Is Zosyn hard on the kidneys?
If alternative treatment options are inadequate or unavailable, monitor renal function during treatment with Zosyn. Precautions section stating that combined use of these two drugs may be associated with an increased incidence of acute kidney injury.May 5, 2017
What type of bacteria does Zosyn treat?
Aerobic and facultative gram-positive microorganisms: Staphylococcus aureus. Aerobic and facultative gram-negative microorganisms: Acinetobacter baumannii, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
Is Zosyn a strong antibiotic?
Zosyn (piperacillin / tazobactam) is a broad spectrum antibiotic, which means that it works against many types of bacteria. This is why it is often used for people who are very sick or have serious infections.
How long should piperacillin and tazobactam infusion?
Treatment duration Piperacillin/Tazobactam 2 g / 0.25 g is administered by intravenous infusion (over 30 minutes). Piperacillin/Tazobactam 4 g / 0.5 g is administered by intravenous infusion (over 30 minutes). For reconstitution instructions, see section 6.6.
How do you know if Zosyn is working?
Your doctor will check your or your child's progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.Jul 2, 2021
Does Zosyn help with inflammation?
Zosyn is used to treat bacterial infections such as pneumonia, appendicitis, pelvic inflammatory disease, E. coli cellulitis, and postpartum endometriosis.
Does Zosyn affect the liver?
Most cases of liver injury related to piperacillin are linked to the combination of piperacillin with the beta-lactamase inhibitor tazobactam (Zosyn and generics), which is more commonly used than piperacillin alone. Likelihood score: B (known rare cause of clinically apparent liver injury).Oct 20, 2020
How long does IV Zosyn stay in your system?
Tazobactam is metabolized to a single metabolite that lacks pharmacological and antibacterial activities. Following single or multiple ZOSYN doses to healthy subjects, the plasma half-life of piperacillin and of tazobactam ranged from 0.7 to 1.2 hours and was unaffected by dose or duration of infusion.
Is Zosyn good for pneumonia?
Piperacillin and tazobactam is a combination penicillin antibiotic that is used to treat many different infections caused by bacteria, such as stomach infections, skin infections, pneumonia, and severe uterine infections.Jul 22, 2020
When should you hold Zosyn?
Single-dose vials should be used immediately after reconstitution. Discard any unused portion after 24 hours if stored at room temperature, or after 48 hours if stored at refrigerated temperature. IV bags must be used within 24 hours at room temperature and up to one week if refrigerated.Sep 1, 2020
Does Zosyn cover C diff?
Conclusions: Our findings suggest that piperacillin/tazobactam achieves sufficient concentrations in the intestinal tract to inhibit C. difficile colonization during therapy.Apr 18, 2016
How long is Zosyn good after mixing?
Discard any unused portion after 24 hours if stored at room temperature (20°C to 25°C [68°F to 77°F]), or after 48 hours if stored at refrigerated temperature (2°C to 8°C [36°F to 46°F]). Vials should not be frozen after reconstitution.Sep 3, 2017
Is Zosyn (piperacillin / tazobactam) a broad spectrum antibiotic?
Yes. Zosyn (piperacillin / tazobactam) is a broad spectrum antibiotic, which means that it works against many types of bacteria. This is why it is...
How long does it take Zosyn (piperacillin / tazobactam) to work?
Zosyn (piperacillin / tazobactam) will start working right away to fight the infection in your body. You should start to feel better within 2 days,...
Is Zosyn (piperacillin / tazobactam) bad for the kidneys?
Zosyn (piperacillin / tazobactam) can cause kidney damage, but this usually happens to people who are very sick and in the hospital or those who al...
Will Zosyn (piperacillin / tazobactam) cover MRSA?
No. Zosyn (piperacillin / tazobactam) will not treat infections caused by MRSA (methicillin-resistant Staphylococcus aureus). MRSA is a bacteria th...
Is Zosyn (piperacillin / tazobactam) a penicillin?
Zosyn (piperacillin / tazobactam) contains piperacillin, which is a penicillin-type antibiotic. It works against some of the same bacteria that reg...
Toxicity
- The usual total daily dose of ZOSYN for adults is 3.375 g every six hours totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam). The usual duration of ZOSYN treatment is from 7 to 10 days.
Administration
- ZOSYN should be administered by intravenous infusion over 30 minutes. For patients on hemodialysis, the maximum dose is 2.25 g every twelve hours for all indications other than nosocomial pneumonia and 2.25 g every eight hours for nosocomial pneumonia. Since hemodialysis removes 30% to 40% of the administered dose, an additional dose of 0.75 g ZOSY…
Treatment
- Initial presumptive treatment of patients with nosocomial pneumonia should start with ZOSYN at a dosage of 4.5 g every six hours plus an aminoglycoside, totaling 18.0 g (16.0 g piperacillin/2.0 g tazobactam). The recommended duration of ZOSYN treatment for nosocomial pneumonia is 7 to 14 days. Treatment with the aminoglycoside should be continued in patients from whom P. aeru…
Contraindications
- In patients with renal impairment (creatinine clearance 40 mL/min) and dialysis patients (hemodialysis and CAPD), the intravenous dose of ZOSYN should be reduced to the degree of actual renal function impairment. The recommended daily doses of ZOSYN for patients with renal impairment are as follows:
Availability
- For children with appendicitis and/or peritonitis 9 months of age or older, weighing up to 40 kg, and with normal renal function, the recommended ZOSYN dosage is 100 mg piperacillin/12.5 mg tazobactam per kilogram of body weight, every 8 hours. For pediatric patients between 2 months and 9 months of age, the recommended ZOSYN dosage based on pharmacokinetic modeling, is …
Interactions
- In circumstances where co-administration via Y-site is necessary, ZOSYN formulations containing EDTA are compatible for simultaneous co-administration via Y-site infusion only with the following aminoglycosides under the following conditions: Only the concentration and diluents for amikacin or gentamicin with the dosages of ZOSYN listed above have been established as com…