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how dangerous is fluconazole

by Prof. Zelma Marquardt Published 2 years ago Updated 2 years ago
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This medicine may cause adrenal gland problems. Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting.

Precautions

What is fluconazole?

How is fluconazole taken?

What should I avoid while using fluconazole?

What other drugs will affect fluconazole?

How to give fluconazole injection?

Why is fluconazole used for meningitis?

How to store fluconazole?

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What should I avoid while taking fluconazole?

Common medications that may interact with fluconazole include: anticoagulants or antiplatelet agents (blood thinners), such as warfarin, and clopidogrel (may prolong bleeding time) biologics, such as acalabrutinib, bosutinib, or entrectinib. albuterol.

What are the long term effects of fluconazole?

The most common adverse effects were xerosis (16.9%), alopecia (16.1%) and fatigue (11.3%). Of the 64 patients experiencing adverse effects, 42 (65.6%) required a therapeutic intervention such as dose reduction, discontinuation or switch to a new antifungal.

How long can you stay on fluconazole?

If symptoms continue despite appropriate treatment, fluconazole may be prescribed for every day use for ten to fourteen days, and even continued once per week for six months. Fluconazole is an antifungal medicine and is used to treat infections caused by fungus.

Are there side effects to fluconazole?

Increased side effects can include headache, tiredness, loss of appetite, nausea, and vomiting. Pain drugs, such as methadone and fentanyl. The levels of these drugs may be increased in your body when taken with fluconazole. Increased side effects include slower breathing, confusion, and drowsiness.

When do fluconazole side effects start?

Fluconazole side effects such as headache, nausea, and stomach pain can start quickly when given an injection. When fluconazole is taken by mouth, minor side effects could appear within an hour or two, the amount of time it normally takes an oral dose of fluconazole to hit its peak in the bloodstream.

What happens if you take fluconazole without yeast infection?

If you don't really have a yeast infection, antifungals won't help you get better. They can actually prolong the real problem, because while you'll think you're treating the issue, the real cause will continue to develop. There are several reasons you might have symptoms that are like a yeast infection.

What infection does fluconazole cure?

Fluconazole is used to treat serious fungal or yeast infections, including vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (including urinary tract infections, peritonitis [inflammation of the lining of the stomach], and ...

Is one fluconazole pill enough?

Fluconazole (Diflucan) is a popular yeast infection medication that only requires one dose. However, yeast infection pills require a prescription and are not available over-the-counter (OTC).

Why is fluconazole given once a week?

Conclusion: Fluconazole administered once weekly is safe and effective in eradicating distal subungual onychomycosis of the fingernail caused by dermatophytes.

How often can I take fluconazole?

Adults—150 milligrams (mg) once a day.

Does fluconazole cause anxiety?

The commonest side effects were dry skin (xerosis), hair loss (alopecia) and fatigue. Other side effects included nausea and vomiting, loss of appetite, headache, joint discomfort, dry lips, dry mouth and loss of taste, dizziness or low blood pressure, neuropathy, impotence, anxiety, and brittle nails.

Can I take a probiotic while taking fluconazole?

Another 2015 study found that combining a prescription antifungal medication — such as fluconazole (Diflucan) — with probiotic vaginal suppositories made the antifungal more effective. The combination also reduced the chances that a yeast infection would return.

Is hair loss from fluconazole permanent?

Valley fever survivors turning to fluconazole, however, may take comfort in one small solace: Hair loss from the drug is not necessarily permanent. Once the medication is out of the body's system, hair typically grows back.

What are the side effects of fluconazole 150mg?

Common side effects of Diflucan include:headache,dizziness,drowsiness,stomach or abdominal pain,upset stomach,diarrhea,heartburn,loss of appetite, and.More items...

Can Diflucan damage nerves?

Serious Side Effects of Diflucan Patients taking Diflucan have reported incidences of liver damage, impairment of the nervous system, kidney failure, cardiovascular issues, and blood-related conditions. In some cases, the damage to a patient's liver is so severe that the organ's tissue dies.

How often can you take fluconazole for yeast infection?

Yes, fluconazole (Diflucan) should be taken once a day, preferably at the same time every day. Depending on what infection you're taking it for and how bad the infection is, you'll either need to take fluconazole (Diflucan) once a day for several days or as a single, one-time dose.

Before Taking This Medicine

You should not use fluconazole if you are allergic to it.Some medicines can cause unwanted or dangerous effects when used with fluconazole. Your do...

How Should I Take Fluconazole?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.Your do...

