Precautions
a bleeding disorder or blood clotting disorder. Plavix may not work as well if you have certain genetic factors that affect the breakdown of this medicine in your body. Your doctor may perform a blood test to make sure Plavix is right for you.
Is there a blood test for Plavix?
Plavix may not work as well if you have certain genetic factors that affect the breakdown of this medicine in your body. Your doctor may perform a blood test to make sure Plavix is right for you.
Why does Plavix not work as well as it used to?
In the event that the antiplatelet effect of Plavix needs to be reversed, platelet transfusions may be administered. However, these are less effective if given within 4 hours of a loading dose or within 2 hours of a maintenance dose of Plavix. 7.
Can platelets be given after taking Plavix?
Human data have not identified an association with Plavix use in pregnancy and major birth defects, miscarriage, or adverse fetal outcomes. Animal studies corresponding to 65 to 78 times the recommended daily human dose revealed no evidence of impaired fertility or fetotoxicity due to clopidogrel.
Is it safe to take Plavix during pregnancy?
How do you monitor for Plavix?
Most clinical studies on clopidogrel rely on standard platelet aggregometry to measure inhibition of ADP-induced aggregation (4)(5). In addition to aggregometry, cytometric determination of surface expression of platelet proteins, in particular P-selectin (CD62P), is commonly used to monitor platelet activation.
What labs do you monitor for Plavix?
Test results are in P2Y12 reaction units (PRU). This test measures the extent of platelet aggregation in the presence of P2Y12 inhibitor drugs such as clopidogrel (Plavix), prasugrel (Effient), ticagrelor (Brilinta) and ticlopidine (Ticlid).
Does Plavix require blood testing?
Clopidogrel doesn't require regular blood test monitoring, but it affects platelet function and bleeding times for up to 7–10 days. You may need to avoid elective dental work and elective operations while taking aspirin or clopidogrel due to risks of bleeding.
How do you monitor the effects of clopidogrel?
Because the mechanism of clopidogrel's antiplatelet effect is blockade of the P2Y12 ADP receptor (Figure 1), clopidogrel's effect on platelet function can be measured by stimulation of platelets with ADP and the use of 1 of a number of readouts (eg, phosphorylation of vasodilator-stimulated phosphoprotein measured by ...
What should I watch out when taking Plavix?
Here's some detail on several of the side effects this drug may or may not cause.Allergic reaction. As with most drugs, some people can have an allergic reaction after taking Plavix. ... Bruising. You may have bruising while you're taking Plavix. ... Skin rash. ... Nosebleeds. ... Headaches. ... Blood in your urine. ... Itching. ... Diarrhea.More items...
Do you monitor INR with Plavix?
The PT/INR is prolonged by the new direct oral anticoagulants rivaroxaban (Xarelto) and apixaban (Eliquis), and the PTT is prolonged by the direct thrombin inhibitor dabigatran (Pradaxa). Neither test is prolonged by the antiplatelet drugs aspirin, Plavix, prasugrel, or ticagrelor.
What is the black box warning for Plavix?
The Boxed Warning is about patients who do not effectively metabolize the drug (i.e. "poor metabolizers") and therefore may not receive the full benefits of the drug. The Boxed Warning in the drug label will include information to: Warn about reduced effectiveness in patients who are poor metabolizers of Plavix.
What blood thinner does not require monitoring?
The DOACs — apixaban (Eliquis®), dabigatran (Pradaxa®), edoxaban (Savaysa®), and rivaroxaban (Xarelto®) — are given in fixed doses, do not require INR monitoring, have few medication interactions, do not require dietary restrictions, and carry a lower risk of bleeding compared with warfarin, Dr. Bartholomew says.
What is the most serious adverse effect of clopidogrel?
The main side effect of clopidogrel is bleeding more easily than normal. You may have nosebleeds, heavier periods, bleeding gums or bruising. You can drink alcohol with clopidogrel. But do not drink too much while taking this medicine.
When Should clopidogrel be stopped?
While current guidelines recommend cessation of clopidogrel 5 to 7 days before an operative procedure, our data demonstrate that timing of clopidogrel cessation within 7 days of an operative procedure does not affect the prevalence of postoperative bleeding requiring transfusion or mortality.
What are the long term effects of clopidogrel?
Clopidogrel may make you bruise and bleed more easily, have nosebleeds, and it will take longer than usual for bleeding to stop. You should tell your doctor about any serious bleeding, such as: unexplained, prolonged, or excessive bleeding. blood in your urine or stool.
How do you monitor an antiplatelet?
