conversion of fructosamine to approximate HbA1c level
- as with many lab values, the reference range is different from laboratory to laboratory, so all results must be interpreted within the context of the institution you are practicing in
- HbA1c and fructosamine are highly correlated with following formula (2) HbA1c = 0.017 X fructosamine level (µmol/L) + 1.61 (HbA1c is in DCCT% terms)
What is a good fructosamine level?
Fructosamine concentrations between approximately 350 and 450 μmol/L reflect good glycemic control, concentrations between 450 and 550 μmol/L suggest moderate, and concentrations above 550 to 600 μmol/L suggest poor glycemic control.
What is normal fructosamine level?
For people without diabetes, the fructosamine range should be 175-280 millimoles per liter (mmol/L). For people with controlled diabetes, the fructosamine range should be 210-421 millimoles per liter (mmol/L). For people with uncontrolled diabetes, the fructosamine range should be 268-870 millimoles per liter (mmol/L). 2
What is a high fructosamine level?
A high fructosamine level means that the average blood glucose over the previous 2 to 3 weeks has been elevated. In general, the higher the fructosamine level, the higher the average blood glucose level. Monitoring the trend of values may be more important than a single high value.
What is the reference range of fructosamine?
Type 2 Diabetes Doctor Discussion Guide
- For people without diabetes, the fructosamine range should be 175-280 mmol/L.
- For people with controlled diabetes, the fructosamine range should be 210-421 mmol/L.
- For people with uncontrolled diabetes, the fructosamine range should be 268-870 mmol/L. 2
What is the formula for calculating HbA1c?
The calculator below can be used to estimate the average blood sugar level based on the measured percentage of glycosylated hemoglobin (HbA1c). FORMULAS : Average Plasma Blood Glucose (mg/dl) = (HbA1c * 35.6) - 77.3. Average Plasma Blood Glucose (mmol/L) = (HbA1c * 1.98) - 4.29.
What is the difference between fructosamine and HbA1c?
Conclusions: In type 2 diabetes, serum fructosamine assay can better reflect average blood glucose concentration over the previous 3 to 6 weeks and HbA1c is better reflective over the previous 8 to 10 weeks.
Which is more accurate fructosamine or A1C?
Discussion: HbA1c evaluated by CGM underestimates plasma glucose levels in patients receiving HD. The underestimation represents a clinical challenge in optimizing glycemic control in the HD population. Fructosamine is unaffected by the factors affecting HbA1c and appears to be more accurate for glycemic monitoring.
Are fructosamine tests used instead of HbA1c?
HbA1c is most frequently used being a very reliable marker. Fructosamine may be useful in situations where HbA1c cannot be reliably measured however measurement is not standardised meaning no reference intervals can be recommended and one laboratory's results can be compared to another.
Why do we use fructosamine instead of HbA1c?
The advantage of fructosamine over HbA1c is that it's not affected by changes in red blood cells and hemoglobin caused by anemia, blood loss, or nutrient deficiencies [1].
When do you use fructosamine instead of A1c?
Fructosamine testing may be used to help people with diabetes monitor and control their blood glucose levels in cases where the A1c test cannot be used and/or a shorter-term monitoring window is desired. The level of fructosamine in the blood is a reflection of glucose levels over the previous 2-3 weeks.
What is a healthy fructosamine level?
A reference range for fructosamine in non-diabetic individuals is generally 200 to 285 umol/L. While GA assays also suffer from standardization, the newer assay developed by Asahi Kasei appears to be much improved. According to this assay, normal persons have values around 14% and those with diabetes greater than 17%.
What is the highest acceptable A1C?
Your A1C Result A normal A1C level is below 5.7%, a level of 5.7% to 6.4% indicates prediabetes, and a level of 6.5% or more indicates diabetes.
Why is A1C unreliable?
Conditions such as acute and chronic blood loss, hemolytic anemia, and splenomegaly can all cause falsely lowered A1c results. Patients with end-stage renal disease generally have falsely low A1c values. This is primarily due to the associated chronic anemia with decreased red cell survival.
What is the best method to measure HbA1c?
It can be measured by affinity chromatographic methods. Four basic types of methods are used most commonly to measure HbA1c: immunoassay, ion-exchange high-performance liquid chromatography (HPLC), boronate affinity HPLC, and enzymatic assays.
Which is more accurate fasting glucose or HbA1c?
However, in an epidemiological study, it has been concluded that FBS is more accurate than HbA1c. The best cutoff point for defining high HbA1c is another important issue. The Diabetes Control and Complications Trial suggested the value of 6% as HbA1c cut point.
Is HbA1c alone enough to diagnose diabetes?
HbA1c can be used as a diagnostic test for diabetes providing that stringent quality assurance tests are in place and assays are standardised to criteria aligned to the international reference values, and there are no conditions present which preclude its accurate measurement.
Why is HbA1c the best test for diabetes?
HbA1c reflects average plasma glucose over the previous eight to 12 weeks (15). It can be performed at any time of the day and does not require any special preparation such as fasting. These properties have made it the preferred test for assessing glycaemic control in people with diabetes.
Which is more accurate fasting glucose or HbA1c?
However, in an epidemiological study, it has been concluded that FBS is more accurate than HbA1c. The best cutoff point for defining high HbA1c is another important issue. The Diabetes Control and Complications Trial suggested the value of 6% as HbA1c cut point.
What do fructosamine levels indicate?
The fructosamine test is one way to estimate the amount of glucose in the blood of people with diabetes. If you have diabetes, your doctor may order a fructosamine test to get a sense of how well your glucose levels have been managed in the last few weeks.
What is the difference between HbA1c and A1c?
Blood sugar, or glucose, is generally measured in two ways. The first way is usually done in a lab and tells your doctor about your HbA1c, or often just referred to as A1c. This measurement is a percentage of hemoglobin that is bound with glucose in your blood.