- 1. Pour some diethyl ether into a borosilicate beaker.
- 2. Chuck some ground cocaine HCl that is adultered with benzocaine (and possibly other cuts)
- 3. Proceed to stir SLOWLY (as diethyl ether isn't something to be taken lightly) with a glass rod, and make sure all the powder comes into contact with the Et2O.
What should I do before applying benzocaine topical?
Clean the area with soap and water before applying benzocaine topical. Wash your hands before and after inserting a rectal suppository. Do not take a rectal suppository by mouth. It is for use only in your rectum.
How does benzocaine topical work?
It works by blocking nerve signals in your body. Benzocaine topical is used to reduce pain or discomfort caused by minor skin irritations, sore throat, sunburn, vaginal or rectal irritation, ingrown toenails, hemorrhoids, and many other sources of minor pain on a surface of the body.
Can You Spray benzocaine on your face?
If using the spray, hold the container 6 to 12 inches away from the skin. Do not spray this medication onto your face. Spray it instead on your hands and then rub it onto the face, avoiding contact with your eyes. Clean the area with soap and water before applying benzocaine topical.
What are benzocaine wipes?
Benzocaine wipes, also called premature ejaculation wipes, are disposable wipes moistened with a numbing agent. They’re meant to numb your penis nerves and slow down the process of ejaculation.
How do you synthesize Benzocaine?
Synthesis of benzocaine: Into a 100 ml flask, mix 1.25 g of p-aminobenzoic acid hydrochloride, 10 ml of EtOH, and 0.5 ml H2SO4 (conc.). Heat the mixture at reflux for 2 h. After cooling the mixture, neutralize with an aqueous sodium carbonate solution (10%).
What is the effect of the 95% ethanol on the solubility of benzocaine?
While the solubility of benzocaine increases over 200 times from water ( 1.0 mg/ml) to pure ethanol (207 mg/ml), the membrane solubility of benzocaine was much less sensitive to the ethanol content change in the vehicle.
Why does benzocaine precipitate during neutralization?
Benzocaine precipitates during the neutralization since it becomes uncharged. In an acidic and basic medium, benzocaine is protonated and deprotonated, respectively, making it soluble in solution. However, it loses its net charge in a neutral solution, causing it to precipitate out.
Why is absolute ethanol used in the synthesis of benzocaine?
Explanation: Benzocaine is soluble in Ethanol, Methanol and Diethyl Ether. But it is not very soluble in water. Having water in the solution would decrease the solubility and would create a lot of hassle later.
How do you dissolve benzocaine in water?
Benzocaine contains not less than 98.0% and not more than 101.0% of C9H11NO2, calculated with reference to the dried substance. A. Dissolve 0.10 g in 5 mL of water, add 3 drops of hydrochloric acid (~70 g/l) TS and 5 drops of iodine TS; a brown precipitate is produced.
How do you dissolve benzocaine powder?
It is very slightly soluble in water (1 in 2,500) and freely soluble in alcohol (1 in 5-8) and ether (1 in 4). Benzocaine is sparingly soluble in almond and olive oil (1 in 30-50), and it will dissolve in dilute acids. It should be protected from light and stored in tight containers.
How does benzocaine work chemistry?
Benzocaine binds to the sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited, thereby blocking the initiation and conduction of nerve impulses.
Why is sulfuric acid added dropwise?
Water is added dropwise to the reaction mixture. One of the main reasons for this is that, if sulphuric acid is not added dropwise, it will react with water molecules very vigorously. This will cause the production of a large quantity of heat, making the reaction exothermic.
Why is it necessary to use absolute ethanol if you were preparing an ester using ethanol?
By using absolute ethanol, ester becomes acid due to the hydrogen from water. Therefore, absolute ethanol is chosen for this reaction which will lead the reaction to right (Forward reaction), rather than using any forms of diluted ethanol that could only negatively influence reaction for ester formation.
What is the difference between absolute ethanol and 95% ethanol?
The ethanol-based products commonly used in laboratories are 95% pure. In this environment, ethanol is typically used to fuel alcohol lamps, preserve biological specimens, disinfect laboratory equipment, and dissolve organic compounds. Absolute ethanol, on the other hand, has a purity level of between 99% and 100%.
