How is diazepam administered intravenously?
Intravenous Administration Do not use small veins, such as those of the dorsum of the hand or wrist. Inject slowly, taking at least 1 minute for each 5 mg. If it is not feasible to administer diazepam directly intravenous, may inject slowly through the infusion tubing as close as possible to the vein insertion.
Can diazepam injection be given intramuscularly?
Diazepam may be administered intravenously or intramuscularly (deep into the muscle). However, absorption following I.M. administration is slow and erratic; thus, this route of administration should be avoided if possible.
Can diazepam injection be given IV?
Diazepam Injection BP may be given IV injection, IM injection, or by IV infusion. The absorption from IM injection of diazepam may be variable, particularly for the gluteal muscles, and therefore the IM route of administration should only be used if IV administration is not possible.
Why diazepam is not given intramuscularly?
As diazepam is not water soluble, an organic solvent has to be incorporated into the formulation of the triple injection solution. This lack of water solubility limits the value of diazepam given by i.m. injection when pharmacologically effective blood levels are required to be attained rapidly.
How do you prepare diazepam injections?
Dissolve the diazepam and benzoic acid in the solution. Slowly add Sterile Water for Injection to a volume of 75 to 80 mL. Add the sodium benzoate and mix until dissolved; then add the sodium hydroxide solution or hydrochloric acid to adjust the pH to the range of 6.2 to 6.9.
How do you dilute diazepam injections?
However, if in some circumstances it is necessary to administer diazepam as an infusion, it is recommended that it be diluted in dextrose 5% in water, normal saline, Ringer's injection or lactated Ringer's injection to a dilution of at least 1:40 and used within 6 hours or to a dilution of 1:50 and used within 24 hours ...
How fast does diazepam injection work?
1 When administered via injection, valium takes just one to five minutes to take effect. When taken orally, people usually begin to feel the effects 15 to 60 minutes after ingestion. Rectal gel may be used for those who are experiencing seizures and begins working quickly after administration.
How many mg is diazepam injection?
Diazepam Injection, USP is a sterile, nonpyrogenic solution intended for intramuscular or intravenous administration. Each milliliter (mL) contains 5 mg diazepam; 40% propylene glycol; 10% alcohol; 5% sodium benzoate and benzoic acid added as buffers; and 1.5% benzyl alcohol added as a preservative.
What is the function of diazepam injection?
Diazepam injection is used to relieve symptoms of anxiety and alcohol withdrawal. It is also used to relieve anxiety before surgery or certain procedures. When diazepam is used before surgery, the patient will not remember some of the details about the procedure.
Can benzodiazepines be given IM?
Although a common practice, the intramuscular administration of most benzodiazepines is not the preferred route. With the exception of lorazepem, intramuscular absorption of these drugs is slow, erratic, and sometimes incomplete, probably owing to precipitation of drug at the injection site.
Can midazolam be given IM?
Conclusion: Both forms of midazolam, IM and IV, are effective and safe for paediatric sedation in ED. Although the sedative with IV form might appear sooner, IM form of midazolam can be effectively used in patient with limited IV access.
Can diazepam be given subcutaneously?
Medications contraindicated for use via subcutaneous infusion due to severe localised reactions3,11: prochlorperazine (Stemetil, an antiemetic); diazepam (Valium, an anxiolytic); and. chlorpromazine (Largactil, an antipsychotic)
How many mg is diazepam injection?
Diazepam Injection, USP is a sterile, nonpyrogenic solution intended for intramuscular or intravenous administration. Each milliliter (mL) contains 5 mg diazepam; 40% propylene glycol; 10% alcohol; 5% sodium benzoate and benzoic acid added as buffers; and 1.5% benzyl alcohol added as a preservative.