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how does a virus replicate

by Nasir Hyatt Published 3 years ago Updated 2 years ago
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Viruses cannot replicate on their own, but rather depend on their host cell's protein synthesis pathways to reproduce. This typically occurs by the virus inserting its genetic material in host cells, co-opting the proteins to create viral replicates, until the cell bursts from the high volume of new viral particles.

How do viruses replicate steps?

Viral replication involves six steps: attachment, penetration, uncoating, replication, assembly, and release. During attachment and penetration, the virus attaches itself to a host cell and injects its genetic material into it.

What are the 7 steps of viral replication?

As discussed above, they are carried out in a series of 7 steps that is: attachment, penetration and entry, uncoating, replication, synthesis of virus components, assembly of virions and lastly the release of virions.

What is required for a virus to replicate?

Viruses must first get into the cell before viral replication can occur. Through the generation of abundant copies of its genome and packaging these copies, the virus continues infecting new hosts. Replication between viruses is greatly varied and depends on the type of genes involved in them.

How does a virus replicate its DNA?

DNA viruses replicate their genomes using DNA polymerase enzymes and transcribe their mRNA using DNA-dependent RNA polymerase enzymes. Both (+) and (−) ssRNA viruses replicate and transcribe their genomes using RdRp enzymes (Fig. 3.1).

Do all viruses replicate the same way?

As viruses are obligate intracellular pathogens they cannot replicate without the machinery and metabolism of a host cell. Although the replicative life cycle of viruses differs greatly between species and category of virus, there are six basic stages that are essential for viral replication.

What's the life cycle of a virus?

The virus life cycle could be divided into six steps: attachment, penetration, uncoating, gene expression and replication, assembly, and release.

Can virus multiply on their own?

Due to their simple structure, viruses cannot move or even reproduce without the help of an unwitting host cell. But when it finds a host, a virus can multiply and spread rapidly.

How often do viruses replicate?

The reproductive cycle of viruses ranges from 8 hrs (picornaviruses) to more than 72 hrs (some herpesviruses). The virus yields per cell range from more than 100,000 poliovirus particles to several thousand poxvirus particles.

Why Do viruses need a host cell?

A virus cannot replicate alone; instead, it must infect cells and use components of the host cell to make copies of itself. Often, a virus ends up killing the host cell in the process, causing damage to the host organism.

What does a virus inject into a cell?

The virus's genome is uncoated from the protein and injected into the host cell. Then the viral genome hijacks the host cell's machinery, forcing it to replicate the viral genome and produce viral proteins to make new capsids. Next, the viral particles are assembled into new viruses.

Main Steps of Viral Replication

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The replication cycle can be highly diverse between different species and categories of viruses. Despite this, there are generally six broad steps required for viral replication to occur successfully. These include attachment, penetration, uncoating, replication, assembly, and virion release. The first stage, attachment, i…
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Viral Replication and Disease Pathogenicity

  • Viral replication is critical for a virus’s ability to infect its hosts and spread. Because of this, it is a critical aspect of viral pathogenicity to understand. While some viral proteins typically stay in the host cell membrane, these can also occasionally be processed and presented on the surface of MHC class-I molecules. This can enable them to be recognized by T-cells, which play a critical ro…
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Covid-19 and Inhibiting Viral Replication

  • COVID-19has become a recent focus of viral replication studies. So far, over 300 human proteins have been found to interact with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during infection. It is believed that by blocking certain interactions between human and viral proteins, the viral replication can be stopped, thereby stopping transmission. Similar therapeutic …
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References

  1. Goulding, J., 2020. Virus Replication. [online] Immunology.org. Available at: <https://www.immunology.org/public-information/bitesized-immunology/pathogens-and-disease/virus-replication>.
  2. Wang, W., Wu, C., Amarasinghe, G., and Leung, D., 2019. Ebola Virus Replication Stands Out. Trends in Microbiology, 27(7), pp. 565-566.
  1. Goulding, J., 2020. Virus Replication. [online] Immunology.org. Available at: <https://www.immunology.org/public-information/bitesized-immunology/pathogens-and-disease/virus-replication>.
  2. Wang, W., Wu, C., Amarasinghe, G., and Leung, D., 2019. Ebola Virus Replication Stands Out. Trends in Microbiology, 27(7), pp. 565-566.
  3. Marks, R., 2020. Unveiling How Coronavirus Hijacks Our Cells to Help Rush New Drugs to Patients. [online] UCSF.edu. Available at: <https://www.ucsf.edu/news/2020/03/416986/unveiling-how-coronavirus...
  4. Wei, X., Ghosh, S., Taylor, M., Johnson, V., Emini, E., Deutsch, P., Lifson, J., Bonhoeffer, S., Nowak, M., Hahn, B., Saag, M. and Shaw, G., 1995. Viral dynamics in human immunodeficienc…

Further Reading

1.Videos of How Does A virus Replicate

Url:/videos/search?q=how+does+a+virus+replicate&qpvt=how+does+a+virus+replicate&FORM=VDRE

16 hours ago  · After gaining entry into the body, a virus makes physical contact with and crosses the plasma membrane of a target cell. Inside, it releases and replicates its genome while facilitating the manufacture of its proteins by host ribosomes. Virus particles are assembled from these newly synthesized biological molecules and become infectious virions.

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