Precautions
Open the packet of pantoprazole sodium for delayed-release oral suspension. Sprinkle all of the granules in the packet on 1 teaspoon of applesauce. Swallow the granules and applesauce within 10 minutes of putting the granules on the teaspoon of applesauce. Take sips of water to make sure the granules are washed down into the stomach.
How do you take pantoprazole sodium?
Swallow the tablet whole using water. Instead of crushing, chewing, or breaking the tablet, swallow it whole with water. This will help the medication break down in your stomach properly. Crushing the medication can make the pantoprazole release too quickly in your stomach. [3]
How do you break up pantoprazole?
Get your prescription of oral suspension granules fulfilled. If you can't swallow pantoprazole tablets, your doctor can prescribe liquid pantoprazole. When you get the medication from the pharmacy, the pantoprazole will be granular and in several pouches. Each pouch will be 40mg once you properly rehydrate the granules.
How do I get pantoprazole oral suspension granules?
Pantoprazole is a proton pump inhibitor that decreases acid secretion in the stomach and may be given to relieve the symptoms of heartburn or to allow inflamed tissue in the gastrointestinal tract to heal. Pantoprazole tablets are delayed-release and should not be split, crushed, or chewed; pantoprazole oral granules are available.
What is the mechanism of action of pantoprazole?
How do you crush pantoprazole?
Do not split, crush, or chew the medication. Doing so may destroy the drug. If you are taking the granules, take your dose 30 minutes before a meal. To take it by mouth, open the packet and mix the granules in applesauce or apple juice.
Should pantoprazole be crushed?
Swallow the delayed-release tablet whole. Do not split, crush, or chew it. You may take the tablet with or without food.
How do you dissolve Protonix granules?
Empty all of the granules in the packet into a small cup that contains 1 teaspoon of apple juice. Stir the granules-apple juice mixture for 5 seconds. The granules will not break up. Swallow the mixture right away.
Does pantoprazole come in liquid form?
Pantoprazole Sodium 2-mg/mL Oral Liquid.
Can pantoprazole be dissolved in water?
Pantoprazole sodium is freely soluble in water, very slightly soluble in phosphate buffer at pH 7.4, and practically insoluble in n-hexane.
Can I break a pantoprazole in half?
Swallow tablets whole; do not split, crush, or chew. Pantoprazole is best taken before breakfast or 30 to 60 minutes before a meal.
Can you crush PPI?
All generically available PPIs, including capsules and tablets, should be swallowed whole without being split, crushed, or chewed. Omeprazole, lansoprazole, and esomeprazole capsules may be opened and the contents sprinkled on applesauce for patients unable to swallow oral dosage forms.
Can you crush Protonix?
Do not split, crush, or chew PROTONIX For Delayed-Release Oral Suspension and PROTONIX Delayed-Release Tablets. PROTONIX oral suspension packet is a fixed dose and cannot be divided to make a smaller dose. Swallow PROTONIX Delayed-Release Tablets whole, with or without food in the stomach.
Can you open pantoprazole capsules?
The capsules, however, should not be opened. If Zegerid is to be used, the powder for suspension should be prescribed.
Does pantoprazole come in a powder?
Therefore, as soon as oral therapy is possible, treatment with Pantoprazole 40 mg powder for solution for injection/infusion should be discontinued and 40 mg pantoprazole p.o. should be administered instead. The recommended intravenous dose is one vial of Pantoprazole (40 mg pantoprazole) per day.
What happens if I take pantoprazole after eating?
Pantoprazole can be taken before or after food, although taking it before food is preferable. If you forget to take a dose at your usual time, you can take it when you remember (unless it is nearly time for your next dose, in which case leave out the missed dose).
How long does it take for pantoprazole to work for acid reflux?
You should start to feel better within 2 to 3 days. It may take up to 4 weeks for pantoprazole to work properly so you may still have some symptoms during this time. If you bought pantoprazole without a prescription, and feel no better after 2 weeks, tell your doctor.
Can Protonix pills be crushed?
Do not split, crush, or chew PROTONIX For Delayed-Release Oral Suspension and PROTONIX Delayed-Release Tablets. PROTONIX oral suspension packet is a fixed dose and cannot be divided to make a smaller dose. Swallow PROTONIX Delayed-Release Tablets whole, with or without food in the stomach.
