Precautions
How to use Pylera. Take this medication by mouth 4 times daily (after meals and at bedtime) for 10 days. Take each dose (3 capsules) with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise. Swallow the capsules whole.
How do I take Pylera?
Oct 04, 2021 · How should I take Pylera? Take Pylera exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Take your medicine with a full glass (8 ounces) of water. Swallow the capsule whole. Do not take with milk. Pylera is usually taken after meals and at bedtime.
What is Pylera used for?
1 1 PYLERA™ Capsules 2 (bismuth subcitrate potassium, metronidazole, 3 and tetracycline hydrochloride) 4 140 mg/125 mg/125 mg 5 6 7 To reduce the development of drug-resistant bacteria and maintain the effectiveness of 8 PYLERA™ and other antibacterial drugs, PYLERA™ should be used only to treat or 9 prevent infections that are proven or strongly suspected to be …
What is the best way to store Pylera?
How to use Pylera Take this medication by mouth 4 times daily (after meals and at bedtime) for 10 days. Take each dose (3 capsules) with a full glass …
How do you take Pylera 10 day blister pack?
Pharmacist tips for Pylera. A single capsule of Pylera contains 3 different medications. Take your dose (3 capsules at a time) after meals and at bedtime for a total of 4 daily doses. In addition, a stomach acid reducing medication is to be taken along with …
How many hours apart should I take Pylera?
Administer three PYLERA capsules 4 times a day (after meals and at bedtime) for 10 days. One omeprazole 20 mg capsule should be taken twice a day with PYLERA after the morning and evening meal for 10 days (Table 1).
What happens after taking Pylera?
SIDE EFFECTS: Nausea, diarrhea, upset stomach, abdominal pain, changes in taste, headache, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Your tongue may turn dark in color while you are taking this medication.
When should I take omeprazole with Pylera?
Typical dosing for Pylera Also, one omeprazole 20 mg capsule should be taken by mouth twice a day with Pylera after the morning and evening meal for 10 days.
Does Pylera cure H pylori?
Preliminary data show that the new 10-day treatment with 3-in-1 bismuth-based quadruple therapy (Pylera®) yields optimal rates of H. pylori eradication in clinical practice, ranging from 93 to 98% [17–19]. The results of this study confirm that Pylera® is effec- tive in real life, reaching >90% eradication rate.Apr 17, 2018
How do you know Pylera is working?
You will know whether Pylera has worked for you and has successfully treated your peptic ulcer when your doctor performs a test at least four weeks after you take your last pills. He or she will use a breath test or a stool test to determine if the Helicobacter pylori bacteria that caused your ulcer have been killed.
Can I eat after taking Pylera?
Foods that contain calcium (such as dairy products and calcium-fortified foods and juices) should be eaten at least two hours before or one hour after Pylera. Iron supplements should be taken at least three hours before or two hours after.
Does H. pylori treatment make you sick?
The most frequent and common adverse reactions related to clarithromycin therapy for both adult and pediatric populations are abdominal pain, diarrhea, nausea, vomiting, and dysgeusia. These adverse reactions are consistent with the known safety profile of macrolide antibiotics.
Is Pylera Safe?
In conclusion, the new 3-in-1 bismuth-containing quadruple therapy seems to be very effective and safe in real life, and should be advised as first-line therapy in all patients carrying H. pylori infection.Apr 17, 2018
How do you take bismuth quadruple therapy?
Completely chew and swallow 2 bismuth tablets. Swallow the metronidazole tablets and tetracycline capsules with a full glass (8 ounces) of water. Do not chew, crush, or break the metronidazole tablets and tetracycline capsules. Take this medicine with meals and at bedtime.
How long does it take to eradicate H. pylori?
Most people are cured after finishing two weeks of medicine. Some people need to take another two weeks of medicine. It is important to finish all of the medicine to ensure that the bacteria are killed. Guidelines recommend that all patients treated for H.Jul 6, 2020
Can H. pylori be eliminated?
Helicobacter pylori can be eradicated with the use of antibiotics; however, more than 1 agent has to be used in combination with either a proton pump inhibitor or bismuth to achieve eradication rates of 90% or greater.Apr 27, 1998
Can I take Pylera and omeprazole together?
Pylera should be taken in combination with omeprazole, and it should be used only to treat or prevent infections that are proven to be or are strongly suspected of being caused by susceptible bacteria.Aug 16, 2007
Before Taking This Medicine
You should not use Pylera if: 1. you have severe liver or kidney disease; 2. you are pregnant or breast-feeding; 3. you drink alcohol daily; 4. you...
How Should I Take Pylera?
Take Pylera exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller...
Pylera Dosing Information
Usual Adult Dose for Helicobacter pylori Infection:Bismuth subcitrate potassium/metronidazole/tetracycline 140 mg-125 mg-125 mg oral capsule:3 caps...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
What Should I Avoid While Taking Pylera?
Do not drink alcohol while you are taking Pylera and for at least 1 day after you stop taking it. Drinking alcohol while taking this medicine may c...
What Other Drugs Will Affect Pylera?
Tell your doctor about all your current medicines and any you start or stop using, especially: 1. busulfan; 2. cimetidine; 3. lithium; 4. a blood t...
What are Pylera capsules used for?
Pylera is a combination medication that contains bismuth subcitrate potassium, metronidazole, and tetracycline. These medications work together to...
Can you take Pylera on an empty stomach?
You will take Pylera (3 capsules) 4 times a day each day (after breakfast, lunch, dinner and at bedtime), with a full glass of water. You should no...
What are the ingredients in Pylera?
