Precautions
Take each dose with a full glass (8 ounces) of water. Flucytosine may cause nausea and vomiting. If you take more than one capsule per dose, swallow one capsule at a time over a 15-minute period to help prevent nausea and vomiting.
How do you take flucytosine?
Flucytosine can be administered orally and has a very useful pharmacokinetic profile (including the ability to penetrate the CNS, eye, and urinary tract). Single-step mutation to resistance is common and is the reason for using amphotericin to protect the flucytosine.
What is the pharmacokinetic profile of flucytosine?
Flucytosine was shown to be teratogenic (vertebral fusions) in the rat at doses of 40 mg/kg/day (298 mg/M2/day or 0.051 times the human dose) administered on days 7 to 13 of gestation.
What is the teratogenic dose of flucytosine?
What is flucytosine? Flucytosine is an antifungal medication that fights infections caused by fungus. Flucytosine is used to treat serious fungal infections of the blood, lungs, heart, central nervous system, and urinary tract. Flucytosine is sometimes given with another medicine called amphotericin B.
What is flucytosine used for?
What is flucytosine?
What should I avoid while taking flucytosine?
Can flucytosine cause nausea?
Can you take flucytosine if you are allergic to it?
Can flucytosine be taken with other medications?
Can you breastfeed while taking flucytosine?
Can flucytosine be stored at room temperature?
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Is flucytosine oral or IV?
In patients receiving intravenous flucytosine, the median 24-h area under the concentration-time curve was significantly higher than in the oral group. Despite this difference, there was no difference in early fungicidal activity between patients on intravenous compared with patients on oral flucytosine.
Is flucytosine given orally?
For oral dosage form (capsules): For fungus infections: Adults—Dose is based on body weight and must be determined by your doctor. The dose is usually 50 to 150 milligrams (mg) per kilogram (kg) of body weight per day, taken every 6 hours.
When should I take flucytosine?
Flucytosine is a medication used in the management and treatment of systemic and severe candida and cryptococcus infections. It is in the antimetabolite, antifungal class of drugs.
Why flucytosine is not given?
Flucytosine has significant toxicity for the bone marrow, liver, and gastrointestinal tract. Toxicity can manifest as diarrhea, hepatitis, or potentially life-threatening bone marrow suppression.
What type of drug is flucytosine?
Flucytosine (5-fluorocytosine, 5-FC) is an antifungal agent originally developed in 1957 as an antimetabolite. Although it has found no role as an anti-tumor agent, it is used for the treatment of certain fungal infections.
What is another name for flucytosine?
Flucytosine, also known as 5-fluorocytosine (5-FC), is an antifungal medication. It is specifically used, together with amphotericin B, for serious Candida infections and cryptococcosis. It may be used by itself or with other antifungals for chromomycosis.
What are side effects of flucytosine?
AdvertisementAgitation.black, bloody, tarry stools.blistering, peeling, or loosening of the skin.burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings.burning upper abdominal or stomach pain.change in consciousness.chest pain or tightness.cough or hoarseness.More items...•
What is the mechanism of action of flucytosine?
Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism.
How do you adjust flucytosine?
Renal Dose AdjustmentsCrCl at least 40 mL/min: 25 mg/kg orally every 6 hours.CrCl 20 to 40 mL/min: 25 mg/kg orally every 12 hours.CrCl 10 to 20 mL/min: 25 mg/kg orally every 24 hours.CrCl less than 10 mL/min: 25 mg/kg orally every 48 hours.
Is flucytosine toxic?
Flucytosine can cause bone marrow suppression and GI toxicity, although these side effects are seen less frequently with the current recommended dosage (100 mg/kg/day in 4 divided doses) than with the higher dosage that was used for many years (150 mg/kg/day in 4 divided doses).
Why is flucytosine given with amphotericin?
The combination of amphotericin B (AMB) and flucytosine (FC) is the treatment of choice for cryptococcal meningitis (21). The higher efficacy of the combination compared to that of AMB alone has been demonstrated in human immunodeficiency virus-negative (2) and human immunodeficiency virus-positive (6, 27) patients.
Is flucytosine a pro drug?
