosis). If left untreated, metabolic acidosis can cause brittle or soft bones, kidney stones, can slow the rate of growth in children, and may possibly harm your baby if you are pregnant. Metabolic acidosis can happen with or without symptoms.
Is there a lawsuit against Topamax?
Topamax lawsuits have been filed against the drug's manufacturer Ortho MacNeil-Janssen Pharmaceuticals, Inc., and it's parent company Johnson & Johnson.
Why is Topamax called Dopamax?
In fact, the brain fog has earned Topamax a nickname in the migraine community: “Dopamax.” Other common side effects are weight loss due to loss of appetite, tiredness, drowsiness, dizziness, tingling of the hands/feet, or a metallic taste in your mouth.
Can drug-induced thrombocytopenia be reversed?
Recovery from DITP usually begins within 1 to 2 days of stopping the drug and is typically complete within a week. Drug-dependent antibodies can persist for many years; therefore, it is important that the drug etiology be confirmed and the drug be avoided thereafter.
Does thrombocytopenia go away?
Acute ITP in children often goes away on its own within a few weeks or months and does not return. For a small number of children, ITP does not go away on its own, and the child may need treatment. Chronic ITP varies from person to person and can last for many years.
Can drug-induced thrombocytopenia be cured?
If your thrombocytopenia is caused by an underlying condition or a medication, addressing that cause might cure it. For example, if you have heparin-induced thrombocytopenia, your doctor can prescribe a different blood-thinning drug. Other treatments might involve: Blood or platelet transfusions.
Who shouldnt take Topamax?
chronic kidney disease stage 3B (moderate) chronic kidney disease stage 4 (severe) chronic kidney disease stage 5 (failure) kidney disease with likely reduction in kidney function.
Can topiramate cause permanent damage?
Most Topamax side effects aren't permanent, and go away with time. For example, fatigue (low energy) and feelings of burning or numbness in your hands and feet may go away as you continue taking Topamax.
Can Topamax cause blood clots?
Topiramate was associated with an increased frequency of anorexia, depression, diarrhea, ecchymosis, nausea, kidney calculus, paresthesia, taste perversion, thinking abnormalities, weight loss, and abnormal blood clotting (pulmonary embolism and deep venous thrombosis).
What are the main side effects of topiramate?
Side effects of topiramateFeeling sick (nausea) Stick to simple meals and do not eat rich or spicy food. ... Feeling sleepy, dizzy or tired. Do not drink alcohol, as this will make you feel more tired. ... Diarrhoea. ... Feeling depressed. ... Loss of appetite or weight loss.
What does Topamax do to your eyes?
Ocular adverse effects reported as attributable to Topiramate are: acute angle closure glaucoma, ocular pain, headache, hyperaemia, mydriasis, uveitis, visual field defects, acute onset myopia, suprachoroidal effusions, blepharospasm, oculogyric crisis, scleritis, and retinal haemorrhage [5].
What should you not take with Topamax?
What not to take with topiramate?Valproic acid (brand name examples: Depakote). ... Zonisamide (brand name example: Zonegran). ... Glaucoma medications, including eye drops.Birth control pills. ... Any medicines that impair or decrease your thinking, concentration, or muscle coordination.
Can topiramate cause heart problems?
Topiramate has not been associated with increased CV risk, and has been associated with decreased systolic and diastolic BP (69). Zonisamide is another anti-epileptic medication that has been used for weight loss, and has a similar purported mechanism of weight loss action to topiramate.
When was Topamax last updated?
Last updated on July 26, 2020. Note: This document contains side effect information about topiramate. Some of the dosage forms listed on this page may not apply to the brand name Topamax.
What are the side effects of topiramate?
Check with your doctor immediately if any of the following side effects occur while taking topiramate: More common. Blurred vision. burning, prickling, or tingling sensations. clumsiness or unsteadiness. confusion.
What are the most common CNS adverse reactions?
Most CNS adverse reactions can be classified into 3 categories: cognitive-related dysfunction (e.g. confusion psychomotor slowing, difficulty with concentration/attention, difficulty with memory, speech, or language problems, particularly word-finding difficulties); psychiatric/behavioral disturbances (e.g. depression or mood problems); and somnolence or fatigue. Most were mild to moderate in severity and frequently occurred in isolation. Rapid titration rate and higher initial dose was associated with a higher occurrence. [ Ref]
What are the symptoms of overdose on topiramate?
pain or tenderness in the upper stomach. red skin lesions, often with a purple center. sores, ulcers, or white spots in the mouth or on the lips. yellow eyes or skin. Get emergency help immediately if any of the following symptoms of overdose occur while taking topiramate: Symptoms of overdose.
Can antiepileptics cause nausea?
The more commonly reported adverse reactions for use as an antiepileptic have included paresthesia, anorexia, weight loss, speech disorders/related speech problems, fatigue, dizziness, somnolence, nervousness, psychomotor slowing, abnormal vision and fever. For use in migraine, the more commonly reported adverse events have included paresthesia, anorexia, weight loss, difficulty with memory, taste perversion, diarrhea, hypoesthesia, nausea, abdominal pain and upper respiratory tract infection.
