Precautions
Cholecalciferol (vitamin D3) has been used for decades. It is considered a safe dietary supplement for humans. At high doses this hormone causes blood calcium to rise to toxic levels. This in turn leads to kidney damage, bleeding and heart problems.
Is Cholecalciferol safe to take?
Cholecalciferol side effects. early signs of vitamin D overdose--weakness, metallic taste in your mouth, weight loss, muscle or bone pain, constipation, nausea, and vomiting. Less serious side effects may be more likely, and you may have none at all. This is not a complete list of side effects and others may occur.
What are the side effects of cholecalciferol?
Vitamin D3 as a Mouse and Rat Poison Cholecalciferol (vitamin D3) has been used for decades. It is considered a safe dietary supplement for humans. At high doses this hormone causes blood calcium to rise to toxic levels.
Is Cholecalciferol safe for rats?
Cholecalciferol is vitamin D3. Vitamin D helps your body absorb calcium. Cholecalciferol is used as a dietary supplement in people who do not get enough vitamin D in their diets to maintain adequate health.
What is Cholecalciferol?
How much cholecalciferol is toxic?
Toxic doses of cholecalciferol are much lower than reported acute lethal doses (13 mg/kg) and median lethal doses (88 mg/kg), and important clinical changes with notable morbidity, even mortality, may be noted with relatively low doses.
Does cholecalciferol have side effects?
Cholecalciferol side effects chest pain, feeling short of breath; growth problems (in a child taking cholecalciferol); or. early signs of vitamin D overdose--weakness, metallic taste in your mouth, weight loss, muscle or bone pain, constipation, nausea, and vomiting.
Is cholecalciferol a poison?
Unfortunately, cholecalciferol has a very narrow margin of safety, which means that even small ingestions of this poison can result in severe clinical signs or death. Toxic ingestions must be treated quickly and appropriately to prevent kidney failure.”
Is vitamin D3 toxic to humans?
Although vitamin D toxicity is a very rare condition, recent increases in supplement use may lead to an increase in reported cases. A daily intake ranging from 40,000–100,000 IU (1,000–2,500 mcg), for 1 to several months, has been shown to cause toxicity in humans ( 15 , 19 , 20 , 21 , 22 ).
What is the difference between vitamin D and cholecalciferol?
Vitamin D, also known as cholecalciferol, is a vitamin that your body needs to absorb calcium. Vitamin D is made in the skin when it is exposed to sunlight. It can also be found in some foods like fatty fish and eggs. Your body needs vitamin D to maintain strong bones and muscles.
Is cholecalciferol natural or synthetic?
Cholecalciferol is a form of vitamin D which is naturally synthesized in skin and functions as a pro-hormone, being converted to calcitriol. This is important for maintaining calcium levels and promoting bone health and development.
What happens when you take cholecalciferol?
Cholecalciferol is a dietary supplement that is used to treat vitamin D deficiency. It is also used with calcium to maintain bone strength. This medicine is available both over-the-counter (OTC) and with your doctor's prescription.
Where does D3 cholecalciferol come from?
Vitamin D3 (cholecalciferol) – Which, as mentioned above, is formed naturally in the skin when exposed to sunlight, is present in certain fish and eggs, and is also commercially made from lanolin washed from lambs' wool.
What is meant by cholecalciferol?
A steroid hormone produced in the skin when exposed to ultraviolet light or obtained from dietary sources. The active form of cholecalciferol, 1,25-dihydroxycholecalciferol (calcitriol) plays an important role in maintaining blood calcium and phosphorus levels and mineralization of bone.
What are signs of vitamin D toxicity?
Confusion, apathy, recurrent vomiting, abdominal pain, polyuria, polydipsia, and dehydration are the most often noted clinical symptoms of vitamin D toxicity (VDT; also called vitamin D intoxication or hypervitaminosis D).
Can too much D3 cause joint pain?
Vitamin D toxicity can cause hypercalcemia and subsequent problems with the bones, including a loss of bone density . Some symptoms include: aching or painful bones.
How common is vitamin D toxicity?
Although vitamin D toxicity is a very rare condition, recent increases in supplement use may lead to an increase in reported cases. A daily intake ranging from 40,000–100,000 IU (1,000–2,500 mcg), for 1 to several months, has been shown to cause toxicity in humans ( 15 , 19 , 20 , 21 , 22 ).
What is the best time to take cholecalciferol?
Try taking it alongside breakfast or with a bedtime snack — as long as it doesn't interfere with your sleep. The key is to find what works for you and stick with it to ensure you're meeting your vitamin D needs. Taking vitamin D with a meal can increase its absorption, but studies on specific timing are limited.