Can you crush Tecta?
TECTA® (pantoprazole magnesium) is formulated as an enteric-coated tablet. A whole tablet should not be chewed or crushed, and should be swallowed with fluid in the morning either before, during, or after breakfast.
Which PPI can be crushed?
All generically available PPIs, including capsules and tablets, should be swallowed whole without being split, crushed, or chewed. Omeprazole, lansoprazole, and esomeprazole capsules may be opened and the contents sprinkled on applesauce for patients unable to swallow oral dosage forms.
How do you take pantoprazole 40 mg?
It's best to take pantoprazole an hour before a meal. Swallow tablets whole with a drink of water.
How do I wean myself off pantoprazole?
A: Its hard to say how youre feeling, but pantoprazole is a medication that has been known to cause withdrawal symptoms. They tend to be mild and u...
Do you have to wean off pantoprazole?
A: No, not necessarily. If you are on a stable dose of pantoprazole then it is safe to stop taking the medication gradually. However, if your sympt...
How long does it take to wean off pantoprazole?
A: It takes time to wean off of any medication. In some cases, it can take up to six weeks for you body get used to taking less and then gradually...
How long can you take pantoprazole?
Adults—40 milligrams (mg) once a day for up to 8 weeks. Your doctor may want you to take pantoprazole for more than 8 weeks for certain conditions. Children 5 years of age and older weighing 40 kilograms (kg) or more—40 mg once a day for up to 8 weeks.
How to take a granule of apple juice?
Open packet. 2. Mix the packet contents with 1 teaspoon of apple juice in a small cup or container. 3. Stir for 5 seconds (granules will not dissolve) and swallow it immediately or take it at least 30 minutes before a meal. 4.
How to store a med?
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use.
Can you take IBM Micromedex more than once?
Drug information provided by: IBM Micromedex. Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine comes with a Medication Guide. Read and follow these instructions carefully.
How to break down pantoprazole?
Swallow the tablet whole using water. Instead of crushing, chewing, or breaking the tablet, swallow it whole with water. This will help the medication break down in your stomach properly. Crushing the medication can make the pantoprazole release too quickly in your stomach.
How to take pantoprazole if you forgot to take it?
If you forget to take your pantoprazole in the morning, take it as soon as you remember. Then, take the following dose at the normal time. Avoid waiting for the next dose to take twice the recommended amount.
How long after taking pantoprazole can you take the next dose?
If you remember the missed dose and you're supposed to take the next dose in less than 12 hours, skip the missed dose. Tip: If you typically take pantoprazole twice in a day, take the skipped dose as soon as you remember, unless you're supposed to take the second dose in less than 4 hours.
How old do you have to be to take pantoprazole?
Pantoprazole is often prescribed for people over 12 years old. Tip: It's important to let your doctor know which medications you're currently taking. Some antibiotics, HIV medications, cancer treatments, and salts for anemia can interact with pantoprazole. ...
What are some other medications that are similar to pantoprazole?
There are many other medicines that fulfill the same role as pantoprazole, such as omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), esomeprazole (Nexium), dexlansoprazole (Dexilant).
How long do you have to take a pill to get rid of stomach acid?
You'll need to take tablets or an oral solution for a few weeks before seeing an improvement in your symptoms. Fortunately, if you take it before your morning meal, there are few side effects and you should feel relief from your stomach acid troubles. Steps.
What is the best medicine for acid reflux?
If you have heartburn, acid reflux, ulcers, or gastroesophageal reflux disease (GERD), your doctor might prescribe pantoprazole. This proton pump inhibitor works by blocking the production of acid in your stomach. You'll need to take tablets or an oral solution for a few weeks before seeing an improvement in your symptoms.
How to give pantoprazole sodium?
Connect the catheter tip of the syringe to a 16 French (or larger) tube. Hold the syringe attached to the tubing as high as possible while giving pantoprazole sodium for delayed-release oral suspension to prevent any bending of the tubing. Empty the contents of the packet into the barrel of the syringe.
How long can you take Pantoprazole?
Pantoprazole sodium delayed-release tablet was well tolerated at these dose levels for prolonged periods (greater than 2 years in some patients).
How to take pantoprazole with apple juice?
