Precautions
Along with its needed effects, bortezomib (the active ingredient contained in Velcade) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Are there any side effects to taking Velcade?
Your risk of low blood pressure may increase if you have a condition that can cause it, such as dehydration or a history of fainting. Your risk also may also increase if you take Velcade with medications that lower your blood pressure. Diabetes. Velcade treatment can cause your blood sugar to be higher or lower than usual.
What increases my risk of low blood pressure from Velcade?
But chemotherapy can also destroy healthy cells in your body that are rapidly multiplying. Velcade is a type of targeted therapy called a proteasome inhibitor. It works by blocking the action of a type of protein called a proteasome. As a result, Velcade kills cancer cells that have this protein.
How does Velcade work to treat cancer?
Can you drive if you have dizziness?
Can you talk to your doctor about Velcade?
Can you change your dose of Velcade?
Can you give Velcade to a doctor?
What are long term side effects of Velcade?
Examples of long-term side effects that Velcade may cause include:heart failure or other heart diseases.lung problems, such as swelling in your lungs.liver problems, such as hepatitis.blood clotting conditions.kidney problems, such as kidney failure.
How does myeloma affect the cardiovascular system?
Multiple myeloma puts you at risk for heart and lung problems, including blood clots, pulmonary hypertension, heart failure, and irregular heartbeat (arrhythmias) among other problems. Your risk for these problems is greater if you already have high blood pressure, type 2 diabetes, or high cholesterol.
Can Darzalex cause heart problems?
Yes, Darzalex can sometimes cause cardiac (heart) problems when it's used to treat multiple myeloma. In studies of Darzalex, a type of irregular heartbeat called atrial fibrillation (AFib) was reported in some people.
Does Velcade cause shortness of breath?
In 100 people receiving Velcade, Revlimid, Dexamethasone, 3 or fewer may have: Bleeding from sores in stomach. Broken bones. Allergic reaction which may cause rash, low blood pressure, wheezing, shortness of breath, swelling of the face or throat.
What is the most frequent cause of death in a patient with multiple myeloma?
Infection is a major complication and a leading cause of death in patients with multiple myeloma (MM) [1]. The risk of infection is due to a multifactorial immunodeficiency caused by the disease itself and the treatment regimens given during the different phases of therapy [2].
Can revlimid affect the heart?
REVLIMID may cause you to have serious heart problems that can lead to death, including atrial fibrillation, heart attack, or heart failure. You should not take REVLIMID if you have CLL unless you are participating in a controlled clinical trial.
Can daratumumab cause heart problems?
Of all of the newly FDA approved multiple myeloma agents, elotuzumab, Ixazomib, daratumumab, panobinostat showed significant cardiac adverse events. Interestingly, cardiac failure, atrial fibrillation and coronary artery diseases were profoundly the highest of all reported cardiotoxicity.
Is Velcade chemotherapy or immunotherapy?
VELCADE (bortezomib) is a type of chemotherapy called a targeted therapy. VELCADE belongs to a class of medicines called proteasome inhibitors. It is approved by the FDA for the treatment of multiple myeloma and mantle cell lymphoma. VELCADE has been studied in many important clinical trials.
Does Revlimid cause chest pain?
Call your healthcare provider or get medical help right away if you get any of the following during treatment with REVLIMID: Signs or symptoms of a blood clot in the lung, arm, or leg may include: shortness of breath, chest pain, or arm or leg swelling.
How long can you take Velcade?
VELCADE is given intravenously twice a week for 2 weeks followed by a 10-day rest period. This can be repeated for up to 6 cycles.
How long does it take for Velcade to get out of your system?
You could expect Velcade to stay in your system ranging from 9 days (220 hours) to 44 days (1061 hours) depending on which dose you receive. The elimination half life is the time it takes for your body to reduce the plasma levels of the drug by one-half (50%).
How long is Velcade treatment for multiple myeloma?
Velcade is given for nine 6-week treatment cycles.
Can multiple myeloma affect the heart?
Common manifestations of multiple myeloma include osteolytic lesions, cytopenias, hypercalcemia, and renal insufficiency. Patients may also exhibit heart failure which is often associated with either past therapy or cardiac amyloidosis. A less recognized mechanism is high-output heart failure.
Does multiple myeloma affect blood pressure?
Hypertension is commonly reported in multiple myeloma (MM) patients and may be associated with older age, disease-related complications and consequences of MM treatments.
Can multiple myeloma cause atrial fibrillation?
Atrial fibrillation (AF) often develops in patients with multiple myeloma following autologous stem cell transplantation (ASCT), but the exact incidence of, and the risk factors for AF have not been described.
Can multiple myeloma affect the lungs?