Flow cytometry assays can measure circulating activated platelets, in vitro platelet activation, and platelet–leucocyte interactions, to diagnose inherited or acquired platelet disorders, monitor antiplatelet therapy, and so on.
Do you monitor liver function with clopidogrel?
It is important to periodically check a complete blood cell count and liver function tests as early as 1 week after clopidogrel is introduced. This drug should be used with caution in patients who have preexisting liver disease.
Do you have to watch vitamin K with Plavix?
Interactions between your drugs No interactions were found between Plavix and Vitamin K. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Does Plavix affect red blood cells?
Severe side effects of Plavix include: Anemia due to chronic blood loss. Gastrointestinal bleeding, blood in the stool, or vomiting blood. Bleeding in the lungs and coughing up blood.
What does Plavix do to red blood cells?
It prevents platelets (a type of blood cell) from sticking together and forming a dangerous blood clot. Taking clopidogrel helps prevent blood clots if you have an increased risk of having them. Your risk is higher if you have or have had: a heart attack.
Before Taking This Medicine
You should not use Plavix if you are allergic to clopidogrel, or if you have: 1. any active bleeding; or 2. a stomach ulcer or bleeding in the brai...
How Should I Take Plavix?
Take Plavix exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sh...
Plavix Dosing Information
Usual Adult Dose for Acute Coronary Syndrome:Unstable Angina (UA)/Non-ST-Elevation Myocardial Infarction (NSTEMI):-Loading dose: 300 mg orally once...
What Happens If I Miss A Dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What Happens If I Overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can cause excessive bleeding.
What Should I Avoid While Taking Plavix?
Avoid alcohol. It can increase your risk of stomach bleeding.Avoid activities that may increase your risk of bleeding or injury. Use extra care to...
What Other Drugs Will Affect Plavix?
Certain other medicines may increase your risk of bleeding, including aspirin. Avoid taking aspirin unless your doctor tells you to.Tell your docto...
What is Plavix?
Plavix ( clopidogrel) prevents platelets in your blood from sticking together to form an unwanted blood clot that could block an artery.
How should I take Plavix?
Take Plavix exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use these medicines exactly as directed.
What other drugs will affect Plavix?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Why is Plavix not working?
Plavix may not work as well if you have certain genetic factors that affect the breakdown of this medicine in your body. Your doctor may perform a blood test to make sure Plavix is right for you. This medicine is not expected to harm an unborn baby.
How to prevent bleeding while shaving?
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth. If you also take aspirin: Ask a doctor or pharmacist before using medicines for pain, fever, swelling, or cold/flu symptoms.
How to tell if you have a blood clot?
signs of a blood clot - sudden numbness or weakness, confusion, problems with vision or speech. Common Plavix side effects may include: bleeding. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the name of the medication that is used to treat depression?
an antidepressant such as citalopram, fluoxetine, sertraline, Cymbalta, Effexor, Lexapro, Pristiq, or Prozac;
What are the side effects of Plavix?
The most regularly occurring side effects include headache in 7.6 percent of users, flu like symptoms in 7.5 percent, dizziness in 6.2 percent, pain in 5.6 percent, bruising in 5.3 percent, upset stomach in 5.2 percent, diarrhea in 4.5 percent, unexplained rash in 4.2 percent, major bleeding in 3.7 percent, and itchy skin in 3.3 percent. These side effects are not usually serious, but should be reported to your doctor to ensure that you are being treated the way you should be. If you begin to experience major bleeding, this could be extremely serious or potentially fatal. Contact emergency medical services to get help if you begin to have trouble with bleeding or cannot seem to get bleeding to stop.
How much Plavix is available?
Plavix is available in 75 and 300 mg forms. Patients will be given one or the other depending on the condition that is being treated and the severity of the condition. Those being treated for acute coronary syndrome will be started on a 300 mg loading dose which will be followed by 75 mg daily. In many cases this dose will be combined with an aspirin regimen and thrombolytic to help stabilize the body. Doses of 75 mg will also be given to those who are recovering from a stroke or peripheral arterial disease.
What is Plavix used for?
Plavix is used as a platelet inhibitor that is prescribed to help combat acute coronary syndrome. These may also be prescribed to help stabilize the patient's condition after a potentially fatal cardiac issue. These side effects are not usually serious, but they will need to be monitored by a doctor to help ensure that your condition is being treated the way it should be. Your doctor should set up a monitoring schedule with you to ensure that your condition is progressing the way it should be.
Can you take Plavix with omeprazole?
