Precautions
Can Imdur be taken long term?
Your dose may need to be gradually decreased. Although unlikely, when this medication is used for a long time, it may not work as well and may require different dosing. Tell your doctor if this medication stops working well (for example, you have more frequent or worsening chest pain).
Can you take isosorbide long term?
Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This form of nitrate is used to reduce the number of angina attacks over a long time. It will not relieve an attack that has already started because it works too slowly.
How long should you take isosorbide mononitrate?
In patients taking isosorbide mononitrate twice daily, the second dose should be taken 8 hours after the 1st dosage. If the dose is one three times daily, take one every 6 hours. This provides a nitrate-free period of 6 – 8 hours.
What does isosorbide mononitrate do to your heart?
Isosorbide mononitrate belongs to the group of medicines called nitrates. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. When used regularly on a long-term basis, this helps prevent angina attacks from occurring.
When should you not take Imdur?
Who should not take Imdur Oral?significant anemia.methemoglobinemia, a type of blood disorder.a heart attack.hypertrophic cardiomyopathy.a hemorrhage in the brain.low blood pressure.abnormal absorption of food nutrients in the gastrointestinal tract.high pressure within the skull.
What happens if you stop taking isosorbide mononitrate?
What will happen if I stop taking it? Talk to your doctor if you want to stop taking isosorbide mononitrate or dinitrate. If you have been taking it regularly and you stop taking it, your angina symptoms or heart failure may get worse.
Does Imdur affect heart rate?
Imdur side effects worsening angina pain; fast or slow heart rate; or. pounding heartbeats or fluttering in your chest.
Is there an alternative to isosorbide mononitrate?
In patients treated with maximal beta-blocking therapy, nifedipine is an effective alternative to isosorbide as a combination agent with propranolol. The salutary effects of nifedipine included afterload reduction with exercise and possible improvements in coronary blood supply.
What should you avoid when taking isosorbide?
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
How much does isosorbide mononitrate lower blood pressure?
In 11 patients who received 10 mg of isosorbide dinitrate, blood pressure (BP) dropped from 205 +/- 8/131 +/- 3 to 166 +/- 9/106 +/- 5 mm Hg at 120 minutes. In eight patients who received placebo, BP dropped from 203 +/- 8/130 +/- 3 to 193 +/- 11/122 +/- 5 mm Hg at 120 minutes.
Does isosorbide slow heart rate?
Compared to the findings after the placebo, the blood pressure level fell and the heart rate increased after the ingestion of isosorbide dinitrate. The changes were more striking with the patients standing than with them supine, and the larger dose of the drug produced greater changes than the smaller dose.
Can isosorbide cause fatigue?
Body as a Whole: Asthenia, back pain, chest pain, edema, fatigue, fever, flu-like symptoms, malaise, rigors.
Is isosorbide good for the heart?
Isosorbide mononitrate belongs to the group of medicines called nitrates. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. When used regularly on a long-term basis, this helps prevent angina attacks from occurring.
Does isosorbide mononitrate affect your kidneys?
Does isosorbide mononitrate (Monoket) affect your kidneys? Isosorbide mononitrate (Monoket) is not known to affect the kidneys.
Does isosorbide lower blood pressure?
Sublingual isosorbide safely and effectively lowers systolic and diastolic BP in patients with severe, uncontrolled arterial hypertension.
What are the most common side effects of isosorbide dinitrate?
Common side effects of Isordil include:headache,weakness,mild dizziness, and.skin changes such as redness, tingling, or warmth.
Before Taking This Medicine
You should not use Imdur if: 1. you are allergic to isosorbide mononitrate, isosorbide dinitrate, or nitroglycerin; or 2. you have early signs of a...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
What Happens If I Overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of isosorbide mononitrate can be fatal.Overdose sympto...
What Should I Avoid While Taking Imdur?
This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fas...
What Other Drugs Will Affect Imdur?
Taking Imdur with certain other medicines can cause severely low blood pressure. This includes medicine to treat erectile dysfunction or pulmonary...
What is Imdur used for?
Imdur is used to prevent angina (chest pain) caused by coronary artery disease (heart disease). Imdur is a medication used for heart-related chest...
