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does nph insulin have to be refrigerated

by Dr. Maiya Terry Published 2 years ago Updated 2 years ago
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Opened vials: Store in the refrigerator or at room temperature in a cool place, away from sunlight and heat. Use within 31 days. Opened prefilled pens: Store at room temperature, away from direct heat and light. Do not refrigerate.Aug 1, 2022

Does insulin need to be refrigerated?

According to the product labels from all three U.S. insulin manufacturers, it is recommended that insulin be stored in a refrigerator at approximately 36°F to 46°F. Unopened and stored in this manner, these products maintain potency until the expiration date on the package.

Should NPH insulin be kept at room temperature?

The benefit of keeping NPH insulin at room temperature is that it would decrease the amount of discomfort during injection. Never refrigerate an in-use injection pen. An in-use NPH insulin (after opening) should be kept at room temperature below 30 degrees C (86 degrees F). Protect opened insulin from heat and light.

How do you store Novolin N insulin?

PATIENT PACKAGE INSERT. Keep vials away from direct heat or light. Throw away an opened vial after 6 weeks (42 days) of use, even if there is insulin left in the vial. Unopened vials can be used until the expiration date on the Novolin N label, if the medicine has been stored in a refrigerator.

What should I know about insulin NPH and insulin regular (vials)?

Tell all of your health care providers that you take insulin NPH and insulin regular (vials). This includes your doctors, nurses, pharmacists, and dentists. Allergic reactions have happened with insulin NPH and insulin regular (vials). Rarely, some reactions can be very bad or life-threatening. Talk with the doctor.

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How long can NPH insulin be unrefrigerated?

Insulin products contained in vials or cartridges supplied by the manufacturers (opened or unopened) may be left unrefrigerated at a temperature between 59°F and 86°F for up to 28 days and continue to work.

Does NPH pen need to be refrigerated?

Store unused Pens in the refrigerator at 36°F to 46°F (2°C to 8°C). Do not freeze your insulin. Do not use if it has been frozen. Unused Pens may be used until the expiration date printed on the Label, if the Pen has been kept in the refrigerator.

Does novolin NPH need to be refrigerated?

If not in use or unopened, the Novolin N vials can be stored in a refrigerator until the expiration date, or at room temperature for 42 days. If currently in use, opened vials can be stored at room temperature for 42 days. Do not refrigerate opened vials.

What happens if insulin is left out of fridge?

Insulin could freeze if it was left outside in extreme cold temperature, for example if it was delivered on a cold day and stayed outside for a while, or if it was left in your car. But insulin could also freeze in your refrigerator.

How long is NPH insulin good for after opening?

Vials:Insulin NameExpiration Upon Opening or Removing from RefrigeratorStorage of Opened Vial Special InstructionsRegular Insulin; Isophane Insulin (NPH) (Novolin 70/30)42 daysStore at room temperature; do not refrigerate.13 more rows•Jun 4, 2021

Which insulin can be stored at room temperature?

Always follow the manufacturer's instructions on how to dilute it. After diluting insulin aspart (Novolog), you can keep it at room temperature for 28 days. After diluting insulin lispro (Humalog) you can keep it refrigerated for 28 days or at room temperature up to 86°F for 14 days.

Can NPH insulin be stored in room temperature?

Do not freeze. Do not use if it has been frozen. If an unopened container has been stored at room temperature, be sure you know how long you can leave insulin NPH and insulin regular (vials) at room temperature before you need to throw it away.

Do you roll NPH insulin?

Mix the insulin by slowly rolling the bottle between your hands or gently tipping the bottle over a few times. Never shake the bottle vigorously (hard). Do not use the insulin if it looks lumpy or grainy, seems unusually thick, sticks to the bottle, or seems to be even a little discolored.

Can I put insulin back in the fridge?

Moving an opened insulin bottle back and forth between refrigeration and room temperature shouldn't affect it as long as it's not kept out too long. Once you open an insulin pen and begin to use it, it should not go back in the fridge.

How long does insulin last at room temperature?

Although manufacturers recommend storing your insulin in the refrigerator, injecting cold insulin can sometimes make the injection more painful. To avoid this, many providers suggest storing the bottle of insulin you are using at room temperature. Insulin kept at room temperature will last approximately one month.

How do you travel with insulin that needs to be refrigerated?

