Full Answer
Is Basaglar the same as Levemir?
Levemir (insulin detemir [rDNA origin] injection) and Basaglar (insulin glargine injection) are long-acting human insulin analogs used to treat diabetes in adults and children. Side effects of Levemir and Basaglar that are similar include low blood sugar (hypoglycemia), injection site reactions (e.g., pain, redness, irritation), weight gain, headache, and cold symptoms such as stuffy nose, sneezing, sore throat.
Is Toujeo and Basaglar the same thing?
While Toujeo, Lantus, and Basaglar contain the same active drug, the main difference between them is that Toujeo is more concentrated than either Lantus or Basaglar. So, you can’t use Toujeo in place of Lantus or Basaglar, and you can’t use Lantus or Basaglar in place of Toujeo.
Is Basaglar a long acting insulin?
What is Basaglar? Basaglar ( insulin glargine) is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Basaglar is used to improve blood sugar control in adults and children with diabetes mellitus.
Is Basaglar a biosimilar?
Technically, Basaglar is not a biosimilar biological drug product because insulin products and new versions of insulin products are regulated and approved under the Food, Drug, and Cosmetic Act (FD&C Act), section 505 (b) ( 2 ), new drug application pathway ( 13, 14 ). In all essence, however, Basaglar is a biosimilar.
Why are Lantus and Basaglar different?
Although Lantus and Basaglar contain the same active ingredient, they are made differently. Lantus is made by the manufacturer Sanofi-Aventis, while another manufacturer, Eli Lilly, started making Basaglar when the patent for Lantus expired in 2015.
How are Lantus and Basaglar taken?
Both Lantus and Basaglar are generally injected around the stomach where they are slowly absorbed into the body. Lantus is available in both vial and pen dispensers, whereas Basaglar is only available in a pen dispenser. Both are commonly taken once per day. As with all insulins, how much insulin you need will depend on how your blood sugar levels respond to your dosing schedule; your provider may adjust your dosing over time.
What are the possible side effects of Lantus and Basaglar?
The most likely side effect of any insulin —including Basaglar and Lantus—is low blood sugar, or hypoglycemia. Symptoms of hypoglycemia include:
Do Lantus and Basaglar interact with any other medications?
Many drugs can interact with insulins to make them work less effectively or cause them to lower blood glucose more than expected. The following are some drugs to watch out for (not an all-inclusive list):
Who shouldn’t take Lantus or Basaglar?
If you are sensitive to or have a history of any allergic reactions to ingredients in Lantus or Basaglar, then you should not take them. If you experience these reactions, your provider may prescribe you a different insulin or an oral diabetes medication (one you take by mouth) instead.
How much do Lantus and Basaglar cost?
Looking at average retail prices across the U.S., Basaglar is slightly cheaper than Lantus. Lantus costs $0.34 per insulin unit (regardless of whether you get it as a vial or pen). Basaglar’s average retail price is about 20% less at $0.27 per insulin unit.
What is the active ingredient in Lantus and Basaglar?
Insulin glargine is the active ingredient in both Lantus and Basaglar. As we mentioned, it’s a long-acting insulin that controls blood sugar all day. This is in contrast to rapid- and short-acting insulins that people with diabetes might take to bring blood sugar levels back to normal after a meal.
What is Basaglar?
Basaglar, developed by Eli Lilly & Company, was first introduced in 2015. The reason for the 15-year delay was that Lantus was patent-protected for the first 15 years, and until those patents expired, other insulin manufacturers could not make similar insulins that would compete for market share.
What is Lantus?
Lantus was first developed by the insulin manufacturer Sanofi in 2000 and is used to treat both type 1 and type 2 diabetes.
What is the difference between these two insulins?
While these insulins are remarkably similar , people may react differently to their chemical makeup.
What are the side effects of these two insulins?
The main side effect of these two insulins is hypoglycemia ( low blood sugar). Symptoms of hypoglycemia include:
What are the two most popular insulins?
While there are many different types of insulin glargine, two of the most popular are Lantus and Basaglar.
Which companies are working on biosimilar insulins?
Other pharmaceutical companies, such as Mylan/Biocon and Merk/Samsung Bioepis are also working on biosimilar glargine insulins as well, which should drive down prices as competition increases.
What is the function of basal insulin?
Basal insulin or “background” insulin has one primary job: to keep your blood sugars level when you’re not eating (when you’re fasting) and overnight when you’re asleep.
What is Basaglar injection?
