
Examples of mild side effects that have been reported with Rexulti include:
- akathisia (feeling restless, such as a constant, uncontrollable urge to move around)
- indigestion (upset stomach)
- headache*
- diarrhea
- constipation
- insomnia (trouble sleeping)*
- abnormal dreams*
- fatigue (lack of energy)
Can Rexulti make you feel restless?
It’s possible to feel restless while taking Rexulti. This feeling of restlessness can lead to symptoms such as restless legs and tremors. In clinical studies of people with depression: 2% to 14% of people taking Rexulti had restlessness (also called akathisia)
What does Rexulti do to dopamine and serotonin?
Specifically, Rexulti is thought to work on dopamine and serotonin. It’s believed this drug works by balancing dopamine and serotonin to help reduce symptoms of depression and schizophrenia. Is Rexulti used for depression? If you’ve been diagnosed with depression or schizophrenia, your doctor may discuss Rexulti with you.
How is Rexulti broken down in the body?
Rexulti is broken down in your body by a set of enzymes (certain proteins) that also break down other medications. If you take Rexulti with certain other drugs, the enzymes may not be able to fully break down either Rexulti or the other drugs.
What are the symptoms of an allergic reaction to Rexulti?
Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. They can also include swelling of your tongue, mouth, or throat, which can cause you to have trouble breathing. Call your doctor right away if you have an allergic reaction to Rexulti.

Does Rexulti make you feel good?
A Brief Overview of Rexulti (Brexpiprazole) There are many benefits to this medication, but it is important to look at the costs and all potential side effects. Rexulti helps a patient feel less nervous, clears some mental fog, decreases hallucinations, and improves mood, sleep, energy levels, and appetite.
What does Rexulti make you feel like?
It's possible that Rexulti may make you feel tired. In studies, fatigue (lack of energy) and drowsiness were reported by people taking Rexulti to treat depression. Keep in mind that for depression, Rexulti is prescribed along with antidepressant medication. Tiredness is a side effect of antidepressants as well.
What can I expect from Rexulti?
Some people taking Rexulti develop unusual urges such as gambling, binge eating, or eating that they cannot control (compulsive), compulsive shopping, and sexual urges. Talk to your healthcare provider if you or your family members notice that you are having unusual urges or behaviors.
Is Rexulti a mood stabilizer?
Generic Name: brexpiprazole In addition, this medication may improve your mood, sleep, appetite, and energy level. Brexpiprazole is a psychiatric medication that belongs to the class of drugs called atypical antipsychotics. It works by helping to restore the balance of certain natural substances in the brain.
Does Rexulti calm you down?
Rexulti is not approved to treat anxiety. But the drug may be prescribed off-label to treat this condition. Off-label drug use means using a drug for a purpose other than what it's been approved for. Rexulti has been studied for depression treatment in people who also have depression with symptoms of anxiety.
How long does it take for Rexulti to kick in?
It may take two to three months before you feel the full effect of brexpiprazole. Brexpiprazole tablets are usually taken once a day with or without food. Typically, patients begin at a low dose of medication and the dose is increased slowly over several weeks.
What does Rexulti do to the brain?
Rexulti is thought to work by adjusting the balance of natural chemicals (neurotransmitters) in your brain such as dopamine and serotonin. An imbalance of neurotransmitters is thought to be linked to several mental health conditions, including depression and schizophrenia.
Is Rexulti good for anxiety?
No, Rexulti is not approved for anxiety. The drug may be used off-label for anxiety, but there are other treatments for anxiety that have been approved. (With off-label use, a drug is used to treat conditions other than those it's been approved for.)
What medication is similar to Rexulti?
Besides Abilify and Rexulti, other second-generation antipsychotics include:Geodon (ziprasidone)Risperdal (risperidone)Seroquel (quetiapine)Latuda (lurasidone)Vraylar (cariprazine)Zyprexa (olanzapine)Clozaril (clozapine) has restricted distribution in the US because of its severe side effects.
Is Rexulti better than Wellbutrin?
Rexulti has an average rating of 6.4 out of 10 from a total of 383 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 28% reported a negative effect. Wellbutrin has an average rating of 6.8 out of 10 from a total of 644 ratings on Drugs.com.
What time of day should you take Rexulti?
