| Quantity | Per unit | Price |
|---|---|---|
| 250 (25 x 10 milliliters) | $1.49 | $373.39 |
Precautions
Nitroglycerin Injection is supplied in 5 mg/mL solution. A dilution and administration scheme for Nitroglycerin Injection is shown in Table 1 below. Each mL of Nitroglycerin Injection contains 5 mg of nitroglycerin. Total Contents: Each 10 mL vial contains 50 mg of nitroglycerin.
How many mg of nitroglycerin is in a 5 ml injection?
Nitroglycerin IV is available under the following different brand names: Glyceryl trinitrate IV, IV Nitroglycerin, NitroBid IV, NTG, Tridil What Are Dosages of Nitroglycerin IV? Increase by 5 mcg/min every 3-5 min up to 20 mcg/min, then increase by 10 mcg/min. What Are Side Effects Associated with Using Nitroglycerin IV?
What are the different types of nitroglycerin IV?
Brand names for nitroglycerin include Nitrostat, Nitro-Dur, Minitran, and NitroMist. This nitroglycerin price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies. The cost for nitroglycerin intravenous solution (5 mg/mL) is around $309 for a supply of 250 milliliters, depending on the pharmacy you visit.
How much does nitroglycerin cost?
Nitroglycerin via a sublingual spray, which is given with 1 spray equivalent to .4 mg in metered doses. This, too, can be repeated in 5 minute intervals to a maximum of three sprays Nitroglycerin can be administered via IV and may increase to 10 mcg/min every 3 to 5 minutes until desired effect is reached
How do you administer nitroglycerin?
What is the cost of nitroglycerin?
Nitroglycerin dilates or widens blood vessels allowing more blood to flow to the heart. The retail price of Nitroglycerin is usually $33.55 for 1, 25 Tablets Sublingual Tablet Sublingual, but a SingleCare Nitroglycerin coupon reduces Nitroglycerin price to $2.49 for 1, 25 Tablets Sublingual Bottle.
Can nitroglycerin be given IV?
In a controlled setting, such as during surgery, IV nitroglycerin can be used to produce hypotension. Nitrate therapy can worsen angina due to hypertrophic cardiomyopathy. Sublingual nitroglycerin tablets are contraindicated for use in patients with acute myocardial infarction (MI).
When do you give IV nitroglycerin?
Nitroglycerin injection is used to treat hypertension (high blood pressure) during surgery or to control congestive heart failure in patients who have had a heart attack. It may also be used to produce hypotension (low blood pressure) during surgery.
How much does nitroglycerin gel cost?
NITROGLYCERIN is a type of vasodilator that can decrease pressure within the anus. It is used to treat moderate to severe pain caused by a tear in the skin lining the anal canal. The lowest GoodRx price for the most common version of Rectiv is around $637.35, 17% off the average retail price of $773.87.
Why is nitroglycerin IV used?
Nitroglycerin injection is used to treat hypertension (high blood pressure) during surgery or to control congestive heart failure in patients who have had a heart attack. It may also be used to produce hypotension (low blood pressure) during surgery.
How is IV nitroglycerin administered?
Dosage and Administration Nitroglycerin in 5% Dextrose Injection is intended for intravenous administration using sterile equipment. Administer Nitroglycerin in 5% Dextrose Injection only via an infusion pump that can maintain a constant infusion rate.
What are the side effects of IV nitroglycerin?
AdvertisementBluish-colored lips, fingernails, or palms.difficulty with breathing.dizziness or lightheadedness.headache.rapid heart rate.sore throat.unusual tiredness or weakness.
What is the maximum doses of nitroglycerin?
Adults—1 or 2 packets placed under the tongue at the first sign of an angina attack. 1 packet may be used every 5 minutes as needed, for up to 15 minutes. Do not take more than 3 packets in 15 minutes. Children—Use and dose must be determined by your doctor.
What is the most serious side effect of nitroglycerin?
Many people using this medication do not have serious side effects. Tell your doctor right away if any of these unlikely but serious side effects occur: fainting, fast/irregular/pounding heartbeat. A very serious allergic reaction to this drug is rare.
How much does nitroglycerin cost without insurance?
The cost for nitroglycerin sublingual spray 0.4 mg is around $93 for a supply of 4.9 grams, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
Can you buy nitroglycerin gel over the counter?