What Happens If I Miss A Dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What Happens If I Overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include confusion or unusual thoughts or beh...

What Should I Avoid While Taking Fluconazole?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.Avoid driving or hazardous activity until you know how thi...

What Other Drugs Will Affect Fluconazole?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may in...

Fluconazole 200 MG Tablet - Uses, Dosage, Side Effects, Price ... - Practo

Fluconazole 200 MG Tablet is an anti-fungal medicine. It is used in the treatment of various fungal infections affecting your skin, lungs, mouth, throat, meninges (protective layer covering the brain and spinal cord), etc. It works by stopping the growth of fungi, thus preventing the spread of infections. Fluconazole 200 MG Tablet can cause side effects like nausea, vomiting, headache, stomach ...

Fluconazole 200 MG Tablet - Uses, Side Effects, Substitutes ... - Lybrate

Fluconazole 200 MG Tablet is used for Oropharyngeal Candidiasis, Esophageal Candidiasis, Cryptococcal Meningitis etc. Know Fluconazole 200 MG Tablet uses, side-effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on Lybrate.com

Fluconazole Side Effects: Common, Severe, Long Term - Drugs.com

Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 1 Sep 2022), Cerner Multum™ (updated 5 Sep 2022), ASHP (updated 12 Sep 2022 ...

Fluconazole Oral: Uses, Side Effects, Interactions, Pictures ... - WebMD

Find patient medical information for fluconazole oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

Fluconazole Oral: Uses, Side Effects, Interactions, Pictures ... - WebMD

Find patient medical information for fluconazole oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

Fluconazole: Side effects, dosage, uses, and more - Medical News Today

Fluconazole oral tablet is used to prevent and treat candidiasis, a fungal infection. It’s also used to treat meningitis (infection of the brain or spinal cord, or both). The tablet is available ...

What are the side effects of fluconazole?

Check with your doctor immediately if any of the following side effects occur while taking fluconazole: Rare. Chills. clay-colored stools. cough.

What are the symptoms of overdose on fluconazole?

Get emergency help immediately if any of the following symptoms of overdose occur while taking fluconazole: Symptoms of overdose. Fearfulness, suspiciousness, or other mental changes. seeing, hearing, or feeling things that are not there.

What are the side effects of vaginal meds?

The most common side effects reported in patients receiving a single 150 mg dose of this drug for vaginitis were headache, nausea, and abdominal pain. Most side effects were of mild to moderate severity .

Is a hepatic drug tolerated?

This drug was generally well tolerated. Changes in renal and hematological function test results and hepatic abnormalities reported during therapy with this and comparative agents in some patients, primarily those with serious underlying diseases (e.g., AIDS, cancer); clinical significance and relationship to therapy unclear.

Can you have seizures after 100 mg?

Rare cases of seizures have been reported, but a causal relationship was difficult to establish, since some of these patients had cryptococcal meningitis or severe underlying disease. Nonetheless, at least 1 case of seizure following a 100 mg oral dose has been reported .

Does fluconazole need immediate medical attention?

Side effects not requiring immediate medical attention. Some side effects of fluconazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.

What are the side effects of taking fluconazole?

The levels of these drugs may be increased in your body when taken with fluconazole. Increased side effects include slower breathing, confusion, and drowsiness. Carbamazepine.

How does fluconazole work?

Fluconazole works by blocking the ability of the fungi Candida and Cryptococcus to reproduce. For people with infections from these fungi, this drug helps to get rid of the infection. For people at higher risk of candidiasis, it helps to prevent infection.

Why is fluconazole used for candida?

Why it’s used. Fluconazole is used to prevent and treat candidiasis. This condition is caused by infection with one of the many types of the fungus Candida. Examples of candidiasis include vaginal yeast infection, as well as oral yeast infection (thrush).

What is the name of the heart rhythm condition caused by fluconazole?

Terfenadine. When used with fluconazole at doses of 400 mg or higher, this drug can cause a life-threatening heart rhythm condition called torsades de pointes.

What is the brand name of diflucan?

Brand name: Diflucan . Fluconazole comes as a tablet or suspension you take by mouth. It also comes in an injectable form that can only be given to you by a healthcare provider. Fluconazole oral tablet is used to prevent and treat candidiasis, a fungal infection.

Can fluconazole cause headaches?

Taking this drug with fluconazole can cause muscle cramps, headache, low blood pressure, and seizures. Your doctor will measure blood levels of phenytoin while you’re taking fluconazole. Zidovudine. Increased side effects can include headache, tiredness, loss of appetite, nausea, and vomiting.