Those using CYP2C19 inhibitors or proton pump inhibitors may not be able to use Plavix, especially in conjunction with omeprazole or esomeprazole. These can affect the level of the platelets in your blood which will affect your risk of bleeding. For similar reasons you should avoid using nonsteroidal anti-inflammatory NSAIDS, or warfarin. If you are on these medications or those which are similar, let your doctor know before you start using Plavix to avoid a potentially serious reaction.
Can Plavix be adjusted?
Those taking CYP2C19 metabolizers may need to adjust their Plavix prescription in order to see optimum effects. Those using proton pump inhibitors should also discuss their dosing with their doctor to help ensure that they can take their medication safely.
Can Plavix cause hives?
In some cases, allergic reactions to Plavix have occurred . If any side effects including rash, itching skin, trouble breathing, swelling or hives begin to come on suddenly, then contact poison control or emergency medical services immediately to get help. Have any information about your dosing and how recently it was taken ready if possible.
Can you bleed while taking Plavix?
Elderly patients may be at an increased risk of bleeding while using Plavix. Talk with your doctor about this risk and make sure you have a plan set up to help watch for this condition so you can get treatment right away if excessive bleeding begins to occur.
How It Works
Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease). It is also used with aspirin to treat new/worsening chest pain (new heart attack, unstable angina) and to keep blood vessels open and prevent blood clots after certain procedures (such as cardiac stent).
May Treat: Acute coronary syndrome · Cerebral thromboembolism · Myocardial reinfarction · Peripheral arterial thromboembolism · Thrombosis after PCI
Drug Class: Platelet Aggregation Inhibitors - Thienopyridine Agents
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
May Treat: Acute coronary syndrome · Cerebral thromboembolism · Myocardial reinfarction · Peripheral arterial thromboembolism · Thrombosis after PCI
Drug Class: Platelet Aggregation Inhibitors - Thienopyridine Agents
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
Alcohol: Limit intake while taking this medication
Driving: May cause drowsiness or dizziness. Use caution
Manufacturer: BMS PRIMARYCARE · SANOFI-AVENTIS
- Before use, important to read the Medication Guide
- Tell Dr/dentist on drug prior to any surgery.
- Review all drugs you are taking with your doctor
- Before use, important to read the Medication Guide
- Tell Dr/dentist on drug prior to any surgery.
- Review all drugs you are taking with your doctor
- Avoid taking grapefruit juice/grapefruit with med
- Reduce or avoid drinking alcohol
- Only use aspirin/aspirin- like meds with MD ok.
- Do not stop medicine without calling doctor
- Call Dr if you have black stools or stomach pain
Upsides
Downsides
Bottom Line
Tips
Response and Effectiveness
- Plavix may be used for the treatment of unstable angina and for certain types of heart attack (myocardial infarction) to reduce the risk of stroke or heart attack. Plavix should be administered in...
- May also be given to people with established peripheral arterial disease or with a recent history of heart attacks or stroke to reduce the risk of a further heart attack or stroke.
- Plavix may be used for the treatment of unstable angina and for certain types of heart attack (myocardial infarction) to reduce the risk of stroke or heart attack. Plavix should be administered in...
- May also be given to people with established peripheral arterial disease or with a recent history of heart attacks or stroke to reduce the risk of a further heart attack or stroke.
- Can be administered as a loading dose (a bigger than normal, one-off dose) if an antiplatelet effect is needed within hours. Otherwise, it takes several days for the full antiplatelet effect of Pla...
- The dosage of Plavix does not need adjusting in people with liver disease.
Interactions
- If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: 1. An increased risk of bleeding from any wound, nosebleeds, blood in the urine, and an increased likelihood of bruising are the most commonly reported side effects. The risk of this side effect is increased when Plavix is tak…
References
- Plavix may be given to reduce the risk of a heart attack or stroke in certain cardiovascular conditions or following a heart attack or ischemic stroke. People who are poor metabolizers at CYP2C19 may not respond very well to Plavix. Bleeding is the main side effect of Plavix.
Further Information
- May be taken with or without food.
- Take exactly as prescribed and do not discontinue except on a doctor's advice.
- Plavix is often taken in conjunction with aspirin. Your doctor will advise you if you need to take aspirin as well.
- Do not take omeprazole or esomeprazole while taking Plavix as these will reduce its activity. …
- May be taken with or without food.
- Take exactly as prescribed and do not discontinue except on a doctor's advice.
- Plavix is often taken in conjunction with aspirin. Your doctor will advise you if you need to take aspirin as well.
- Do not take omeprazole or esomeprazole while taking Plavix as these will reduce its activity. Talk to a pharmacist or your doctor before buying any over-the-counter medicine to check if it is compa...