The intraparenchymal causes of respiratory failure from multiple myeloma include alveolar septal amyloidosis, plasma cell infiltration of lung parenchyma, accumulation of alveolar paraproteins, and metastatic calcification of the alveolar walls and blood vessels.
How long will Velcade stay in my body?
The length of time that Velcade stays in your body depends on a couple things, such as: your liver function your kidney function how quickly your b...
Can I use Velcade if I have multiple myeloma and I’ve had a stem cell transplant?
Yes, you may be able to if your doctor recommends it. In fact, Velcade is quickly becoming the main therapy for multiple myeloma in people who’ve h...
How long should I take Velcade if I’ve never had treatment for my cancer before?
How long you’ll need to take Velcade depends on a few things. These include: the condition you’re treating how well your body is tolerating treatme...
Is Velcade chemotherapy?
No, Velcade isn’t a chemotherapy drug. (Chemotherapy is used to describe traditional drugs used to treat cancer.) Chemotherapy drugs work by killin...
Common and Rare Side Effects for Velcade Vial - WebMD
COMMON side effects If experienced, these tend to have a Severe expression i ; shingles ; dehydration ; low amount of potassium in the blood ; anemia ; decreased blood platelets
Velcade Side Effects: Common, Severe, Long Term - Drugs.com
Velcade Side Effects. Generic name: bortezomib Medically reviewed by Drugs.com. Last updated on Jul 19, 2022. Consumer; Professional; FAQ; Note: This document contains side effect information about bortezomib. Some of the dosage forms listed on this page may not apply to the brand name Velcade.. For the Consumer
Velcade side effects: What they are and how to manage them
Mild side effects can occur with Velcade use. This list doesn’t include all possible mild side effects of the drug. For more information, you can refer to Velcade’s prescribing information ...
Bortezomib Side Effects: Common, Severe, Long Term - Drugs.com
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 4 Oct 2022), Cerner Multum™ (updated 21 Sep 2022), ASHP (updated 12 Sep 2022 ...
Velcade: Side Effects and What to Do About Them - Healthline
Velcade is a prescription drug that’s used to treat certain types of cancer. Learn about its common, mild, and serious side effects and how to manage them.
What are the serious side effects of Velcade?
Even so, it’s important to be aware of serious side effects that may occur so that you can get treatment for them right away. In rare cases, serious side effects can be fatal if not treated.
What is Velcade used for?
Velcade is a prescription medication used in adults with either multiple myeloma or mantle cell lymphoma. These are both cancers that occur in your white blood cells.
How long does it take for a reaction to go away after a Velcade injection?
For example, if you experience injection site reactions such as pain or swelling, the reaction may go away a few days after you get your Velcade dose. But you might have these reactions with each injection you receive.
How long after stopping Velcade can you breastfeed?
Breastfeeding is not recommended during Velcade treatment or for at least 2 months after stopping treatment. This is because it’s not known if Velcade may pass into breast milk or what effects it may have on a breastfed child.
Does Velcade cause hair loss?
No, hair loss was not a side effect reported by people taking Velcade by itself in studies. However, hair loss may be caused by other cancer medications that you take with Velcade.
Can Velcade cause diarrhea?
Your doctor will monitor you for symptoms of digestive problems throughout your treatment with Velcade. You may need to take medications to treat these side effects, such as medication for nausea or diarrhea. Your doctor or pharmacist can advise you on the best treatments for these conditions.
Does Velcade cause digestive problems?
Digestive problems are possible during treatment with Velcade. These side effects were very common in studies of the drug. Examples of digestive problems include:
What is Velcade used for?
It’s approved by the Food and Drug Administration (FDA) to treat mantle cell lymphoma (MCL) and multiple myeloma in adults.
Why does Velcade cause bruises?
Bruising may develop during Velcade treatment. This side effect can be caused by a condition called thrombocytopenia ( low levels of platelets). Platelets are cells that help your blood to clot.
Is it safe to use Velcade while pregnant?
Pregnancy. It is not safe to use Velcade while pregnant. This is because animal studies have shown that Velcade may cause pregnancy loss when used during pregnancy. Animal studies don’t always predict what will happen in humans. But it’s safest to avoid using Velcade while you’re pregnant.
Can Velcade cause allergic reactions?
As with most drugs, Velcade can cause an allergic reaction in some people. But it’s not known how often this occurred in clinical studies of the drug.
Can you stop Velcade if your platelet count is low?
They may also recommend that you stop using Velcade until your condition improves.
Does Velcade cause heart failure?
For example, using Velcade can lead to new or worsened cardiac problems, such as heart failure. (“Cardiac” means heart-related.) And these heart-related conditions can continue to worsen over time.