How safe is Imdur?
Do not take more or less of it or take it more often than prescribed by your doctor. Imdur chest pain but does not cure coronary artery disease. Co...
How does Imdur work?
Imdur works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload.
What are the common side effects of Imdur?
Common side effects of Imdur are include: low blood pressure. dizziness. temporary redness of face and neck. headache. nervousness. a f...
Is Imdur safe during pregnancy?
Imdur should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby. No studies have been done in ani...
Is Imdur safe during breastfeeding?
Use is not recommended. Caution is recommended and this Imdur should be used only if the benefits outweigh the risks.
Can I drink alcohol with Imdur ?
Do not drink alcohol. It could increase the effect of Imdur Tablets and lower your blood pressure too much. If this happens, you may feel dizzy or...
Can I drive after taking Imdur ?
Do not drive, use machinery, or do anything that needs alertness until you can do it safely.
When is the best time to take Imdur?
You should take this medicine first thing in the morning and follow the same schedule each day. This medicine works best if you have a "drug-free"...
How should I take Imdur?from drugs.com
Take Imdur exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. If you use too much isosorbide mononitrate, it might stop working as well in controlling your condition.
How does Imdur work?from 1mg.com
It does not treat an angina attack that has already begun and should not be used for this purpose. It works by relaxing and widening blood vessels in the heart. This makes it easier for blood to flow to the heart, so it gets more oxygen. This medicine thus helps to increase your ability to exercise and go about your daily life more easily and confidently. It should be taken regularly to be effective.
What if you forget to take Imdur Tablet PR?from 1mg.com
If you miss a dose of Imdur 30mg Tablet PR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
What are the interactions of Imdur 30 MG Tablet ?from lybrate.com
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
What is isosorbide mononitrate used for?from webmd.com
Isosorbide mononitrate is used to prevent chest pain (angina) in patients with a certain heart condition (coronary artery disease). This medication belongs to a class of drugs known as nitrates.
What to do if you are allergic to isosorbide mononitrate?from drugs.com
Tell your doctor if you have ever had any unusual or allergic reaction to isosorbide mononitrate or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
What is the FDA number for Imdur?from drugs.com
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Imdur side effects (more detail)
How long does it take for Imdur to work?from drugs.com
Imdur Tablets, during long-term use over 42 days dosed at 120 mg once daily, continued to improve exercise performance at 4 hours and at 12 hours after dosing but its effects (although better than placebo) are less than or at best equal to the effects of the first dose of 60 mg.
How should I take Imdur?from drugs.com
Take Imdur exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. If you use too much isosorbide mononitrate, it might stop working as well in controlling your condition.
What is Imdur?from drugs.com
Imdur (isosorbide mononitrate) is a nitrate that dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.
How long does it take for Imdur to increase tolerance?from rxlist.com
Pooled data from two other trials, comparing Imdur Tablets 60 mg once daily, ISDN 30 mg QID, and placebo QID in patients with chronic stable angina using a randomized, double-blind, three-way crossover design found statistically significant increases in exercise tolerance times for Imdur Tablets compared to placebo at hours 4, 8 and 12 and to ISDN at hour 4. The increases in exercise tolerance on day 14, although statistically significant compared to placebo, were about half of that seen on day 1 of the trial.
How long does it take for isosorbide to be cleared?from drugs.com
Isosorbide mononitrate is cleared by denitration to isosorbide and glucuronidation as the mononitrate, with 96% of the administered dose excreted in the urine within 5 days and only about 1% eliminated in the feces.
How to maintain the efficacy of Imdur?from drugs.com
Patients should be told that the antianginal efficacy of Imdur Tablets can be maintained by carefully following the prescribed schedule of dosing. For most patients, this can be accomplished by taking the dose on arising.
What is the effect of ISMN on the heart?from rxlist.com
The principal pharmacological action of ISMN and all organic nitrates in general is relaxation of vascular smooth muscle, producing dilatation of peripheral arteries and veins , especially the latter. Dilatation of the veins promotes peripheral pooling of blood, decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure and mean arterial pressure (afterload). Dilatation of the coronary arteries also occurs. The relative importance of preload reduction, afterload reduction, and coronary dilatation remains undefined.