A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
How is 5 Fluorocytosine excreted?
Flucytosine is excreted via the kidneys by means of glomerular filtration without significant tubular reabsorption. A small portion of the dose is excreted in the feces. 2.4 to 4.8 hours.
What is the treatment for cryptococcal meningitis?
To reduce mortality from cryptococcal infection, CD4 testing is also needed to identify patients with low CD4 counts, who are at highest risk for cryptococcal meningitis. Amphotericin B, flucytosine, and fluconazole are antifungal medications shown to improve survival in patients with cryptococcal infections.
What are side effects of flucytosine?
AdvertisementAgitation.black, bloody, tarry stools.blistering, peeling, or loosening of the skin.burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings.burning upper abdominal or stomach pain.change in consciousness.chest pain or tightness.cough or hoarseness.More items...•
What is the mechanism of action of flucytosine?
Mechanism of Action. 5-FU inhibits fungal protein synthesis following incorporation into fungal RNA in place of uridylic acid or through inhibition of thymidylate synthetase, thus inhibiting fungal DNA synthesis.
Flucytosine Side Effects: Common, Severe, Long Term - Drugs.com
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 4 Oct 2022), Cerner Multum™ (updated 21 Sep 2022), ASHP (updated 12 Sep 2022 ...
Flucytosine Dosage Guide + Max Dose, Adjustments - Drugs.com
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 12 Oct 2022), Cerner Multum™ (updated 21 Sep 2022), ASHP (updated 12 Oct 2022 ...
(flucytosine) dosing, indications, interactions, adverse effects, and more
Contraindications. Hypersensitivity. Patients with known complete dihydropyrimidine dehydrogenase (DPD) enzyme deficiency. Cautions. Measurement of serum creatinine levels should be determined by Jaffé reaction since this drug does not interfere with determination of creatinine values by this method; most automated equipment for measurement of creatinine makes use of the Jaffé reaction
Flucytosine - Wikipedia
Flucytosine, also known as 5-fluorocytosine (5-FC), is an antifungal medication. It is specifically used, together with amphotericin B, for serious Candida infections and cryptococcosis. It may be used by itself or with other antifungals for chromomycosis. Flucytosine is used by mouth and by injection into a vein.. Common side effects include bone marrow suppression, loss of appetite, diarrhea ...
Flucytosine | Johns Hopkins ABX Guide
Coelho C, Casadevall A. Cryptococcal therapies and drug targets: the old, the new and the promising. Cell Microbiol. 2016;18(6):792-9.[PMID:26990050] Comment: Authors highlight difficulties with cryptococcus and that emergence of resitance occurs so frequently with 5-FC monotherapy, hence why it is not used except in compination. Yao ZW, Lu X, Shen C, et al. Comparison of flucytosine and ...
Flucytosine: Uses, Interactions, Mechanism of Action - DrugBank
Pharmacodynamics. Flucytosine is an antimetabolite that acts as an antifungal agent with in vitro and in vivo activity against Candida and Cryptococcus. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms.
How is flucytosine taken up?
Inside the fungal cell, Flucytosine is rapidly converted to fluorouracil by the enzyme cytosine deaminase. Fluorouracil exerts its antifungal activity through the subsequent conversion into several active metabolites, which inhibit protein synthesis by being falsely incorporated into fungal RNA or interfere with the biosynthesis of fungal DNA through the inhibition of the enzyme thymidylate synthetase.
What infections are treated with flucytosine?
Candida: Septicemia, endocarditis and urinary system infections have been effectively treated with Flucytosine. Limited trials in pulmonary infections justify the use of Flucytosine. Cryptococcus: Meningitis and pulmonary infections have been treated effectively.
What should be monitored before taking flucytosine?
Before therapy with Flucytosine Capsules USP is instituted, electrolytes (because of hypokalemia) and the hematologic and renal status of the patient should be determined (see WARNINGS ). Close monitoring of the patient during therapy is essential.
How to manage overdose?
In the management of overdosage, prompt gastric lavage or the use of an emetic is recommended. Adequate fluid intake should be maintained, by the intravenous route if necessary, since Flucytosine Capsules USP is excreted unchanged via the renal tract. The hematologic parameters should be monitored frequently; liver and kidney function should be carefully monitored. Should any abnormalities appear in any of these parameters, appropriate therapeutic measures should be instituted.
