Precautions
Dilute 200 mg labetalol in 160 mL of a compatible IV solution for a final concentration of 1 mg/mL. Alternatively, dilute 200 mg in 250 mL of a compatible IV solution for a final concentration of approximately 2 mg/3 mL. Infuse at a rate of 2 mg/minute, initially; adjust infusion rate according to blood pressure response.
How do you dilute labetalol in IV solution?
2 to 8 mg/minute continuous IV infusion until desired effect then transition to oral labetalol. Usual total dose: 50 to 200 mg. Max total dose: 300 mg.
How many milligrams of labetalol can you take in an IV?
Monitor supine blood pressure immediately before and 5 and 10 minutes after injection. Inject slowly over 2 minutes. [42601] Preparation of IV Infusion from Vials. Dilute 200 mg labetalol in 160 mL of a compatible IV solution for a final concentration of 1 mg/mL.
How is labetalol administered in the treatment of high blood pressure?
Administration For acute hypertensive events (emergent/urgent) the IV formulation is indicated and an initial dose of a 10- to 20-mg IV push, with repeat boluses administered every 10 minutes until the systolic blood pressure is within the desired range or a maximum dose of 300 mg per 24-hour period is reached.
How do you administer an IV push for high blood pressure?
Does labetalol IV need to be diluted?
For intravenous infusion of Labetalol Synchrony 5mg/ml solution for injection a solution containing 1mg/ml needs to be used. This solution can be made by diluting the contents of four 10ml ampoules (200mg) to 200ml with the solution for infusion.
How long do you push IV labetalol?
IV push labetalol is given over 2 minutes. One regimen is to escalate or layer the doses for severe hypertension: 20-mg initial dose. 40-mg dose 10 minutes later.
How fast should labetalol be pushed?
When administered to treat hypertensive crisis, the initial dose of labetalol should be administered over 2 minutes to prevent a sudden, severe drop in blood pressure.
How do you give labetalol to hypertensive emergency?
For hypertensive emergencies, reported dosing regimens for IV labetalol include a loading dose of 20 mg followed by 20 to 80 mg doses repeated every 10 minutes until desired BP is attained, or the loading dose can be administered followed by a 1 to 2 mg/min continuous infusion; all regimens have a total effective dose ...
When is IV labetalol given?
Labetalol injection is used to treat severe high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly.
Is labetalol compatible with normal saline?
Labetalol injection is compatible with the following I.V. infusion fluids: 5% Dextrose BP. 0.18% Sodium Chloride and 4% Dextrose BP.
How often can you give labetalol IV?
DOSAGE & INDICATIONS May give total daily dose in 3 divided doses. Max: 2,400 mg/day. 0.2 to 1 mg/kg/dose (Max: 40 mg/dose) IV every 10 minutes until goal blood pressure is attained.
What is the nursing consideration for labetalol?
Report any rhythm disturbances or symptoms of increased arrhythmias, including palpitations, chest discomfort, shortness of breath, fainting, and fatigue/weakness. Assess routinely for signs of CHF and pulmonary edema, including dyspnea, rales/crackles, weight gain, peripheral edema, and jugular venous distention.
How fast do you push hydralazine?
Use solution as quickly as possible after drawing through needle into syringe. Concentration: 20 mg/mL. Rate: Administer over at least 1 min.
How do you calculate labetalol infusion?
Commence infusion at 10 mL/hour (20mg/hour). Titrate to target BP by doubling or halving the infusion every 30 minutes. Record BP and HR every 15 minutes until blood pressure stabilizes then record hourly. If BP decreases precipitously, halve the infusion rate or cease depending on severity.
How often can you give labetalol IV?
DOSAGE & INDICATIONS May give total daily dose in 3 divided doses. Max: 2,400 mg/day. 0.2 to 1 mg/kg/dose (Max: 40 mg/dose) IV every 10 minutes until goal blood pressure is attained.
What is the nursing consideration for labetalol?