Does Velcade affect your body?
Velcade may affect fewer healthy cells in your body than chemotherapy does. This could mean that Velcade causes fewer side effects than chemotherapy drugs.
How long do side effects from Velcade last?
Velcade’s side effects will likely affect each person a little differently. And how long certain side effects of Velcade last will vary from person to person . If you have side effects from Velcade, talk with your doctor about how long you can expect them to last. Your doctor may be able to advise whether certain side effects will go away over time.
What is Velcade a class of drugs?
Velcade contains the active drug bortezomib. It belongs to a class of drugs called proteasome inhibitors. (A class of drugs is a group of medications that work in the same way.) Velcade works by inhibiting (blocking) the action of certain proteins called proteasomes.
How long does it take to get Velcade for multiple myeloma?
If you have untreated multiple myeloma, you’ll likely receive Velcade over nine 6-week treatment cycles. And Velcade is typically given with the chemotherapy drug melphalan and the steroid prednisone.
How long does it take for Velcade to work?
Velcade may start working within 5 minutes after it’s been given to you. However, you may not notice that Velcade is working. This is because the drug works to stop your cancer from worsening. But it may not reduce symptoms you’re having from your cancer.
How is Velcade given?
Velcade is given by either intravenous (IV) injection (an injection into your vein) or subcutaneous injection (an injection under your skin). You’ll receive doses of Velcade from a healthcare provider at a medical facility.
How much Velcade is in a vial?
Velcade comes as a powder that’s mixed with liquid to form a solution. It’s available in one strength: 3.5 milligram (mg) of drug per vial of medication.
Does Velcade cause a rash?
11% of people taking Velcade with melphalan and prednisone had a rash. (Melphalan and prednisone are other drugs that are sometimes used in multiple myeloma treatment.) 2% of people taking melphalan and prednisone alone had a rash. Another study looked at people with relapsed multiple myeloma.
What are the side effects of Bortezomib?
Check with your doctor or nurse immediately if any of the following side effects occur while taking bortezomib: More common. Black, tarry stools. bleeding gums. blood in the urine or stools. blurred vision. body aches or pain. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings. chest pain.
What are the side effects of a syringe?
Side effects requiring immediate medical attention 1 Black, tarry stools 2 bleeding gums 3 blood in the urine or stools 4 blurred vision 5 body aches or pain 6 burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings 7 chest pain 8 chills 9 confusion 10 cough 11 cough producing mucus 12 decreased urination 13 difficult or labored breathing 14 dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position 15 dry mouth 16 ear congestion 17 fainting 18 fever 19 headache 20 increase in heart rate 21 loss of voice 22 lower back or side pain 23 nerve pain 24 painful blisters on the trunk of the body 25 painful or difficult urination 26 pale skin 27 pinpoint red spots on the skin 28 rapid breathing 29 runny nose 30 sneezing 31 sore throat 32 stuffy nose 33 sunken eyes 34 sweating 35 swollen glands 36 thirst 37 tightness in the chest 38 troubled breathing with exertion 39 ulcers, sores, or white spots in the mouth 40 unsteadiness or awkwardness 41 unusual bleeding or bruising 42 unusual tiredness or weakness 43 weakness in the arms, hands, legs, or feet 44 wrinkled skin
Does Velcade have side effects?
Side effects requiring immediate medical attention. Along with its needed effects, bortezomib (the active ingredient contained in Velcade) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any ...
Does Bortezomib need immediate medical attention?
Side effects not requiring immediate medical attention. Some side effects of bortezomib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
Does bortezomib cause neuropathy?
Bortezomib treatment causes a peripheral neuropathy that is predomina ntly sensory. However, cases of severe sensory and motor peripheral neuropathy have been reported. Patients with preexisting symptoms (numbness, pain or a burning feeling in the feet or hands) and/or signs of peripheral neuropathy may experience worsening peripheral neuropathy during treatment with bortezomib. Patients should be monitored for symptoms of neuropathy, such as a burning sensation, hyperesthesia, hypoesthesia, paresthesia, discomfort, neuropathic pain or weakness. Patients experiencing new or worsening peripheral neuropathy may require change in the dose and schedule of bortezomib.
What are the risks of Velcade?
To make sure Velcade is safe for you, tell your doctor if you have ever had: 1 nerve problems such as numbness, tingling, or burning pain; 2 diabetes; 3 liver disease; 4 kidney disease, or if you are on dialysis; 5 a low level of platelets or white or red blood cells; 6 heart disease, congestive heart failure; 7 lung disease or breathing problems; 8 herpes or shingles ( herpes zoster ); 9 high or low blood pressure; or 10 if you are dehydrated.