Taking pantoprazole sodium for delayed-release oral suspension with apple juice: Open the packet of pantoprazole sodium for delayed-release oral suspension. Empty all of the granules in the packet into a small cup that contains 1 teaspoon of apple juice. Stir the granules-apple juice mixture for 5 seconds.
How long does it take for pantoprazole to reach peak concentration?
After administration of a single or multiple oral 40 mg doses of pantoprazole sodium delayed-release tablets, the peak plasma concentration of pantoprazole was achieved in approximately 2.5 hours, and C max was 2.5 mcg/mL. Pantoprazole undergoes little first-pass metabolism, resulting in an absolute bioavailability of approximately 77%. Pantoprazole absorption is not affected by concomitant administration of antacids.
How long does pantoprazole last?
In children 5 years of age and older, pantoprazole sodium for delayed-release oral suspension is used for: up to 8 weeks for the healing and symptom relief of EE. It is not known if pantoprazole sodium for delayed-release oral suspension is safe if used longer than 8 weeks in children.
How long does it take for pantoprazole to be detected in milk?
Pantoprazole was detectable in milk only 2 and 4 hours after the dose with milk levels of approximately 36 mcg/L and 24 mcg/L, respectively. A milk-to-plasma ratio of 0.022 was observed at 2 hours after drug administration. Pantoprazole was not detectable (<10 mcg/L) in milk at 6, 8 and 24 hours after the dose.
What is the metabolite of pantoprazole?
Pantoprazole is metabolized mainly by CYP2C19 and to minor extents by CYPs 3A4, 2D6, and 2C9. In in vivo drug-drug interaction studies with CYP2C19 substrates (diazepam [also a CYP3A4 substrate] and phenytoin [also a CYP3A4 inducer] and clopidogrel), nifedipine, midazolam, and clarithromycin (CYP3A4 substrates), metoprolol (a CYP2D6 substrate), diclofenac, naproxen and piroxicam (CYP2C9 substrates), and theophylline (a CYP1A2 substrate) in healthy subjects, the pharmacokinetics of pantoprazole were not significantly altered.
How long does it take to swallow Protonix?
Sprinkle all of the granules in the packet on 1 teaspoon of applesauce. Swallow the granules and applesauce within 10 minutes of putting the granules on the teaspoon of applesauce. Take sips of water to make sure the granules are washed down into the stomach.
How to make granules from apple juice?
Stir the granules-apple juice mixture for 5 seconds. The granules will not break up. Swallow the mixture right away. To make sure that the entire dose is taken, add more apple juice to the cup, stir and swallow the apple juice right away. Repeat step 5 if there are granules left in the cup.
How to empty a catheter tip syringe?
Add 10 mL (2 teaspoons) of apple juice into the catheter-tip syringe and gently tap or shake the syringe to help empty the syringe. Repeat step 6 at least 2 more times until there are no granules left in the catheter-tip syringe.
What is the PPI that suppresses the final step in gastric acid production?
Pantoprazole is a PPI that suppresses the final step in gastric acid production by covalently binding to the (H...
How long to soak granules in applesauce?
Swallow the granules and applesauce within 10 minutes of putting the granules on the teaspoon of applesauce.
What is the active ingredient in Protonix?
The active ingredient in PROTONIX (pantoprazole sodium) For Delayed-Release Oral Suspension and PROTONIX (pantoprazole sodium) Delayed-Release Tablets, a PPI, is a substituted benzimidazole, sodium 5- (...
Is Protonix delayed release?
PROTONIX is supplied as delayed-release granules in packets for preparation of oral suspensions or as...
What color ink is used on pantoprazole?
40 mg pantoprazole, yellow oval biconvex tablets imprinted with PROTONIX (brown ink) on one side
How long does it take for Protonix to heal?
For adult patients who have not healed after 8 weeks of treatment, an additional 8-week course of PROTONIX may be considered.
What is the PPI that suppresses the final step in gastric acid production?
Pantoprazole is a PPI that suppresses the final step in gastric acid production by covalently binding to the (H...
What is the active ingredient in Protonix?
The active ingredient in PROTONIX (pantoprazole sodium) For Delayed-Release Oral Suspension and PROTONIX (pantoprazole sodium) Delayed-Release Tablets, a PPI, is a substituted benzimidazole, sodium 5- (...
Can Protonix be given with a gastrostomy tube?
