How do you administer MMRV?
For Adults. The dosage for MMR vaccine is 0.5 mL by the subcutaneous route. If a second dose is indicated, the minimum interval between the first and second doses should be separated by at least 4 weeks (28 days). The preferred injection site for adults is the posterior triceps aspect of the upper arm.
What happens if you give ProQuad IM?
The most common adverse events reported with the use of ProQuad were: injection site reactions including pain/tenderness/soreness, redness, swelling or bruising; fever (≥39.4°C rectal equivalent); irritability; rash (including measles-like rash, varicella-like rash, and injection site rash); upper respiratory infection ...
Can ProQuad be given to a 2 year old?
How should MMRV be used? ProQuad was licensed in 2005 for use in children ages 12 months through 12 years. It combines the MMR and varicella vaccines and therefore can be used in place of the individual MMR and varicella vaccines given at ages 12–15 months and 4–6 years.
What is ProQuad vial?
This medication is a combination of vaccines against several virus infections: measles (also known as rubeola), mumps, rubella (also known as German measles), and varicella (also known as chickenpox).
Is ProQuad subcutaneous or IM?
ProQuad® is a vaccine indicated for active immunization for the prevention of measles, mumps, rubella, and varicella in children 12 months through 12 years of age. Each 0.5-mL dose of ProQuad is administered subcutaneously.
Can MMRV be given IM?
All live injected vaccines (MMR, varicella, and yellow fever) are recommended to be given subcutaneously. However, intramuscular administration of any of these vaccines is not likely to decrease immunogenicity, and doses given IM do not need to be repeated. We often need to give MMR vaccine to large adults.
What is the age limit for ProQuad?
ProQuad is a vaccine indicated for active immunization for the prevention of measles, mumps, rubella, and varicella in children 12 months through 12 years of age.
What type of vaccine is ProQuad?
ProQuad® is a combination measles, mumps, rubella, and varicella (MMRV) vaccine.
At what age can MMRV be given?
MMRV vaccine may be given to children 12 months through 12 years of age, usually: First dose at age 12 through 15 months. Second dose at age 4 through 6 years.
How do you reconstitute ProQuad?
Before reconstitution, the lyophilized vaccine is a white to pale yellow compact crystalline plug. ProQuad, when reconstituted, is a clear pale yellow to light pink liquid. Withdraw the entire amount of the reconstituted vaccine from the vial into the same syringe, inject the entire volume, and discard vial.
How does the ProQuad vaccine work?
ProQuad (MMRV vaccine) can lower your platelet count temporarily within 4 to 6 weeks after you've received it. Platelets are cells in your blood that form clots to stop you from bleeding. A low platelet count raises your risk for severe bleeding.
Does ProQuad need to be frozen?
To maintain potency, ProQuad must be stored frozen between –58ºF and +5ºF (–50ºC to –15ºC). Use of dry ice may subject ProQuad to temperatures colder than –58ºF (–50ºC).
Is ProQuad a live vaccine?
ProQuad (Measles, Mumps, Rubella and Varicella Virus Vaccine Live) is a combined, attenuated, live virus vaccine containing measles, mumps, rubella, and varicella viruses.
Can an adult have ProQuad?
Adolescents (≥13 years of age) and Adults: 2 doses, to be administered with a minimum interval of 4 weeks between doses.
Indications and Usage For Proquad
Dosage Forms and Strengths
- ProQuad is a suspension for injection supplied as a single dose vial of lyophilized vaccine to be reconstituted using the accompanying sterile diluent [see Dosage and Administration (2.2) and How Supplied/Storage and Handling (16)]. A single dose after reconstitution is 0.5 mL.
Contraindications
- Hypersensitivity
Do not administer ProQuad to individuals with a history of hypersensitivity to any component of the vaccine (including gelatin) {1} or to a previous dose of M-M-R II® (Measles, Mumps, Rubella, Live), ProQuad or VARIVAX® (Varicella Virus Vaccine Live) vaccine, or any other measles, mump… - Immunosuppression
Do not administer ProQuad vaccine to individuals who are immunodeficient or immunosuppressed due to disease or medical therapy. Measles inclusion body encephalitis {2} (MIBE), pneumonitis {3} and death as a direct consequence of disseminated measles vaccine vir…
Warnings and Precautions
- Fever and Febrile Seizures
Administration of ProQuad (dose 1) to children 12 to 23 months old who have not been previously vaccinated against measles, mumps, rubella, or varicella, nor had a history of the wild-type infections, is associated with higher rates of fever and febrile seizures at 5 to 12 days after vacci… - Hypersensitivity to Eggs
Individuals with a history of anaphylactic, anaphylactoid, or other immediate reactions (e.g., hives, swelling of the mouth and throat, difficulty breathing, hypotension, or shock) subsequent to egg ingestion may be at an enhanced risk of immediate-type hypersensitivity reactions after receivin…
Adverse Reactions
- Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a vaccine cannot be directly compared to rates in the clinical trials of another vaccine and may not reflect the rates observed in practice. Vaccine-related adverse r… - Post-Marketing Experience
The following adverse events have been identified during post-approval use of either the components of ProQuad or ProQuad. Because the events are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or esta…
Drug Interactions
- Immune Globulins and Transfusions
Administration of immune globulins and other blood products concurrently with ProQuad vaccine may interfere with the expected immune response [see Warnings and Precautions (5.7)] {9-11}. The ACIP has specific recommendations for intervals between administration of antibody contai… - Salicylates
Reye syndrome has been reported following the use of salicylates during wild-type varicella infection. Vaccine recipients should avoid use of salicylates for 6 weeks after vaccination with ProQuad [see Warnings and Precautions (5.8) and Patient Counseling Information (17)].
Use in Specific Populations
- Pregnancy
Risk Summary ProQuad vaccine contains live attenuated measles, mumps, rubella and varicella viruses. The vaccine is contraindicated for use in pregnant women because infection during pregnancy with the wild-type viruses is associated with maternal and fetal adverse outcomes. F… - Lactation
Risk Summary It is not known whether varicella, measles, or mumps vaccine virus is excreted in human milk. Studies have shown that lactating postpartum women vaccinated with live rubella vaccine may secrete the virus in breast milk and transmit it to breastfed infants [see Warnings a…
Proquad Description
- ProQuad (Measles, Mumps, Rubella and Varicella Virus Vaccine Live) is a combined, attenuated, live virus vaccine containing measles, mumps, rubella, and varicella viruses. ProQuad is a sterile lyophilized preparation of (1) the components of M-M-R II (Measles, Mumps, and Rubella Virus Vaccine Live): Measles Virus Vaccine Live, a more attenuated line of measles virus, derived fro…
Proquad - Clinical Pharmacology
- Mechanism of Action
ProQuad has been shown to induce measles-, mumps-, rubella-, and varicella-specific immunity, which is thought to be the mechanism by which it protects against these four childhood diseases. The efficacy of ProQuad was established through the use of immunological correlates for prote… - Persistence of Antibody Responses after Vaccination
The persistence of antibody at 1 year after vaccination was evaluated in a subset of 2107 children enrolled in the clinical trials. Antibody was detected in 98.9% (1722/1741) for measles, 96.7% (1676/1733) for mumps, 99.6% (1796/1804) for rubella, and 97.5% (1512/1550) for varicella (≥5 …
Nonclinical Toxicology
- Carcinogenesis, Mutagenesis, Impairment of Fertility
ProQuad has not been evaluated for its carcinogenic, mutagenic, or teratogenic potential, or its potential to impair fertility.