What is the cause of flucytosine resistance?
Flucytosine resistance may arise from a mutation of an enzyme necessary for the cellular uptake or metabolism of Flucytosine or from an increased synthesis of pyrimidines, which compete with the active metabolites of Flucytosine (fluorinated antimetabolites). Resistance to Flucytosine has been shown to develop during monotherapy after prolonged exposure to the drug.
What is flucytosine capsule?
Flucytosine Capsules USP, an antifungal agent, is available as 250 mg and 500 mg capsules for oral administration. Each capsule also contains lactose monohydrate, colloidal silicon dioxide, talc, sodium starch glycolate, magnesium stearate and hard gelatin capsule shell which contains gelatin, purified water, black iron oxide, FD&C Blue No.1, titanium dioxide and sodium lauryl sulfate for 250 mg strength; gelatin, purified water, black iron oxide and titanium dioxide for 500 mg strength. The imprinting ink contains black iron oxide, shellac, potassium hydroxide, titanium dioxide, povidone, sodium hydroxide and FD &C Red No. 40 aluminum lake for 250 mg and 500 mg strengths. Chemically, Flucytosine is 5-fluorocytosine, a fluorinated pyrimidine which is related to fluorouracil and floxuridine. It is a white or almost white crystalline powder with a molecular weight of 129.09 and the following structural formula:
What is the color of Flucytosine 250 mg?
Flucytosine Capsules USP, 250 mg are size 2 hard gelatin capsule with blue opaque cap and grey opaque body imprinted with "NL 771" on the cap with black ink and "250" on the body with red ink filled with white to off white powder.
How does flucytosine work?
It works by being converted into fluorouracil inside the fungus, which impairs its ability to make protein. Flucytosine was first made in 1957. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.
What is flucytosine used for?
It is specifically used, together with amphotericin B, for serious Candida infections and cryptococcosis. It may be used by itself or with other antifungals for chromomycosis. Flucytosine is used by mouth and by injection into a vein.
How long does flucytosine stay in your system?
In normal patients flucytosine has reportedly a half-life of 2.5 to 6 hours. In patients with impaired renal function higher serum levels are seen and the drug tends to accumulate. The drug is mainly excreted unchanged in the urine (90% of an oral dose) and only traces are metabolized and excreted in the feces.
How long does it take for flucytosine to be absorbed?
Flucytosine is well absorbed (75 to 90%) from the gastrointestinal tract. Intake with meals slows the absorption, but does not decrease the amount absorbed. Following an oral dose of 2 grams peak serum levels are reached after approximately 6 hours. The time to peak level decreases with continued therapy.
How often should you do a serum level test for flucytosine?
Hematological, renal and liver function studies should be done frequently during therapy (initially daily, twice a week for the rest of treatment).
Can flucytosine be used as a sole agent?
Flucytosine must not be used as a sole agent in life-threatening fungal infections due to relatively weak antifungal effects and fast development of resistance, but rather in combination with amphotericin B and/or azole antifungals such as fluconazole or itraconazole.
Can flucytosine cause nausea?
Flucytosine is used by mouth and by injection into a vein. Common side effects include bone marrow suppression, loss of appetite, diarrhea, vomiting, and psychosis. Anaphylaxis and other allergic reactions occasionally occur. It is unclear if use in pregnancy is safe for the baby.
How does flucytosine enter a cell?
Flucytosine appears to enter fungal cells via the action of fungal-specific cytosine permease. Inside the cell, flucytosine is converted into fluorouracil ( 5-FU) by cytosine deaminase and then after several intermediate steps is converted into 5-fluorouridine triphosphate ( FUTP ).
What is flucytosine used for?
Flucytosine is an antifungal agent used to treat severe infections caused by candida and cryptococcus. Flucytosine therapy can cause transient mild-to-moderate serum aminotransferase elevations and has been mentioned as a very rare cause of clinically apparent acute drug induced liver injury.
What is 5-fluorouracil used for?