REXULTI is taken once daily, and you can take it with or without food. It's important to follow the dosing schedule prescribed by your healthcare provider.
Does Rexulti help with intrusive thoughts?
Rexulti isn't currently approved to treat bipolar disorder or intrusive thoughts. Bipolar disorder is a mental health condition that causes extreme changes in mood and energy levels. Intrusive thoughts are bothersome thoughts that enter your head suddenly.
Is Rexulti good for anxiety?
No, Rexulti is not approved for anxiety. The drug may be used off-label for anxiety, but there are other treatments for anxiety that have been approved. (With off-label use, a drug is used to treat conditions other than those it's been approved for.)
Does Rexulti increase dopamine?
Rexulti is classified as a serotonin-dopamine activity modulator (SDAM). Rexulti works by adjusting the imbalance of natural chemicals (called neurotransmitters) in the brain to help lower symptoms of these diseases. These chemicals include dopamine and serotonin.
Does Rexulti help with intrusive thoughts?
Rexulti isn't currently approved to treat bipolar disorder or intrusive thoughts. Bipolar disorder is a mental health condition that causes extreme changes in mood and energy levels. Intrusive thoughts are bothersome thoughts that enter your head suddenly.
What time is best to take Rexulti?
REXULTI is taken once daily, and you can take it with or without food. It's important to follow the dosing schedule prescribed by your healthcare provider.
Why does Rexulti cause weight gain?
Rexulti (brexpiprazole) is in a class of medicines known as atypical antipsychotics used to treat schizophrenia and depression. Although your resul...
How long does it take for Rexulti to work?
Rexulti (generic name: brexpiprazole) is an atypical antipsychotic used to treat adults with schizophrenia or depression. In Rexulti studies, some...
What is Rexulti used for and how well does it work?
Rexulti (brexpiprazole) is an atypical antipsychotic used to treat adults with schizophrenia or depression. In a 6-week long study in adults, addin...
How does Rexulti work?
Rexulti (brexpiprazole) works by altering chemicals in the brain that can lead to schizophrenia or depression. It is classified as a serotonin-dopa...
What are the side effects of Rexulti?
Serious side effects of Rexulti that have been reported include: behavior changes, such as anger or aggression. sexual side effects, such as compulsive behaviors including sexual urges.
What are the interactions with Rexulti?
Interactions. Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. These effects are called interactions. Before taking Rexulti, be sure to tell your doctor about all medications you take, including prescription and over-the-counter types.
Is Rexulti used for anxiety? If so, what’s the dosage for anxiety?
No, Rexulti is not approved for anxiety. The drug may be used off-label for anxiety, but there are other treatments for anxiety that have been approved. (With off-label use, a drug is used to treat conditions other than those it’s been approved for.)
Does Rexulti treat bipolar disorder?
No, Rexulti is not approved for bipolar disorder. The drug may be used off-label for this condition, but there are other medications that are approved for bipolar disorder and may be better options. (With off-label use, a drug is used to treat conditions other than those it’s been approved to treat.)
What is the active ingredient in Rexulti?
Rexulti contains the active drug brexpiprazole and comes as tablets you’ll swallow.
How is Rexulti broken down?
Rexulti is broken down in your liver by certain enzymes (types of proteins). If you take drugs with Rexulti that are also broken down by these enzymes, the drugs may interact and cause side effects. Some types of drugs can increase the effects of Rexulti.
How often should I take Rexulti?
For depression, you’ll take Rexulti once each day, along with another depression medication. Your doctor will start you on a low dose of Rexulti, and they’ll monitor your body’s response to treatment. After your first few weeks of treatment, your doctor will likely increase your Rexulti dosage.
What receptors does Rexulti work on?
REXULTI was specifically designed to have similar activity at 2 of these receptors: serotonin and dopamine.
What to do if you take too much Rexulti?
If you take too much REXULTI, call your healthcare provider or the Poison Control Center at 1-800-222-1222 right away or go to the nearest hospital emergency room.
What are the symptoms of an allergic reaction?
Allergic reactions have included rash, facial swelling, hives and itching, and anaphylaxis, which may include difficulty breathing, tightness in the chest, and swelling of the mouth, face, lips, or tongue.
When was Rexulti approved?
