How long does chlorzoxazone stay in your system?
Less than one percent of a dose of Chlorzoxazone is excreted unchanged in the urine in 24 hours. Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions.
What should I know about chlorzoxazone before taking it?
Older adults should not usually take chlorzoxazone because it is not as safe or effective as other medications) that can be used to treat the same condition. you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
What is the mechanism of action of chlorzoxazone?
Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties.
How often should I take chlorzoxazone for muscle relaxation?
Chlorzoxazone does not directly relax tense skeletal muscles in man. DOSAGE AND ADMINISTRATION Usual Adult Dosage One tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to one and one-half tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
Is Chlorzoxazone a strong muscle relaxer?
Chlorzoxazone (95-25-0) is a strong oxidizing agent and used as a skeletal muscle relaxant and as an analgesic.
How long does Chlorzoxazone stay in your system?
Chlorzoxazone is rapidly metabolized and is excreted in the urine, primarily in a conjugated form as the glucuronide. Less than one percent of a dose of Chlorzoxazone is excreted unchanged in the urine in 24 hours.
Does Chlorzoxazone help with pain?
Chlorzoxazone is used to relieve pain and stiffness caused by muscle strains and sprains. It is used in combination with physical therapy, analgesics (such as aspirin or acetaminophen), and rest.
Can I take 2 Chlorzoxazone?
Chlorzoxazone is usually taken 3 or 4 times per day. Follow your doctor's dosing instructions very carefully. Chlorzoxazone is only part of a complete program of treatment that may also include rest, physical therapy, or other pain relief measures. Follow your doctor's instructions.
How long does it take for muscle relaxers to start working?
You also shouldn't drive or operate heavy machinery while taking muscle relaxants. Some muscle relaxers start working within 30 minutes of taking them, and the effects can last anywhere from 4 to 6 hours.
What is a stronger muscle relaxer?
Metaxalone is a muscle relaxant suitable for sprains, strains, and other muscle-based pain. Compared to the other muscle relaxers, Metaxalone provides a moderately strong relaxing action and produces lesser side effects. Nausea, drowsiness, vomiting, dizziness, and irritability are among the known side effects.
Does chlorzoxazone reduce inflammation?
Yes, chlorzoxazone (Lorzone) helps relieve pain caused by muscle spasms. It won't help with pain caused by inflammation (swelling) or nerve damage.
What is chlorzoxazone similar to?
Are Chlorzoxazone and Robaxin the Same Thing? Chlorzoxazone and Robaxin (methocarbamol) are skeletal muscle relaxants indicated as adjuncts to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions and injuries.
Is chlorzoxazone anti-inflammatory?
CHLORZOXAZONE+IBUPROFEN+PARACETAMOL belongs to the class of drugs known as 'non-steroidal anti-inflammatory drug' (NSAID).
Is chlorzoxazone a sedative?
Chlorzoxazone is a benzoxazolone derivative with mild sedative and centrally-acting muscle relaxant activities.
What drugs interact with chlorzoxazone?
View interaction reports for chlorzoxazone and the medicines listed below.Adderall (amphetamine / dextroamphetamine)Ambien (zolpidem)Aspirin Low Strength (aspirin)Benadryl (diphenhydramine)Cymbalta (duloxetine)Fish Oil (omega-3 polyunsaturated fatty acids)Lexapro (escitalopram)Lipitor (atorvastatin)More items...
Does chlorzoxazone cause euphoria?
Most skeletal muscle relaxants (carisoprodol, cyclobenzaprine, chlorzoxazone, diazepam, methocardamol, and orphenadrine) function by significantly depressing the CNS. The effects of these compounds include sedation, relaxation, euphoria, and mood alteration.
How long does it take for chlorzoxazone to be excreted?
Less than one percent of a dose of Chlorzoxazone is excreted unchanged in the urine in 24 hours.
How does chlorzoxazone work?
The clinical result is a reduction of the skeletal muscle spasm with relief of pain and increased mobility of the involved muscles. Blood levels of Chlorzoxazone can be detected in people during the first 30 minutes and peak levels may be reached, in the majority of the subjects, in about 1 to 2 hours after oral administration of Chlorzoxazone. Chlorzoxazone is rapidly metabolized and is excreted in the urine, primarily in a conjugated form as the glucuronide. Less than one percent of a dose of Chlorzoxazone is excreted unchanged in the urine in 24 hours.
When should chlorzoxazone be discontinued?
Chlorzoxazone use should also be discontinued if a patient develops abnormal liver enzymes (e.g., AST, ALT, alkaline phosphatase and bilirubin).
Is chlorzoxazone safe for pregnancy?
Usage in Pregnancy. The safe use of Chlorzoxazone has not been established with respect to the possible adverse effects upon fetal development. Therefore, it should be used in women of childbearing potential only when, in the judgement of the physician, the potential benefits outweigh the possible risks.
Is chlorzoxazone soluble in water?
Chlorzoxazone USP is a white or practically white, practically odorless, crystalline powder. Chlorzoxazone is slightly soluble in water; sparingly soluble in alcohol, in isopropyl alcohol, and in methanol; soluble in solutions of alkali hydroxides and ammonia.
Does chlorzoxazone cause gastrointestinal bleeding?
Chlorzoxazone containing products are usually well tolerated. It is possible in rare instances that Chlorzoxazone may have been associated with gastrointestinal bleeding. Drowsiness, dizziness, light- headedness, malaise, or overstimulation may be noted by an occasional patient. Rarely, allergic-type skin rashes, petechiae, or ecchymoses may develop during treatment. Angioneurotic edema or anaphylactic reactions are extremely rare. There is no evidence that the drug will cause renal damage. Rarely, a patient may note discoloration of the urine resulting from a phenolic metabolite of Chlorzoxazone. This finding is of no known clinical significance.
Is chlorzoxazone a sedative?
Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
Missed Dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
What do I need to tell my doctor BEFORE I take this drug?
If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
What are some things I need to know or do while I take this drug?
Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
What are some other side effects of this drug?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
How is this drug best taken?
Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.
What do I do if I miss a dose?
If you take this drug on a regular basis, take a missed dose as soon as you think about it.
General drug facts
If your symptoms or health problems do not get better or if they become worse, call your doctor.
What to tell your doctor before taking chlorzoxazone?
Before taking chlorzoxazone, tell your doctor and pharmacist if you are allergic to chlorzoxazone or any other medications. tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially sedatives, sleeping pills, tranquilizers, and vitamins. tell your doctor if you have or have ever had liver disease. ...
What is chlorzoxazone used for?
Expand Section. Chlorzoxazone is used to relieve pain and stiffness caused by muscle strains and sprains. It is used in combination with physical therapy, analgesics (such as aspirin or acetaminophen), and rest.
What is the phone number to call for poison control?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Can chlorzoxazone make you drowsy?
you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you. ask your doctor about the safe use of alcohol during your treatment with chlorzoxazone. Alcohol can make the side effects of this medication worse.
Does chlorzoxazone cause red urine?
Chlorzoxazone may cause side effects. Your urine may turn purple or red; this effect is not harmful. Tell your doctor if any of these symptoms are severe or do not go away: upset stomach. drowsiness. dizziness. lightheadedness.
Can you get pregnant while taking chlorzoxazone?
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking chlorzoxazone, call your doctor . talk to your doctor about the risks and benefits of taking chlorzoxazone if you are 65 years of age or older.
Can you take chlorzoxazone more than once?
Take chlorzoxazone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
How long does it take for chlorzoxazone to peak?
Blood levels of chlorzoxazone can be detected in people during the first 30 minutes and peak levels may be reached, in the majority of the subjects, in about 1 to 2 hours after oral administration of chlorzoxazone.
How does chlorzoxazone work?
The clinical result is a reduction of the skeletal muscle spasm with relief of pain and increased mobility of the involved muscles. Blood levels of chlorzoxazone can be detected in people during the first 30 minutes and peak levels may be reached, in the majority of the subjects, in about 1 to 2 hours after oral administration of chlorzoxazone. Chlorzoxazone is rapidly metabolized and is excreted in the urine, primarily in a conjugated form as the glucuronide. Less than one percent of a dose of chlorzoxazone is excreted unchanged in the urine in 24 hours.
What is chlorzoxazone USP?
Chlorzoxazone USP is a centrally acting skeletal muscle relaxant, available as tablets of 500 mg for oral administration. Its chemical name is 5-Chloro-2-benzoxazolinone, and its structural formula is: Chlorzoxazone USP is a white or practically white, practically odorless, crystalline powder.
What temperature to store chlorzoxazone?
Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Dispense contents with a child-resistant closure ...
Is chlorzoxazone soluble in water?
Chlorzoxazone is slightly soluble in water; sparingly soluble in alcohol, in isopropyl alcohol, and in methanol; soluble in solutions of alkali hydroxides and ammonia. Chlorzoxazone tablets contain the inactive ingredients Docusate Sodium, Lactose (hydrous), Magnesium Stearate, Microcrystalline Cellulose, Pregelatinized Starch, Sodium Benzoate, ...
Is chlorzoxazone safe for pregnancy?
Usage in Pregnancy. The safe use of chlorzoxazone has not been established with respect to the possible adverse effects upon fetal development. Therefore, it should be used in women of childbearing potential only when, in the judgment of the physician, the potential benefits outweigh the possible risks.
Is chlorzoxazone a sedative?
Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties.
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
No information is available on the relationship of age to the effects of chlorzoxazone in the pediatric population. Safety and efficacy have not been established.
Geriatric
No information is available on the relationship of age to the effects of chlorzoxazone in geriatric patients. However, elderly patients are more likely to have age-related liver problems, which may require caution in patients receiving chlorzoxazone.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary.
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
GENERIC NAME: CHLORZOXAZONE - ORAL (klor-ZOX-a-zone)
USES: Chlorzoxazone is used to treat muscle spasms / pain. It is usually used along with rest, physical therapy, and other treatment. It works by helping to relax the muscles.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Chlorzoxazone - Clinical Pharmacology
Indications and Usage
- Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Chlorzoxazone does not directly relax tense skeletal muscles in man.
Warnings
- Serious (including fatal) hepatocellular toxicity has been reported rarely in patients receiving Chlorzoxazone. The mechanism is unknown but appears to be idiosyncratic and unpredictable. Factors predisposing patients to this rare event are not known. Patients should be instructed to report early signs and/or symptoms of hepatotoxicity such as fever, rash, anorexia, nausea, vomi…
Precautions
- Chlorzoxazone should be used with caution in patients with known allergies or with a history of allergic reactions to drugs. If a sensitivity reaction occurs such as urticaria, redness, or itching of the skin, the drug should be stopped. If any symptoms suggestive of liver dysfunction are observed, the drug should be discontinued.
Adverse Reactions
- Chlorzoxazone containing products are usually well tolerated. It is possible in rare instances that Chlorzoxazone may have been associated with gastrointestinal bleeding. Drowsiness, dizziness, light-headedness, malaise, or overstimulation may be noted by an occasional patient. Rarely, allergic-type skin rashes, petechiae, or ecchymoses may develop during treatment. Angioneuroti…
Overdosage
- Symptoms:Initially, gastrointestinal disturbances such as nausea, vomiting, or diarrhea together with drowsiness, dizziness, lightheadedness or headache may occur. Early in the course there may be malaise or sluggishness followed by marked loss of muscle tone, making voluntary movement impossible. The deep tendon reflexes may be decreased or absent. The sensorium r…
Dosage and Administration
- Usual Adult Dosage Chlorzoxazone tablets 375 mg: One tablet three or four times daily. If adequate response is not obtained with this dose, the 375 mg tablets may be increased to two tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced. Chlorzoxazone tablets 500 mg: One tablet three or four times daily. If adequate respon…
How Is Chlorzoxazone Supplied
- Chlorzoxazone tablets, USP are supplied as follows: 375 mg White to off white capsule shaped tablet, debossed ‘126’ on one side and plain on other side. Bottle of 100 tablets with child-resistant closure, NDC 16571-725-01 Bottle of 500 tablets with continuous thread (CT) closure, NDC 16571-725-50 500 mg White to off white capsule shaped tablet, debossed with a break line between “1 …
Package LABEL.PRINCIPAL Display Panel
- Rising® NDC 16571-725-01 Chlorzoxazone Tablets, USP 375 mg 100 Tablets Rx only Rising® NDC 16571-726-01 Chlorzoxazone Tablets, USP 500 mg 100 Tablets Rx only Rising® NDC 16571-727-01 Chlorzoxazone Tablets, USP 750 mg 100 Tablets Rx only Medical Disclaimer