A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections. It has a role as a prodrug. It is an organofluorine compound, a pyrimidone, an aminopyrimidine, a nucleoside analogue and a pyrimidine antifungal drug. It derives from a cytosine.
What is flucytosine metabolized to?
Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. Antifungal synergism between Ancobon and polyene antibiotics, particularly amphotericin B, has been reported.
How does flucytosine affect fungal cells?
Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. It also appears to be an inhibitor of fungal thymidylate synthase.
What is the resistance to flucytosine?
Strains of Candida or Cryptococcus resistant to flucytosine have been isolated from patients who have never received the drug, and resistant strains of Candida, C. neoformans, or Cladosporium have emerged in patients receiving oral flucytosine alone or in conjunction with IV amphotericin B. Resistance to flucytosine can develop during prolonged monotherapy with the drug. While the reported incidence of flucytosine-resistant Candida has ranged from 4-15.5% in some studies, up to about 50% of clinical isolates were resistant to the drug in other studies. Resistance in C. neoformans generally has been reported to range from 1-4%; however, in some institutions, up to 24% of isolates may be resistant to flucytosine. Resistance to flucytosine may be related to mutations that affect the production of fungal enzymes (e.g., uridine monophosphate pyrophosphorylase, cytosine permease, cytosine deaminase) important to the mechanism of action of the drug. Resistance also may result from mutations that result in increased production of pyrimidines.
How long does it take for flucytosine to be absorbed?
Flucytosine is rapidly and well absorbed from the GI tract, with plasma levels peaking in 1-2 hr in animals that have received the drug for several days. The drug is widely distributed in the body, with a volume of distribution approximating the total body water. Flucytosine is minimally bound to plasma proteins.
How to administer flucytosine?
Flucytosine is usually administered by mouth at 100 mg/kg/day in four divided doses. Patients with a serum creatinine level of 1.7 mg/dL or greater usually require dose reduction. As an approximation, the total daily dose should be reduced to 75 mg/kg, with a creatinine clearance of 26 to 50 mL/min and to 37 mg/kg when the creatinine clearance is 13 to 25 mL/min.59 Ideally, the blood level should be measured in azotemic patients 2 hours after the last dose and immediately before the next dose. The target blood level range has long been thought to be between 20 and 100 µg/mL, although recent pharmacodynamic work suggests that levels of 10 to 50 µg/mL would be adequate. 60,61 Patients requiring hemodialysis may be given a single postdialysis dose of 37.5 mg/kg. Further doses are adjusted by blood level. Reliable biologic, 62 enzymatic, 63 and physical 64 methods are available to assay flucytosine, even in the presence of amphotericin B.
Where does flucytosine go?
Conversion of flucytosine to 5-fluorouracil within the human body occurs to a sufficient degree to possibly account for the drug's toxicity to bone marrow and the gastrointestinal tract. It is likely that the drug is secreted into the gut, where flucytosine becomes deaminated by intestinal bacteria and is reabsorbed as 5-fluorouracil.
What is the effect of flucytosine on DNA?
The most common side effects seen with flucytosine are abdominal pain, leukopenia, and myelosuppresssion. Because of these side effects, flucytosine use today is mainly limited to treatment of Cryptococcal meningitis in combination with amphotericin.
Why is amphotericin used to protect flucytosine?
Single-step mutation to resistance is common and is the reason for using amphotericin to protect the flucytosine. Flucytosine has therapeutic effects related to its effects on nucleic acid synthesis. Toxicities include the bone marrow and liver.
How long does flucytosine stay in your system?
Flucytosine has a half-life of 3 to 6 hours and is excreted unchanged in the urine. The major toxicity of flucytosine is depression of the bone marrow, resulting in anemia, leukopenia, and thrombocytopenia. This effect is dose related and is reversible.
How long does it take for flucytosine to reach peak concentration?
Flucytosine is well absorbed from the gastrointestinal tract, and the peak plasma concentration is attained within 1 to 2 hours after oral administration. The drug is widely distributed throughout the body; it attains a concentration in cerebrospinal fluid approximately 65% to 90% that of the plasma.
What is 5-fluorocytosine used for?