With a vast amount of experience of plane travel I can tell you the key is the same as anywhere else, use a Frio bag or similar insulin travel case. Just activate them in cold water and your insulin pens and cartridges will stay at a cool temperature on the plane for any length of flight!

How do you store insulin without refrigeration?

If refrigeration is not possible, it can be kept at room temperature [15-25 degrees C] for 28 days. The in use vial may be kept at room temperature [15-25 degrees C] for 28 days. In use cartridges should be kept at room temperature and SHOULD NOT be kept in the refrigerator.

Can NPH insulin be stored in room temperature?

Do not freeze. Do not use if it has been frozen. If an unopened container has been stored at room temperature, be sure you know how long you can leave insulin NPH and insulin regular (vials) at room temperature before you need to throw it away.

Should I keep my dogs insulin in the fridge?

Insulin is a hormone that will lose its effectiveness if exposed to direct sunlight or high temperatures. It should be kept in the refrigerator, but it should not be frozen. If you have any doubt about the storage of your dog's insulin, it is safer to replace it rather than risk using ineffective insulin.

Does Humulin N need to be refrigerated?

Not in-use (unopened): Humulin N Pens not in-use should be stored in a refrigerator, but not in the freezer. In-use (opened): Humulin N Pens in-use should NOT be refrigerated but should be kept at room temperature [below 86°F (30°C)] away from direct heat and light.

Does insulin need to be kept in the fridge?

Keep It Cool According to the product labels from all three U.S. insulin manufacturers, it is recommended that insulin be stored in a refrigerator at approximately 36°F to 46°F. If you are using ice, avoid freezing the insulin.

Where to store insulin?

Insulin shouldn't be exposed to extreme temperatures, so don't leave it in the car, next to the stove, in the freezer, or in the bathroom. If the bottle freezes, it must be discarded.

How long is insulin good for?

Expert Answers As a general rule, most bottles of insulin are good for 28 days once they're opened. Of course, how quickly a person goes through a vial is highly individual. Some may go through a bottle in a week or two. Others, on a lower dosage, may not use all the insulin within four weeks.

How Long Should Insulin Be Used Once A Vial Is Started?

and the American Diabetes Association, and all of these combined in this commentary. The commenting letter and individual responses were authored separately and are completely independent of each other. Diabetic patients treated with insulin, whether for type 1 or type 2 diabetes, are prone to often unexplained swings in their blood glucose. These swings can vary from dangerously low to persistently high levels. Most diabetic patients, and most physicians, will adjust insulin regimens so as to avoid hypoglycemia at the expense of hyperglycemia. Among the “textbook” reasons for variable glucose responses to any given insulin regimen are 1) site of administration, 2) exercise, 3) bottles not adequately mixed before drawing the insulin (for NPH, Lente, or Ultralente), and 4) duration of treatment with insulin (1). A new insulin was marketed by Aventis Pharmaceuticals about 1 year ago, insulin glargine (Lantus). The manufacturer seemed to stress that patients not use a started bottle of this insulin for >28 days (2). Two patients of mine highlighted this point. L.K. is a 76-year-old woman with type 2 diabetes, diagnosed at 55 years of age, and treated with insulin since age 56. Her insulin regimen was changed to Lantus at night together with Novolog before meals. She monitors her blood glucose four times a day. She used a bottle of Lantus until it ran out; therefore, a bottle lasted for 2 months. Her recent HbA1c was 7.6%. I retrospectively analyzed her home glucose readings by averaging her fasting blood glucose levels for the first 15 days of a new bottle and the last 15 days of tha Continue reading >>

Can Insulin Vials Be Kept Safely Outside The Refrigerator?

I am on a website where information is exchanged between people with type 1 diabetes. Half the people say that insulin doesn’t need refrigeration after it is opened and half say that it still needs refrigeration. After having diabetes for 42 years, I have never heard that keeping insulin at room temperature is okay. Is it? Doesn’t temperature affect how well the insulin works? A. The American Diabetes Association recommends that a bottle of insulin can be stored at room temperature (59 to 86 degrees F) for up to one month after it is opened. Storing it in the refrigerator after opening does not make it last longer. Unopened insulin can be stored at room temperature for one month or in the refrigerator (not in the freezer!) until it reaches its expiration date. Insulin must be protected from extremes of heat or cold, which means not leaving it in the glove box or trunk of the car during the summer. Mail order delivery can pose problems. One reader had a delivery of insulin sit outside for hours in the winter. The pharmacy told her it should be fine, but it did not control her blood sugar properly. If you get your insulin by mail order, check with the pharmacy to verify that it will not sit in a hot delivery truck or mailbox in warm weather. Continue reading >>

Do I Need To Throw Out All My Insulin?