Is Rectiv (nitroglycerin) available over-the-counter? Rectiv (nitroglycerin) requires a prescription from your healthcare provider. There are limited over-the-counter options to help with anal fissures, although you might want to consider something with lidocaine to help with the pain.
Is nitroglycerin ointment sold over the counter?
Nitroglycerin belongs to the group of medicines called nitrates. It works to relax the muscles around the anus so there is less pressure in the area. This medicine is available only with your doctor's prescription.
Is Nitro compatible with normal saline?
Compatible with both Normal Saline and D5W. Piggy back nitro infusion–never give directly into main line. 4.
What IV tubing is used for nitroglycerin?
Abstract. Nitroglycerin is absorbed in vitro into polyvinyl chloride tubing, and it has been recommended that nitroglycerin be administered intravenously through specialized polyethylene infusion sets.
How do you make a nitroglycerin infusion?
Initial Dilution: Aseptically transfer the desired amount of Nitroglycerin Injection, USP (as noted in the table below) into a glass I.V. bottle containing the stated volume of 5% Dextrose Injection, USP or 0.9% Sodium Chloride Injection, USP and mix well. This yields a final concentration of 50 mcg/mL to 400 mcg/mL.
How long is nitroglycerin IV stable?
The concentration of NTG in the i.v. solutions was determined spectrophotometrically. Nitroglycerin was found to be stable for at least 70 days when stored in glass containers, regardless of source, diluent (5% dextrose in water or normal saline) and storage temperature.
What is the name of the brand of Nitroglycerin?
Brand names for nitroglycerin include Nitrostat, Nitro-Dur, NitroMist, and Nitro-Time .
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
When there is a range of pricing, should consumers expect to pay the lower price?
Important: When there is a range of pricing, consumers should normally expect to pay the lower price. However, due to stock shortages and other unknown variables we cannot provide any guarantee.
Is Nitroglycerin a valid insurance?
Prices are for cash paying customers only and are not valid with insurance plans. This nitroglycerin price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
How much nitroglycerin is in a bottle?
Aseptically transfer the contents of one nitroglycerin vial (containing 25 mg or 50 mg of nitroglycerin) into a 500 mL glass bottle of either Dextrose (5%) Injection or Sodium Chloride Injection (0.9%). This yields a final concentration of 50 mcg/mL or 100 mcg/mL. Diluting 5 mg nitroglycerin into 100 mL will also yield a final concentration of 50 mcg/mL.
What is nitroglycerin injection?
Nitroglycerin Injection is indicated for treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction;for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and b-blockers; and for induction of intraoperative hypotension.
Why use non-PVC tubing for nitroglycerin injection?
Because of the problem of nitroglycerin absorption by polyvinyl chloride (PVC ) tubing, Nitroglycerin Injection should be used with the least absorptive infusion tubing (i.e., non-PVC tubing) available.
Can nitroglycerin be mixed with heparin?
More generally, nitroglycerin in 5% dextrose or so dium chloride 0.9% should not be mixed with any other medication of any kind. Intravenous nitroglycerin interferes, at least in some patients, with the anticoagulant effect of heparin.
Does nitroglycerin migrate into plastic?
Nitroglycerin readily migrates into many plastics, including the polyvinyl chloride (PVC) plastics commonly used for intravenous administration sets. Nitroglycerin absorption by PVC tubing is increased when the tubing is long, the flow rates are low, and the nitroglycerin concentration of the solution is high.
Does nitroglycerin increase fluid volume?
Lower concentrations of nitroglycerin increase the potential precision of dosing, but these concentrations increase the total fluid volume that must be delivered to the patient. Total fluid load may be a dominant consideration in patients with compromised function of the heart, liver, and/or kidneys.
Can you get allergic to nitrates?
Allergic reactions to organic nitrates are extremely rare, but they do occur. Nitroglycerin Injection is contraindicated in patients who are allergic to it. In patients with pericardial tamponade, restrictive cardiomyopathy, or constrictive pericarditis, cardiac output is dependent upon venous return.
What is nitroglycerin injection?
Nitroglycerin injection is used to treat hypertension (high blood pressure) during surgery or to control congestive heart failure in patients who have had a heart attack. It may also be used to produce hypotension (low blood pressure) during surgery. Nitroglycerin injection is sometimes used to treat angina (chest pain) in patients who have been treated with other medicines that did not work well.
How does nitroglycerin work?
It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its work load.
What is nitroglycerin injection?