Can fluconazole cause slurred speech?

Phenytoin. Taking this drug with fluconazole can cause trouble with coordination, slurred speech, and confusion. Your doctor will measure blood levels of phenytoin while you’re taking fluconazole .

What is fluconazole used for?

Fluconazole is used to treat serious fungal or yeast infections , such as vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (including urinary tract infections, peritonitis [inflammation of the lining of abdomen or stomach], and infections that may occur in different parts of the body), or fungal (cryptococcal) meningitis. This medicine works by killing the fungus or yeast, or preventing its growth.

How old is too old to take fluconazole?

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of fluconazole in children 6 months to 13 years of age. However, safety and efficacy have not been established in children younger than 6 months of age.

Can elderly people take fluconazole?

However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving fluconazole.

What is Fluconazole?

Fluconazole, or Diflucan, is a medication used to treat fungal infections, like vaginal yeast infections, among others. It can also be used to prevent fungal infections in certain patients who are vulnerable to them for various health reasons. It is available as a tablet and liquid suspension, taken orally. Pfizer first developed fluconazole in the 1980s and was approved by the FDA and brought to market in 1990

Is fluconazole a generic?

Fluconazole is the generic name for a drug that was developed as the brand name medication Diflucan by Pfizer. It first came on the market in 1990 and since the patent ran out it is available through several manufacturers as a generic drug as well as through Pfizer as Diflucan. Fluconazole is an antifungal and is used to treat a variety of fungal infections for patients with varied conditions.

Can diflucan cause birth defects?

In 2011 the FDA announced that Diflucan and other fluconazole products could cause serious and specific birth defects. This risk occurred when women took higher doses of the drug during pregnancy. Doses considered high enough to cause birth defects were between 400 and 800 milligrams. A more typical dose used to treat yeast infections in women is 150 milligrams.

How many milligrams of fluconazole are there?

The warning and class change came on the heels of a study that uncovered the disturbing fact that doses between 400 and 800 milligrams of fluconazole cause specific birth defects when women use the drug at these doses over the long-term during pregnancy.

What is fluconazole used for?

Fluconazole belongs to the triazole class of antifungal medications. These drugs treat and cure fungal infections by acting on an enzyme on fungal cells. The result is that it slows the growth of the fungus and slows and stops the spread of the infection. The FDA approved fluconazole to treat a number of fungal infections, especially yeast infections. These include vaginal, abdominal, esophageal, lung, blood, and mouth yeast infections.

Where does fluconazole come from?

Fluconazole Uses. Fluconazole came from Pfizer, the major drug maker that developed it in the 1980s and received U.S. Food and Drug Administration (FDA) approval in 1990. Pfizer marketed and sold the drug as Diflucan. Since 1990 the patent has run out and while Pfizer still offers Diflucan, other companies have also gotten in on making ...

When did the FDA start warning about fluconazole?

The first official warning only came in 2011 from the FDA when the agency upgraded the pregnancy class of higher doses of fluconazole from C to D, a classification that communicates this drug is known to cause harm to human fetuses.

Can fluconazole be given to AIDS patients?

Patients with cancer or AIDS who are vulnerable to developing fungal infections may be given fluconazole to prevent fungal infections. In fewer cases the drug may be used to treat skin, eye and prostate fungal infections.

Does fluconazole cause miscarriages?

As if all the previous side effects were not troubling enough, fluconazole has recently been found to cause birth defects and miscarriages. Since the drug came on the market in 1990 millions of women and their babies were exposed to this risk without warning. The first official warning only came in 2011 from the FDA when the agency upgraded the pregnancy class of higher doses of fluconazole from C to D, a classification that communicates this drug is known to cause harm to human fetuses.

Is fluconazole safe for fungal infections?

Fluconazole is effective at treating fungal infections, but it also has the potential to cause a long list of side effects. Some of these are common and not serious, but others are devastating and some may even be life threatening. Fluconazole side effects must be carefully weighed and balanced against its benefits before patients and their doctors decide to use it.

What is fluconazole used for?

Fluconazole is used to prevent and treat a variety of fungal and yeast infections. It belongs to a class of drugs called azole antifungals. It works by stopping the growth of certain types of fungus.

Can fungusto cause nausea?

Stopping the medication too early may allow the fungusto continue to grow, which may result in a return of the infection. Tell your doctor if your condition persists or if it worsens. Side Effects . Nausea, vomiting, diarrhea, stomachupset/pain, headache, dizziness, or hair lossmay occur.