Is hyperammonemia a concomitant with valproic acid?
Hyperammonemia with and without encephalopathy has been reported in the post-marketing period. Hyperammonemia appears to be more common when used concomitantly with valproic acid. [ Ref]
Does topiramate cause acidosis?
Generally, topiramate-induced metabolic acidosis occurs early in treatment; however, it can occur any time. Average decreases of serum bicarbonate of 4 mEq/L have been observed in adults receiving 400 mg/day and pediatrics receiving approximately 6 mg/kg/day. Values below 10 mEq/L have been rarely reported.
What is myopia with topamax?
A syndrome consisting of acute myopia associated with secondary angle closure glaucoma has been reported in patients receiving Topamax ®. Symptoms include acute onset of decreased visual acuity and/or ocular pain. Ophthalmologic findings can include myopia, anterior chamber shallowing, ocular hyperemia (redness), and increased intraocular pressure. Mydriasis may or may not be present. This syndrome may be associated with supraciliary effusion resulting in anterior displacement of the lens and iris, with secondary angle closure glaucoma. Symptoms typically occur within 1 month of initiating Topamax ® therapy. In contrast to primary narrow angle glaucoma, which is rare under 40 years of age, secondary angle closure glaucoma associated with topiramate has been reported in pediatric patients as well as adults. The primary treatment to reverse symptoms is discontinuation of Topamax ® as rapidly as possible, according to the judgment of the treating physician. Other measures, in conjunction with discontinuation of Topamax ®, may be helpful.
How much topiramate is reduced?
The clearance of topiramate was reduced by 42% in subjects with moderate renal impairment (creatinine clearance 30 to 69 mL/min/1.73 m 2) and by 54% in subjects with severe renal impairment (creatinine clearance <30 mL/min/1.73 m 2) compared to subjects with normal renal function (creatinine clearance >70 mL/min/1.73 m 2) [see Dosage and Administration (2.4) and (2.5)].
Is topiramate safe for pregnancy?
Consider the benefits and risks of topiramate when prescribing this drug to women of childbearing potential, particularly when topiramate is considered for a condition not usually associated with permanent injury or death. Because of the risk of oral clefts to the fetus, which occur in the first trimester of pregnancy, all women of childbearing potential should be informed of the potential risk to the fetus from exposure to topiramate. Women who are planning a pregnancy should be counseled regarding the relative risks and benefits of topiramate use during pregnancy, and alternative therapeutic options should be considered for these patients.
Can Topamax cause fetal harm?
SGA has been observed at all doses and appears to be dose-dependent. The prevalence of SGA is greater in infants of women who received higher doses of topiramate during pregnancy. In addition, the prevalence of SGA in infants of women who continued topiramate use until later in pregnancy is higher compared to the prevalence in infants of women who stopped topiramate use before the third trimester.
Can Topamax be used with alcohol?
Concomitant administration of Topamax ® and alcohol or other CNS depressant drugs has not been evaluated in clinical studies. Because of the potential of topiramate to cause CNS depression, as well as other cognitive and/or neuropsychiatric adverse reactions, Topamax ® should be used with extreme caution if used in combination with alcohol and other C NS depressants.
Does topiramate cause kidney stones?
Concomitant use of topiramate, a carbonic anhydrase inhibitor, with any other carbon ic anhydrase inhibitor (e.g., zonisamide or acetazolamide) may increase the severity of metabolic acidosis and may also increase the risk of kidney stone formation. Therefore, patients given Topamax ® concomitantly with another carbonic anhydrase inhibitor should be monitored particularly closely for the appearance or worsening of metabolic acidosis [see Clinical Pharmacology (12.3)].
Does Topamax lower topiramate?
Concomitant administration of phenytoin or carbamazepine with Topamax ® resulted in a clinically significant decrease in plasma concentrations of topiramate when compared to Topamax ® given alone. A dosage adjustment may be needed [see Dosage and Administration (2.1), Clinical Pharmacology (12.3) ].
How many interactions are there with Topamax?
There are 9 disease interactions with Topamax (topiramate):
How much topiramate is cleared on hemodialysis?
Topiramate is cleared by hemodialysis at a rate that is 4 to 6 times greater than that in a normal individual. A prolonged period of dialysis may cause plasma topiramate level to fall below that required to maintain an anti-seizure effect, thus a supplemental dose may be required in patients undergoing hemodialysis.
Does zonisamide cause hyperthermia?
Oligohidrosis (decreased sweating) and hyperthermia have been reported in association with the use of some carbonic anhydrase inhibitor anticonvulsants such as topiramate and zonisamide. Most of the reports have been in children. Caution and close monitoring of body temperature is advised when prescribing these drugs, especially in patients with a fever, in hot weather, or if combined with other drugs that predispose to heat related disorders. Zonisamide is not approved for use in pediatric patients in the U.S.
Can carbonic anhydrase inhibitors cause bone marrow suppression?