How should I take Imdur?from drugs.com
Take Imdur exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. If you use too much isosorbide mononitrate, it might stop working as well in controlling your condition.
How long does it take for IMDUR to increase tolerance?from rxlist.com
Pooled data from two other trials, comparing IMDUR Tablets 60 mg once daily, ISDN 30 mg QID, and placebo QID in patients with chronic stable angina using a randomized, double-blind, three-way crossover design found statistically significant increases in exercise tolerance times for IMDUR Tablets compared to placebo at hours 4, 8 and 12 and to ISDN at hour 4. The increases in exercise tolerance on day 14, although statistically significant compared to placebo, were about half of that seen on day 1 of the trial.
What is Imdur?from drugs.com
Imdur (isosorbide mononitrate) is a nitrate that dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.
How long does it take for ISMN to be released?from rxlist.com
After oral administration of ISMN as a solution or immediate-release tablets, maximum plasma concentrations of ISMN are achieved in 30 to 60 minutes, with an absolute bioavailability of approximately 100%. After intravenous administration, ISMN is distributed into total body water in about 9 minutes with a volume of distribution of approximately 0.6-0.7 L/kg. Isosorbide mononitrate is approximately 5% bound to human plasma proteins and is distributed into blood cells and saliva . Isosorbide mononitrate is primarily metabolized by the liver, but unlike oral isosorbide dinitrate, it is not subject to first-pass metabolism. Isosorbide mononitrate is cleared by denitration to isosorbide and glucuronidation as the mononitrate, with 96% of the administered dose excreted in the urine within 5 days and only about 1% eliminated in the feces. At least six different compounds have been detected in urine, with about 2% of the dose excreted as the unchanged drug and at least five metabolites. The metabolites are not pharmacologically active. Renal clearance accounts for only about 4% of total body clearance. The mean plasma elimination half-life of ISMN is approximately 5 hours.
What is isosorbide mononitrate used for?from webmd.com
Isosorbide mononitrate is used to prevent chest pain ( angina) in patients with a certain heart condition ( coronary artery disease ). This medication belongs to a class of drugs known as nitrates. It works by relaxing and widening blood vessels so blood can flow more easily to the heart .This medication will not relieve chest pain once it occurs. Also, it is not intended to be taken just before physical activities (such as exercise or sexual intercourse) to prevent chest pain. Other medications may be prescribed by your doctor for these conditions. Consult your doctor for more details.
How to maintain IMDUR?from rxlist.com
Patients should be told that the antianginal efficacy of IMDUR Tablets can be maintained by carefully following the prescribed schedule of dosing. For most patients, this can be accomplished by taking the dose on arising.
What is the effect of ISMN on the heart?from rxlist.com
The principal pharmacological action of ISMN and all organic nitrates in general is relaxation of vascular smooth muscle, producing dilatation of peripheral arteries and veins , especially the latter. Dilatation of the veins promotes peripheral pooling of blood, decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure and mean arterial pressure (afterload). Dilatation of the coronary arteries also occurs. The relative importance of preload reduction, afterload reduction, and coronary dilatation remains undefined.
How should I take Imdur?from drugs.com
Take Imdur exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. If you use too much isosorbide mononitrate, it might stop working as well in controlling your condition.
How long does it take for IMDUR to increase tolerance?from rxlist.com
Pooled data from two other trials, comparing IMDUR Tablets 60 mg once daily, ISDN 30 mg QID, and placebo QID in patients with chronic stable angina using a randomized, double-blind, three-way crossover design found statistically significant increases in exercise tolerance times for IMDUR Tablets compared to placebo at hours 4, 8 and 12 and to ISDN at hour 4. The increases in exercise tolerance on day 14, although statistically significant compared to placebo, were about half of that seen on day 1 of the trial.
What is Imdur?from drugs.com
Imdur (isosorbide mononitrate) is a nitrate that dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.
