how do you use dornase alfa

Precautions

Each ampule contains one full dose of dornase alfa. Do not use an ampule that has already been opened. Do not use a cloudy or discolored inhalation solution. Remove the ampule from the pouch. Place the inhalation solution in the medicine reservoir or nebulizer cup on the machine.

How do you use a Dornase alfa ampule?

Dornase alfa inhalation solution is used together with other medicines (eg, antibiotics, bronchodilators, and steroids) to control symptoms of cystic fibrosis. Cystic fibrosis is a condition in which a thick mucus is formed in the lungs and breathing passages. The mucus blocks the airways and increases the chance of lung infections.

What is Dornase alfa inhalation solution used for?

Do not dilute or mix dornase alfa with other drugs in the nebulizer. Inhalation devices require regular cleaning. Follow the manufacturer's written instructions for the care of the nebulizer. Do not let anyone else use your medication.

How should I take care of my Dornase alfa nebulizer?

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take dornase alfa with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Is it safe to take Dornase alfa with other medications?

What are the side effects of dornase alfa?

Common side effects of Pulmozyme include:sore/dry throat and hoarseness,eye redness and irritation,rash,laryngitis,eye inflammation, or.runny or stuffy nose.

What does Pulmozyme dornase alfa do?

Laboratory studies show that Pulmozyme (dornase alfa) cuts apart extracellular DNA by acting like an enzyme* naturally found in the lungs. By cutting this extracellular DNA, Pulmozyme helps make the thick, sticky mucus that your lungs produce thinner and looser.

Why is dornase alfa used in the treatment of cystic fibrosis?

Dornase alfa is used to reduce the number of lung infections and to improve lung function in patients with cystic fibrosis. It breaks down the thick secretions in the airways, allowing air to flow better and preventing bacteria from building up.

What kind of drug is dornase alfa?

Pulmozyme is a prescription medicine used to treat the symptoms of Cystic Fibrosis. Pulmozyme may be used alone or with other medications. Pulmozyme belongs to a class of drugs called Enzymes, Mucolytic.

When should I take dornase alfa?

In order to receive the full effects of this medicine, you must use it every day as ordered by your doctor. If possible, dornase alfa should be used at about the same time each day. You may notice some improvement in your condition within the first week of treatment.

When do you use Pulmozyme?

This medication is used to improve breathing and reduce the risk of lung infections in people with cystic fibrosis. It is used along with other treatments for this disease (such as chest physical therapy, medications, nutritional supplements).

Is dornase alfa a mucolytic?

Dornase Alfa. Dornase alfa (Pulmozyme®) is an inhaled medication that thins mucus. Sometimes referred to as a mucolytic or DNase, dornase alfa acts like scissors by cutting up the long DNA strands contained in white blood cells.

How does Pulmozyme break down mucus?

Dornase alfa (Pulmozyme®) also helps thin mucus when inhaled. This drug acts like scissors cutting up the long DNA strands in white blood cells. Cutting the strands into shorter bits helps break up the thick, sticky mucus of CF.

How is dornase alfa made?

Dornase alfa is a biosynthetic form of human deoxyribunuclease I (DNase I) enzyme. It is produced in genetically modified Chinese hamster ovary (CHO) cells using recombinant DNA technology. The 260-amino acid sequence of dornase alfa is identical to the endogenous human enzyme.

How do you store dornase alfa?

Storage and Handling Store PULMOZYME ampules in their protective foil pouch under refrigeration and protected from light. Refrigerate ampules during transport and do not expose to room temperatures for a total time of 24 hours.

What drugs should not be taken with theophylline?

Examples of drugs not found to have a significant effect on theophylline pharmacokinetics are ranitidine, josamycin, midecamycin, amoxycillin, tetracycline, cephalexin, cefaclor, orciprenaline, metoprolol, antacids, medroxyprogesterone acetete, metoclopramide, and metronidazole.

How long does it take for Pulmozyme to work?

This recommendation is based on evidence that Pulmozyme® makes CF sputum pourable within 30 minutes (Shak 1990).