Can fluconazole prolong QT?

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using fluconazole, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems ( heart failure, slow heartbeat, QT prolongation in the EKG ), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Can fluconazole cause QT prolongation?

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease. Fluconazole may cause a condition that affects the heartrhythm (QT prolongation).

Can you take fluconazole if you are allergic to it?

Precautions . Before taking fluconazole, tell your doctor or pharmacistif you are allergic to it; or to other azole antifungaldrugs (such as ketoconazole, itraconazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.

Are you currently using Fluconazole?

This survey is being conducted by the WebMD marketing sciences department.

Proper Use

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

What are the side effects of diflucan?

Common side effects of Diflucan include: 1 headache, 2 dizziness, 3 drowsiness, 4 stomach or abdominal pain, 5 upset stomach, 6 diarrhea, 7 heartburn, 8 loss of appetite, and 9 allergic reactions including skin inflammation, itching, rash, and unusual or unpleasant taste in your mouth.

How long does diflucan last?

Diflucan is taken once a day and may be taken for several weeks depending on the condition being treated.

How many patients have had diarrhea with difucan?

The following treatment-related clinical adverse events occurred at an incidence of 1% or greater in 4048 patients receiving DIFLUCAN for 7 or more days in clinical trials: nausea 3.7%, headache 1.9%, skin rash 1.8%, vomiting 1.7%, abdominal pain 1.7%, and diarrhea 1.5%.

What is diflucan used for?

What Is Diflucan? Diflucan (fluconazole) is an antifungal medication prescribed to treat Candida fungal infections of the mouth, vagina , esophagus, lungs, urinary tract, abdomen, and other organs. Diflucan is also used to treat fungal meningitis and may be prescribed to ward off fungal infections in patients being treated with chemotherapy ...

Does fluconazole affect renal function?

In some patients, particularly those with serious underlying diseases such as AIDS and cancer, changes in renal and hematological function test results and hepatic abnormalities have been observed during treatment with fluconazole and comparative agents, but the clinical significance and relationship to treatment is uncertain.

Can you take diflucan while pregnant?

Diflucan During Pregnancy and Breastfeeding. Diflucan is not usually recommended for pregnant women or nursing mothers. Diflucan has been used in the pediatric population, but its dose is determined by pediatric patient weight ranges and a mg/Kg sliding scale.

Does Fluconazole cause transaminase elevation?

In two comparative trials evaluating the efficacy of DIFLUCAN for the suppression of relapse of cryptococcal meningitis, a statistically significant increase was observed in median AST (SGOT) levels from a baseline value of 30 IU/L to 41 IU/L in one trial and 34 IU/L to 66 IU/L in the other. The overall rate of serum transaminase elevations of more than 8 times the upper limit of normal was approximately 1% in fluconazole-treated patients in clinical trials. These elevations occurred in patients with severe underlying disease, predominantly AIDS or malignancies, most of whom were receiving multiple concomitant medications, including many known to be hepatotoxic. The incidence of abnormally elevated serum transaminases was greater in patients taking DIFLUCAN concomitantly with one or more of the following medications: rifampin, phenytoin, isoniazid, valproic acid, or oral sulfonylurea hypoglycemic agents.

What is Fluconazole?

Fluconazole has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 51,309 Fluconazole users for its effectiveness, alternative drugs and more.

What is phase IV fluconazole?

The phase IV clinical study analyzes which people take Fluconazole and have Withdrawal syndrome. It is created by eHealthMe based on reports of 50,263 people who have side effects when taking Fluconazole from the FDA, and is updated regularly.

What is fluconazole?

Fluconazole is an antifungal medicine that is used to treat infections caused by fungus, which can invade any part of the body including the mouth, throat, esophagus, lungs, bladder, genital area, and the blood.

How is fluconazole taken?

Fluconazole oral is taken by mouth. Fluconazole injection is given as an infusion into a vein.

What should I avoid while using fluconazole?

Avoid driving or hazardous activity until you know how fluconazole will affect you. Your reactions could be impaired.

What other drugs will affect fluconazole?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

How to give fluconazole injection?

Fluconazole injection is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself. Prepare an injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Why is fluconazole used for meningitis?

Fluconazole is also used to prevent fungal infection in people who have a weak immune system caused by cancer treatment, bone marrow transplant, or diseases such as AIDS. Fluconazole is also used to treat a certain type of meningitis in people with HIV or AIDS.

How to store fluconazole?

Store fluconazole at room temperature away from moisture and heat. Do not freeze.