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community So my fridge door was left a little open last night. The thermometer showed a temp of about 11 degrees this morning. Will my insulin be okay given it was only at the increased temperature for a short while or should it be thrown away? I know it's probably safer to not risk it but I have a fair quantity so would rather not waste it if the risk of it being damaged is very low. You can still use the insulin over the next 4 weeks, but just to be safe I wouldn't risk keeping it any longer and would just reorder more. On a pump forum it was stated that it takes ages for insulin in cartridges and vials to deteriate at room temperature apparently so even if a fridge malfunctions, the insulin should still be ok but if in doubt then see a pharmacist I wouldn't throw it away yet, at least not until you have checked with a pharmacist as they're the experts in medicines use, storage etc. For a start, temperature of 11oC isn't much above 4 - 8oC of normal refridgeration, and anyway, temperature varies within fridge - lowest in bottom drawers and back of fridge, slightly higher in door and top of main body of fridge. If and when you get new insulin, make your you mark packs, so you know the difference between the batch you have now and the next lot, so if you do find this batch is less effective than usual, you only discard this batch, not both old and new. I keep my insulin at room temperature for years with no effect. Keep it chilled if you prefer & ask pharmacist on Tues!! So my fridge door was left a little open last night. The thermometer showed a temp of about 11 degrees this morning. Will my insulin be okay given it was only at the increased temperature for a Continue reading >>

How to measure insulin?

Insulin is measured in units. Most bottles, cartridges, and pens of insulin sold in the United States have 100 units of insulin per milliliter of fluid and are labeled U-100. Different strengths, like U-500, also are available in the U.S. Different strengths are used in other countries. It's important to know the type of insulin you take and whether it should appear cloudy or clear. When you prepare to use a bottle, cartridge, or pen, check the insulin: NPH should look uniformly cloudy after you gently roll the bottle or pen. All other insulin should look clear. If your insulin doesn't look right, don't use it. Take it back to your pharmacy. Don't shake your insulin. Gently roll it. Don't toss it around or handle it roughly. If you don't handle your insulin correctly, it's more likely to clump or frost. Don't use the insulin if you can see clumps after you gently roll the bottle or pen, or if the sides look frosted. Storage Guidelines Take steps to store your insulin correctly, or it might not work. Keep your insulin away from heat and light. Any insulin that you don't store in the refrigerator should be kept as cool as possible (between 56°F and 80°F.) Never let your insulin freeze. If your insulin freezes, don't use it, even after it's thawed. Keep unused bottles, cartridges, and pens of insulin in the refrigerator (between 36°F and 46°F). If stored properly, these will be good until the expiration date listed on the insulin. Keep insulin cartridges and pens that you're currently using at room temperature (between 56°F and 80°F.) Expiration Guidelines An open insulin bottle, cartridge, or pen is only good for a limited time. Follow these guidelines for discarding insulin: Glargine (Lantus): Discard opened bottles, pens, and cartridges 28 days after you've starte Continue reading >>

Why is there ice in my insulin bottle?

There were ice crystals in the bottle because the insulin had been frozen. Whenever insulin freezes there is a possibility that it will no longer be effective. I found out from the patient that some of the bottles had got pushed to the far back corner of the fridge and must have frozen.

When to refrigerate insulin?

If you live in a warmer climate, it’s safer for you to refrigerate your insulin when the temperature goes above about 80 degrees Fahrenheit, even if the maximum 28 days are not over.

How long can insulin be kept in the refrigerator?

As a general rule, insulin should be refrigerated. However, insulin can be kept at room temperature, meaning not in the refrigerator for an approximate of 28-30 days. Up to a maximum of one month, insulin should be refrigerated at a temperature between 36 degrees and 46 degrees Fahrenheit.

How long does an insulin pen last?

An opened disposable insulin pen will last for only four weeks maximum regardless of the temperature it is stored in. So, it’s important to remember that merely refrigerating will not make insulin more effective or last longer.

Why is insulin refrigerated?

