How long does it take for convenica to work on dogs?
What drugs compete with cefovecin?
How many milligrams of cefovecin are in a vial?
How is cefovecin absorbed?
What is the synergistic activity of cephalosporins plus fluoroquinolones against?
Can you use cefovecin on dogs?
Can cephalosporin cause neutropenia?
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About this website
What type of antibiotic is Convenia?
The active substance in Convenia is cefovecin which belongs to a class of antibiotics called third generation cephalosporins. All these cephalosporin antibiotics, including cefovecin, kill bacteria by disrupting the building of the bacterial cell walls, so the bacteria die and the infection is cured.
What is the spectrum of Convenia?
Cefovecin is a third generation cephalosporin with a broad-spectrum of activity against Gram-positive and Gram-negative bacteria. As with all cephalosporins, the action of cefovecin results from the inhibition of bacterial cell wall synthesis. Cefovecin has bactericidal activity.
What class of antibiotic is cefovecin?
Cefovecin (brand name: Convenia®) is a cephalosporin antibiotic used most commonly for skin infections, periodontal disease, and urinary tract infections.
Is Convenia a good antibiotic for cats?
Convenia treats common bacterial skin infections in dogs, including superficial pyoderma in dogs as well as abscesses and wounds for both cats and dogs.
What is the best broad spectrum antibiotic for cats?
Doxycycline is recommended because of its broad spectrum of activity against common feline nasal pathogens and because it is well-tolerated by cats.
What is the most broad spectrum antibiotic?
Examples of broad-spectrum antibioticsDoxycycline.Minocycline.Aminoglycosides (except for streptomycin)Ampicillin.Amoxicillin/clavulanic acid (Augmentin)Azithromycin.Carbapenems (e.g. imipenem)Piperacillin/tazobactam.More items...
What is the strongest antibiotic for cats?
Amoxicillin—Amoxicillin is prescribed by veterinarians to treat bacterial infections in cats. It is highly effective against everything from skin infections to gastrointestinal infections.
What is the most common antibiotic for cats?
Amoxicillin: A good all-around antibiotic, amoxicillin for cats works to stop bacterial growth and is typically used to treat a variety of infections. It's available in capsule form and is administered orally. Amoxicillin for cats can also be given with food and comes in multiple dosage forms for fussier pets.
How quickly does Convenia work?
In some cats, Convenia can start doing its job after just 3 hours following its administration. In others, the effects might not last for two full weeks – rather 10 to 12 days. By that time, however, most bacterial infections are resolved.
How effective is Convenia for cats?
Convenia is most commonly used for the prolonged treatment of skin and soft tissue infections, for infections of the urinary tract, and as part of the management of severe periodontal disease. It generally has good efficacy against the bacteria commonly associated with these conditions.
How often can a cat get a Convenia shot?
Cats. CONVENIA should be administered as a single, one-time subcutaneous injection at a dose of 3.6 mg/lb (8 mg/kg) body weight. After an injection of CONVENIA, therapeutic concentrations are maintained for approximately 7 days for Pasteurella multocida infections.
How long does Convenia injection last in cats?
Convenia is a long-acting broad spectrum antibiotic called cefovecin. Once injected, it attaches to blood proteins and works for up to 14 days.
What is moderate spectrum antibiotics?
Moderate Spectrum Penicillins are a type of antibiotic such as amoxycillin and ampicillin. They have a similar range of activity as Narrow Spectrum Penicillin, but are more active against extra bacteria such as those responsible for chest infections and urinary tract infections.
What does spectrum mean in antibiotics?
The antimicrobial spectrum of an antibiotic means the range of microorganisms it can kill or inhibit. Antibiotics can be divided into broad-spectrum antibiotics, extended-spectrum antibiotics and narrow-spectrum antibiotics based on their spectrum of activity.
Is Convenia safe for older cats?
Third, a reduced dose should be given if cats with renal failure are being treated. Fourth, and obviously, it should not be given to cats with known hypersensitivity to β–lactam antibiotics. Convenia is safe for older cats, but as stated previously, this decision is for a vet to make rather than the owner.
How often can a cat get a Convenia shot?
Cats. CONVENIA should be administered as a single, one-time subcutaneous injection at a dose of 3.6 mg/lb (8 mg/kg) body weight. After an injection of CONVENIA, therapeutic concentrations are maintained for approximately 7 days for Pasteurella multocida infections.
CONVENIA Dosing Chart at DOG 3.6 mg/lb (8 mg/kg or 0.045 mL ... - Zoetis US
DOG focus 2 20+ CONVENIA® (cefovecin sodium) Convenia in your practice CONVENIA Dosing Chart at 3.6 mg/lb (8 mg/kg or 0.045 mL/lb) Dog Weight 5 lb 10 lb 15 lb 20 lb 30 lb 40 lb 50 lb 60 lb
Convenia for Cats: Uses, Doses, & Side Effects (Vet Answer)
Convenia is licensed to treat skin, soft tissue, and urinary tract infections caused by certain bacteria but is it right for your cat? Find out what our vet says.