Nitroglycerin injection is used to treat hypertension (high blood pressure) during surgery or to control congestive heart failure in patients who have had a heart attack. It may also be used to produce hypotension (low blood pressure) during surgery. Nitroglycerin injection is sometimes used to treat angina (chest pain) in patients who have been treated with other medicines that did not work well.
How does nitroglycerin work?
It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its work load. Nitroglycerin is to be given only by or under the direct supervision of your doctor.
Can you take riociguat with nitroglycerin?
Do not take riociguat (Adempas®), sildenafil (Viagra®), tadalafil (Cialis®), or vardenafil (Levitra®) while you are using nitroglycerin. Using these medicines together may cause blurred vision, dizziness, lightheadedness, or fainting.
What are the medical problems with nitroglycerin?
Make sure you tell your doctor if you have any other medical problems, especially: Allergy to corn or corn products or. Constrictive pericarditis (a heart disease) or. Pericardial tamponade (a heart disease) or.
Can you take nitroglycerin with tadalafil?
Tadalafil. Vardenafil. Using nitroglycerin with any of the following medicines is usually not recommended , but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Alteplase, Recombinant.
Is nitroglycerin safe for children?
Appropriate studies have not been performed on the relationship of age to the effects of nitroglycerin injection in the pediatric population. Safety and efficacy have not been established.
Does nitroglycerin cause headaches?
Nitroglycerin may cause headaches. These headaches are a sign that the medicine is working. If you have severe pain, talk with your doctor.
How much nitroglycerin is in a tablet?
Generic nitroglycerin comes in the form of a sublingual tablet. The strengths of these tablets are 0.3 mg, 0.4 mg, and 0.6 mg.
What are the side effects of nitroglycerin?
Severe side effects that healthcare professionals associate with a nitroglycerin overdose include: a sudden drop in blood pressure. increased heart rate. increased blood flow and pressure in the brain.
Why do doctors use nitroglycerin?
Uses. Doctors usually use nitroglycerin to treat the pain that angina causes. Narrowing of the arteries that supply the heart with blood is what causes unstable angina. Doctors call this condition coronary artery disease (CAD). CAD is the most common type of heart disease. More than 370,000 people.
Why do people take nitroglycerin?
People often use the drug nitroglycerin to relieve chest pain that angina causes . Most often, the reason for the decrease in blood flow is plaque formation and narrowing of the arteries supplying blood to the heart. Nitroglycerin helps to open up the blood vessels and allow blood to flow. People also use nitroglycerin to treat chronic anal fissures.
What is the best medicine for angina?
Doctors usually use nitroglycerin to treat the pain associated with angina.
How long before an activity can you take nitroglycerin?
People can also take fast-acting nitroglycerin formulations 5 to 10 minutes before doing an activity that may cause an angina attack.
Where to put nitroglycerin patch?
A person places the patch on their skin anywhere except the areas below the knee and elbow. Most people place the patch on their chest. The area should be clean, dry, and hairless to allow the nitroglycerin to absorb across the skin.
Where was nitroglycerin made?
This amount required at least 336 tonnes of nitroglycerin per week (assuming no losses in production). The Royal Navy had its own factory at the Royal Navy Cordite Factory, Holton Heath, in Dorset, England. A large cordite factory was also built in Canada during World War I. The Canadian Explosives Limited cordite factory at Nobel, Ontario, was designed to produce 1,500,000 lb (680 t) of cordite per month, requiring about 286 tonnes of nitroglycerin per month.
How hot is nitroglycerin?
Early in its history, liquid nitroglycerin was found to be " desensitized " by freezing it, at a temperature below 45 to 55 °F (7 to 13 °C) depending on its purity.
Why was nitroglycerin banned in California?
In April 1866, three crates of nitroglycerin were shipped to California for the Central Pacific Railroad, which planned to experiment with it as a blasting explosive to expedite the construction of the 1,659-foot-long (506 m) Summit Tunnel through the Sierra Nevada Mountains. One of the crates exploded, destroying a Wells Fargo company office in San Francisco and killing 15 people. This led to a complete ban on the transportation of liquid nitroglycerin in California. The on-site manufacture of nitroglycerin was thus required for the remaining hard-rock drilling and blasting required for the completion of the First Transcontinental Railroad in North America.
What happened to the nitroglycerin wagons?