What is the limiting reagent in benzocaine synthesis?
As the 4-aminobenzoic acid is the limiting amount, it is this quantity that we should use in our yield calculation.
What is the melting point of benzocaine?
88–90 °CBenzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol, chloroform, and ethyl ether. The melting point of benzocaine is 88–90 °C, and the boiling point is about 310 °C.
Is benzocaine soluble in ethanol?
QUICK LINKS. Benzocaine is a surface anesthetic that reversibly inactivates voltage-dependent sodium channels. Solubility : Soluble in water (0.4 mg/ml at 20° C), methanol, chloroform (500 mg/ml), ethanol (50 mg/ml), and ether (250 mg/ml).
Why do you think absolute ethanol is preferable to 95% ethanol in these reactions?
By using absolute ethanol, ester becomes acid due to the hydrogen from water. Therefore, absolute ethanol is chosen for this reaction which will lead the reaction to right (Forward reaction), rather than using any forms of diluted ethanol that could only negatively influence reaction for ester formation.
What is the difference between absolute ethanol and 95% ethanol?
The ethanol-based products commonly used in laboratories are 95% pure. In this environment, ethanol is typically used to fuel alcohol lamps, preserve biological specimens, disinfect laboratory equipment, and dissolve organic compounds. Absolute ethanol, on the other hand, has a purity level of between 99% and 100%.
Is benzocaine soluble in ether?
Benzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol, chloroform, and ethyl ether.
What Is Benzocaine Topical?
Benzocaine is a local anesthetic (numbing medication). It works by blocking nerve signals in your body.Benzocaine topical is used to reduce pain or...
Before Taking This Medicine
Do not use benzocaine topical if you have ever had methemoglobinemia in the past.Do not use benzocaine topical on a child younger than 2 years old....
How Should I Use Benzocaine Topical?
Use exactly as directed on the label, or as prescribed by your doctor. Read all medication guides or instruction sheets.Your body may absorb more o...
What Happens If I Miss A Dose?
Since benzocaine topical is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose.
What Happens If I Overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of benzocaine topical applied to the skin can cause li...
What Should I Avoid While Using Benzocaine Topical?
Avoid eating within 1 hour after using benzocaine topical on your gums or inside your mouth.Benzocaine topical is for use only on the surface of yo...
Benzocaine Topical Side Effects
Benzocaine topical used in the mouth may cause a condition in which the oxygen in your body tissues can become dangerously low. This is a potential...
What Other Drugs Will Affect Benzocaine Topical?
Medicine used on the skin is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healt...
What are some things I need to know or do while I take Benzocaine Oral Spray?from drugs.com
Tell all of your health care providers that you take benzocaine oral spray. This includes your doctors, nurses, pharmacists, and dentists.
How is this medicine (Benzocaine Oral Suspension) best taken?from drugs.com
Use benzocaine oral suspension as ordered by your doctor. Read all information given to you. Follow all instructions closely.
What are some other side effects of Benzocaine Oral Spray?from drugs.com
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
How to report side effects of benzocaine?from drugs.com
Irritation where benzocaine oral spray is used. Mouth tingling. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-332-1088.
How old do you have to be to give benzocaine?from drugs.com
If the patient is a child younger than 2 years of age. Do not give benzocaine oral spray to a child younger than 2 years of age. Do not use benzocaine oral spray for teething.
How to keep a drug out of your system?from drugs.com
Protect from heat. Protect from heat or open flame. Do not puncture or burn even if it seems empty. Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets. Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so.
What to do if you think you have an overdose?from drugs.com
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How is benzocaine prepared?from en.wikipedia.org
Benzocaine can be prepared by esterification using 4-aminobenzoic acid and ethanol. It can also be prepared by reduction of ethyl 4-nitrobenzoate to the amine. In industrial practice, the reducing agent is usually iron and water in the presence of a little acid.