After years of research and testing, REXULTI was approved for use in the United States by the Food and Drug Administration (FDA) in 2015.
Does Rexulti help with depression?
When taken with an antidepressant,* REXULTI was proven to reduce depression symptoms an extra 62% compared to the antidepressant alone—which may help you feel better without feeling like you have to start over. *REXULTI is for people who have been on an antidepressant for at least 2 months and are still experiencing symptoms of depression.
Does Rexulti work with antidepressants?
REXULTI works with your antidepressant to help build on any progress you've already made. 6-week study in adults, with ongoing symptoms of depression, still taking an antidepressant. Individual results may vary. When taken with an antidepressant,* REXULTI was proven to reduce depression symptoms an extra 62% compared to ...
Can you take 2 Rexulti pills at the same time?
Do not take 2 doses of REXULTI at the same time. If you are not sure about your dosing, call your healthcare provider.
What are the side effects of Rexulti?
Examples of mild side effects that have been reported with Rexulti include: akathisia (feeling restless, such as a constant, uncontrollable urge to move around) indigestion (upset stomach) headache*. diarrhea. constipation. insomnia (trouble sleeping)*. abnormal dreams*.
How long do side effects from Rexulti last?
How long you experience side effects from Rexulti can vary. Some side effects may be temporary, while others can be long term.
What is a boxed warning on Rexulti?
A boxed warning is the most serious warning from the Food and Drug Administration (FDA). It alerts doctors and patients about a drug’s effects that may be dangerous.
Does Rexulti go away?
Some side effects of Rexulti don’t go away on their own. These include hyperglycemia (high blood sugar) and high levels of cholesterol or triglycerides. To treat these side effects, your doctor may recommend long-term management with medication, diet, and exercise, even after you stop using Rexulti.
Is Rexulti a side effect of antidepressants?
Keep in mind that for depression, Rexulti is prescribed along with antidepressant medication. Tiredness is a side effect of antidepressants as well.
Does Rexulti cause restlessness?
In studies of Rexulti, restlessness and akathisia were reported more often in people taking higher strengths than in those taking lower strengths. (With akathisia, you have feelings of restlessness, such as a constant, uncontrollable urge to move around.) But not all side effects of Rexulti vary by tablet strength.
Can Rexulti be life threatening?
These symptoms could be life threatening and require immediate medical care. If your doctor confirms you had a serious allergic reaction to Rexulti, they may have you switch to a different treatment. Keeping track of side effects. During your Rexulti treatment, consider keeping notes on any side effects you’re having.
How long do Rexulti side effects last?
It depends. Some side effects of Rexulti may be temporary and last a few days or weeks.
What to do if you have rexulti side effects?
If you develop serious side effects while taking Rexulti, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number .
How much Rexulti should I take a day?
In clinical studies, people taking 3 mg of Rexulti per day reported akathisia (feelings of restlessness and inability to sit still) more often than people taking 2 mg or 1 mg. If you’d like to know more about specific side effects of Rexulti that may vary by strength, check out the medication’s prescribing information.
What is Rexulti used for?
Major depressive disorder (MDD), which is usually called depression. Rexulti is taken in combination with another antidepressant when used to treat depression. Schizophrenia, a condition that causes symptoms such as confused speech and thinking, delusions, and hallucinations.
What is the boxed warning on Rexulti?
Rexulti has a boxed warning#N#Trusted Source#N#about the risk of death in certain adults ages 65 years and older. A boxed warning alerts doctors and patients about drug effects that may be dangerous. It’s the most serious warning from the Food and Drug Administration (FDA).
What happens after the FDA approves Rexulti?
Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. If you develop a side effect while taking Rexulti and want to tell the FDA about it, visit MedWatch.
Why did I stop taking Rexulti?
Some people in these trials stopped taking Rexulti due to weight gain. How much weight you might gain can depend on a variety of factors. These include your dosage of Rexulti, your condition, your diet and your exercise level, and other conditions you have.
What should I know before taking Rexulti?
Before taking REXULTI, tell your healthcare provider if you: have diabetes or high blood sugar or a family history of diabetes or high blood sugar. Your healthcare provider should check your blood sugar before you start REXULTI and during your treatment.
What is rexulti used for?