The FDA has approved Basaglar (insulin glargine injection; Eli Lilly and Company), a long-acting human insulin analog, to improve glycemic control in adults and children with type 1 diabetes and in adults with type 2 diabetes . The approval carries the limitation that Basaglar should not be used for the treatment of diabetic ketoacidosis.1 Basaglar has an identical amino acid sequence as Lantus, another U-100 insulin glargine,2 and was approved through an abreviated approval process that partly relied on the FDA’s previous finding of safety and effectiveness for Lantus. Basaglar was found sufficiently similar to Lantus, and data were provided specific to Basaglar to establish its safety and efficacy for its approved uses.3 PHARMACOLOGY AND PHARMACOKINETICS Insulin’s primary activity is the regulation of glucose metabolism. Insulin and insulin analogs stimulate peripheral glucose uptake, especially by skeletal muscle and fat, and inhibit hepatic glucose production to lower blood glucose. A single subcutaneous 0.5-U/kg dose of Basaglar demonstrated a serum concentration with a slow and prolonged absorption and a relatively constant concentration/ time profile over 24 hours, with no pronounced peak. The average time to maximum serum insulin concentration was 12 hours after injection. Serum insulin concentrations declined to baseline by approximately 24 hours.1 DOSAGE AND ADMINISTRATION The dose of Basaglar should be individualized based on metabolic needs, blood glucose monitoring, glycemic control, type of diabetes, and prior insulin use. It should be given subcutaneously once daily, at the same time each day. The injection sites should be rotated to reduce the risk of lipodystrophy. When treatment with Basaglar begins, blood glucose levels should be monitored closely Continue reading >>
What is insulin glargine?
Insulin glargine, marketed under the names Lantus, among others, is a long-acting basal insulin analogue, given once daily to help control the blood sugar level of those with diabetes. It consists of microcrystals that slowly release insulin, giving a long duration of action of 18 to 26 hours, with a "peakless" profile (according to the insulin glargine package insert). Pharmacokinetically, it resembles basal insulin secretion of non-diabetic pancreatic beta cells. Sometimes, in type 2 diabetes and in combination with a short acting sulfonylurea (drugs which stimulate the pancreas to make more insulin), it can offer moderate control of serum glucose levels. In the absence of endogenous insulin—type 1 diabetes, depleted type 2 (in some cases) or latent autoimmune diabetes of adults in late stage—insulin glargine needs the support of fast acting insulin taken with food to reduce the effect of prandially derived glucose. Medical uses The long-acting insulin class, which includes insulin glargine, do not appear much better than neutral protamine Hagedorn (NPH) insulin but have a significantly greater cost making them, as of 2010, not cost effective. [1] It is unclear if there is a difference in hypoglycemia and not enough data to determine any differences with respect to long term outcomes. [2] Mixing with other insulins Unlike some other longer-acting insulins, glargine must not be diluted or mixed with other insulin or solution in the same syringe. [3] However, this restriction has been questioned. [4] Adverse effects Cancer As of 2012 tentative evidence shows no association between insulin glargine and cancer. [5] Previous studies had raised concerns. [6] Pharmacology Mechanism of action Insulin glargine has a substitution of glycine for Continue reading >>
How does Levemir work?
It helps convert the glucose (sugar) in your bloodstream into energy. This energy is then distributed to cells throughout your body. With diabetes, your pancreas produces little or no insulin or your body is unable to use the insulin correctly. Without insulin, your body can’t use the sugars in your blood and can become starved for energy. The excess sugar in your blood can also damage different parts of your body, including your blood vessels and kidneys. Everyone with type 1 diabetes and many people with type 2 diabetes must use insulin to maintain healthy blood sugar levels. Levemir is a solution of insulin detemir, and Lantus is a solution of insulin glargine. Both are basal insulin formulas. That means that they work slowly to lower your blood sugar levels . They’re both absorbed into your body over a 24-hour period. They keep blood sugar levels lowered for longer than short-acting insulins do. Although the formulations are slightly different, Levemir and Lantus are very similar drugs. There are only a few differences between them. Children and adults can use both Levemir and Lantus. Specifically, Levemir can be used by people who are 2 years or older. Lantus can be used by people who are 6 years or older. Levemir or Lantus can help with daily management of diabetes. However, you may still need to use short-acting insulin to treat spikes in your blood sugar levels and diabetic ketoacidosis (a dangerous buildup of acids in your blood). Learn more: All about diabetic ketoacidosis » Administration Both Levemir and Lantus are given through injection in the same way. You can gi Continue reading >>
Is Basaglar U-100 insulin a biologic?
