How do you administer ProQuad vaccine?
Each 0.5-mL dose of ProQuad is administered subcutaneously. The first dose is usually administered at 12 to 15 months of age but may be given anytime through 12 years of age. If a second dose of measles, mumps, rubella, and varicella vaccine is needed, ProQuad may be used.
Can you give ProQuad vaccine to adults?
Adolescents (≥13 years of age) and Adults: 2 doses, to be administered with a minimum interval of 4 weeks between doses.
Can ProQuad be given to a 2 year old?
ProQuad was licensed in 2005 for use in children ages 12 months through 12 years. It combines the MMR and varicella vaccines and therefore can be used in place of the individual MMR and varicella vaccines given at ages 12–15 months and 4–6 years.Oct 22, 2020
When can you give MMRV?
MMRV vaccine may be given to children 12 months through 12 years of age, usually: First dose at age 12 through 15 months. Second dose at age 4 through 6 years.
What happens if you give MMR intramuscular?
All live injected vaccines (MMR, varicella, and yellow fever) are recommended to be given subcutaneously. However, intramuscular administration of any of these vaccines is not likely to decrease immunogenicity, and doses given IM do not need to be repeated.Oct 22, 2020
What happens if varicella vaccine is given IM?
Although varicella vaccine is recommended to be given subcutaneously, the results of this study indicate that inadvertent intramuscular administration of varicella vaccine is not reason for revaccination.
What is the difference between MMR 2 and ProQuad?
M-M-R II® is a combination measles, mumps, and rubella (MMR) vaccine. ProQuad® is a combination measles, mumps, rubella, and varicella (MMRV) vaccine.
Is ProQuad a live vaccine?
ProQuad [Measles, Mumps, Rubella and Varicella (Oka/Merck) Virus Vaccine Live] is a "live" vaccine used to prevent the diseases of measles, mumps, rubella and varicella.
Why is MMR not given before 18 months?
This is due to an increased risk of febrile convulsions in children under four years of age who receive their first dose of MMR as MMRV. Immunisation with MMRV vaccine at 18 months gives very young children early protection against measles, mumps, rubella and chickenpox.
How do you administer MMRV?
The dosage for MMR vaccine is 0.5 mL by the subcutaneous route. If a second dose is indicated, the minimum interval between the first and second doses should be separated by at least 4 weeks (28 days). The preferred injection site for adults is the posterior triceps aspect of the upper arm.
Can MMRV be given early?
CDC recommends that children get one dose of MMRV vaccine at 12 through 15 months of age, and the second dose at 4 through 6 years of age. Children can receive the second dose of MMRV vaccine earlier than 4 through 6 years. This second dose of MMRV vaccine can be given 3 months after the first dose.
Can you give MMRV at 12 months?
As their child's healthcare provider, you remain parents' most trusted source of information about vaccines. For the first dose of measles, mumps, rubella, and varicella vaccines given at ages 12-47 months, either MMR and varicella vaccines or MMRV vaccine can be used.
Indications and Usage For Proquad
Dosage Forms and Strengths
- ProQuad is a suspension for injection supplied as a single dose vial of lyophilized vaccine to be reconstituted using the accompanying sterile diluent [see Dosage and Administration (2.2) and How Supplied/Storage and Handling (16)]. A single dose after reconstitution is 0.5 mL.
Contraindications
- Hypersensitivity
Do not administer ProQuad to individuals with a history of hypersensitivity to any component of the vaccine (including gelatin) {1} or to a previous dose of M-M-R II® (Measles, Mumps, Rubella, Live), ProQuad or VARIVAX® (Varicella Virus Vaccine Live) vaccine, or any other measles, mump… - Immunosuppression
Do not administer ProQuad vaccine to individuals who are immunodeficient or immunosuppressed due to disease or medical therapy. Measles inclusion body encephalitis {2} (MIBE), pneumonitis {3} and death as a direct consequence of disseminated measles vaccine vir…
Warnings and Precautions
- Fever and Febrile Seizures
Administration of ProQuad (dose 1) to children 12 to 23 months old who have not been previously vaccinated against measles, mumps, rubella, or varicella, nor had a history of the wild-type infections, is associated with higher rates of fever and febrile seizures at 5 to 12 days after vacci… - Hypersensitivity to Eggs
Individuals with a history of anaphylactic, anaphylactoid, or other immediate reactions (e.g., hives, swelling of the mouth and throat, difficulty breathing, hypotension, or shock) subsequent to egg ingestion may be at an enhanced risk of immediate-type hypersensitivity reactions after receivin…
Adverse Reactions
- Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a vaccine cannot be directly compared to rates in the clinical trials of another vaccine and may not reflect the rates observed in practice. Vaccine-related adverse r… - Post-Marketing Experience
The following adverse events have been identified during post-approval use of either the components of ProQuad or ProQuad. Because the events are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or esta…
Drug Interactions
- Immune Globulins and Transfusions
Administration of immune globulins and other blood products concurrently with ProQuad vaccine may interfere with the expected immune response [see Warnings and Precautions (5.7)] {9-11}. The ACIP has specific recommendations for intervals between administration of antibody contai… - Salicylates
Reye syndrome has been reported following the use of salicylates during wild-type varicella infection. Vaccine recipients should avoid use of salicylates for 6 weeks after vaccination with ProQuad [see Warnings and Precautions (5.8) and Patient Counseling Information (17)].
Use in Specific Populations
- Pregnancy
Risk Summary ProQuad vaccine contains live attenuated measles, mumps, rubella and varicella viruses. The vaccine is contraindicated for use in pregnant women because infection during pregnancy with the wild-type viruses is associated with maternal and fetal adverse outcomes. F… - Lactation
Risk Summary It is not known whether varicella, measles, or mumps vaccine virus is excreted in human milk. Studies have shown that lactating postpartum women vaccinated with live rubella vaccine may secrete the virus in breast milk and transmit it to breastfed infants [see Warnings a…
Proquad Description
- ProQuad (Measles, Mumps, Rubella and Varicella Virus Vaccine Live) is a combined, attenuated, live virus vaccine containing measles, mumps, rubella, and varicella viruses. ProQuad is a sterile lyophilized preparation of (1) the components of M-M-R II (Measles, Mumps, and Rubella Virus Vaccine Live): Measles Virus Vaccine Live, a more attenuated line of measles virus, derived fro…
Proquad - Clinical Pharmacology
- Mechanism of Action
ProQuad has been shown to induce measles-, mumps-, rubella-, and varicella-specific immunity, which is thought to be the mechanism by which it protects against these four childhood diseases. The efficacy of ProQuad was established through the use of immunological correlates for prote… - Persistence of Antibody Responses after Vaccination
The persistence of antibody at 1 year after vaccination was evaluated in a subset of 2107 children enrolled in the clinical trials. Antibody was detected in 98.9% (1722/1741) for measles, 96.7% (1676/1733) for mumps, 99.6% (1796/1804) for rubella, and 97.5% (1512/1550) for varicella (≥5 …
Nonclinical Toxicology
- Carcinogenesis, Mutagenesis, Impairment of Fertility
ProQuad has not been evaluated for its carcinogenic, mutagenic, or teratogenic potential, or its potential to impair fertility.