Calculating GFR using the Cockcroft-Gault equation: MEN: GFR = ((140 - A) * W / (72 * Cr) WOMEN: GFR = 0.85 * GFR formula for men
Full Answer
How do you calculate the Cockcroft Gault equation?
Cockcroft Gault Calculator - (With SI Units) 4 variable Cockcroft Gault equation (with SI Units) using serum creatinine, age, weight, gender. by Stephen Z. Fadem, M.D., FACP, FASN. (Age, Weight, Gender, Serum creatinine) Creatinine Clearance Value = (140-age)(weight kg) / (72 X Scr) in mL/min.
Is there a calculator for GFR?
GFR Calculator. The GFR (glomerular filtration rate) Calculator estimates GFR values based on factors including serum creatinine value, age, race, and gender. For comparison purposes, the results for three prevalent formulas used for estimating GFR are provided. This calculator is for people aged 18 years or older.
Can CrCL and GFR be predicted from Cockcroft and Gault formulas?
Both CrCl and GFR were predicted from the Cockcroft and Gault formula. Estimates of bias and precision were obtained and Bland and Altman analysis performed. Body fat was measured by DEXA scan.
Is there a Cockcroft-Gault equation for standardized creatinine results?
Unfortunately, the creatinine method used in the development of the Cockcroft-Gault equation is no longer in use and samples from the study are not available to evaluate how the results might compare to standardized creatinine values. There is no version of the Cockcroft Gault equation for use with standardized creatinine results.
How do you use the Cockcroft-Gault equation?
Cockcroft-Gault equation is often used as a method of estimating GFR (although it was developed as a method of predicting creatinine clearance) from knowledge of serum creatinine, age and weight: creatinine clearance = (((140 - age in years) x (wt in kg)) x 1.23) / (serum creatinine in micromol/l)
What is the formula to calculate the GFR?
RaceSexEquation (age in years for ≥ 18)White or otherFemaleGFR = 144 × (Scr/61.9)-0.329 × (0.993)AgeWhite or otherFemaleGFR = 144 × (Scr/61.9)-1.209 × (0.993)AgeWhite or otherMaleGFR = 141 × (Scr/79.6)-0.411 × (0.993)AgeWhite or otherMaleGFR = 141 × (Scr/79.6)-1.209 × (0.993)Age4 more rows
How do you calculate GFR clearance?
0:535:43Estimating glomerular filtration rate (GFR) - YouTubeYouTubeStart of suggested clipEnd of suggested clipGfr is equal to ua multiplied by v divided by p a where u a is the concentration of a solute inMoreGfr is equal to ua multiplied by v divided by p a where u a is the concentration of a solute in urine v is the volume of urine in ml per minute.
What is GFR and how is it calculated?
What is estimated GFR? Your estimated glomerular filtration rate (eGFR) is the calculation that indicates your level of kidney function, based on the results of a creatinine serum test and other factors—such as age, gender, muscle mass, and ethnicity.
What is 140 in Cockcroft Gault formula?
Two methods were used to estimate renal function: the Cockcroft-Gault formula for creatinine clearance in ml/min ((140 - age in years) x body weight in kg/(serum creatinine in umol/l x 0.81) x 0.85 if female); and Modification of Diet in Renal Disease (MDRD) formula for glomerular filtration rate (GFR) in ml/min/1.73 ...
What is the most accurate GFR calculator?
Glomerular filtration rate (GFR) is the best overall index of kidney function. Normal GFR varies according to age, sex, and body size, and declines with age. The National Kidney Foundation recommends using the CKD-EPI Creatinine Equation (2021) to estimate GFR.
What does modified Cockcroft-Gault measure?
A modified Cockcroft-Gault formula taking into account the body surface area gives a more accurate estimation of the glomerular filtration rate.
What does 1.73 m2 mean in GFR?
An eGFR of >90 ml/min/1.73m2 is considered normal kidney function. If these patients have evidence of kidney disease* (see below) these patients have CKD stage G1. Patients with an eGFR of 60-90 ml/min/1.73m2 have mildly reduced kidney function which may be appropriate for their age.
What is the most accurate GFR calculator?
Glomerular filtration rate (GFR) is the best overall index of kidney function. Normal GFR varies according to age, sex, and body size, and declines with age. The National Kidney Foundation recommends using the CKD-EPI Creatinine Equation (2021) to estimate GFR.
What does 1.73 m2 mean in GFR?
An eGFR of >90 ml/min/1.73m2 is considered normal kidney function. If these patients have evidence of kidney disease* (see below) these patients have CKD stage G1. Patients with an eGFR of 60-90 ml/min/1.73m2 have mildly reduced kidney function which may be appropriate for their age.
How do you calculate GFR inulin?
Plasma clearance of inulin can be calculated by dividing the dose by the area under the plasma concentration/time curve. This method has been shown to give accurate results in adults.