INDICATION: REXULTI is a prescription medicine used to treat: Major depressive disorder (MDD): REXULTI is used with antidepressant medicines, when your healthcare provider determines that an antidepressant alone is not enough to treat your depression.
How old do you have to be to take Rexulti?
It is not known if REXULTI is safe and effective in people under 18 years of age.
Can you take Rexulti while pregnant?
If you become pregnant while taking REXULTI, talk to your healthcare provider about registering with the National Pregnancy Registry for Atypical Antipsychotics.
Can Rexulti cause dementia?
Medicines like REXULTI can raise the risk of death in elderly who have lost touch with reality (psychosis) due to confusion and memory loss ( dementia). REXULTI is not approved for the treatment of patients with dementia-related psychosis. Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, ...
What are the symptoms of an allergic reaction?
Allergic reactions have included rash, facial swelling, hives and itching, and anaphylaxis, which may include difficulty breathing, tightness in the chest, and swelling of the mouth, face, lips, or tongue. Stroke in elderly people (cerebrovascular problems) that can lead to death.
Does Rexulti affect other medicines?
REXULTI and other medicines may affect each other causing possible serious side effects. REXULTI may affect the way other medicines work, and other medicines may affect how REXULTI works.
How long does it take for Rexulti to work?
The length of time it takes for Rexulti to work will vary from person to person. And it very much depends on the severity of the condition you’re using Rexulti to treat.
How long does Rexulti stay in your system?
Rexulti may stay in your system for about 18 to 19 days, which is a little less than 3 weeks.
Is Rexulti an SSRI?
No, Rexulti isn’t a selective serotonin reuptake inhibitor (SSRI). SSRIs are a class of antidepressants that are used for a variety of medical conditions, including depression. (A class of drugs describes a group of medications that work in the same way.)
Do side effects of Rexulti go away?
Yes, some side effects of Rexulti may go away as you continue with treatment. Examples of these side effects include:
Can Rexulti be crushed, split, or chewed?
Rexulti tablets should be swallowed whole. According to the manufacturer, they shouldn’t be cut in half, crushed, or chewed.
How much Rexulti should I take daily?
1 mg taken once daily. After 1 to 2 weeks of therapy, your doctor will likely increase your Rexulti dosage to 2 mg daily. And they’ll see how well your condition responds to the drug. If your doctor feels that you need a higher dosage of Rexulti, they may increase your dosage to 3 mg each day.
How much weight did Rexulti gain?
People who took Rexulti gained an average of 2.8 to 3.5 pounds (1.3 to 1.6 kilograms), depending on their dose of the drug. In comparison, people who took a placebo gained an average of 0.7 lb (0.3 kg).
How does Rexulti make you feel?
This drug can make you feel drowsy, dizzy, lightheaded, and restless. It can also reduce your ability to concentrate as well as impair your thinking and judgment abilities. The extent of this is very dependent upon the individual patient. Many patients tolerate this medication well. It is important to take your medication as prescribed and give it a full month to determine if it is helping. Your doctor may recommend a dose decrease if side effects are severe.
Can Rexulti cause tardive dyskinesia?
Rarely, Rexulti can cause a condition called tardive dyskinesia that in some cases may be permanent. Signs that you may be developing tardive dyskinesia are unusual or uncontrolled movements, particularly of the face, lips, mouth, tongue, arms, or legs.
Should I take Rexulti at night?
You can take it day or night. Always follow your doctor advice when taking this medication.
How many ratings does Rexulti have?
Rexulti has an average rating of 6.4 out of 10 from a total of 177 ratings for the treatment of Major Depressive Disorder. 51% of users who reviewed this medication reported a positive effect, while 26% reported a negative effect.
Is anxietynachill a miracle?
Yes No. 25 Report. anxioustrynachill · Taken for 2 to 5 years December 16, 2019. “I’ve been on Rexulti (had Anxiety and Depression) for about two years now and it has been an absolute miracle for me. I had been on Zoloft for 5 years prior and had been on Abilify before switching to Rexulti.
Is Rexulti good for depression?
Depression is a very serious disease but there CAN be relief. It may not be Rexulti for you, your body chemistry may react better to something else, but please don’t give up hope and please take your meds as prescribed. For me I was mentally better in less than 1 week, but it can take up to 5. DON’T give up hope!