What if you forget to take Imdur Tablet PR?from 1mg.com
If you miss a dose of Imdur 30mg Tablet PR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
What are the interactions of Imdur 30 MG Tablet ?from lybrate.com
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
How long does it take for ISMN to be released?from rxlist.com
After oral administration of ISMN as a solution or immediate-release tablets, maximum plasma concentrations of ISMN are achieved in 30 to 60 minutes, with an absolute bioavailability of approximately 100%. After intravenous administration, ISMN is distributed into total body water in about 9 minutes with a volume of distribution of approximately 0.6-0.7 L/kg. Isosorbide mononitrate is approximately 5% bound to human plasma proteins and is distributed into blood cells and saliva . Isosorbide mononitrate is primarily metabolized by the liver, but unlike oral isosorbide dinitrate, it is not subject to first-pass metabolism. Isosorbide mononitrate is cleared by denitration to isosorbide and glucuronidation as the mononitrate, with 96% of the administered dose excreted in the urine within 5 days and only about 1% eliminated in the feces. At least six different compounds have been detected in urine, with about 2% of the dose excreted as the unchanged drug and at least five metabolites. The metabolites are not pharmacologically active. Renal clearance accounts for only about 4% of total body clearance. The mean plasma elimination half-life of ISMN is approximately 5 hours.
What is Imdur 30 mg used for?from lybrate.com
Imdur 30mg Tablet PR is used to prevent heart-related chest pain (angina). It works by relaxing and widening blood vessels so blood can flow more easily to the heart. This medicine will not treat an angina attack that has already begun.
How should I take Imdur?from drugs.com
Take Imdur exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. If you use too much isosorbide mononitrate, it might stop working as well in controlling your condition.
How long does it take for IMDUR to increase tolerance?from rxlist.com
Pooled data from two other trials, comparing IMDUR Tablets 60 mg once daily, ISDN 30 mg QID, and placebo QID in patients with chronic stable angina using a randomized, double-blind, three-way crossover design found statistically significant increases in exercise tolerance times for IMDUR Tablets compared to placebo at hours 4, 8 and 12 and to ISDN at hour 4. The increases in exercise tolerance on day 14, although statistically significant compared to placebo, were about half of that seen on day 1 of the trial.
What is Imdur?from drugs.com
Imdur (isosorbide mononitrate) is a nitrate that dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.
How long does it take for ISMN to be released?from rxlist.com
After oral administration of ISMN as a solution or immediate-release tablets, maximum plasma concentrations of ISMN are achieved in 30 to 60 minutes, with an absolute bioavailability of approximately 100%. After intravenous administration, ISMN is distributed into total body water in about 9 minutes with a volume of distribution of approximately 0.6-0.7 L/kg. Isosorbide mononitrate is approximately 5% bound to human plasma proteins and is distributed into blood cells and saliva . Isosorbide mononitrate is primarily metabolized by the liver, but unlike oral isosorbide dinitrate, it is not subject to first-pass metabolism. Isosorbide mononitrate is cleared by denitration to isosorbide and glucuronidation as the mononitrate, with 96% of the administered dose excreted in the urine within 5 days and only about 1% eliminated in the feces. At least six different compounds have been detected in urine, with about 2% of the dose excreted as the unchanged drug and at least five metabolites. The metabolites are not pharmacologically active. Renal clearance accounts for only about 4% of total body clearance. The mean plasma elimination half-life of ISMN is approximately 5 hours.
How to maintain IMDUR?from rxlist.com
Patients should be told that the antianginal efficacy of IMDUR Tablets can be maintained by carefully following the prescribed schedule of dosing. For most patients, this can be accomplished by taking the dose on arising.
What is the effect of ISMN on the heart?from rxlist.com
The principal pharmacological action of ISMN and all organic nitrates in general is relaxation of vascular smooth muscle, producing dilatation of peripheral arteries and veins , especially the latter. Dilatation of the veins promotes peripheral pooling of blood, decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure and mean arterial pressure (afterload). Dilatation of the coronary arteries also occurs. The relative importance of preload reduction, afterload reduction, and coronary dilatation remains undefined.
What is the FDA number for Imdur?from drugs.com
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Imdur side effects (more detail)