Basaglar U-100 insulin glargine, which is a follow-on biologic insulin to Lantus is now available by prescription in the US. Basaglar, from Eli Lilly and Company and Boehringer Ingelheim Pharmaceuticals, Inc. is not technically a generic to Lantus but it does have an amino acid sequence identical to Lantus and has been FDA approved as a long-acting insulin for patients of all ages with type 1 diabetes and adults with type 2 diabetes. David Kendall, M.D. and the vice president of Global Medical Affairs for Lilly Diabetes said in Lilly’s press release, “Lilly and Boehringer Ingelheim are proud to bring another proven effective diabetes treatment choice to people who may need a long-acting insulin to help control their blood sugar,” and that “We know that starting insulin can be a challenging experience for some people with type 2 diabetes. As part of our continuing commitment to the diabetes community, we are expanding our educational resources.” Is it Cheaper? Business Insider reported that Basaglar “is 15% less than the list price of Lantus and Toujeo, two long-acting insulins made by Sanofi Aventis, 21% less than the list price of Levemir, and 28% less than Tresiba, two long-acting insulins made by Novo Nordisk.” An Eli Lilly spokesperson told Business Insider that before discounts or insurance coverage, the list price for a 5-pen pack of Basaglar is $316.85. You will be able to get Basaglar from retail and mail order pharmacies. Basaglar has also been chosen for the formularies of the top three pharmacy benefit managers and is expected to be covered by many commercial insurance plans. The pharmacy benefit manager CVS Health has dropped Lantus and replaced it with Basaglar for their next year’s formulary. In their announcement, CVS Health stated that th Continue reading >>
Is Basaglar the same as Lantus?
Basaglar (insulin glargine) is the newest brand of long-acting insulin to hit the market. It shares its active ingredient (insulin glargine) with Lantus, but is not a generic equivalent and the two can’t be substituted for each other. Long-acting insulin like Basaglar (also sometimes referred to as basal insulin) are used to keep blood glucose levels stable throughout the day. There are now four long-acting insulins approved by the FDA: Lantus, Levemir (insulin detemir), Toujeo (insulin glargine recombinant), Tresiba (insulin degludec), and Basaglar. Is there anything unique about Basaglar? Yes. Basaglar has been available in Europe, Canada, Columbia, Japan, and Australia as a new insulin glargine biosimilar to Lantus. It’s now on its way to the US. Does that mean Basaglar can be substituted for Lantus at the pharmacy? No. In the US, Basaglar was approved as a new drug, which means it has to prescribed by your doctor—or approved as a new prescription if you switch from Lantus. Although both Basaglar and Lantus are both insulin glargine they cannot be automatically substituted for one another without your doctor’s approval. How is Basaglar used? Dosing with Basaglar is individualized and will be determined by your doctor—not everyone will use the same amount. Basaglar is injected once-daily at any time of the day (but should be used at the same time every day). How will Basaglar be available? Basaglar is a solution for injection (100 units/mL) in a box of five 3 mL prefilled KwikPens. What are the side effects of Basaglar? The most common side effects associated with Basaglar are low blood sugar, allergic reactions, injection site reactions, itching, rash, and retaining water. When was Basaglar approved? Basaglar was approved by the FDA on December 16, 2015. Wh Continue reading >>
How effective is Basaglar vs Lantus?
Both Lantus and Basaglar are effective treatments for type 1 and 2 diabetes. A single daily injection of either taken consistently over time can help lower your A1C (a measure of your average blood glucose level over 3 months) to safe levels.
Who makes lantus?
Lantus is produced by Sanofi-Aventis and Basaglar by Eli Lilly. Both medications are injected under the skin (subcutaneous injection) but are done so using different devices. Basaglar is injected using a pre-filled, self-injecting Basaglar KwikPen or Basaglar Tempo Pen.
How does insulin help with blood sugar?
Your pancreas secretes insulin into your bloodstream where it helps to balance your blood glucose in two ways. Insulin accompanies the glucose in your blood and helps your cells absorb it. If you have more glucose in your blood than your cells need, insulin also signals to your liver to absorb and store the excess glucose so it can be used later when your blood glucose has fallen.
How much does NiceRx cost?
If you are approved for Lantus or Basaglar assistance through NiceRx you could get your prescription for only $49 per month. We may be able to help you even if you have insurance. Fill in our online enrollment application to find out more.
What is the name of the disease that affects the body's ability to use a type of sugar?
Diabetes is a group of diseases that affect your body’s ability to use a type of sugar (glucose) that the cells in your body need for energy. When you digest food and drink, glucose is released into your bloodstream. It is transported around your body in your blood so it can be taken to all the cells that need it.
How old do you have to be to have Basaglar?
Are allergic to any of the other ingredients in Basaglar. Are under 18 years of age for type 2 diabetes. Are under six years of age for type 1 diabetes. Have diabetic ketoacidosis – a condition where high blood sugar causes high levels of ketones to build up in your body.
How often do you give a diabetic injection?
Type 2 diabetes in adults. Frequency of injection: Once per day. Frequency of injection: Once per day. Duration of action: Up to 24 hours.
What is Basaglar insulin?
Basaglar is a trade name for the long-acting, synthetic insulin glargine. Eli Lilly and Company manufactures this medication.
What is the name of the insulin glargine?
Like Basaglar, Lantus is another trade-name formulation of insulin glargine. Sanofi produces this drug.
Is basaglar the same as lantus?