What are side effects of too much vitamin D?
The main consequence of vitamin D toxicity is a buildup of calcium in your blood (hypercalcemia), which can cause nausea and vomiting, weakness, and frequent urination. Vitamin D toxicity might progress to bone pain and kidney problems, such as the formation of calcium stones.
What medications should not be taken with vitamin D3?
Possible interactions include:Aluminum. ... Anticonvulsants. ... Atorvastatin (Lipitor). ... Calcipotriene (Dovonex, Sorilux). ... Cholestyramine (Prevalite). ... Cytochrome P-450 3A4 (CYP3A4) substrates. ... Digoxin (Lanoxin). ... Diltiazem (Cardizem, Tiazac, others).More items...
Is it OK to take vitamin D3 everyday?
Some people may need a higher dose, however, including those with a bone health disorder and those with a condition that interferes with the absorption of vitamin D or calcium, says Dr. Manson. Unless your doctor recommends it, avoid taking more than 4,000 IU per day, which is considered the safe upper limit.
Before Taking This Medicine
You should not use cholecalciferol if you have had an allergic reaction to vitamin D, or if you have: 1. high levels of vitamin D in your body (hyp...
How Should I Take Cholecalciferol?
Follow all directions on your prescription label. Use only the recommended dose of cholecalciferol. Do not use this medicine in larger or smaller a...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
What Happens If I Overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of vitamin D can cause serious or life-threatening sid...
What Should I Avoid While Taking Cholecalciferol?
Ask a doctor or pharmacist before taking any multivitamins, mineral supplements, or antacids while you are taking cholecalciferol.
Cholecalciferol Side Effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.St...
Cholecalciferol Dosing Information
Usual Adult Dose for Vitamin D Insufficiency:600 to 2,000 international units, orally, once a dayMaximum dose: 4,000 international units per dayUsu...
What Other Drugs Will Affect Cholecalciferol?
Certain medications can make it harder for your body to absorb vitamin D. If you take other medications, take them at least 2 hours before or 2 hou...
Why is vitamin D toxic?
Vitamin D toxicity is usually caused by large doses of vitamin D supplements — not by diet or sun exposure. That's because your body regulates the amount of vitamin D produced by sun exposure, and even fortified foods don't contain large amounts of vitamin D. The main consequence of vitamin D toxicity is a buildup of calcium in your blood ...
What happens if you take too much vitamin D?
The main consequence of vitamin D toxicity is a buildup of calcium in your blood (hypercalcemia), which can cause nausea and vomiting, weakness, and frequent urination . Vitamin D toxicity might progress to bone pain and kidney problems, such as the formation of calcium stones.
Which fat soluble vitamins are toxicity?
It has been hypothesized that two other fat-soluble vitamins, vitamin K and vitamin A, may play important roles in vitamin D toxicity. Vitamin K helps regulate where calcium ends up in the body, and high amounts of vitamin D may deplete the body’s stores of vitamin K ( 29. Trusted Source. , 30. Trusted Source.
How much vitamin D is toxic?
Individuals with vitamin D toxicity usually have blood levels above 150 ng/ml (375 nmol/L). Several cases have also been caused by errors in manufacturing, when the supplements had 100-4000 times higher amounts of vitamin D than stated on the package ( 18. Trusted Source.
What does it mean when you have vitamin D toxicity?
Vitamin D toxicity implies that vitamin D levels in the body are so high that they cause harm.
How many IU of a sulfate ion is safe?
To be safe, you should not exceed the 4,000 IU (100 mcg) upper limit without consulting with a doctor or dietitian.
Is vitamin D toxicity rare?
The Surprising Truth. Written by Adda Bjarnadottir, MS, RDN (Ice) on June 4, 2017. Vitamin D toxicity is extremely rare, but does occur with extreme doses. It usually develops over time, since extra vitamin D can build up in the body. Nearly all vitamin D overdoses result from taking high amounts of vitamin D supplements.
Can vitamin D cause kidney failure?
There have been reports of people taking very large doses of vitamin D for months without symptoms, yet blood tests revealed severe hypercalcemia and symptoms of kidney failure ( 28 ).
Can vitamin D be high?
Trusted Source. ). However, when vitamin D intake is extreme, the levels can become so high that there isn’t any room left on the receptors or carrier proteins. This may lead to elevated levels of “free” vitamin D in the body, which may travel inside cells and overwhelm the signalling processes affected by vitamin D.
Is D3 a rat poison?