What is Velcade?
Velcade (bortezomib) interferes with the growth of some cancer cells and keeps them from spreading in your body.
What should I avoid while receiving Velcade?
Avoid becoming dehydrated if you have any vomiting or diarrhea. Talk with your doctor about how best to keep yourself hydrated.
What other drugs will affect Velcade?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
How long does Velcade last?
In cycles 5 through 9, Velcade is administered once weekly (days 1, 8, 22, and 29).#N#Comments:#N#-At least 72 hours should elapse between consecutive doses of Velcade.#N#FOR USE IN THE TREATMENT OF RELAPSED MULTIPLE MYELOMA:#N#-Usual dose: 1.3 mg/m2 as a bolus intravenous injection or subcutaneously twice weekly for two weeks (days 1, 4, 8, and 11) followed by a ten day rest period (days 12 through 21). Therapy extending beyond 8 cycles may be administered by the standard schedule or may be given once weekly for 4 weeks (days 1, 8, 15, and 22), followed by a 13-day rest (days 23 through 35).#N#Comments:#N#-Velcade may be administered alone or in combination with dexamethasone.#N#-The three week period is considered a treatment cycle.#N#-A minimum of 72 hours should elapse between consecutive doses of Velcade.#N#-Patients with multiple myeloma who have previously responded to treatment with Velcade (either alone or in combination) and who have relapsed at least 6 months after their prior therapy may be started on the last tolerated dose.#N#Use: For the treatment of multiple myeloma (who had previously responded to treatment with this drug and who have relapsed at least 6 months after completing treatment)
What to do if you miss your appointment for Velcade?
Call your doctor for instructions if you will miss an appointment for your Velcade injection.
What are the side effects of a syringe?
numbness or tingly feeling; loss of appetite, nausea, vomiting; diarrhea, constipation; fever, chills, cold or flu symptoms; rash; or. feeling tired. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is velcade injection?
VELCADE is an injection that is given intravenously (into your vein) or subcutaneously (under your skin) by a healthcare professional.
What is velcade used for?
VELCADE belongs to a class of medicines called proteasome inhibitors. It is approved by the FDA for the treatment of multiple myeloma and mantle cell lymphoma. VELCADE has been studied in many important clinical trials.
How long do you have to wait between Velcade and Prednisone?
You must wait at least 3 days between VELCADE doses. Two drugs called melphalan and prednisone (MP) are also taken on the first 4 days of every cycle throughout the year.
How does Velcade work?
As a targeted therapy, VELCADE works by blocking or slowing down the action of proteasomes inside cells. The function of proteasomes is to break down proteins in both healthy and cancerous cells.
How long does it take for Velcade to respond to treatment?
In this study of VELCADE, in previously untreated people, some people had their best response as early as 6 weeks. Others continued to respond after 6 months of treatment. If you don’t respond early, don’t be discouraged. It’s important to stick with your treatment plan if you and your doctor decide it’s right for you.
Does Velcade cause nerve pain?
It’s important to stick with your treatment plan if you and your doctor decide it’s right for you. The most common side effects reported by people receiving VELCADE in this study included abnormal blood cell counts; numbness, tingling, burning, or weakness in hands or feet; nausea; diarrhea; and nerve pain.
Can you take Velcade with multiple myeloma?
Yes. The FDA has approved VELCADE for people with newly diagnosed as well as relapsed multiple myeloma, including people who previously received VELCADE. The clinical trial included people who had received a stem cell transplant. Talk with your doctor or healthcare team about whether VELCADE may be right for you.
Can you drive if you have dizziness?
If you are having dizziness, fatigue, or fainting spells, you should not drive or operate machinery. If you are vomiting or having diarrhea, you should remember to drink adequate amounts of liquids to avoid dehydration. When you’re in doubt about any symptoms you might be having, call your doctor or nurse.
Can you talk to your doctor about Velcade?
Your healthcare team may be able to help you manage side effects. When starting treatment, be sure to talk with your doctor about any other health conditions you have or medications you’re taking. While you’re receiving VELCADE (bortezomib), it’s important to speak up about how you feel.
Can you change your dose of Velcade?
If you have any side effects with VELCADE, it’s important to tell your doctor or nurse right away. Your healthcare team might decide to change your dose or schedule of VELCADE to help manage side effects. This may help you stay on VELCADE.
Can you give Velcade to a doctor?
Your doctor may prescribe medicines to help lessen or even avoid some side effects. He or she may decide to give you VELCADE subcutaneously (an injection), lower your dose of VELCADE, or, in some cases, stop treatment with VELCADE. Click here for tips on talking to your healthcare team. You should call your doctor or healthcare team ...