So, like any other protein, insulin can spoil. This is why it needs to be refrigerated – to keep it from spoiling. Think of insulin as a form of meal. If you keep it out for long enough, it’s going to spoil.

How long can you keep an insulin pen outside?

As a good example, an unopened disposable insulin pen can be kept outside at room temperature below 86 degrees Fahrenheit (30 degrees Celsius) for a maximum of 4 weeks. And when refrigerating, it has to be kept between 35.6 and 46.4 degrees Fahrenheit (2 degrees to 8 degrees Celsius) until expiry.

How long can you keep insulin at room temperature?

The standard recommendation from all insulin manufacturers says a vial of insulin in use can be kept at room temperature for 28 days. Room temperature for insulin in use specifies a temperature range between 59 degrees and 86 degrees Fahrenheit.

What temperature should insulin be refrigerated?

For this, you should look at keeping a thermometer in the fridge and check for a stable temperature of 39° F (or 4° C).

How long can insulin be stored in the refrigerator?

Insulin from various manufacturers is often made available to patients in an emergency and may be different from a patient's usual insulin. After a disaster, patients in the affected area may not have access to refrigeration. According to the product labels from all three U.S. insulin manufacturers, it is recommended that insulin be stored in a refrigerator at approximately 36°F to 46°F. Unopened and stored in this manner, these products maintain potency until the expiration date on the package.

What temperature should insulin be stored at?

This can result in loss of blood glucose control over time. Under emergency conditions, you might still need to use insulin that has been stored above 86°F. You should try to keep insulin as cool as possible.

How long does it take for insulin to be injected?

Insulin mixes containing a rapid-acting insulin analog (e.g., Humalog Mix, Novolog Mix) should be injected closer (within 15 minutes) to the start of the meal compared to mixes containing regular insulin (e.g., Humulin 70/30). If an insulin mix is not available, patients should follow this two-step process:

How long can insulin be left unopened?

Insulin products contained in vials or cartridges supplied by the manufacturers (opened or unopened) may be left unrefrigerated at a temperature between 59°F and 86°F for up to 28 days and continue to work.

When is close monitoring of blood glucose and adjustment in insulin dose needed?

Close monitoring of blood glucose and adjustment in insulin dose may be needed in the transition period.

How long should insulin be in a pump?

Insulin contained in the infusion set of a pump device (e.g., reservoir, tubing, catheters) should be discarded after 48 hours. Insulin contained in the infusion set of a pump device and exposed to temperature exceeding 98.6°F should be discarded.

What is the number to call for insulin?

If patients or healthcare providers have specific questions about the suitability of their insulin, they may call the respective manufacturer at the following numbers: Lilly: 1-800-545-5979. Sanofi-Aventis: 1-800-633-1610. Novo Nordisk: 1-800-727-6500.

Why Not Continue To Refrigerate Open Insulin Pens?

Why Not Continue to Refrigerate Open Insulin Pens? I will definitely share anything I find. What I'm looking for is actual documentation or a valid technological explanation. I know that the manufacturers, as well as their legal and scientific teams, would NOT casually state or withhold information in the specs or the white papers for their products. I get the impression that you believe the manufacturers have control over the content of the drug info sheet packaged with insulin. That they can include any information so long as they feel reasonably certain that it is factual & pertinent. I actually don't know, but I very much doubt that this is the case. So I will also be interested what you find out if you pursue this further. My speculation is that they are much more limited in the US by FDA rules & regulations in terms of what they can include in those documents. There is probably some sort of established testing procedure that has to be completed, certified, and accepted before they can include "facts" in the document. Just because they tested something in their labs & feel it's factually true is probably insufficient. My opinion on this comes from similar "nonsense" (IMO) which I have bumped up against while scanning for info on CGMs. Take the sites on a person's body which are "indicated" as acceptable for inserting a CGM. The official response from the companies usually boils down to inserting on the abdomen and not much else. Why? Well, in the case of Medtronic they say very carefully that these are the best insertion sites based on the US clinical trials for their sensor. My understanding is that they are not allowed to say other sites might also work, although they certainly do in my own & others experience. In order to do that they probably need to complete Continue reading >>

How Long Does Insulin Last Once It's Been Opened?