Also vitamin d3 shares the same pathway as vitamin A, to much D3 and you are deficient in vitamin A. And the other way round. It´s so complex, you just cannot make a statement it´s rat poison. First most of the d3 is carboxulated into osteocalcin or creates Antimicrobial peptides.
Is vitamin D3 poisonous to rats?
Cholecalciferol which is another name for Vitamin D3 is produced Naturally when we are exposed to sun light, and although is poisonous for Rats is very small doses and even Dogs in slightly higher doses, it doesn’t mean that is also poisonous for Humans.
Is cholecalciferol a steroid?
It´s true Cholecalciferol is the rare mix of a vitamin that acts more like a steroid, a healthy supplement as well as a rat poison and something that can both cause and heal bone pain. It´s better to be on the safer side and not take it if it contains this chemical.
Is vitamin D a rat poison?
Mikael Ssol: vor 3 Monaten: Calcium, not vitamin D, is rat poison. Vitamin D is just the substance used in rat poison to increase the amount of calcium in the rat’s blood. Then calcium does it’s job and calcifies the rat’s heart.
Is vitamin D3 safe for humans?
Tonya Tipton: vor 8 Monaten: Vitamin D3 is just fine for us humans to take since we’re not rats. There are so many things that can hurt you if you over use them. What I worry about is the illnesses you can get because you don’t get enough vitamin D3, I don’t know of one human who died from taking vitamin D3.
How many people have toxic levels of nmol/l?
It found that only 37 people had levels above 100 ng/ml (250 nmol/l). Only one person had true toxicity, at 364 ng/ml (899 nmol/l) ( 8 ).
What are the side effects of vitamin D?
Supplements 101: Vitamin D. 3. Nausea, vomiting, and poor appetite. Many side effects of too much vitamin D are related to excessive calcium in the blood. These include nausea, vomiting, and poor appetite. However, these symptoms don’t occur in everyone with elevated calcium levels.
How long does vitamin D intoxication last?
Because the vitamin is stored in body fat and released into the bloodstream slowly, the effects of toxicity may last for several months after you stop taking supplements ( 4. Trusted Source. ).
How many people don't get enough vitamin D?
What’s more, most people don’t get enough sun exposure to produce adequate vitamin D. Thus, deficiency is very common. In fact, it’s estimated that about 1 billion people worldwide don’t get enough of this vitamin ( 1. Trusted Source.
Can you get too much vitamin D?
Most people don’t get enough vitamin D, so supplements are common. However, it’s also possible — although rare — for this vitamin to build up and reach toxic levels in your body. This article discusses 6 potential side effects of getting excessive amounts of this important vitamin.
How much vitamin D is safe for humans?
As with all poisons, the dose is critical. That is why the tolerable upper limit is set at 4,000 IUs for adult humans. Some people believe that if a little is good then a lot is better. Anyone who uses a lot more than 4,000 IU daily should monitor blood levels of 25-hydroxy vitamin D regularly.
Is bromethalin poisonous to cats?
Bromethalin is a neurotoxin that leads to paralysis. This chemical can be very dangerous for pets. Cats may be especially vulnerable to bromethalin. Anyone who uses a mouse and rat poison must pet proof the house!
Is vitamin D3 safe for rats?
Vitamin D3 as a Mouse and Rat Poison. Cholecalciferol (vitamin D3) has been used for decades. It is considered a safe dietary supplement for humans. At high doses this hormone causes blood calcium to rise to toxic levels. This in turn leads to kidney damage, bleeding and heart problems.
What is the normal range of calcifediol?
The normal range of calcifediol is 30.0 to 74.0 ng/mL. "Vitamin D toxicity can result from regular excess intake of this vitamin, and may lead to hypercalcemia and excess bone loss. Individuals at particular risk include those with hyperparathyroidism, kidney disease, sarcoidosis, tuberculosis, or histoplasmosis.
Is cholecalciferol poisonous to dogs?
At high doses cholecalciferol is poisonous. Rodents are somewhat more susceptible to high doses than other species, and cholecalciferol has been used in poison bait for the control of these pests. It has been claimed that the compound is less toxic to non-target species. However, in practice it has been found that use of cholecalciferol in rodenticides represents a significant hazard to other animals, such as dogs and cats. "Cholecalciferol produces hypercalcemia, which results in systemic calcification of soft tissue, leading to renal failure, cardiac abnormalities, hypertension, CNS depression, and GI upset. Signs generally develop within 18-36 hr of ingestion and can include depression, anorexia, polyuria, and polydipsia.