In June 1869, two one-ton wagons loaded with nitroglycerin, then known locally as Powder-Oil, exploded in the road at the North Wales village of Cwm-y-glo. The explosion led to the loss of six lives, many injuries and much damage to the village. Little trace was found of the two horses. The UK Government was so alarmed at the damage caused and what could have happened in a city location (these two tons were part of a larger load coming from Germany via Liverpool) that they soon passed The Nitro-Glycerine Act of 1869. Liquid nitroglycerin was widely banned elsewhere, as well, and these legal restrictions led to Alfred Nobel and his company's developing dynamite in 1867. This was made by mixing nitroglycerin with diatomaceous earth (" Kieselguhr " in German) found in the Krümmel hills. Similar mixtures, such as "dualine" (1867), "lithofracteur" (1869), and " gelignite " (1875), were formed by mixing nitroglycerin with other inert absorbents, and many combinations were tried by other companies in attempts to get around Nobel's tightly held patents for dynamite.
How does nitroglycerin deflagrate?
Nitroglycerin and any diluents can certainly deflagrate (burn). The explosive power of nitroglycerin derives from detonation: energy from the initial decomposition causes a strong pressure wave that detonates the surrounding fuel. This is a self-sustained shock wave that propagates through the explosive medium at 30 times the speed of sound as a near-instantaneous pressure-induced decomposition of the fuel into a white-hot gas. Detonation of nitroglycerin generates gases that would occupy more than 1,200 times the original volume at ordinary room temperature and pressure. The heat liberated raises the temperature to about 5,000 °C (9,000 °F). This is entirely different from deflagration, which depends solely upon available fuel regardless of pressure or shock. The decomposition results in much higher ratio of energy to gas moles released compared to other explosives, making it one of the hottest detonating high explosives .
How to desensitize nitroglycerin?
Early in its history, liquid nitroglycerin was found to be " desensitized " by freezing it, at a temperature below 45 to 55 °F (7 to 13 °C) depending on its purity. Its sensitivity to shock while frozen is somewhat unpredictable: "It is more insensitive to the shock from a fulminate cap or a rifle ball when in that condition but on the other hand it appears to be more liable to explode on breaking, crushing, tamping, etc." Frozen nitroglycerine is much less energetic than liquid, and so must be thawed before use. Thawing it out can be extremely sensitizing, especially if impurities are present or the warming is too rapid. Ethylene glycol dinitrate or another polynitrate may be added to lower the melting and thereby avoid the necessity of thawing frozen explosive.
What is nitrocellulose powder used for?
Nitroglycerin has been used for over 130 years in medicine as a potent vasodilator (dilation of the vascular system) to treat heart conditions, such as angina pectoris and chronic heart failure.
How many times can you take nitroglycerin?
Nitroglycerin via a sublingual spray, which is given with 1 spray equivalent to .4 mg in metered doses. This, too, can be repeated in 5 minute intervals to a maximum of three sprays. Nitroglycerin can be administered via IV and may increase to 10 mcg/min every 3 to 5 minutes until desired effect is reached.
What are the effects of nitroglycerin?
The Effects of Nitroglycerin: Nitroglycerin, a nitrate, causes smooth muscle relaxation. This produces systemic venous pooling of blood through the action of vasodilation. This, in turn, decreases venous blood flow return to the heart and reduces preload as well as venous afterload.
What is nitroglycerin used for?
Nitroglycerin is indicated to relieve chest discomfort suspected to be the result of an acute myocardial infarction (AMI). It can also relieve cardiogenic pulmonary edema related to left-side heart failure.
Is nitroglycerin contraindicated for right ventricular infarction?
Nitroglycerin Precautions & Contraindications: Nitroglycerin is not indicated or may even be contraindicated if the patient is suffering from: Low systolic blood pressure of less than 90 mm/Hg. Right-sided ventricular infarction. Use of tadalafil (sometimes better known as brand names Cialis or Adcirca) within the past 48 hours.
Can nitroglycerin cause hypotension?
When the patient is taking a phosphodiesterase type 5 inhibitor (a class of medications including Sildenafil) within the past 24 hours, nitroglycerin could cause severe hypotensive side effects. It is important to gather a thorough medication list from the patient to avoid these serious contraindications.
How much Nitroglycerin should be in a nitroglycerin infusion?
The concentration of the infusion solution should not exceed 400 mcg/mL of nitroglycerin. See chart.
How long is nitroglycerin stable?