What is the normal value of GFR?
According to the National Kidney Foundation, normal results range from 90 to 120 mL/min/1.73 m2. Older people will have lower than normal GFR levels, because GFR decreases with age. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples.
Why Is The Cockcroft-Gault Formula Provided on This website?
1. The Cockcroft-Gault (CG) formula is provided on this website for research purposes only. It should not be used for drug dosing or to estimate GF...
Why Isn’T The Cockcroft-Gault Formula Recommended For Clinical use?
1. The Cockcroft-Gault (CG) formula has not been expressed using standardized creatinine values. This means it will give inaccurate results. It is...
Is There A Role For The Cockcroft-Gault equation?
1. Creatinine measurement has now been standardized. Unfortunately, the creatinine method used in the development of the Cockcroft-Gault equation i...
When was the Cockcroft and Gault formula developed?from kidney.org
The Cockcroft and Gault formula (CG) was developed in 1973 using data from 249 men with creatinine clearance (CCr) from approximately 30 to 130 mL/m2. It is not adjusted for body surface area. CG is no longer recommended for use because it has not been expressed using standardized creatinine values.
Can Cockcroft-Gault be used for drug dosing?from kidney.org
The Cockcroft-Gault (CG) formula is provided on this website for research purposes only. It should not be used for drug dosing or to estimate GFR.
Is there a version of the Cockcroft Gault equation for creatinine?from kidney.org
There is no version of the Cockcroft Gault equation for use with standard ized creatinine results.
Does MDRD have greater concordance with GFR?from kidney.org
Multiple studies have compared the equations for their impact on drug dosages. In the few studies that compared estimated GFR from the various equations to measured GFR, the studies have shown that the MDRD Study or CKD-EPI equation had greater concordance with measured GFR than the Cockcroft-Gault. One study of inpatients receiving aminoglycoside or vancomycin compared the area under the curve for actual drug levels to the eGFR and showed greater precision for the MDRD Study equation.
Can Cockcroft-Gault overestimate kidney function?from kidney.org
Since the Cockcroft-Gault can overestimate kidney function, there is a risk of overdosing drugs with narrow therapeutic index that has occurred with chemotherapeutic agents. For more information, see http://ckdepi.org/equations/drug-dosing/.
Is there a role for the Cockcroft-Gault equation?from kidney.org
Unfortunately, the creatinine method used in the development of the Cockcroft-Gault equation is no longer in use and samples from the study are not available to evaluate how the results might compare to standardized creatinine values.
About the Creator
Donald W. Cockcroft, MD, is a professor of medicine at the University of Saskatchewan. He is co-chair of Airways Research Group and the chair of the Quality Assurance Committee. Dr. Cockcroft specializes in asthma practice and research.
About the Creator
Henry Gault, MD, MSc, (d. 2003) was named professor emeritus in 1993 after nearly 20 years as a physician and professor at Memorial University of Newfoundland. He was also director for the Division of Nephrology at the General Hospital and of the Renal Laboratory. Dr.
What is the best estimate of renal function?from pubmed.ncbi.nlm.nih.gov
The CG provides the best estimate of kidney function. The limitations of renal function prediction equations should be kept in mind when making clinical decisions. All renal function prediction equations are biased when used in overweight or obese diabetic populations with preserved renal function. The CG provides the best estimate ...
Which is more accurate, CKD or CG?from kidney.org
The best way to determine drug dosing is with the CKD-EPI Creatinine Equation (2009) or the MDRD Study. Both have been shown to be more accurate than the CG formula.
Is there a version of the Cockcroft Gault equation for creatinine?from kidney.org
There is no version of the Cockcroft Gault equation for use with standard ized creatinine results.
Does MDRD have greater concordance with GFR?from kidney.org
Multiple studies have compared the equations for their impact on drug dosages. In the few studies that compared estimated GFR from the various equations to measured GFR, the studies have shown that the MDRD Study or CKD-EPI equation had greater concordance with measured GFR than the Cockcroft-Gault. One study of inpatients receiving aminoglycoside or vancomycin compared the area under the curve for actual drug levels to the eGFR and showed greater precision for the MDRD Study equation.
Is Cockcroft Gault a standardized formula?from kidney.org
The Cockcroft-Gault (CG) formula has not been expressed using standardized creati nine values. This means it will give inaccurate results. It is not recommended for clinical use. Creatinine assays are standardized to reference methods.
Can Cockcroft-Gault overestimate kidney function?from kidney.org
Since the Cockcroft-Gault can overestimate kidney function, there is a risk of overdosing drugs with narrow therapeutic index that has occurred with chemotherapeutic agents. For more information, see http://ckdepi.org/equations/drug-dosing/.
