How long does it take alogliptin to work?
How long does it take for Nesina (alogliptin) to work? While you may see some effect after 2 weeks, it could take 18 to 20 weeks before you see the full effects of this medication on lowering your blood sugar and improving your A1c level.
How much does alogliptin lower blood sugar?
It is reported that a 0.72% reduction in HbA1c levels with alogliptin add-on therapy for metformin for 2 years was observed in patients with type 2 diabetes [8].
What time of day should you take alogliptin?
It is usually taken with or without food once a day. Take alogliptin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
What is the difference between alogliptin and metformin?
Metformin, a biguanide, works by lowering the amount of sugar your liver releases into your blood and helps your body respond better to insulin. Alogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, works by increasing the amount of insulin your body makes.
Is alogliptin hard on kidneys?
Kidney disease, moderate or severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Does alogliptin make you lose weight?
You take alogliptin once a day. The most common side effects of alogliptin are headaches, indigestion, diarrhoea and skin rashes. This medicine does not usually make you put on weight. If you have diabetes, you're entitled to free prescriptions for all of your medicines, not just your diabetes ones.
Does alogliptin raise blood pressure?
This article investigated the effect of alogliptin (Nesina) on blood pressure (BP) in patients with hypertension (HTN; high blood pressure) and type 2 diabetes (T2D). The authors concluded that alogliptin was associated with improved blood sugar control, BP and arterial stiffness in these patients.
How good is alogliptin?
Results of the large, well designed EXAMINE trial revealed that alogliptin was not associated with an increased risk of major cardiovascular events in patients with type 2 diabetes and recent acute coronary syndrome. In conclusion, alogliptin is a useful option for the treatment of patients with type 2 diabetes.
How long does alogliptin stay in your system?
Single doses of alogliptin from 25 to 800 mg produced peak DPP-4 inhibition ranging from 93.3% to 98.8%. The mean DPP-4 inhibition ranged from 74.3% to 97% at 24 hours and from 47.5% to 83% at 72 hours.
Can I take alogliptin twice a day?
For oral dosage form (tablets): For type 2 diabetes: Adults—At first, 1 tablet 2 times a day. Each tablet contains 12.5 milligrams (mg) of alogliptin and 500 mg of metformin or 12.5 mg of alogliptin and 1000 mg of metformin.
Does alogliptin cause pancreatitis?
In rather short-term clinical trials with well-selected diabetic patients, no increased risk of acute pancreatitis has been observed with any of the five commercialized DPP-4 inhibitors: sitagliptin, vildagliptin, saxagliptin, alogliptin, and linagliptin.
What is the side effects of alogliptin?
Side effects of alogliptinCold-like symptoms. Try taking paracetamol or ibuprofen regularly for a few days. ... Headaches. Make sure you rest and drink plenty of fluids. ... Stomach ache or indigestion. Try to rest and relax. ... Diarrhoea. Drink lots of fluids, such as water or squash, to avoid dehydration. ... Rash or itchy skin.
How good is alogliptin?
Results of the large, well designed EXAMINE trial revealed that alogliptin was not associated with an increased risk of major cardiovascular events in patients with type 2 diabetes and recent acute coronary syndrome. In conclusion, alogliptin is a useful option for the treatment of patients with type 2 diabetes.
Can I take alogliptin twice a day?
For oral dosage form (tablets): For type 2 diabetes: Adults—At first, 1 tablet 2 times a day. Each tablet contains 12.5 milligrams (mg) of alogliptin and 500 mg of metformin or 12.5 mg of alogliptin and 1000 mg of metformin.
What is the side effects of alogliptin 25 mg?
Side effects of alogliptinCold-like symptoms. Try taking paracetamol or ibuprofen regularly for a few days. ... Headaches. Make sure you rest and drink plenty of fluids. ... Stomach ache or indigestion. Try to rest and relax. ... Diarrhoea. Drink lots of fluids, such as water or squash, to avoid dehydration. ... Rash or itchy skin.
How long does alogliptin stay in your system?
Single doses of alogliptin from 25 to 800 mg produced peak DPP-4 inhibition ranging from 93.3% to 98.8%. The mean DPP-4 inhibition ranged from 74.3% to 97% at 24 hours and from 47.5% to 83% at 72 hours.