A fellow caregiver asked... My mother has type 2 diabetes and needs help with her insulin injections. After I open a new bottle, how long does insulin last for, how should I store it, and how do I know whether it's gone bad? Expert Answers As a general rule, most bottles of insulin are good for 28 days once they're opened. Of course, how quickly a person goes through a vial is highly individual. Some may go through a bottle in a week or two. Others, on a lower dosage, may not use all the insulin within four weeks. But the drug's stability and potency is only guaranteed for 28 days. Opened insulin pens typically last 14 days, though some last only 10 days. If you're uncertain, check with your mother's pharmacist to find out how long her insulin should last. When either of you opens a new vial or pen, make a note on the calendar -- and note the date when you'll need to throw out any remaining insulin. It's best to store an opened bottle of insulin at room temperature, even though manufacturers often recommend refrigeration for opened containers. It's usually less painful to inject insulin when it's at room temperature than when it's cold. Store unopened insulin vials and pen cartridges in the fridge, though, where they should last until their expiration date. Insulin shouldn't be exposed to extreme temperatures, so don't leave it in the car, next to the stove, in the freezer, or in the bathroom. If the bottle freezes, it must be discarded. Two typical signs that insulin has gone bad: poor performance and unusual appearance. If your mother is following her treatment plan and her glucose levels stay stubbornly, inexplicably high, her insulin may have lost its potency. Insulin that's cloudy when it's supposed to be clear or that contains particles, crystals, or small clumps Continue reading >>

How Long Should Insulin Be Used Once A Vial Is Started?

and the American Diabetes Association, and all of these combined in this commentary. The commenting letter and individual responses were authored separately and are completely independent of each other. Diabetic patients treated with insulin, whether for type 1 or type 2 diabetes, are prone to often unexplained swings in their blood glucose. These swings can vary from dangerously low to persistently high levels. Most diabetic patients, and most physicians, will adjust insulin regimens so as to avoid hypoglycemia at the expense of hyperglycemia. Among the “textbook” reasons for variable glucose responses to any given insulin regimen are 1) site of administration, 2) exercise, 3) bottles not adequately mixed before drawing the insulin (for NPH, Lente, or Ultralente), and 4) duration of treatment with insulin (1). A new insulin was marketed by Aventis Pharmaceuticals about 1 year ago, insulin glargine (Lantus). The manufacturer seemed to stress that patients not use a started bottle of this insulin for >28 days (2). Two patients of mine highlighted this point. L.K. is a 76-year-old woman with type 2 diabetes, diagnosed at 55 years of age, and treated with insulin since age 56. Her insulin regimen was changed to Lantus at night together with Novolog before meals. She monitors her blood glucose four times a day. She used a bottle of Lantus until it ran out; therefore, a bottle lasted for 2 months. Her recent HbA1c was 7.6%. I retrospectively analyzed her home glucose readings by averaging her fasting blood glucose levels for the first 15 days of a new bottle and the last 15 days of tha Continue reading >>

Does the first patient in diabetes trial need insulin?

First patient in diabetes trial no longer needs insulin therapy

Do insulin pen come back in the fridge?

Insulin Pens Are Welcome Back To The Fridge!

Can Insulin Go Back In The Fridge?

After removing insulin glargine (Lantus) from the refrigerator for use, can it be refrigerated over and over again after having warmed to room temperature, or does this degrade it? Continue reading >>

How long does insulin last in the refrigerator?

Insulin kept at room temperature will last approximately one month.

When to dispose of insulin syringe?

It's time to dispose of an insulin syringe when the needle is dull or bent or has come in contact with anything other than clean skin. If you can do it safely, clip the needles off the syringes so no one can use them. It's best to buy a device that clips, catches, and contains the needle.

How to reuse a syringe?

Here are some tips to keep in mind when reusing syringes: 1 Keep the needle clean by keeping it capped when you're not using it. 2 Never let the needle touch anything but clean skin and the top of the insulin bottle. 3 Never let anyone use a syringe you've already used, and don't use anyone else's syringe. 4 Cleaning it with alcohol removes the coating that helps the needle slide into the skin easily.

What to do if you don't destroy needles?

If you don't destroy your needles, recap them. Place the needle or entire syringe in an opaque (not clear) heavy-duty plastic bottle with a screw cap or a plastic or metal box that closes firmly. Do not use a container that will allow the needle to break through, and do not recycle your syringe container.

How to keep needles clean?

Keep the needle clean by keeping it capped when you're not using it.

How to transport a used syringe?