Is there a role for the Cockcroft-Gault equation?from kidney.org
Unfortunately, the creatinine method used in the development of the Cockcroft-Gault equation is no longer in use and samples from the study are not available to evaluate how the results might compare to standardized creatinine values.
What to do if your GFR is below 30?from davita.com
When CKD has progressed to Stage 4, it's time to begin preparing for dialysis and/or a kidney transplant. If GFR falls below 30, people need to find a kidney doctor (called a nephrologist) and talk about treatment options.
What equation is used to calculate glomerular filtration rate?from niddk.nih.gov
In adults, recommended equations for estimating glomerular filtration rate (GFR) from serum creatinine include the Modification of Diet in Renal Disease (MDRD) Study equation (IDMS-traceable version) and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.
What is the normal GFR for kidneys?from davita.com
Completely healthy kidney function is measured at a glomerular filtration rate (GFR) of around 100, which means that the kidneys are working at 100 percent. Your kidney function is still considered normal if the GFR number is 90 or greater. If your GFR is 45, you know that your kidneys are working at approximately 45 percent of the normal rate.
What are the factors that affect the GFR?from davita.com
In addition to serum creatinine, other factors in the equation include age, race and gender. Sometimes, optional factors such as weight, blood urea nitrogen (BUN) and serum albumin are used to get a patient's GFR level.
What is the GFR of stage 3A?from davita.com
Stage 3A & 3B Kidney Disease. Stage 3 CKD, a moderate decrease in kidney function, is divided into 3A (GFR is 45 to 59) and 3B (GFR is 30 to 44). The following can occur when someone is in stage 3 of CKD: Waste products build up in the blood.
What is the GFR of a person with stage 5 CKD?from davita.com
A person with Stage 5 CKD has end stage renal disease (ESRD) with a GFR less than 15 ml/min. At this advanced stage of kidney disease, the kidneys have lost nearly all their ability to do their job effectively, and eventually dialysis or a kidney transplant is needed to live.
What are the early indications of low GFR?from davita.com
As CKD progresses a patient may develop other problems including high blood pressure, anemia, malnutrition, bone disease and problems with the nervous system. Knowing the accurate GFR level helps doctors provide the proper treatment and medication dosages at each stage.
What is creatinine clearance?
Creatinine clearance measures the ratio between the rate of elimination of creatinine by the kidneys (through urine) and its concentration in the blood. Since creatinine is eliminated only by renal filtration, the measurement of its clearance makes it possible to evaluate the filtration rate of the kidneys.
Why prescribe creatinine clearance?
Creatinine clearance is prescribed when the kidney disease is suspected, before prescribing medications that involve having normal kidney function, and when renal blood flow is reduced due to heart disease.
The Cockcroft & Gault formula
The Cockcroft & Gault formula, in medicine, allows the estimation of creatinine clearance in adults. This clearance being very close to the glomerular filtration rate provides information on the state of renal function.
What is the Davita GFR calculator?from davita.com
The DaVita GFR Calculator was designed to help you learn about the stages of kidney disease and provide information about typical steps taken to ensure the best care. See your physician to get a diagnosis of chronic kidney disease and determine your stage.
What happens if your GFR is below 30?from davita.com
If GFR falls below 30, people need to find a kidney doctor (called a nephrologist) and talk about treatment options. People may develop complications, such as high blood pressure, anemia, bone disease and cardiovascular diseases.
What is the GFR of a person with stage 5 CKD?from davita.com
A person with Stage 5 CKD has end stage renal disease (ESRD) with a GFR less than 15 ml/min. At this advanced stage of kidney disease, the kidneys have lost nearly all their ability to do their job effectively, and eventually dialysis or a kidney transplant is needed to live.
How to measure kidney function?from davita.com
Kidney function is measured by how well the kidneys clean the blood. The GFR is a good way to find out a patient's stage of kidney disease. The main factor in estimating the GFR is finding out the level of creatinine in the blood. Your doctor will order blood tests that will list your serum creatinine, a waste product that comes from muscle activity. When kidneys are functioning, they remove creatinine from the blood. As kidney function slows, blood levels of creatinine rise.
What is the normal GFR for kidneys?from davita.com
Completely healthy kidney function is measured at a glomerular filtration rate (GFR) of around 100, which means that the kidneys are working at 100 percent. Your kidney function is still considered normal if the GFR number is 90 or greater. If your GFR is 45, you know that your kidneys are working at approximately 45 percent of the normal rate.
What does a GFR of 60 mean?from davita.com
Knowing the accurate GFR level helps doctors provide the proper treatment and medication dosages at each stage. If you score above 60 mL/min on the GFR calculator, it doesn't necessarily mean you have Stage 1 or Stage 2 CKD ; it does, however, apply to people with existing kidney damage.
How to determine kidney disease stage?from davita.com
Determine which stage of kidney disease you’re in by calculating a glomerular filtration rate (GFR) and start managing your health.