For patients who have a nasogastric tube or gastrostomy tube in place, PROTONIX For Delayed-Release Oral Suspension can be given as follows:
Can you take Protonix with apple juice?
Because proper pH is necessary for stability, do not administer PROTONIX For Delayed-Release Oral Suspension in liquids other than apple juice, ...
How long do you stir a granule of saline?
Stir for 5 seconds (granules will not dissolve) and swallow immediately.
How long does pantoprazole last?
It will last for one or two months if it is to allow an ulcer to heal. For all other reasons for taking pantoprazole, your treatment will last for as long as is necessary to control your symptoms. Some foods may make your symptoms worse.
How often should I take pantoprazole?
There are different strengths of tablets available so your doctor will tell you which is right for you. It is usually taken once a day. If you are taking it for either Helicobacter pylori eradication or for Zollinger-Ellison syndrome, it is likely you will be asked to take two doses a day. Your doctor will tell you which dose is right for you and the directions will also be on the label of the pack to remind you.
What is the treatment for acid reflux?
This is often referred to as ' acid reflux '. Proton pump inhibitors such as pantoprazole stop cells in the lining of the stomach from producing too much acid. This helps to prevent ulcers from forming, or assists the healing process where damage has already occurred.
How many people are affected by pantoprazole?
Pantoprazole side-effects (these affect fewer than 1 in 100 people)
Does pantoprazole help with heartburn?
By decreasing the amount of acid, they can also help to reduce the symptoms of acid reflux disease, such as heartburn. Pantoprazole is also given as one part of a treatment to get rid of Helicobacter pylori, a bacterium found in the stomach, which can cause ulcers. Pantoprazole is available on prescription.
Does pantoprazole cause stomach upset?
Pantoprazole reduces the amount of acid produced in your stomach. Swallow the tablet whole - do not chew or crush it before you swallow. The most common side-effects are stomach upset and headache. These effects are generally mild and do not last long.
Can acid break down the stomach?
In some people, this barrier can break down allowing the acid to damage the stomach, causing inflammation, ulcers and other conditions. Other people can have a problem with the muscular band at the top of the stomach that keeps the stomach tightly closed.
How Does Pantoprazole Work?
Proton pump inhibitors like pantoprazole work by blocking the action of the proton pumps in the body , which are actually a chemical system called the hydrogen-potassium adenosine triphosphatase enzyme system. The stomach is lined with proton pumps, which are responsible for producing hydrochloric acid; hydrochloric acid is one of the main components of stomach acid. Medications like pantoprazole stop the proton pumps from producing too much acid, helping to lower the levels in the stomach. With less acid in the stomach, existing ulcers can begin to heal, new ulcers are less likely to form, and acid reflux symptoms, such as heartburn and regurgitation, are reduced.
What Is Pantoprazole?
Pantoprazole is a generic medication that belongs to a class of drugs called proton pump inhibitors (PPIs). Like other proton pump inhibitors, pantoprazole/pantoprazole sodium, also sold under the brand name Protonix, is used to treat digestive conditions, including GERD. The medication was first approved under the brand name Protonix by the U.S. Food and Drug Administration (FDA) in 1985, making it a first-generation proton pump inhibitor. Following the expiration of the Protonix patent, the generic pantoprazole was introduced.
What is Pantoprazole Used to Treat?
Pantoprazole is used to treat digestive conditions that are characterized by the overproduction of stomach acid, including gastroesophageal reflux disease, associated erosive esophagitis (damage to the esophagus as a result of GERD), and Zollinger-Ellison syndrome. Each condition and its symptoms are briefly described below.
How Long Does Pantoprazole Take to Work?
Proton pump inhibitors like pantoprazole are intended for the long term treatment of acid reflux symptoms. The medication takes approximately two and a half hours to begin working, so it won't be effective for current symptoms. However, patients who need immediate relief from their acid reflux symptoms can combine pantoprazole with fast-acting Tums or Maalox to reduce the amount of acid.
What Dose of Pantoprazole Should I Take?