What is the mechanism of action of Pulmozyme?

Pulmozyme is inhaled and goes directly to the lungs to help reduce viscosity by cleaving extracellular DNA. This breaks up sticky mucus, making it looser and thinner.

How does Pulmozyme break down mucus?

Dornase alfa (Pulmozyme®) also helps thin mucus when inhaled. This drug acts like scissors cutting up the long DNA strands in white blood cells. Cutting the strands into shorter bits helps break up the thick, sticky mucus of CF.

What human enzyme does the dornase alfa gene encode?

Dornase alfa is a synthetic form of human deoxyribonuclease I used to break down extracellular DNA in the lungs, a major source of mucous viscosity in cystic fibrosis. Dornase alfa is a biosynthetic form of human deoxyribunuclease I (DNase I) enzyme.

How long does it take for Pulmozyme to work?

This recommendation is based on evidence that Pulmozyme® makes CF sputum pourable within 30 minutes (Shak 1990).

How to use dornase alfa?

Read all information given to you. Follow all instructions closely. You will use by breathing in from the mouth with a special machine (nebulizer). Your doctor will teach you the right way to use. Only use the type of nebulizer that you have been told to use.

What to do if you are allergic to hamsters?

If you are allergic to hamsters, talk with the doctor. If you are allergic to dornase alfa; any part of dornase alfa; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. This medicine may interact with other drugs or health problems.

What to do if you have an overdose on dornase alfa?

If you have any questions about dornase alfa, please talk with your doctor, nurse, pharmacist, or other health care provider. If you think there has been an overdose, call your poison control center or get medical care right away.

What are the symptoms of an allergic reaction?

Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Chest pain or pressure. Fever.

What to do if you think you have an overdose?

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Can you use dornase alfa after opening?

Do not use if the solution is cloudy, leaking, or has particles. Do not use if solution changes color. Use right after opening. Throw away any part not used after use. Keep using dornase alfa as you have been told by your doctor or other health care provider, even if you feel well.

Can you take Dornase Alfa with all your medications?

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take dornase alfa with all of your drugs and health problems.

How long can you keep dornase alfa out of the refrigerator?

However, keep the medicine from freezing. Do not leave dornase alfa out of the refrigerator for longer than 24 hours. If an ampule of medicine is left out for longer than this, it should be thrown away and a new ampule should be used.

How long to use dornase alfa in a nebulizer?

Do not use a cloudy or discolored inhalation solution. You will need to use the nebulizer for about 10 to 15 minutes, or until the medicine in the nebulizer cup is gone.

What is Dornase Alfa used for?

Dornase alfa inhalation solution is used together with other medicines (eg, antibiotics, bronchodilators, and steroids) to control symptoms of cystic fibrosis. Cystic fibrosis is a condition in which a thick mucus is formed in the lungs and breathing passages. The mucus blocks the airways and increases the chance of lung infections.

What to do if you miss a dose of dornase alfa?

However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

How much ampule for cystic fibrosis?

For cystic fibrosis: Adults and children 5 years of age and older—2.5 milligrams (mg) (one ampule) once a day in the nebulizer. Children 3 months to 4 years of age—Dose must be determined by your doctor. The dose is usually 2.5 mg (one ampule) once a day in the nebulizer.

Why is it important to check your child's progress?

This is to make sure that the medicine is working properly and to check for unwanted effects.

Does dornase alfa cause side effects?

Dornase alfa side effects. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common. Body aches or pain.

What to tell your doctor before taking Dornase Alfa?

tell your doctor and pharmacist what prescription and nonprescription medications you are taking, including vitamins. tell your doctor if you are pregnant , plan to become pregnant , or are breast-feeding.

Can you dilute dornase alfa?

Your doctor may order certain lab tests to check your response to dornase alfa. Do not dilute or mix dornase alfa with other drugs in the nebulizer. Inhalation devices require regular cleaning. Follow the manufacturer's written instructions for the care of the nebulizer. Do not let anyone else use your medication.

Can you take dornase alfa with cystic fibrosis?

Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use dornase alfa exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. Dornase alfa is used to treat cystic fibrosis but does not cure it.

How to know if you have a symtom?

If you experience either of the following symptoms, call your doctor immediately. 1 increased difficulty breathing 2 chest pain

Can you stop using dornase alfa?

Continue to use dornase alfa even if you feel well. Do not stop using dornase alfa without talking to your doctor. Before you use dornase alfa the first time, read the written instructions that come with it. Ask your doctor, pharmacist, or respiratory therapist to demonstrate the proper technique.

Can you discard ampules?

Discard ampules if the solution is cloudy or discolored. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily.

How to use Dornase Alfa Solution

Read the Instructions for Use if available from your pharmacist before you start using dornase alfa and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Are you currently using Dornase Alfa Solution?

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What is Multum's drug information?

Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

What are the side effects of a syringe?

Talk to your doctor if you experience any of the following side effects: voice alteration; sore throat; rash; laryngitis; eye redness, irritation, or inflammation; or. nasal stuffiness or discharge. Side effects other than those listed here may also occur.

How to store Dornase alfa?

Once opened, the entire contents of the ampule must be used or discarded. Dornase alfa must be stored in the refrigerator between 36 and 46 degrees Fahrenheit (2 and 8 degrees Celsius) and protected from strong light. Keep unused ampules in the protective foil pouch.

What is the purpose of dronase alfa?

Dornase alfa is a synthetic protein that breaks down excess DNA in the pulmonary secretions of people with cystic fibrosis. Dornase alfa is used to improve lung function in people with cystic fibrosis by thinning pulmonary secretions and reducing the risk of respiratory tract infections. Dornase alfa may also be used for purposes other ...

Does Multum cover all medical issues?

Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

Can you take Dornase Alfa with other medications?

There are no known interactions between dornase alfa and other medicines. Talk to your doctor or pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with dornase alfa.

Can you use Dornase Alfa on cloudy ampules?

Do not use any dornase alfa solution that is cloudy or discolored. Throw away any unused dornase alfa on the expiration date stamped on the ampule. Dornase alfa should be used on a regular basis to get the most benefit.

How to administer Pulmozyme?

Administer PULMOZYME via the eRapid Nebulizer System or via a jet nebulizer connected to an air compressor with an adequate air flow and equipped with a mouthpiece or suitable face mask (see Table 1). No data are currently available to support the administration of PULMOZYME with other nebulizer systems.

How is Pulmozyme administered?

PULMOZYME is administered by inhalation of an aerosol mist produced by a compressed air driven nebulizer or an approved nebulizer system [see Clinical Studies and DOSAGE AND ADMINISTRATION ].

How much Pulmozyme can you give to rats?

Single dose oral administration of PULMOZYME in doses up to 200 mg/kg are also well tolerated by rats.

What is Pulmozyme used for?

Pulmozyme (dornase alfa) Inhalation Solution is a synthetic protein used to improve lung function in people with cystic fibrosis by thinning pulmonary secretions and reducing the risk of respiratory tract infections.

What is this medicine used for?

This medicine is inhaled to improve lung function and to help prevent lung infections in people with cystic fibrosis.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had an allergic reaction to any medicine or to hamsters.

How do I use it?

You must use this medicine in a power-operated nebulizer. A nebulizer provides a precise amount of medicine as an aerosol mist that you breathe through your mouth and into your lungs. Use only the nebulizer that is prescribed by your healthcare provider.

What if I miss a dose?

If you miss a dose, use it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and use the next one as directed. Do not use double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What should I watch out for?

Do not use this medicine if it has become cloudy or discolored. Throw out any part of a vial that is not used right away.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

How should I store this medicine?

Store this medicine in the refrigerator until you use it. Do not let it reach room temperature for more than 24 hours. Also, refrigerate it during transport. Keep this medicine in its original foil pouch and away from strong light.

Medical uses

Administration

Risks

Prevention

Diagnosis

• The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of...

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Preparation