How does benzocaine function?from healthtap.com
Benzocaine : Benzocaine is a commonly used local anesthetic. It is an ester anesthetic that blocks both the initiation and conduction of nerve impulses by decreasi... Read More
What is the definition or description of: benzocaine overdose?from healthtap.com
Benzocaine OD: Benzocaine is a topical pain medication. According to Drugs.Com "An overdose of benzocaine topical applied to the skin can cause life-threatening sid... Read More
How is a benzodiazepine overdose treated?from drugs.com
Oxygen therapy will be used to help you breathe easier. You may also need a medicine called flumazenil. Flumazenil helps to reverse some of the effects of benzodiazepines.
How can benzocaine 7.5% works on premature ejectculation/?from healthtap.com
Topical anesthesia: By decreasing sensation from the genitalia. The medicine is an analogue to the numbing medication that dentists use, for example.
How long does it take for benzocaine to cause methemoglobinemia?from en.wikipedia.org
In European countries, the contraindication applies to children under 12 years of age. Symptoms of methemoglobinemia usually occur within minutes to hours of applying benzocaine, and can occur upon the first-time use or after additional use. Benzocaine may cause allergic reactions. These include:
What is the bath solution used for amphibians?from en.wikipedia.org
A bath solution of benzocaine has been used to anesthetize amphibians for surgery.
How should I use benzocaine topical?from drugs.com
Use exactly as directed on the label, or as prescribed by your doctor. Read all medication guides or instruction sheets.
What is the purpose of Benzocaine?from fda.gov
Benzocaine is a topical anesthetic contained in some marketed over-the-counter (OTC) oral drug products intended to relieve pain from a variety of conditions such as sore throats, canker sores, and irritation of the mouth and gums.
What other drugs will affect benzocaine topical?from drugs.com
Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.
How many cases of benzocaine methemoglobinemia have been reported?from fda.gov
We have been closely monitoring this safety risk and estimate that more than 400 cases of benzocaine-associated methemoglobinemia have been reported to the FDA Adverse Event Reporting System (FAERS) or published in the medical literature since 1971. As part of our continued monitoring of this safety risk, we recently evaluated 119 cases of benzocaine-associated methemoglobinemia reported to FAERS and identified in the medical literature between February 26, 2009, and October 6, 2017. The patients’ ages were reported in 116 cases and ranged from 1 day to 85 years. Twenty-two cases involved patients younger than 18 years, 11 of which described a patient younger than 2 years. A transesophageal echocardiogram was the reported reason for benzocaine use for 53 cases (45 percent), and other cases commonly cited endoscopy, intubation, oral pain, and feeding tube pain. Among the thirty cases (25 percent) describing oral pain, the specific conditions cited included toothache or dental pain, teething, throat pain, tonsillectomy pain, and mucositis. Approximately two-thirds (n=75) of the 119 cases specified that the benzocaine product used was a topical spray. The second most common dosage form was oral gel (n=20).
How long after taking benzocaine can you eat?from drugs.com
Avoid eating within 1 hour after using benzocaine topical on your gums or inside your mouth.
What is the bath solution used for amphibians?from en.wikipedia.org
A bath solution of benzocaine has been used to anesthetize amphibians for surgery.
How is benzocaine made?from en.wikipedia.org
Synthesis. Benzocaine can be prepared by esterification using 4-aminobenzoic acid and ethanol. It can also be prepared by reduction of ethyl 4-nitrobenzoate to the amine. In industrial practice, the reducing agent is usually iron and water in the presence of a little acid.
Roman Swipes
You have to purchase Roman Swipes on a subscription basis. The good thing is that they are delivered to your door in discreet packaging.
Hims Clockstopper Climax Delay Wipes
Hims will send you a starter pack of three Clockstopper wipes for $19. There’s also a $5 processing fee. On the 3-month subscription plan, you’ll get two packs of 12 wipes every 3 months. The 3-month plan costs $65, not including the processing fee.
RexMD Performance Wipes
RexMD Performance Wipes offers discreet packaging, door-to-door shipping, and low cost. A 1-month box costs $14.95 and comes with 10 wipes. RexMD also includes free shipping as a perk. As with the other companies, they offer varied subscriptions that include savings.
Are premature ejaculation wipes safe?
PE wipes are safe for the user and their partner. They can, however, cause skin irritation among other side effects.
Do they affect your partner?
The benzocaine can transfer to your partner. It’s important to allow the full amount of time for the product to dry, usually 5 minutes, to reduce these effects.