Stability: Source [ Lexi-drugs]: "Nitroglycerin diluted in D5W or NS in glass containers is physically and chemically stable for 48 hours at room temperature and 7 days under refrigeration; in D5W or NS in Excell®/PAB® containers is physically and chemically stable for 24 hours at room temperature and 14 days under refrigeration"
How many microdrops/mL is a peristaltic action infusion pump?
If a peristaltic action infusion pump is used, an appropriate administration set should be selected with a drip chamber that delivers approximately 60 microdrops/mL. The dilution and administration tables below may be used to calculate the nitroglycerin dilution and flow rate in microdrops/minute to achieve the desired nitroglycerin injection administration rate.
Why invert a parenteral bottle?
Invert the glass parenteral bottle several times to assure uniform dilution of nitroglycerin.
When should parenteral drug products be inspected?
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Discard unused portion.
Is there a fixed nitroglycerin dose?
There is no fixed optimum dose of nitroglycerin. Due to variations in the responsiveness of individual patients to the drug, each patient must be titrated to the desired level of hemodynamic function. Therefore, continuous monitoring of physiologic parameters (i.e., blood pressure and heart rate in all patients, other measurements such as pulmonary capillary wedge pressure, as appropriate) MUST be performed to achieve the correct dose. Adequate systemic blood pressure and coronary perfusion pressure must be maintained.
Can a volumetric infusion pump be used to determine flow rate?
If a volumetric infusion pump is used, the dilution and administration table below may still be used; however, flow rate will be determined directly by the infusion pump independent of the drop size of the drop chambers. Thus, the reference to “microdrops/min” is not applicable, and the corresponding flow rate in the mL/hr should be used to determine pump settings.
Description
This medication is used to relieve chest pain (angina) in people that have a certain heart condition (coronary artery disease). It may also be used before physical activities (such as exercise, sexual activity) to help prevent chest pain.
May Treat: Acute myocardial infarction · Acute episode of anginal pain · Anal fissure · Induction of intraoperative hypotension · Left ventricular dysfunction following MI and more
Brand Names: Nitrolingual · Nitrostat · Minitran · Nitro-Dur · Nitro-Bid and more
Drug Class: Anal Fissure Pain/Treatment Agents - Nitrates · Antianginal - Coronary Vasodilators (Nitrates)
Availability: Prescription Required
Pregnancy: Consult a doctor before using
May Treat: Acute myocardial infarction · Acute episode of anginal pain · Anal fissure · Induction of intraoperative hypotension · Left ventricular dysfunction following MI and more
Brand Names: Nitrolingual · Nitrostat · Minitran · Nitro-Dur · Nitro-Bid and more
Drug Class: Anal Fissure Pain/Treatment Agents - Nitrates · Antianginal - Coronary Vasodilators (Nitrates)
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
Alcohol: Limit intake while taking this medication
Driving: May cause drowsiness or dizziness. Use caution
- Tell Dr. of all drugs as some drugs may interact
- Be careful not to stand up too quickly
- Limit its use
- Tell Dr. of all drugs as some drugs may interact
- Be careful not to stand up too quickly
- Limit its use
- Do not swallow whole or chew
- For aerosol, spray products : Get exact instructions for use from MD. If available, read the patient package insert. Do not shake the container. Spray onto or under the tongue. Do not inhale. Use at first sign of chest pain. After 1st dose, call 911 if pain is not improved. Caution.
- For capsule, extended release products : Swallow whole. Do not break/chew/crush/dissolve. Take doses regularly, even when feeling well. This medicine is usually not taken at night. Do not use to stop angina attack. Use regularly. May make you dizzy. Use caution when driving. May cause headache. May cause flushing.
- For ointment products : Know how to use before taking. For rectal use only. This medicine is usually not used at night. Alcohol can affect blood pressure. Check warnings on OTC medications. Close container tightly when not in use.
- For patch, transdermal 24 hours products : Apply to skin on abdomen upper arms, or shoulders. Dispose patch by folding sticky sides together. If having MRI, check if patch should be removed. MD may need to reduce the dose before you stop it.
- For powder in packet products : Read instructions carefully. Open with dry hands and place under the tongue. Store in a cool and dry place at room temperature.
- For tablet, sublingual products : Dissolve under tongue. Store tightly closed in the original container.
Clinical Pharmacology
Indications and Usage
Contraindications
Warnings
Precautions
Adverse Reactions
Overdosage
Dosage and Administration
How Supplied