Basaglar and Lantus are extremely similar since they contain insulin glargine; they even have the same amino-acid chain sequence. Not only are they taken the same way, but they are also fairly equitable in terms of safety and efficacy. The differences between these two drugs are relatively minor.
Can Basaglar be used for diabetics?
The FDA does not advise this medication for treating diabetic ketoacidosis (diabetic acidosis or DKA). Additionally, people prone to hypoglycemia (low blood sugar) episodes or are otherwise hypersensitive to Basaglar or any of its components should not take this medication.
Can you take Basaglar with Lantus?
As is the case with Basaglar, people should not use Lantus if they have diabetic ketoacidosis, are experiencing a hypoglycemic episode, and/or are hypersensitive to this drug or any of its components.
Is Basaglar cheaper than U-100?
While they are fairly close in price, Basaglar is currently the slightly cheaper option in the United States. Although, these price differences can change based on insurance. Finally, Basaglar is only available as a prefilled 3 mL pen [100 units/mL (U-100) ...
What is the difference between Lantus and Basaglar?
The main difference between Lantus and Basaglar is the cost, as Basaglar is slightly less expensive. They may also vary in potential side effects, depending on the patient's risk.
How much is a basaglar vs lantus?
The out-of-pocket costs for each Lantus and Basaglar are as follows: The cash price for Lantus is $425 for 5 pens (300 units each) or about $285 for one vial (1000 units).
What is Basaglar insulin pen?
Basaglar only comes in the form of an insulin pen, known as the Basaglar KwikPen. The Lantus and Basaglar insulin pens are very similar in the way in which they are used. The pens have 300 units per pen and have a dial that allows you to adjust your dose. Each pen will require pen needles to inject Lantus and Basaglar.
How much is Basaglar?
Basaglar is cheaper than Lantus, but it is still very expensive for individuals. The out-of-pocket costs for each Lantus and Basaglar are as follows: 1 The cash price for Lantus is $425 for 5 pens (300 units each) or about $285 for one vial (1000 units). 2 The cash price for Basaglar is $326 for 5 pens (300 units each).
What are the side effects of Lantus and Basaglar?
Side Effects of Lantus and Basaglar. The most common side effect of both Lantus and Basaglar is low blood sugar. Hypoglycemia is severe and can be life-threatening. Symptoms of low blood sugar include: dizziness or light-headedness. sweating .
What is insulin glargine?
Insulin Glargine. Insulin glargine is a long-acting insulin that is manmade. Patients with type 1 diabetes will use insulin glargine in combination with rapid-acting insulin. Patients with type 2 diabetes may use insulin glargine alone or in combination with another insulin to treat their condition.
When was Lantus invented?
Lantus was developed in 2000 and is one of the most popular insulin medications used. Basaglar was not made until 2015. It is important to note that patents protect brand-name medications by being copied.
Common Side Effects Of Basaglar (basaglar Insulin Glargine Subcutaneous Injection) Drug Center - Rxlist
Medical Editor: John P. Cunha, DO, FACOEP Basaglar (insulin glargine injection) is a long-acting human insulin analog indicated to improve glycemic control in adults and pediatric patients with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus.
Key Facts About Basaglar: A Less Expensive Long-acting Insulin
If you’ve been using a long-acting insulin like Lantus, you might have heard about a friendly competitor called Basaglar which is coming soon to pharmacies. Basaglar is insulin glargine known as a biosimilar (also called a follow-on biologic).
Basaglar (insulin Glargine) Dose, Indications, Adverse Effects, Interactions... From Pdr.net
Hormone secreted by pancreatic beta-cells of the islets of Langerhans and essential for the metabolism and homeostasis of carbohydrate, fat, and protein. Insulin glargine is a once-daily basal insulin analog without pronounced peaks.
Cheaper Insulin Is On The Way
With commentary by Alissa R. Segal , Pharm.D., RPh, CDE, CDTC, a Clinical Pharmacist at the Joslin Diabetes Center.
Similar, But Not Biosimilar: Lilly And Bi's Lantus Copy Approved In Us
Basaglar was tentatively given the thumbs up by the US Food and Drug Administration (FDA) in August 2014, but it was dependent upon resolving patent litigation with makers of fellow insulin glargine Lantus, Sanofi.
Prepare Your Patients For An Insulin Change For 2017
Mo st insurance plans will be dropping Lantus from formularies. Guest Post by David Kliff, Diabetic Investor Sometimes I’m amazed at how oblivious some people in this wacky world can be. Actually, I should say it really doesn’t amaze me given this is the wacky world of diabetes, which is full of clueless opinions.
A Cheaper Version Of The Lifesaving Diabetes Medication Just Launched In The Us
A Type 1 diabetes patient holds up bottles of insulin.Reuters/Lucy Nicholson A new form of insulin just hit American markets.