The use of carbonic anhydrase inhibitors may rarely cause bone marrow suppression and blood dyscrasias at recommended dosages. Aplastic anemia, thrombocytopenia or thrombocytopenia purpura, leukopenia, agranulocytosis, and hemolytic anemia have been reported. Extreme caution should be exercised if carbonic anhydrase inhibitors are administered to patients with these preexisting conditions. A baseline CBC and platelet count is recommended, as well as monitoring at regular intervals during therapy.
Does topiramate cause glaucoma?
A syndrome consisting of acute myopia associated with secondary angle closure glaucoma has been reported in patients receiving topiramate. Symptoms include acute onset of visual acuity and/or ocular pain. It typically occurs within 1 month of treatment initiation and it has been reported in both pediatric and adult patients. Caution is recommended when prescribing topiramate in patients with elevated intraocular pressure regardless of the etiology.
Does topiramate cause kidney stones?
The use of topiramate may infrequently be associated with the development of kidney stones. The reported incidence was 1.5% (32 of 2,086 patients) during premarketing use, which is about 2 to 4 times that expected in a similar, untreated population. Topiramate is a weak carbonic anhydrase inhibitor and may promote stone formation by reducing urinary citrate excretion and increasing urinary pH. Therapy with topiramate should be administered cautiously with adequate hydration in patients with a history of nephrolithiasis. The concomitant use of topiramate with other carbonic anhydrase inhibitors should be avoided. Patients who are dehydrated may be at increased risk for the development of nephrolithiasis and should be encouraged to consume additional amounts of liquid during topiramate therapy.
How many people have adverse reactions to TOPAMAX?
Table 6 presents the incidence of adverse reactions occurring in at least 3% of adult patients treated with 200 to 400 mg/day TOPAMAX® and was greater than placebo incidence. The incidence of some adverse reactions (e.g., fatigue, dizziness, paresthesia, language problems, psychomotor slowing, depression, difficulty with concentration/attention, mood problems) was dose-related and much greater at higher than recommended TOPAMAX® dosing (i.e., 600 mg - 1000 mg daily) compared to the incidence of these adverse reactions at the recommended dosing (200 mg to 400 mg daily) range.
What are the side effects of TOPAMAX 100 mg?
The most common adverse reactions with TOPAMAX® 100 mg in the clinical trials for the preventive treatment of migraine of predominantly adults that were seen at an incidence higher (≥ 5 %) than in the placebo group were: paresthesia, anorexia, weight loss, taste perversion, diarrhea, difficulty with memory, hypoesthesia, and nausea (see Table 8).
Why did TOPAMAX discontinue?
The most common (≥2% more frequent than low-dose 50 mg/day TOPAMAX®) adverse reactions resulting in discontinuation were difficulty with concentration/attention, fever, flushing, and confusion.
Does Topamax cause a bad taste?
bad taste in your mouth, confusion, slowed thinking, trouble concentrating or paying attention, memory problems, and cold symptoms such as stuffy nose, sneezing, or sore throat. Tell your doctor if you have unlikely but serious side effects of Topamax including: signs of kidney stones (such as severe back/side/abdominal/ groin pain, fever, chills, ...
Can you take Topamax while pregnant?
There are no adequate studies of Topamax in pregnant women and it is not known if Topamax is secreted in human breast milk. Use during pregnancy is not recommended unless the potential benefit outweighs the potential unknown risk to the fetus. Consult your doctor before breastfeeding.
Does Topamax cause dizziness?
Common side effects of Topamax include: tiredness, drowsiness, dizziness, nervousness, numbness or tingly feeling in the hands or feet, coordination problems, diarrhea, weight loss,
Is fatigue a side effect of TOPAMAX?
The incidence of some adverse reactions (e.g., fatigue, dizziness, somnolence, difficulty with memory, difficulty with concentration/attention) was dose-related and greater at higher than recommended TOPAMAX® dosing (200 mg daily) compared to the incidence of these adverse reactions at the recommended dosing (100 mg daily).
What is Thrombocytopenia?
Thrombocytopenia (decrease of platelets in blood) is found to be associated with 3,624 drugs and 3,961 conditions by eHealthMe.
What is Fosamax?
Fosamax has active ingredients of alendronate sodium. It is often used in osteoporosis. eHealthMe is studying from 95,593 Fosamax users for its effectiveness, alternative drugs and more.
How many drugs are associated with thrombocytopenia?
Thrombocytopenia (decrease of platelets in blood) is found to be associated with 3,551 drugs and 3,917 conditions by eHealthMe.
What is Thrombocytopenia?
Thrombocytopenia (decrease of platelets in blood) is found to be associated with 3,617 drugs and 3,954 conditions by eHealthMe.
Does Topamax cause thrombocytopenia?
Thrombocytopenia is found among people who take Topamax, especially for people who are female, 50-59 old, have been taking the drug for < 1 month.
Is Topamax good for migraines?
Topa max has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 50,991 Topamax users for its effectiveness, alternative drugs and more.