In general, the conditions treated by pantoprazole require a dose of 40 mg taken once per day for eight weeks. Patients with Zollinger-Ellison syndrome are more likely to take a 40 mg dose twice per day by mouth but may take up to 240 mg per day to control symptoms. Because Zollinger-Ellison syndrome is a chronic disease, most patients with the condition will take a proton pump inhibitor for an extended period of time. GERD can also be chronic, but it should only be treated with long term use of proton pump inhibitors like pantoprazole with a doctor's approval. Be sure to inform your health care professional and pharmacist of all the prescription drugs and over-the-counter medications that you are currently using to avoid any drug interactions or allergic reactions .
What Are the Benefits of Using Pantoprazole?
Pantoprazole is one of the oldest proton pump inhibitors on the market, having been sold for 35 years. As a result, researchers have had plenty of time to solidify drug information and study the effects of the drug and thoroughly understand its impacts on the body. Pantoprazole can be purchased over the counter at certain strengths due to the low risk of side effects and other issues associated with taking the medication, making it more accessible for patients. Benefits associated with the use of pantoprazole include:
What are proton pump inhibitors?
Some other common proton pump inhibitors include Prilosec (omeprazole), Prevacid (lansoprazole), Nexium (esomeprazole), and Aciphex (rabeprazole).
How It Works
Pantoprazole is used to treat certain stomach and esophagus problems (such as acid reflux).
May Treat: Gastroesophageal reflux disease · Erosive esophagitis · Zollinger-Ellison syndrome · Acute gastric ulcer with hemorrhage · Gastric hypersecretion with systemic mastocytosis and more
Brand Names: Protonix
Drug Class: Gastric Acid Secretion Reducer - Proton Pump Inhibitors (PPIs)
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
- Call doctor if you are not getting better
- Call doctor if you are not getting better
- Call MD now for heartburn with sweating & dizziness
- Call doctor if you get severe diarrhea
- For granules delayed release for susp packet products : Wash down as directed. DO NOT chew granules.
- For tablet, delayed release products : Before use, important to read the Medication Guide. Call MD or RPh re. timing of taking with other meds. Swallow whole. Do not break/chew/crush/dissolve. Success is dependent on completing therapy course. May increase risk of bone fractures.
- For vial products : For intravenous injection dilute prior to use. Prepare carefully as you have been shown. Take at the same time(s) daily as directed. Recommended for short term use only. Tell doctor your complete medical history.
Upsides
Bottom Line
Tips
Response and Effectiveness
- Pantoprazole is an acid-suppressing agent that may be used to treat conditions associated with excessive stomach acid production, such as gastroesophageal reflux (GERD), stomach ulcers, erosive eso...
- Pantoprazole works by irreversibly blocking the actions of an enzyme responsible for acid production, called H+/K+ ATPase (also known as the gastric proton pump). The proton pum…
- Pantoprazole is an acid-suppressing agent that may be used to treat conditions associated with excessive stomach acid production, such as gastroesophageal reflux (GERD), stomach ulcers, erosive eso...
- Pantoprazole works by irreversibly blocking the actions of an enzyme responsible for acid production, called H+/K+ ATPase (also known as the gastric proton pump). The proton pump is located in the...
- Pantoprazole belongs to the class of medicines known as proton pump inhibitors (PPIs).
Interactions
- Oral pantoprazole may be used for the short-term treatment of erosive or nonerosive gastroesophageal reflux disease (GERD) in adults and children over the age of 5 years. May also be used for the m...
- Both oral and IV pantoprazole may be useful for the treatment of hypersecretory conditions such as Zollinger-Ellison syndrome in adults.
- Oral pantoprazole may be used for the short-term treatment of erosive or nonerosive gastroesophageal reflux disease (GERD) in adults and children over the age of 5 years. May also be used for the m...
- Both oral and IV pantoprazole may be useful for the treatment of hypersecretory conditions such as Zollinger-Ellison syndrome in adults.
- IV pantoprazole may be used short-term to treat gastroesophageal reflux disease associated with a history of erosive esophagitis.
- May be used off-label for aspiration prophylaxis in patients undergoing anesthesia, for Barrett's esophagus, for functional dyspepsia, for helicobacter pylori eradication, for primary prevention of...
Further Information
- Pantoprazole is a proton pump inhibitor that decreases acid secretion in the stomach and may be given to relieve the symptoms of heartburn or to allow inflamed tissue in the gastrointestinal tract to heal. Pantoprazole tablets are delayed-release and should not be split, crushed, or chewed; pantoprazole oral granules are available.