When traveling, bring your used syringes home. Pack them in a heavy-duty holder, such as a hard plastic pencil box, for transport.

Can you reuse insulin syringes?

They can help you decide whether it would be a safe choice for you. If you are ill, have open wounds on your hands, or have poor resistance to infection, you should not risk insulin syringe reuse. Syringe makers will not guarantee the sterility of syringes that are reused.

Does insulin need to be refrigerated?

The short answer: Yes. Most manufacturers recommend refrigerating unopened insulin.

Do different forms of insulin have unique storage instructions?

Different forms of insulin, and even different brands, may have different storage instructions. Below, we’ll discuss how different forms of insulin are stored. Always read the instructions on your insulin box and ask your pharmacist for specific storage directions.

The bottom line

Insulin is sensitive to extreme temperatures and light. Storing your insulin correctly ensures that it remains effective. If stored incorrectly, it may spoil and become ineffective.

What are some things I need to know or do while I take Insulin NPH and Insulin Regular?

Tell all of your health care providers that you take insulin NPH and insulin regular (vials). This includes your doctors, nurses, pharmacists, and dentists.

How is this medicine (Insulin NPH and Insulin Regular) best taken?

Use insulin NPH and insulin regular ( vials) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

What do I need to tell my doctor BEFORE I take Insulin NPH and Insulin Regular?

If you are allergic to insulin NPH and insulin regular (vials); any part of insulin NPH and insulin regular (vials); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

What are some other side effects of Insulin NPH and Insulin Regular?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

How to avoid driving with insulin?

Avoid driving and doing other tasks or actions that call for you to be alert until you see how insulin NPH and insulin regular (vials) affects you.

Can you take insulin with OTC?

You must check to make sure that it is safe for you to take insulin NPH and insulin regular (vials) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Can insulin cause seizures?

Talk with the doctor. Low blood sugar may happen with insulin NPH and insulin regular (vials). Very low blood sugar can lead to seizures , passing out, long lasting brain damage, and sometimes death.

Why should pen fill cartridges not be shared?

2. To avoid possible transmission of disease, PenFill cartridge should not be shared.

How long does it take for Novolin N to work?

Take Novolin N exactly as prescribed. Novolin N is an intermediate-acting insulin. The effects of Novolin N start working 1½ hours after inject ion. The greatest blood sugar lowering effect is between 4 and 12 hours after the injection.

How many air shots do you need for Novolin?

If not, repeat the procedure until insulin appears. Before the first use of Novolin ® N InnoLet ® you may need to perform up to 6 air shots to get a drop of insulin at the needle tip. If you need to make more than 6 air shots, do not use, and return the product to Novo Nordisk.

How to contact Novolin N?

If you would like more information about Novolin N or diabetes, talk with your healthcare provider. For more information, call 1-800-727-6500 or visit www.novonordisk-us.com.

Why does insulin make my skin red?

This is called a “local reaction” and it may occur if the injection is not properly made, if the skin is sensitive to the cleansing solution , or if you are allergic to the insulin being used.

What happens if you take too much insulin?

This can happen if you take too much insulin, miss or delay a meal, exercise more than usual, or work too hard without eating , or become ill (especially with vomiting or fever). Hypoglycemia can also happen if you combine insulin therapy and other medications that lower blood glucose, such as oral antidiabetic agents or other prescription and over-the-counter drugs. The first symptoms of an insulin reaction usually come on suddenly. They may include a cold sweat, fatigue, nervousness or shakiness, rapid heartbeat, or nausea. Personality change or confusion may also occur. If you drink or eat something right away (a glass of milk or orange juice, or several sugar candies), you can often stop the progression of symptoms. If symptoms persist, call your physician - an insulin reaction can lead to unconsciousness. If a reaction results in loss of consciousness, emergency medical care should be obtained immediately. If you have had repeated reactions or if an insulin reaction has led to a loss of consciousness, contact your physician. Severe hypoglycemia can result in temporary or permanent impairment of brain function and death.

What happens if you forget to take Novolin?

If you forget to take your dose of Novolin N, your blood sugar may go too high (hyperglycemia). If high blood sugar (hyperglycemia) is not treated it can lead to diabetic ketoacidosis, which can lead to serious problems, like loss of consciousness (passing out), coma or even death.

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Url:https://diabetestalk.net/insulin/why-does-insulin-have-to-be-refrigerated

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