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Summary

Fluconazole is used to prevent and treat a variety of fungal and yeast infections.

May Treat: Candidemia · Vulvovaginal candidiasis · Esophageal candidiasis · Candida peritonitis · Oral candidiasis and more

Brand Names: Diflucan

Drug Class: Antifungal - Triazoles

Availability: Prescription Required

Pregnancy: Consult your doctor. This medication may be harmful to an unborn child.

May Treat: Candidemia · Vulvovaginal candidiasis · Esophageal candidiasis · Candida peritonitis · Oral candidiasis and more

Brand Names: Diflucan

Drug Class: Antifungal - Triazoles

Availability: Prescription Required

Pregnancy: Consult your doctor. This medication may be harmful to an unborn child.

Lactation: Does not adversely affect lactation

Alcohol: Limit intake while taking this medication

Driving: May cause drowsiness or dizziness. Use caution

Precautions

  • If available, read the patient package insert
  • Tell doctor if you think you are pregnant
  • May make you dizzy. Use caution when driving.

  • If available, read the patient package insert
  • Tell doctor if you think you are pregnant
  • May make you dizzy. Use caution when driving.
  • Call MD if new abdominal pain/yellowing eyes/skin
  • Tell doctor if fainting or faintness occurs.
  • For suspension, reconstituted, oral products : Shake well & measure with dosing spoon/cup/syringe.
  • For tablet products : Success is dependent on completing therapy course. Review all drugs you are taking with your doctor. Reduce or avoid drinking alcohol. Lab tests may be ordered to monitor therapy. Call doctor if you are not better in 3 days.

For The Consumer

Frequently Asked Questions

Further Information

1.Fluconazole Uses, Side Effects & Warnings - Drugs.com

Url:https://www.drugs.com/mtm/fluconazole.html

17 hours ago  · Fluconazole can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, …

2.Fluconazole Side Effects: Common, Severe, Long Term

Url:https://www.drugs.com/sfx/fluconazole-side-effects.html

4 hours ago  · Taking this drug with fluconazole can cause muscle cramps, headache, low blood pressure, and seizures. Your doctor will measure blood levels of phenytoin while you’re taking …

3.Fluconazole: Side effects, dosage, uses, and more

Url:https://www.medicalnewstoday.com/articles/fluconazole-oral-tablet

34 hours ago It is also possible that fluconazole can cause liver damage and toxicity. Hepatitis, jaundice, death of liver cells, and even liver failure are all possible. Liver failure can be severe enough to lead to …

4.Fluconazole (Oral Route) Side Effects - Mayo Clinic

Url:https://www.mayoclinic.org/drugs-supplements/fluconazole-oral-route/side-effects/DRG-20071428?p=1

22 hours ago Fluconazole may cause liver cell death, hepatitis, jaundice, and liver failure. The latter condition is ultimately fatal if not treated. Fluconazole Side Effects Include Birth Defects As if all the …

5.Fluconazole Overview | Recall Report

Url:https://www.recallreport.org/dangerous-drugs-products/fluconazole/

31 hours ago Fluconazole may cause a condition that affects the heart rhythm (QT prolongation).

6.Fluconazole Side Effects | Recall Report

Url:https://www.recallreport.org/side-effects/fluconazole/

17 hours ago  · The dose is usually 6 milligrams (mg) per kilogram (kg) of body weight on the first day, followed by 3 mg per kg of body weight once a day, for at least 2 weeks. Children younger …

7.Fluconazole Oral: Uses, Side Effects, Interactions, …

Url:https://www.webmd.com/drugs/2/drug-3780-5052/fluconazole-oral/fluconazole-oral/details

8 hours ago  · The most common treatment-related adverse events reported in the patients who received 150 mg single dose fluconazole for vaginitis were headache (13%), nausea (7%), and …

8.Fluconazole (Oral Route) Proper Use - Mayo Clinic

Url:https://www.mayoclinic.org/drugs-supplements/fluconazole-oral-route/proper-use/drg-20071428

1 hours ago Summary: Withdrawal syndrome is found among people who take Fluconazole, especially for people who are female, 60+ old, have been taking the drug for < 1 month. The phase IV clinical …

9.Side Effects of Diflucan (Fluconazole), Warnings, Uses

Url:https://www.rxlist.com/diflucan-side-effects-drug-center.htm

32 hours ago

10.Fluconazole and Withdrawal syndrome, a phase IV …

Url:https://www.ehealthme.com/ds/fluconazole/withdrawal-syndrome/

29 hours ago

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