5-Fluorocytosine (FC) is an anti-fungal agent used for the treatment of severe fungal infections, particularly when combined to amphotericin B. The anti-fungal activity of FC results from the intra-fungal formation of FU leading to the inhibition of RNA processing and DNA synthesis via FNUCt metabolites. Susceptible fungi contain cytosine deaminase (CD), the enzyme that converts FC to FU, whereas human cells lack this enzyme thus creating a theoretical absence of toxicity for FC in humans. However, because FC and FU toxicity profiles are quite similar, it is thought that FU may account for some FC side effects.110 Moreover, FU and FU catabolites (FUPA, FBAL) were detected in biofluids of healthy volunteers or patients receiving FC. 111–113 The evidence of FC conversion into FU by viable and non-viable Escherichia coli as well as by a semi-continuous culture system mimicking human intestinal microflora was clearly demonstrated.114–116
How long does flucytosine treatment last?
Without flucytosine, the recommended amphoB treatment duration is 4-6 weeks.
How does flucytosine interfere with protein synthesis?
Flucytosine interferes with protein synthesis by incorporation into fungal RNA after being converted to 5-FU intracellularly.
Why is 5-FC monotherapy not used in compination?
Comment: Authors highlight difficulties with cryptococcus and that emergence of resitance occurs so frequently with 5-FC monotherapy, hence why it is not used except in compination.
How long does it take to get a drug level?
Obtain drug levels after 3-54 days of continuous dosing.
Does 5FC increase CSF sterilization?
Comment: Addition of 5FC to amphotericin resulted in faster CSF sterilization but did not improve clinical outcome.
Can you breastfeed while on flucytosine?
No data. Breast feeding during flucytosine therapy not recommended because of concern for potential adverse effects.
Does amphotericin B cause yeast clearance?
Comment: Amphotericin B (1 mg/kg/day) plus flucytosine (100 mg/kg/day) was associated with improved survival at day 70 as compared with amphotericin B (1 mg/kg/day) alone. Combination therapy with flucytosine also resulted in more rapid yeast clearance from CSF when compared to amphotericin monotherapy or amphotericin B plus fluconazole (800 mg/kg/day). There was no survival benefit found for those treated with amphotericin B plus fluconazole.
How to administer flucytosine?
The recommended dose of Flucytosine should be usually administered by mouth.
What is flucytosine used for?
Flucytosine specifically is a fluorinated pyrimidine analogue family of medications used for the treatment of severe infections caused by the fungus. It is used together with the other drugs, in order to relieve yeast as well as fungal infections affecting the entire body.
What class of drugs are flucytosine tablets?
The flucytosine tablets belong to the class of drugs named fluorinated pyrimidine analogue.
Can you take flucytosine with kidney disease?
Flucytosine 500 mg tablets should be used with extra caution in patients who are with kidney disease. Dose adjustment may be required. Please consult your healthcare practitioner.
How long does it take for flucytosine to be absorbed?
Flucytosine has a half-life of 3 to 6 hours and is excreted unchanged in the urine.
What is flucytosine 5?
Flucytosine (5-f1uorocytosine) is a fluorinated pyrimidine, synthesized as an antitumor agent in 1957. The drug has a narrow spectrum of activity and is used because of its synergy with amphotericin B against cryptococcus.
What is the name of the enzyme that converts flucytosine to 5-fluorouracil?
Flucytosine is taken up within sensitive fungal cells by cytosine permease, which converts it to 5-fluorouracil. The 5-fluorouracil is then further metabolized to yield 5-fluorodeoxyuridine monophosphate, a competitive inhibitor of thymidylate synthetase. The formation of thymidine monophosphate from deoxyuridine monophosphate is thus blocked and the synthesis of DNA impaired. 5-Fluorouridine triphosphate is also formed in fungal cells, leading to the synthesis of defective RNA. Selective toxicity for fungus is achieved with flucytosine because mammalian cells do not readily take up the drug or convert it to 5-fluorouracil.
What is the effect of flucytosine on DNA?
The most common side effects seen with flucytosine are abdominal pain, leukopenia, and myelosuppresssion. Because of these side effects, flucytosine use today is mainly limited to treatment of Cryptococcal meningitis in combination with amphotericin.