Each Pylera capsule contains 140 mg of bismuth subcitrate potassium, 125 mg of metronidazole, and a smaller capsule inside containing 125 mg of tet...
Can Pylera cause yeast infection?
The use of Pylera for an extended period of time may cause oral thrush (mouth yeast infection) or yeast infection. You should contact your healthca...
How effective is Pylera?
Pylera is generally considered effective and was shown in a clinical study that a 10-day treatment with Pylera was able to effectively kill the bac...
Uses
This combination medication is used with an acid blocker (for example, a proton pump inhibitor such as omeprazole ). It is used to treat stomach /intestinal ulcers caused by the bacteria H. pylori and to prevent the ulcers from returning.Each capsule contains 3 medications: bismuth subcitrate, metronidazole, and tetracycline.
Side Effects
Nausea, diarrhea, upset stomach, abdominal pain, changes in taste, headache, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Overdose
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: seizures.
Images
This survey is being conducted by the WebMD marketing sciences department.
What is Pylera?
Pylera is a combination medication that contains 3 different ingredients that work together to get rid of bacteria in the stomach.
Pros and cons of Pylera
A combination medication so you don't have to take as many pills compared to other treatments available
Pharmacist tips for Pylera
A single capsule of Pylera contains 3 different medications. Take your dose (3 capsules at a time) after meals and at bedtime for a total of 4 daily doses. In addition, a stomach acid reducing medication is to be taken along with your morning and evening doses after a meal.
What are the side effects of Pylera?
With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.
What are the risks and warnings for Pylera?
Pylera can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options
Interactions between Pylera and other medications
Pylera may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.
How much does Pylera cost?
There is currently no generic for Pylera, so it can be expensive, even with insurance. GoodRx coupons, copay cards and patient assistance programs may help lower the cost.
INDICATIONS AND USAGE
Pylera in combination with omeprazole are indicated for the treatment of patients with Helicobacter pylori infection and duodenal ulcer disease (active or history of within the past 5 years) to eradicate H. pylori. The eradication of Helicobacter pylori has been shown to reduce the risk of duodenal ulcer recurrence.
DOSAGE AND ADMINISTRATION
Administer three Pylera capsules 4 times a day (after meals and at bedtime) for 10 days. One omeprazole 20 mg capsule should be taken twice a day with Pylera after the morning and evening meal for 10 days ( Table 1 ).
DOSAGE FORMS AND STRENGTHS
Each Pylera capsule contains 140 mg of bismuth subcitrate potassium, 125 mg of metronidazole, and a smaller capsule inside containing 125 mg of tetracycline hydrochloride. The capsules are white and opaque, with the APTALISTM logo printed on the body and “BMT” printed on the cap.
CONTRAINDICATIONS
Do not administer methoxyflurane to patients taking Pylera. The concurrent use of tetracycline hydrochloride, a component of Pylera, with methoxyflurane has been reported to result in fatal renal toxicity [see Drug Interactions (7.1)].
WARNINGS AND PRECAUTIONS
Metronidazole, a component of Pylera, has been shown to be carcinogenic in mice and rats. Tumors affecting the liver, lungs, mammary and lymphatic tissues have been detected in several studies of metronidazole in rats and mice, but not hamsters [see Nonclinical Toxicology (13)].
ADVERSE REACTIONS
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
DRUG INTERACTIONS
Do not administer methoxyflurane to patients taking Pylera. The concurrent use of tetracycline hydrochloride, a component of Pylera, with methoxyflurane has been reported to result in fatal renal toxicity [see Contraindications (4.1)].
Is it ok to consume coffee when on pylera?
While you’re on Pylera, and for at least 24 hours after you’ve finished your treatment, don’t consume any alcohol. When using Pylera, drinking alcohol might induce unpleasant side effects such as nausea, vomiting, stomach discomfort (abdominal cramps), hot flushes, and headaches.
How long have you been taking pylera?
How to make Pylera work for you. For ten days, take this drug by mouth four times a day (after meals and before night). Unless your doctor tells you differently, take each dosage (3 capsules) with a full glass of water (8 ounces or 240 milliliters). Completely swallow the pills.
How long does it take for H pylori to go away?
At least two of the medications are antibiotics, which aid in the eradication of microorganisms. The other medicine helps the stomach to produce less acid, which aids in the healing of the ulcer. After two weeks of treatment, the majority of patients are healed. Some folks may need to take their prescription for another two weeks.
What is the efficacy of pylera?
When used with omeprazole, the triple capsule Pylera achieved eradication rates of 84 to 97 percent. Pylera-based bismuth-based triple treatment is a simple, effective, and well-tolerated regimen that achieves cure rates of over 90%.
Is pylera associated with black urine?
If you have Cockayne syndrome and are taking Pylera (bismuth subcitrate, metronidazole, and tetracycline), contact your doctor straight away if you have dark urine, are fatigued, aren’t hungry, have an upset stomach or stomach discomfort, have light-colored feces, vomit up, or have yellow skin or eyes.
What causes Helicobacter pylori infection?
When a bacterium called Helicobacter pylori (H. pylori) affects your stomach, it is known as Helicobacter pylori (H. pylori). This is most common in childhood. H. pylori infection, a prevalent cause of peptic ulcers, is thought to be present in more than half of the world’s population.
Is insurance going to cover pylera?
Pylera Costs Depending on the drugstore you visit, Pylera oral capsule (140 mg-125 mg-125 mg) costs roughly $972 for a supply of 120 capsules. Prices are only applicable for cash paying consumers and do not apply to insurance programs. Pylera is only accessible as a brand name medicine; there is no generic equivalent presently.
