Efficacy and Safety Study of Topiramate to Treat Restless Legs Syndrome. Of the anticonvulsants, preliminary reports suggest that gabapentin, carbamazepine, and divalproex can suppress RLS symptoms in some patients, especially those with mild RLS. Side effects include sleepiness, ataxia, and weight gain.
Is topiramate a better alternative to gabapentin for restless legs syndrome?
Topiramate may be a better alternative than the currently available treatments to suppress RLS symptoms. Like gabapentin, it offers the possibility of decreasing RLS symptoms while also diminishing pain, especially in those patients who have limb pain from neuropathy, radiculopathy, or other causes.
What is the role of topiramate in the treatment of RLS?
Iron supplementation is therapeutic in some patients with iron deficiency and RLS. Preliminary anecdotal data suggest that topiramate reduces RLS symptoms. Topiramate has several potential mechanisms of action including enhancement of GABA-mediated inhibition, which may account for the observed benefit in patients with RLS.
What are the possible side effects of anticonvulsants for restless legs syndrome (RLS)?
Common side effects of these drugs include coryza, hypotension, and rash. Of the anticonvulsants, preliminary reports suggest that gabapentin, carbamazepine, and divalproex can suppress RLS symptoms in some patients, especially those with mild RLS. Side effects include sleepiness, ataxia, and weight gain.
Which medications are used in the treatment of restless legs syndrome (RLS)?
Benzodiazepines, levo-dopa/carbidopa, dopamine agonists, anticonvulsants, and opioids have been used with variable success, to treat RLS. Often, RLS patients treated with a benzodiazepine, over the course of several months, develop tolerance to the medication.
Can topiramate make restless leg syndrome worse?
Topiramate may be a better alternative than the currently available treatments to suppress RLS symptoms. Like gabapentin, it offers the possibility of decreasing RLS symptoms while also diminishing pain, especially in those patients who have limb pain from neuropathy, radiculopathy, or other causes.
Does topiramate help with restless leg syndrome?
Conclusions: Topiramate is profiled as an effective treatment in restless legs syndrome, with good tolerability and minimal side effects.
What medications can trigger RLS?
Possible triggers include: Medication -- Your prescription or non-prescription drugs can make your RLS symptoms worse. These include some antihistamines, anti-nausea drugs, antidepressants, and beta blockers.
What is the root cause of restless leg syndrome?
If nerve cells become damaged, the amount of dopamine in the brain is reduced, which causes muscle spasms and involuntary movements. Dopamine levels naturally fall towards the end of the day, which may explain why the symptoms of restless legs syndrome are often worse in the evening and during the night.
What is the most common side effect of topiramate?
Tiredness, drowsiness, dizziness, loss of coordination, tingling of the hands/feet, loss of appetite, bad taste in your mouth, diarrhea, and weight loss may occur.
Does Topamax affect your sleep?
Treatment with Topamax may cause sleepiness as a side effect. This was one of the most common side effects reported by people taking Topamax to treat epilepsy in studies. Sleepiness was less common in people who took Topamax to help prevent migraine in these studies.
How do you calm down restless legs?
Making simple lifestyle changes can help alleviate symptoms of RLS :Try baths and massages. Soaking in a warm bath and massaging the legs can relax the muscles.Apply warm or cool packs. ... Establish good sleep hygiene. ... Exercise. ... Avoid caffeine. ... Consider using a foot wrap or a vibrating pad.
What is the best medication for restless legs?
Your doctor will prescribe the best treatment plan for you. Dopamine agonists: These are most often the first medicines used to treat RLS. These drugs, including pramipexole (Mirapex), rotigotine (Neupro), and ropinirole (Requip), act like the neurotransmitter dopamine in the brain.
What mimics restless leg syndrome?
There are many conditions that can mimic restless leg syndrome, including Parkinson's disease, fibromyalgia, muscle diseases, joint conditions, circulation difficulties, and nerve problems such as peripheral neuropathy caused by diabetes. In children, restless leg syndrome is often misdiagnosed as "growing pains."
Why are my legs so restless in bed?
Restless legs syndrome (RLS) is a condition that causes an uncontrollable urge to move the legs, usually because of an uncomfortable sensation. It typically happens in the evening or nighttime hours when you're sitting or lying down. Moving eases the unpleasant feeling temporarily.
Does magnesium help restless legs?
Magnesium supplementation is often suggested for restless legs syndrome (RLS) or period limb movement disorder (PLMD) based on anecdotal evidence that it relieves symptoms and because it is also commonly recommended for leg cramps.
Is restless leg syndrome neurological?
RLS is both a sleep and a neurological sensory disorder. Treatment is directed toward symptom relief.
Is topiramate 50mg used for weight loss?
Weight-loss and loss of appetite are common adverse effects in persons 16 years and older who are taking 50 mg or 400 mg of topiramate per day. Patients using a 50mg/day dose lost 6% of their body weight, and weight loss was found in 17% of patients using 400mg/day.
Can risperidone cause restless leg syndrome?
Some second-generation antipsychotics such as risperidone,1 olanzapine2 and quetiapine3 4 have been reported to cause secondary RLS, whereas others have been reported to help it.
What is the best treatment for RLS?
Benzodiazepines, levo-dopa/carbidopa, dopamine agonists, anticonvulsants, and opioids have been used with variable success, to treat RLS. Often, RLS patients treated with a benzodiazepine, over the course of several months, develop tolerance to the medication. Also, benzodiazepines can cause confusion or daytime sleepiness and may be addictive. Patients may also develop tolerance to levo-dopa/carbidopa treatment. Because of the short half-life, symptoms may be suppressed for only the first part of the sleep period and then recur later during the night. Rebound has been reported. Worse yet, augmentation, the occurrence of RLS symptoms, often more severe than before treatment began, earlier in the day, may occur in up to 80% of RLS patients treated with levod-dopa/carbidopa. Dopamine agonists, including pergolide, pramipexole, and ropinirole, are effective for some patients but not for others. Common side effects of these drugs include coryza, hypotension, and rash. Of the anticonvulsants, preliminary reports suggest that gabapentin, carbamazepine, and divalproex can suppress RLS symptoms in some patients, especially those with mild RLS. Side effects include sleepiness, ataxia, and weight gain. Opioid treatment for RLS has been described as effective but, aside from the stigma of taking controlled substances regularly, side effects may include nausea, sedation, constipation, and dysequilibrium. Iron supplementation is therapeutic in some patients with iron deficiency and RLS.
When are leg movements recorded during sleep and wakefulness during the PSG?
Periodic leg movements during sleep and wakefulness during the PSG recorded at the end of the double blind phase
Does topiramate help with RLS?
Preliminary anecdotal data suggest that topiramate reduces RLS symptoms . Topiramate has several potential mechanisms of action including enhancement of GABA-mediated inhibition, which may account for the observed benefit in patients with RLS.
What is Topamax used for?
What is Topamax? Topamax has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 50,995 Topamax users for its effectiveness, alternative drugs and more.
What to do when serious adverse effects are detected in your trial?
When serious adverse effects are detected in your trial, your doctor will be notified to check them out promptly. What you need to do:#N#1. start your phase IV clinical trial#N#2. ask your doctor to join eHealthMe professional network
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