What is the name of the compound that is synthesized from fluorouracil?
Flucytosine, 5-fluorocytosine (35.4.4), is synthesized from fluorouracil (30.1.3.3). Fluorouracil is reacted with phosphorous oxychloride in dimethylaniline to make 2,4-dichloro-5-fluoropyrimidine (35.4.2), which is reacted with ammonia to make a product substituted with chlorine at the fourth position of the pyrimidine ring—4-amino-2-chloro-5-fluoropyrimidine (35.4.3). Hydrolysis of the chlorovinyl fragment of this compound in a solution of hydrochloric acid gives the desired flucytosine [52–55 ].
How long does flucytosine stay in the body?
Excretion is primarily renal, with minimal metabolism. The half-life of flucytosine with normal renal function is 3 to 4 hours, but even minor decreases in renal function leads to prolongation. Both peritoneal dialysis and hemodialysis remove the drug.
Why is yeast resistant to flucytosine?
Intrinsic resistance of some yeast strains to flucytosine is due to impaired uptake of the drug. Acquired resistance arises readily from mutations that produce a deficiency of cytosine deaminase or through excessive synthesis of uracil, which competes with the drug.
What is flucytosine?
Flucytosine is an antifungal medication that fights infections caused by fungus.
What should I avoid while taking flucytosine?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Can flucytosine cause nausea?
Flucytosine may cause nausea and vomiting. If you take more than one capsule per dose, swallow one capsule at a time over a 15-minute period to help prevent nausea and vomiting. Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.
Can you take flucytosine if you are allergic to it?
You should not use flucytosine if you are allergic to it. To make sure flucytosine is safe for you, tell your doctor if you have: weak immune system (caused by radiation or by using medicine that causes bone marrow suppression); or. an electrolyte imbalance (such as low levels of potassium in your blood).
Can flucytosine be taken with other medications?
This list is not complete. Other drugs may interact with flucy tosine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Can you breastfeed while taking flucytosine?
It is not known whether flucytosine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Can flucytosine be stored at room temperature?
Skipping doses may also increase your risk of further infection that is resistant to antifungal medicine. Flucytosine will not treat a viral infection such as the flu or a common cold. Store at room temperature away from moisture and heat. Detailed Flucytosine dosage information.
Flucytosine Description
Flucytosine is used to treat serious fungal infections in the body.
May Treat: Candidal urinary tract infection · Fungal infection · Systemic candidiasis treatment adjunct · Systemic cryptococcosis treatment adjunct
Brand Names: Ancobon
Drug Class: Antifungal - Fluorinated Pyrimidine-type Agents
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: This drug should not be given to breastfeeding mothers
- Tell your doctor if you have had kidney problems
- Call MD if new abdominal pain/yellowing eyes/skin
- Call MD for fatigue/sore throat/infection/bleeding
- Tell your doctor if you have had kidney problems
- Call MD if new abdominal pain/yellowing eyes/skin
- Call MD for fatigue/sore throat/infection/bleeding
- Call Dr. if bloody nose, gums or bruising occur
- Not recommended when breast feeding
- Lab tests may be ordered to monitor therapy
- Space doses evenly throughout the day.
- Success is dependent on completing therapy course
Flucytosine - Clinical Pharmacology
Indications and Usage For Flucytosine
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Flucytosine Dosage and Administration
How Is Flucytosine Supplied
Overview
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- The usual dosage of Flucytosine Capsules USP is 50 to 150 mg/kg/day administered in divided doses at 6-hour intervals. Nausea or vomiting may be reduced or avoided if the capsules are given a few at a time over a 15-minute period. If the BUN or the serum creatinine is elevated, or if there are other signs of renal impairment, the initial dose shoul...
Interactions
Overdose
Flucytosine, also known as 5-fluorocytosine (5-FC), is an antifungal medication. It is specifically used, together with amphotericin B, for serious Candida infections and cryptococcosis. It may be used by itself or with other antifungals for chromomycosis. Flucytosine is used by mouth and by injection into a vein.
Common side effects include bone marrow suppression, loss of appetite, diarr…
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