Ranolazine
Ranolazine is used to treat a certain type of chest pain.
What should I know about Ranexa before taking it?
You should not take Ranexa if you are allergic to ranolazine, or if you have cirrhosis of the liver. Many other drugs can interact with ranolazine and should not be used at the same time. Your doctor may need to change your treatment plan if you use any of the following drugs: clarithromycin;
What type of heart disease does Ranexa treat?
Usually, it signals coronary heart disease (CHD) as a result of narrowing of one or more of the coronary arteries, known as ischemia. Ranexa is used to treat chronic angina, but there are many other types of angina as well, including microvascular angina, Prinzmetal's angina, stable angina, unstable angina and variant angina.
What are the uses of Restylane Ranexa?
Ranexa is used to treat chronic angina (chest pain). It is not for use during an acute (emergency) attack of angina. Ranexa may also be used for purposes not listed in this medication guide.
What is Ranexa (ranolazine)?
Ranexa (ranolazine) is a relatively new drug, with a unique mechanism of action, used for the treatment of angina.
How long does it take for Ranexa to start working?
Ranolazine (Ranexa) doesn't work very fast, and usually takes about 4 hours for peak effect. Faster-acting medications, like Nitrostat (nitroglycerin sublingual tablets), are better for quickly treating chest pain that has already started.
Is Ranexa a good drug?
Ranexa is a unique drug that has proven to be useful in the treatment of chronic stable angina. It can be useful to patients with other chest pain syndromes as well. Food and Drug Administration. Ranexa (ranolazine) extended-release tablets.
Is Ranexa good for the heart?
By reducing the flow of calcium into the cells, ranolazine is thought to help the heart to relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.
Does Ranexa help shortness of breath?
Due to its properties, Ranolazine may improve this stiffness. Ranolazine could improve subject's shortness of breath and ability to exercise. Currently, ranolazine carries FDA approval for the treatment of chronic angina only.
Is Ranexa used for heart failure?
Entresto (sacubitril and valsartan) and Ranexa (ranolazine) are used to treat different kinds of heart problems. Entresto is used to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.
Does Ranexa help with blood flow?
Ranexa is used to treat chronic angina (chest pain). It works by improving blood flow to help the heart work more efficiently. Ranexa is not for use during an acute (emergency) attack of angina.
What exactly does Ranexa do?
RANEXA is a prescription medicine used to treat angina that keeps coming back (chronic angina). RANEXA may be used with other medicines that are used for heart problems and blood pressure control. It is not known if RANEXA is safe and effective in children.
When is the best time to take Ranexa?
You can take ranolazine either before or after a meal. Swallow the tablet whole (without chewing or crushing it) with a drink of water. If you forget to take a dose at your usual time, take it when you remember.
Is there an alternative to Ranexa?
Calcium channel blockers such as verapamil and amlodipine are second-line alternatives; (2) Ranolazine is now authorized for symptomatic adjuvant treatment of angina in patients who are poorly controlled by a betablocker and/or a calcium channel blocker.
Does Ranexa make you tired?
This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally.
What does ranolazine do to the body?
Ranolazine is used to treat a certain type of chest pain (chronic stable angina). It decreases the number of times you may get chest pain. Relieving symptoms of angina can increase your ability to exercise and perform strenuous work.
What is chronic stable angina?
What is stable angina? Stable angina (angina pectoris) is a type of chest pain that happens when your heart muscle needs more oxygen than usual but it's not getting it at that moment because of heart disease. This can happen when it's cold outside or you're exercising, for example.
Before Taking This Medicine
You should not take Ranexa if you are allergic to ranolazine, or if you have cirrhosis of the liver.Many other drugs can interact with ranolazine a...
How Should I Take Ranexa?
Take Ranexa exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose t...
Ranexa Dosing Information
Usual Adult Dose of Ranexa for Angina Pectoris:Initial dose: 500 mg orally twice dailyMaintenance dose: 500 mg to 1000 mg orally twice daily. Maxim...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
What Happens If I Overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose can cause nausea, vomiting, numbness or tingling, dizzines...
What Should I Avoid While Taking Ranexa?
Ranexa may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.Grapefruit and grapefruit juice...
What Other Drugs Will Affect Ranexa?
Many drugs can interact with Ranexa. Below is just a partial list. Tell your doctor if you are using: 1. aprepitant (Emend); 2. arsenic trioxide (T...
What is Ranexa?
Ranexa has active ingredients of ranolazine. It is often used in angina. eHealthMe is studying from 10,430 Ranexa users for its effectiveness, alternative drugs and more.
How to use the study?
You can use the report to supplement drug labels on your pill bottles or discuss it with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
How the study uses the data?
The study is based on ranolazine (the active ingredients of Ranexa) and Ranexa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study neither.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature.
We work with your doctor to manage your meds!
When serious adverse effects are detected in your trial, your doctor will be notified to check them out promptly. What you need to do: 1. start your phase IV clinical trial 2. ask your doctor to join eHealthMe professional network
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
What are the side effects of Ranexa?
Ranexa side effects. Get emergency medical help if you have any signs of an allergic reaction to Ranexa: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out;
How to treat chronic angina with Ranexa?
Chronic angina is often treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication.
Can you take Ranexa if you have cirrhosis?
You should not take Ranexa if you have cirrhosis of the liver. Serious drug interactions can occur when certain medicines are used together with ranolazine. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.
Does Ranexa work for angina?