Report any rhythm disturbances or symptoms of increased arrhythmias, including palpitations, chest discomfort, shortness of breath, fainting, and fatigue/weakness. Assess routinely for signs of CHF and pulmonary edema, including dyspnea, rales/crackles, weight gain, peripheral edema, and jugular venous distention.
What is labetalol injection used for?
Labetalol injection is used to treat severe high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .
How does lbetalol work?
Labetalol is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart .
Is labetalol safe for children?
Appropriate studies have not been performed on the relationship of age to the effects of labetalol injection in the pediatric population. Safety and efficacy have not been established .
Is Labetalol available with a prescription?
Labetalol is available only with your doctor's prescription .
Can you have an allergic reaction to labetalol?
Tell your doctor if you have ever had any unusual or allergic reaction to labetalol or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Does labetalol cause heart attacks?
High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled . Labetalol is a beta-blocker.
Can you take labetalol with oral medicine?
Your doctor will only give you a few doses of labetalol, and then you will be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor .
Usual Adult Dose for Hypertension
ORAL: Initial dose: 100 mg orally 2 times a day (alone or added to a diuretic regimen) Titration: Dosage may be increased in increments of 100 mg orally 2 times a day every 2 or 3 days Maintenance dose: 200 to 400 mg orally 2 times a day Maximum dose: Some patients may require 1200 to 2400 mg orally per day (titration increments should not exceed 200 mg orally 2 times a day) PARENTERAL: REPEATED IV INJECTION: -Immediately before the injection and at 5 and 10 minutes after injection, supine blood pressure should be measured to evaluate response. -Initial dose: 20 mg by slow IV injection over a 2-minute period -Additional injections of 40 to 80 mg can be given at 10 minute intervals until a desired supine blood pressure is achieved or a total of 300 mg has been used -The maximum effect usually occurs within 5 minutes of each injection SLOW CONTINUOUS IV INFUSION: -The solution for injection should be prepared according to the manufacturer suggested guidelines for a resultant solution of 1 mg/mL or 2 mg/3 mL: -For 1 mg/mL, the diluted solution should be administered at a rate of 2 mL/min to deliver 2 mg/min. -For 2 mg/3 mL, the diluted solution should be administered at a rate of 3 mL/min to deliver approximately 2 mg/min. -Rate of infusion: The rate of infusion of the diluted solution may be adjusted according to the blood pressure response, at the discretion of the physician.
Dialysis
This drug is not removed by hemodialysis or peritoneal dialysis; a supplemental dose is not needed.
Other Comments
Storage requirements: -Consult the manufacturer product information. Reconstitution/preparation techniques: -Consult the manufacturer product information. IV compatibility: -Consult the manufacturer product information.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
What is labetalol injection?
Labetalol injection is used to treat severe high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .
How does a beta blocker work?
This medicine is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart .
What position should a patient be in during IV administration?
Intravenous Administration. Patients must be kept in a supine position during IV administration as a fall in blood pressure is expected upon standing. Establish the patient's ability to tolerate an upright position before permitting any ambulation.
How long does it take for labetalol to work?
The maximum effect of each intravenous labetalol dose occurs within 5 minutes. An initial 0.25 mg/kg injection decreases blood pressure by an average of 11/7 mmHg. Additional injections of 0.5 mg/kg at 15-minute intervals up to a total cumulative dose of 1.75 mg/kg of labetalol caused further dose-related decreases in blood pressure. Blood pressure decreases by an average of 60/35 mmHg in patients receiving a continuous infusion (mean dose: 136 mg) over 2 to 3 hours. After drug discontinuation, blood pressure rises gradually and progressively approaching pretreatment values within an average of 16 to 18 hours. [42601]
Can you use Labetalol with thyroid?
Labetalol should be used with caution in patients with hyperthyroidism or thyrotoxicosis because beta- blockers can mask tachycardia, which is a useful monitoring parameter in thyroid disease. Abrupt withdrawal of beta-blockers in a patient with hyperthyroidism can precipitate thyroid storm. However, beta-blockers are generally useful in the symptomatic treatment of hyperthyroid-related states.
Can labetalol be used for hepatic impairment?
Use labetalol with caution in patients with hepatic impairment as labetalol metabolism may be impaired.
Does labetalol cause lightheadedness?
Some elderly patients (60 years of age and older) have experienced orthostatic hypotension, dizziness, or lightheadedness during treatment with labetalol. Because geriatric patients are generally more likely than younger patients to experience orthostatic symptoms, they should be cautioned about the possibility of such side effects during treatment with labetalol. When using the injection, the patient's ability to tolerate an upright position should be established before permitting any ambulation. The federal Omnibus Budget Reconciliation Act (OBRA) regulates medication use in residents of long-term care facilities. According to the OBRA guidelines, antihypertensive regimens should be individualized to achieve the desired outcome while minimizing adverse effects. Antihypertensives may cause dizziness, postural hypotension, fatigue, and there is an increased risk for falls. Additionally, as a drug with beta-blocking activity, labetalol may are associated with depression, bronchospasm, and cardiac decompensation that may require dose adjustments in those with acute heart failure. Drugs with beta-blocking activity may mask tachycardia associated with symptomatic hypoglycemia. Labetalol is extensively metabolized in the liver and may have an increased effect or accumulate in those with hepatic impairment. There are many drug interactions that can potentiate the effects of antihypertensives. Labetalol may cause or exacerbate bradycardia, particularly in patients receiving other medications that affect cardiac conduction. When discontinuing, a gradual taper may be required to avoid adverse consequences caused by abrupt discontinuation.
Does labetalol lower blood pressure?
Labetalol has been used to effectively lower blood pressure in patients with pheochromocytoma, due to its effects to block both alpha and beta receptors. However, paradoxical hypertensive episodes have occurred in a few patients with pheochromocytoma while receiving labetalol. Use caution in administering labetalol to patients with pheochromocytoma. In general, an alpha-blocking agent is recommended before initiating beta-blocker therapy.
Can labetalol cause ventricular arrhythmias?
Abrupt discontinuation of any beta-adrenergic blocking agent, including labetalol, can result in the development of myocardial ischemia, myocardial infarction, ventricular arrhythmias, or severe hypertension, particularly in patients with preexisting cardiac disease.
How much glucose is in lbetalol?
Labetalol contains 49.5 mg/ml of glucose monohydrate. This should be taken into account in patients with diabetes mellitus.
How many stereoisomers are in labiletalol?
Labetalol chemically consists of four stereoisomers with different pharmacodynamic effects.
What wavelength does lbetalol fluoride?
Labetalol fluoresces in alkaline solution at an excitation wavelength of 334 nanometres and a fluorescence wavelength of 412 nanometres, and may therefore interfere with the assays of certain fluorescent substances including catecholamines.
Is labetalol safe for peripheral arterial disease?
Labetalol should be used with caution in patients with peripheral vascular disease as their symptoms may be exacerbated. Caution is advised in patients with peripheral arterial disease ( Raynauds syndrome, claudicatio intermittens), as labetalol may exa cerbate their symptoms. Alpha-block may counter the unfortunate effect of beta-blockers.
How long does it take for a syringe to work?
The maximum effect usually occurs within 5 min and the duration of action is usually about 6 h, but may be as long as 18 h.
How long should I take 50 mg of a syringe?
If it is essential to reduce the blood pressure quickly a dose of 50 mg should be given by I.V. injection (dur ing 1 minute) and, if necessary, be repeated at 5-minute intervals until a satisfactory response occurs. The total dose should not exceed 200 mg.
Does labetalol mask tremors?
Care should be taken in case of uncontrolled or difficult-to-control diabetes mellitus. As with other beta-adrenoceptor blocking medicinal products, labetalol may mask the symptoms of hypoglycaemia (tachycardia and tremor) in diabetic patients. The hypoglycaemic effect of insulin and oral hypoglycaemic agents may be enhanced by beta blockers.
Is labetalol safe for children?
Appropriate studies have not been performed on the relationship of age to the effects of labetalol injection in the pediatric population. Safety and efficacy have not been established .
Can you take Vilanterol and Acarbose together?
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acarbose.
