Does lyophilized cathflo need to be refrigerated?
Lyophilized Cathflo should be stored at refrigerated temperatures (2°C-8°C/36°F-46°F). Cathflo should be reconstituted immediately before use. The solution may be used within 8 hours if stored at 2°C to 30°C (36°F-86°F). CVAD=central venous access device; INS=Infusion Nurses Society.
Do you have to refrigerate cathflo activase?
Do not use beyond the expiration date stamped on the vial. Store lyophilized Cathflo Activase at refrigerated temperature (2-8°C/36-46°F). The solution may be used for intracatheter instillation within 8 hours following reconstitution when stored at 2-30°C (36-86°F).
How many milligrams of cathflo can you take at once?
Studies have only evaluated up to two 2-mg doses. No other medication should be added to solutions containing Cathflo. Lyophilized Cathflo should be stored at refrigerated temperatures (2°C-8°C/36°F-46°F). Cathflo should be reconstituted immediately before use.
What is the final concentration of cathflo?
After WASHING hands using aseptic technique, reconstitute Cathflo to a final concentration of 2 mg/2 mL: 1. Aseptically WITHDRAW 2.2 mL of Sterile Water for Injection, USP (diluent is not provided). Do not use Bacteriostatic Water for Injection, USP.
How long is alteplase good for out of the fridge?
Conclusions: Alteplase diluted in normal saline solution at a concentration of 0.01 mg/mL is biochemically stable and active at ambient temperature for as long as 24 hours as assessed by in vitro clot lysis assays.
How long is Cathflo good for after reconstitution?
Cathflo contains no antibacterial preservatives and should be reconstituted immediately before use. However, the solution is recommended to be used for intracatheter instillation within 8 hours following reconstitution when stored at 2 to 30 degrees Celsius, 36 to 86 degrees Fahrenheit.
Is Activase refrigerated?
Store lyophilized Cathflo Activase at refrigerated temperature (2-8°C/36-46°F). Do not use beyond the expiration date on the vial. Protect the lyophilized material during extended storage from excessive exposure to light.
Can Cathflo dwell overnight?
In COOL-1, Cathflo restored function to 88% (112/127) of central lines after up to 2 doses using a 120-minute dwell time for each in catheters with occlusions present for up to 24 hours.
How long is alteplase good for after mixed?
The solution may be used for intravenous administration within 8 hours following reconstitution when stored between 2-30°C (36-86°F). Do not add other medication to solutions containing Activase. Any unused solution should be discarded.
How do you store alteplase?
Lyophilized Cathflo should be stored at refrigerated temperatures (2°C-8°C/36°F-46°F). Cathflo should be reconstituted immediately before use. The solution may be used within 8 hours if stored at 2°C to 30°C (36°F-86°F).
How long does Activase remain stable at room temperature after reconstitution?
If stored between 2-30°C (36-86°F), Activase may be used within 8 hours following reconstitution. Store lyophilized Activase at controlled room temperature not to exceed 30°C (86°F).
Does tPA need to be refrigerated?
How should I keep alteplase (TPA, Activase, Cathflo Activase) stored? The vials are stored at room temperature up to 80 F (30 C) or under refrigeration at 2-8 C (36-46 F). Once mixed with sterile water, it must be used immediately. Any drug not used must be thrown away.
How long do you leave Cathflo in?
If catheter patency has NOT been restored, allow the Cathflo® to dwell another 30-90 minutes, for a total of 120 minutes of dwell time.
How do you clear an occluded PICC line?
How to flush your PICC lineWash your hands. Wash your hands well with soap and warm water. ... Fill the syringe. Open a new bottle of the flushing solution. ... Remove air from the syringe. Hold the syringe with the tip pointing up. ... Inject the flushing solution. ... Finish flushing.
How long does alteplase take to work?
Slight foaming is not unusual; let the vial stand undisturbed to allow large bubbles to dissipate. Mix by gently swirling until the contents are completely dissolved. Complete dissolution should occur within 3 minutes.
What is the half-life of Cathflo?
In patients with acute myocardial infarction administered 100 mg of Activase as an accelerated intravenous infusion over 90 minutes, plasma clearance occurred with an initial half-life of less than 5 minutes and a terminal half-life of 72 minutes. Clearance is mediated primarily by the liver (2).
What is the half life of Cathflo?
In patients with acute myocardial infarction administered 100 mg of Activase as an accelerated intravenous infusion over 90 minutes, plasma clearance occurred with an initial half-life of less than 5 minutes and a terminal half-life of 72 minutes. Clearance is mediated primarily by the liver (2).
How long does it take Cathflo to work?
Mix by gently swirling until the contents are completely dissolved. Complete dissolution should occur within 3 minutes. DO NOT SHAKE. The reconstituted preparation results in a colorless to pale yellow transparent solution containing 1 mg/mL Cathflo Activase at a pH of approximately 7.3.
How do you mix alteplase?
2:024:34tPA (Alteplase) Mixing Video - YouTubeYouTubeStart of suggested clipEnd of suggested clipDevice into the vial containing activase a process that requires approximately two minutes aboutMoreDevice into the vial containing activase a process that requires approximately two minutes about half a milliliter of sterile water may remain in the upper. Vial remove the transfer device and the
How do you administer alteplase to a PICC line?
Doses of 1 to 2 mg injected into the lumen(s) of central venous catheters or PICC lines, allowed to dwell for 15 minutes to 4 hours, then removed by aspiration, have been reported effective in establishing patency. Instill 2 mg/2 ml into the dysfunctional catheter for 2 hours.
How to administer Cathflo Activase?
Withdraw 2 mL (2 mg) of solution from the reconstituted vial. Instill the appropriate dose of Cathflo Activase (see DOSAGE AND ADMINISTRATION) into the occluded catheter. After 30 minutes of dwell time, assess catheter function by attempting to aspirate blood. If the catheter is functional, go to Step 7. If the catheter is not functional, go to Step 5. After 120 minutes of dwell time, assess catheter function by attempting to aspirate blood and catheter contents. If the catheter is functional, go to Step 7. If the catheter is not functional, go to Step 6. If catheter function is not restored after one dose of Cathflo Activase, a second dose of equal amount may be instilled. Repeat the procedure beginning with Step 1 under Preparation of Solution. If catheter function has been restored, aspirate 4-5 mL of blood in patients >/=10 kg or 3 mL in patients <10 kg to remove Cathflo Activase and residual clot, and gently irrigate the catheter with 0.9% Sodium Chloride Injection, USP. Any unused solution should be discarded.
What to do if a catheter is not functional?
If the catheter is not functional, go to Step 6. If catheter function is not restored after one dose of Cathflo Activase, a second dose of equal amount may be instilled. Repeat the procedure beginning with Step 1 under Preparation of Solution.
What is the concentration of alteplase in a catheter?
Intracatheter: Cathflo® Activase® (Alteplase) is for instillation into the dysfunctional catheter at a concentration of 1 mg/mL.
How long does it take to assess a catheter?
After 30 minutes of dwell time, assess catheter function by attempting to aspirate blood. If the catheter is functional, go to Step 7. If the catheter is not functional, go to Step 5. After 120 minutes of dwell time, assess catheter function by attempting to aspirate blood and catheter contents.
Can you use a lyophilized solution after the expiration date?
Any unused solution should be discarded. Do not use beyond the expiration date on the vial. Protect the lyophilized material during extended storage from excessive exposure to light.