It works by improving blood flow to help the heart work more efficiently. Ranexa is not for use during an acute (emergency) attack of angina. Ranexa may also be used for purposes not listed in this medication guide.
What drugs do you need to change your treatment plan?
Your doctor may need to change your treatment plan if you use any of the following drugs: clarithromycin; nefazodone; St. John's wort; antifungal medicine - itraconazole, ketoconazole; HIV or AIDS medicine - indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, saquinavir;
Does Ranexa cause dizziness?
kidney problems - little or no urination; painful or difficult urination, swelling in your feet or ankles; feeling tired or short of breath. Common Ranexa side effects may include: dizziness. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Can you take Ranexa if you are allergic to ranolazine?
You should not take Ranexa if you are allergic to ranolazine, or if you have cirrhosis of the liver. Many other drugs can interact with ranolazine and should not be used at the same time. Your doctor may need to change your treatment plan if you use any of the following drugs: clarithromycin; nefazodone; St. John's wort;
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature.
How we gather our data?
Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference. Browse all drugs on eHealthMe.
DESCRIPTION
Ranolazine is a racemic mixture, chemically described as 1-piperazineacetamide, N- (2,6-dimethylphenyl)-4- [2-hydroxy-3- (2-methoxyphenoxy)propyl]-, (±)-. It has an empirical formula of C 24 H 33 N 3 O 4, a molecular weight of 427.54 g/mole, and the following structural formula:
DOSAGE AND ADMINISTRATION
Initiate RANEXA dosing at 500 mg twice daily and increase to 1000 mg twice daily, as needed, based on clinical symptoms. Take RANEXA with or without meals. Swallow RANEXA tablets whole; do not crush, break, or chew.
HOW SUPPLIED
RANEXA is supplied as film-coated, oblong-shaped, extended-release tablets in the following strengths:
SIDE EFFECTS
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
PRECAUTIONS
Ranolazine blocks I Kr and prolongs the QTc interval in a dose-related manner.
OVERDOSE
High oral doses of ranolazine produce dose-related increases in dizziness, nausea, and vomiting. High intravenous exposure also produces diplopia, paresthesia, confusion, and syncope. In addition to general supportive measures, continuous ECG monitoring may be warranted in the event of overdose.
CLINICAL PHARMACOLOGY
The mechanism of action of ranolazine’s antianginal effects has not been determined. Ranolazine has anti-ischemic and antianginal effects that do not depend upon reductions in heart rate or blood pressure. It does not affect the rate-pressure product, a measure of myocardial work, at maximal exercise.
Most voted positive review
My husband has had angina for several years and it has done wonders for his condition. He has only been on it for a little over a week and has had to take only one nitro pill and he had only been on it for two days,but has not had angina since.
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How to report ranolazine side effects in Canada?
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Precautions. Before taking ranolazine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
What is Ranolazine used for?
Ranolazine is used to treat a certain type of chest pain ( chronic stable angina ). It decreases the number of times you may get chest pain. Relieving symptoms of angina can increase your ability to exercise and perform strenuous work.Ranolazine works differently than other drugs for angina, so it can be used with your other angina medications (including nitrates, calcium channel blockers such as amlodipine, beta blockers such as metoprolol ). It is thought to work by improving how well the heart uses oxygen so that it can do more work with less oxygen.
What to know before taking ranolazine?
Before using ranolazine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems ( heart failure, slow heartbeat, QT prolongation in the EKG ), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).
Can ranolazine make you dizzy?
Talk to your doctor about using ranolazine safely. This drug may make you dizzy. Alcohol or marijuana ( cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Can you take ranolazine without a doctor's approval?
Do not start, stop, or change the dosage of any medicines without your doctor's approval. Many drugs besides ranolazine may affect the heart rhythm (QT prolongation), including amiodarone, pimozide, dofetilide, procainamide, quinidine, sotalol, among others.
Does ranexa help with chest pain?
chest pain with moderate walking was relieved with ranexa. fast walking is still a problem, but have learned how to adjust speed as needed. Initially used 50 mg twice a day, but side effects of dizziness, headache, disorientation were significant so reduced to 500 mg once a day.
Is Ranexa generic?
Everyone should know that there is now a Generic for Ranexa and it is really cheap. Make sure to ask for it. RANOLAZINE ER 500 MG TABLET TABLET EXTENDED RELEASE 12 HR
Treatment
Mechanism of action
- Originally it was believed that Ranexa caused the heart muscle to switch from using fatty acids to glucose for energy production, which would reduce the amount of oxygen the heart muscle needed to function. More recently, however, evidence emerged that showed the principal effect of Ranexa is to actually block what is called the \"late sodium chann...
Symptoms
- Angina is pain or discomfort in the chest that results from the heart muscle being deprived of oxygen-rich blood. Some describe the feeling as pressure or squeezing, and the discomfort can be felt in the shoulders, arms, neck, jaw or back in addition to the chest. Angina pain may even feel like indigestion.
Side effects
- The most common reported side effects of Ranexa are headache, constipation, and nausea. Other less serious side effects may include:
Risks
- In addition, while taking Ranexa, it is important to pay attention to any of the following serious side effects and seek immediate guidance from your physician if they occur: Initially, a chief concern about Ranexa was that it can prolong the \"QT interval\" on the ECG (a measurement of electrical activity within the heart). Some drugs with this effect can increase the risk of developi…
Contraindications
- In addition, people with cirrhosis (scarring) of the liver should not take Ranexa, and neither should people taking St. John's wort and certain other medications for: