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how much aspirin can i take with plavix

by Irwin Blick Published 2 years ago Updated 1 year ago
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If you’re taking Plavix and aspirin together, talk to your healthcare provider and make sure you know exactly how long to continue treatment. The typical dosage of Plavix, which is only available by prescription, is 75 mg once daily. And the typical recommended dosage of aspirin, which is available over the counter, is 81 mg once daily.

Given that the existing body of evidence supports the comparable efficacy and, particularly, superior safety of lower versus higher doses of aspirin, aspirin 81 mg should be the dose used in combination with clopidogrel.

Full Answer

How should I take Plavix?

May be taken with or without food. Take exactly as prescribed and do not discontinue except on a doctor's advice. Plavix is often taken in conjunction with aspirin. Your doctor will advise you if you need to take aspirin as well. Do not take omeprazole or esomeprazole while taking Plavix as these will reduce its activity.

Can you take aspirin and Plavix together?

Take exactly as prescribed and do not discontinue except on a doctor's advice. Plavix is often taken in conjunction with aspirin. Your doctor will advise you if you need to take aspirin as well. Do not take omeprazole or esomeprazole while taking Plavix as these will reduce its activity.

How long does aspirin and clopidogrel (Plavix) work together?

In all, more than 2,700 Korean patients were randomly assigned to receive clopidogrel (Plavix) plus aspirin for at least 12 months. Patients were followed for a median of just over 19 months. Not only were there few differences between the two groups, there was even a sign of benefit in the group taking aspirin alone after 12 months.

Can Plavix help prevent a heart attack?

Aspirin’s ability to prevent heart attacks in men is legendary but it does little for their risk of stroke. In women, aspirin wards off strokes but only reduces heart attack risk in those 65 or older. Adding Plavix to aspirin for people being treated for a heart attack cuts their risk of a second one or death.

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Should Plavix and aspirin be taken at the same time of day?

Platelet aggregation induced by two inducers was significantly higher at 10:00 in day-time group compared to values in night-time group (all P < 0.05). Conclusion: Taking aspirin and clopidogrel at 20:00 was superior to taking the same medications at 8:00 for inhibiting peak platelet aggregation in the morning.

When Should aspirin and Plavix be taken together?

The combination of aspirin and clopidogrel is not recommended for routine use for any longer than 12 months after the acute phase of myocardial infarction (MI), unless there are other indications to continue dual antiplatelet therapy, and the combination is usually recommended for a shorter duration after an ST-segment ...

How much aspirin can I take with clopidogrel?

Do not take aspirin for pain relief (300mg tablets) or ibuprofen while you're taking clopidogrel, unless a doctor has said it's OK. They increase the chance of bleeding. You can take paracetamol together with clopidogrel.

Can Plavix and aspirin be taken together?

Aspirin combined with clopidogrel has been shown to decrease the risk of cardiovascular events in patients at higher risk of cardiovascular disease, as well as in those with acute coronary syndrome.

How long do you take clopidogrel after a stent?

Background: American and European cardiology societies recommend six to 12 months of dual-antiplatelet therapy with aspirin and clopidogrel (Plavix) after drug-eluting stent placement to prevent late stent thrombosis.

Can you still have a stroke while on Plavix?

Summary: The anti-blood clot regimen that adds the drug clopidogrel (Plavix) to aspirin treatment is unlikely to prevent recurrent strokes and may increase the risk of bleeding and death in patients with subcortical stroke, according to new research.

Why is Plavix taken with aspirin?

However, they act in different ways, and just because you take one doesn't mean you shouldn't take the others. Aspirin and clopidogrel (Plavix) help stop platelets from clumping together inside your arteries. This reduces the chances that an artery-closing clot will develop on or near your stent.

Is it better to take Plavix in the morning or at night?

You can take clopidogrel at whatever time of day you find easiest to remember, but take your doses at the same time of day each day. Most people prefer to take it in the morning, as they find this helps them to remember to take it regularly. You can take the tablet either before or after a meal.

Which is safer aspirin or clopidogrel?

The CAPRIE trial reported that patients treated with clopidogrel had lower risk of composite vascular events (ischemic stroke, AMI, or death) than aspirin (5.32% vs 5.83%), with a relative risk reduction (RRR) of 8.7% in favor of clopidogrel (95% CI = 0.3–16.5, p 0.043).

Which causes more bleeding aspirin or Plavix?

In patients with ischemic stroke, clopidogrel was not superior to aspirin for preventing either mortality or recurrent stroke according to real‐world data, even though clinical trials have suggested that clopidogrel users have fewer major bleeding events than aspirin users.

What drugs should not be taken with Plavix?

Several other drugs also block CYP 2C19 and should be avoided. These include two antidepressants: fluoxetine (Prozac, Sarafem, and generic) and fluvoxamine; three anti-fungal drugs: fluconazole, ketoconazole, voriconazole; the blood thinner, ticlopidine; the epilepsy drug, felbamate; and the HIV drug, etravirine.

Does aspirin and Plavix do the same thing?

Aspirin and Plavix (clopidogrel bisulfate) are used to prevent blood clots, and to reduce the risk of strokes and heart attacks. Aspirin is also used to treat fever, pain, and inflammation in the body. Plavix is also used to treat patients with acute coronary syndrome and peripheral vascular disease.

Why do doctors prescribe Plavix and aspirin together?

The combination of Plavix and aspirin is called dual antiplatelet therapy. This is because both drugs work to stop your platelets from sticking together and forming dangerous clots. Several studies have shown a benefit to using these drugs together rather than taking either of the drugs alone.

Can I take Plavix without aspirin?

In patients receiving oral anticoagulants and undergoing percutaneous coronary intervention (PCI), use of clopidogrel without aspirin was found to be associated with a significant reduction in bleeding complications and no increase in the rate of thrombotic events, according to a study published on Feb.

Is it better to take clopidogrel at night?

You can take clopidogrel at whatever time of day you find easiest to remember, but take your doses at the same time of day each day. Most people prefer to take it in the morning, as they find this helps them to remember to take it regularly.

What foods should be avoided when taking Plavix?

Foods to avoid when taking heart medicationsAsparagus.Broccoli.Brussels sprouts.Cauliflower.Green onions.Kale.Parsley.Spinach.

Answers

While you are taking clopidogrel, do not take aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) without your doctor's advice.

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What is the best medicine for a stent?

Aspirin and clopidogrel (Plavix) help stop platelets from clumping together inside your arteries. This reduces the chances that an artery-closing clot will develop on or near your stent. Warfarin ( Coumadin) blocks vitamin K, a key player in the blood clotting cascade.

Does Harvard Health Publishing have archived content?

As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.

How much aspirin is in a baby?

The typical baby aspirin is 81 mg , and an adult tablet is 325 mg. In an earlier report, the combination treatment was found to be superior to aspirin alone, regardless of the aspirin dose given. Continued. In this new study, higher doses of aspirin were no more effective than low-dose aspirin therapy at preventing heart attacks and strokes.

Is aspirin safe for bleeding?

AHA spokesman Sidney C. Smith, MD, agrees that the studies to date suggest that low-dose aspirin therapy is just as effective as higher-dose treatment and probably safer.

Does aspirin cause strokes?

Researchers compared three different daily aspirin therapy doses and found a similar frequency of heart attacks and strokes among patients taking each of them. But those taking the highest doses -- equivalent to roughly an adult-strength tablet every day -- were at much greater risk for developing bleeding complications. The findings are in the Oct. 7 issue of the American Heart Association (AHA) journal Circulation.

What medications interact with Plavix?

Speak to your doctor about how drug interactions should be managed. Common medications that may interact with Plavix include: amiodarone. apixaban. bupropion. calcium channel blockers. corticosteroids, such as prednisone and methylprednisone. dabigatran.

How long does it take for Plavix to work?

Can be administered as a loading dose (a bigger than normal, one-off dose) if an antiplatelet effect is needed within hours. Otherwise, it takes several days for the full antiplatelet effect of Plavix to develop with usual dosages. The dosage of Plavix does not need adjusting in people with liver disease.

How long does Plavix last?

Even though the active form of Plavix doesn't last for very long in the body, its effect on platelets lasts for the lifetime of the platelet (7 to 10 days).

What is Plavix used for?

2. Upsides. Plavix may be used for the treatment of unstable angina and for certain types of heart attack (myocardial infarction) to reduce the risk of stroke or heart attack.

What enzymes are involved in Plavix?

Plavix undergoes activation in the liver, through CYP2C19 hepatic enzymes . Some people have defective CYP2C19 enzymes which means they make less active drug from clopidogrel, and its antiplatelet effect is reduced (these people are termed poor metabolizers).

What is the name of the drug that inhibits platelets from clumping together?

Plavix: 7 things you should know. Medically reviewed by Carmen Fookes, BPharm. Last updated on Oct 7, 2020. 1. How it works. Plavix is a brand (trade) name for clopidogrel. Clopidogrel inhibits the way platelets (a component of blood) clump together (aggregate) to form clots. Its activity is thought to be due to its active metabolite, ...

What is the TPP in Plavix?

May cause a condition called Thrombotic Thrombocytopenic Purpura (TPP) - a blood disorder where blood clots form in the small blood vessels of the body. This can occur anytime during Plavix therapy, even after a short exposure (less than 2 weeks). Some people may not be as responsive to Plavix as others.

What are the NSAIDs?

NSAIDs include ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Cataflam, Voltaren), indomethacin (Indocin), meloxicam (Mobic), and others. Sorry about that Dzoo, and just in time as my life's love is on plavix ... whew!

Can you mix prescription drugs over the counter?

Always talk to your doctor or pharmacist before mixing any kind of prescription, natural products and over the counter drugs. Better to be safe than sorry and even though you may feel fine does not mean you are not causing long term damage...

Does Plavix work for Advil?

A friend of mine also takes Plavix, and that's what she takes, Advil. It works for her with no side effects at all.

Can you take Aleve with plavix?

Do not take Aleve or Naprosyn with plavix. It will increase the possibility of stomach bleeding.

What is the best treatment for DES implants?

The recommended treatment for DES implants is dual therapy of aspirin and plavix up to a year. Combining plavix and aspirin increases the risk of bleeding vs. aspirin alone in patients treated for more than a brief period of time. That is the regimen followed for my DES implant. f you are in this category a prior MI and unstable angina:" In the CAPRIE trial, clopidogrel (plavix) was equivalent to aspirin for patients with a recent (but not acute) MI.

Is a stent better than a plavix?

This is why both are important. So even on both plavix and aspirin, you are only protected against clots, it offers no extra benefits against scar tissue or plaque formation. When a stent is inserted, the plaque is pushed into the artery wall, damaging it further. A normal artery lining is smoother than glass under a microscope, but a stent is very rough in texture, offering a great area for platelets to become active and form a clot.

Can you take aspirin and plavix for open heart surgery?

The contrast is quite amazing when open heart surgery is given to patients who have taken their daily dosage of both aspirin / plavix and very often clexane on top. It makes one wonder how they heal.

Does plavix increase clotting factor?

They should be taking blood tests to make sure her clotting factor is as required. I assume she is on aspirin daily also? Aspirin is for life, but once plavix is eventually stopped, the clotting factor does increase. I have noticed no real problems on plavix. I think the only problem comes if you require further surgery. Stenting is fine with plavix, they gave me 600mg before my last angioplasty.

Can you take aspirin with Plavix?

Sometimes aspirin is used in place of the Plavix, and the patient will be on aspirin and warfarin. That type of combo regimen is used when the doctor doesn't think that one drug alone is enough to do the job, and one drug obviously wasn't enough in your case. It seems that your Plavix and warfarin regimen is working, so I'll join you in giving thanks for that.

How long did Korean patients take clopidogrel?

In all, more than 2,700 Korean patients were randomly assigned to receive clopidogrel (Plavix) plus aspirin for at least 12 months. Patients were followed for a median of just over 19 months. Not only were there few differences between the two groups, there was even a sign of benefit in the group taking aspirin alone after 12 months.

Is bleeding a concern with blood thinners?

Nor were bleeding complications, always a concern with blood-thinning medications, any different between the two groups.

Is Plavix a clotbuster?

Plavix has long been the leader in clot-busting drugs, although new agents are now vying to take its place.

Can you give aspirin with Plavix?

MONDAY, March 15 (HealthDay News) -- After 12 months, giving aspirin alone to patients who have had stents implanted seems just as good as giving aspirin along with the blood thinner Plavix, a new study finds. Researchers discovered that, after an initial year receiving the dual anti-clotting therapy, patients who went off Plavix ...

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How It Works

Upsides

  1. Plavix may be used for the treatment of unstable angina and for certain types of heart attack (myocardial infarction) to reduce the risk of stroke or heart attack. Plavix should be administered in...
  2. May also be given to people with established peripheral arterial disease or with a recent history of heart attacks or stroke to reduce the risk of a further heart attack or stroke.
  1. Plavix may be used for the treatment of unstable angina and for certain types of heart attack (myocardial infarction) to reduce the risk of stroke or heart attack. Plavix should be administered in...
  2. May also be given to people with established peripheral arterial disease or with a recent history of heart attacks or stroke to reduce the risk of a further heart attack or stroke.
  3. Can be administered as a loading dose (a bigger than normal, one-off dose) if an antiplatelet effect is needed within hours. Otherwise, it takes several days for the full antiplatelet effect of Pla...
  4. The dosage of Plavix does not need adjusting in people with liver disease.

Downsides

  • If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: 1. An increased risk of bleeding from any wound, nosebleeds, blood in the urine, and an increased likelihood of bruising are the most commonly reported side effects. The risk of this side effect is increased when Plavix is tak…
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Bottom Line

  • Plavix may be given to reduce the risk of a heart attack or stroke in certain cardiovascular conditions or following a heart attack or ischemic stroke. People who are poor metabolizers at CYP2C19 may not respond very well to Plavix. Bleeding is the main side effect of Plavix.
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Tips

  1. May be taken with or without food.
  2. Take exactly as prescribed and do not discontinue except on a doctor's advice.
  3. Plavix is often taken in conjunction with aspirin. Your doctor will advise you if you need to take aspirin as well.
  4. Do not take omeprazole or esomeprazole while taking Plavix as these will reduce its activity. …
  1. May be taken with or without food.
  2. Take exactly as prescribed and do not discontinue except on a doctor's advice.
  3. Plavix is often taken in conjunction with aspirin. Your doctor will advise you if you need to take aspirin as well.
  4. Do not take omeprazole or esomeprazole while taking Plavix as these will reduce its activity. Talk to a pharmacist or your doctor before buying any over-the-counter medicine to check if it is compa...

Response and Effectiveness

  1. Plavix is rapidly absorbed but has to undergo metabolism via CYP2C19 enzymes in the liver to its active form. People who are poor metabolizers at CYP2C19 will have a poor response to Plavix.
  2. Even though the active form of Plavix doesn't last for very long in the body, its effect on platelets lasts for the lifetime of the platelet (7 to 10 days). Some inhibition of platelet clottin…
  1. Plavix is rapidly absorbed but has to undergo metabolism via CYP2C19 enzymes in the liver to its active form. People who are poor metabolizers at CYP2C19 will have a poor response to Plavix.
  2. Even though the active form of Plavix doesn't last for very long in the body, its effect on platelets lasts for the lifetime of the platelet (7 to 10 days). Some inhibition of platelet clotting is...
  3. In the event that the antiplatelet effect of Plavix needs to be reversed, platelet transfusions may be administered. However, these are less effective if given within 4 hours of a loading dose or w...

Interactions

  • Medicines that interact with Plavix may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with Plavix. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed. Com…
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References

  • Plavix (clopidogrel) [Package Insert]. Revised: 03/2021. sanofi-aventis U.S. LLC https://www.drugs.com/pro/plavix.html
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Further Information

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Plavix only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Copyright 1996-2022 Drugs.com. Revision date: November 3, 2021. Medical Dis…
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1.Plavix plus aspirin a risky combination - NBC News

Url:https://www.nbcnews.com/health/health-news/plavix-plus-aspirin-risky-combination-flna1C9465878

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9.How Long Do People Typically Take Plavix (Clopidogrel)?

Url:https://www.goodrx.com/clopidogrel/how-long-do-i-have-to-take-plavix-clopidogrel

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