Convenia's Many Uses - MyPetsDoctor.com
I have an 11 year old Persian that appears to be on a cycle of URI every few months. This didn’t manifest until he was around 8 yo. It typically started every winter / spring then progressed to late spring and now every few months.
Convenia Long-Acting Antibiotic Injection - MyPetsDoctor.com
I’ve had untold numbers of patients for whom I’ve instituted symptomatic therapy for suspected UTI when the patient’s bladder was empty. Often, especially in cats, I’ve used Convenia for symptomatic treatment. Even if the offending organism isn’t susceptible to cefovecin, it may knock down the infection enough that the immune system can control the rest.
What infections does Convenia treat?
What infections or conditions does Convenia treat? What infections or conditions does <span style="text-transform: uppercase;">Convenia</span> treat? Convenia treats common bacterial skin infections in dogs, including superficial pyoderma in dogs as well as abscesses and wounds for both cats and dogs.
What is the purpose of Convenia?
Convenia is part of the group of antibiotics called cephalosporins, and it works by breaking down cell wall, killing the bacterium.
How long does it take for Convenia to kill bacteria?
1,3 Convenia will continue killing bacteria in the infected tissue for the full treatment period - 14 days.* 3.
How long does Convenia last?
1,2 Just one injection, administered by a veterinarian, lasts up to 14 days.† 3,4. CONVENIA helps improve quality of life for pets and their owners. Watch Success Stories.
How long does it take to get Convenia?
In studies, a single injection of Convenia was found to be the equivalent of 14 days of orally dosed antibiotics* (e.g., tablets or pills, some of which have to be administered by pet owners as often as twice daily). 1,2.
Is cefovecin sodium an extended-spectrum?
Six R, Cleaver DM, Lindeman CJ, et al. Effectiveness and safety of cefovecin sodium, an extended-spectrum injectable cephalosporin, in the treatment of cats with abscesses and infected wounds. J Am Vet Med Assoc. 2009;234 (1):81-87.
Does Convenia help with pyoderma?
Convenia treats common bacterial skin infections in dogs, including superficial pyoderma in dogs as well as abscesses and wounds for both cats and dogs. These conditions can cause itching, scratching, licking and biting, and may be painful.
What Is Convenia?
Convenia is a long-acting broad spectrum antibiotic called cefovecin. Once injected, it attaches to blood proteins and works for up to 14 days.
How long does Convenia work?
Convenia is a long-acting broad spectrum antibiotic called cefovecin. Once injected, it attaches to blood proteins and works for up to 14 days. When Convenia first came on the market it was a godsend, or so we thought. Here was the answer to all those cats and dogs who just couldn’t be given pills.
Is Convenia too convenient?
Convenia Is Too Convenient. There are two good reasons why cefovecin is usually not the best antibiotic, but no others are so easy to administer. This leads are some of the following thoughts a vet might have: I bet this cat is hard to give tablets to. I doubt this owner can give the medication any other way.
Can antibiotic resistance affect humans?
Antimicrobial resistance affects us all. We tend to blame doctors for overprescribing, or the agricultural industries, but people in glasshouses shouldn’t throw stones. The rate of antibiotic resistance in dogs and cats is comparable to that in humans and certainly higher than farm animals.
Does Cefovecin cause allergies?
Cefovecin contains the same base structure as penicillin, and so allergies can occur. When they happen with other antibiotics, we just stop them. With Convenia, blood levels are known to persist for 65 days. That’s an out of control roller coaster you can’t get off.
Is it safe to give antibiotics to cats?
Here was the answer to all those cats and dogs who just couldn’t be given pills. And to our fears that owners would miss antibiotic doses. And in truth it is a remarkable antibiotic. It’s generally safe, highly effective and not too expensive in smaller animals like cats.
Is Convenia a multidrug resistant organism?
The use of third-generation cephalosporins like cefovecin is known to lead to the development of multidrug resistant organisms in people. Convenia is probably a worse offender due to the long ‘tail’ between 14 and 65 days when antibiotics are present in the body at sub-lethal doses to bacteria. This is a boot camp for resistance.
How long does Convenia last?
Enter Convenia, (cefovecin sodium) the long-acting antibiotic from Pfizer Animal Health that lasts 10 to 14 days with a single injection. Convenia is more than just penicillin.
Is Convenia the only antibiotic?
Convenia isn’t right for every infection. If it were, it would be the only antibiotic on the market. Instead, there are hundreds and hundreds of antibiotics, each with a situation or organism on which it works best.
Why are antibiotics used?
In general, antibiotics are indicated for the removal of bacterial infections from the body. Some antibiotics, by their chemical and physical characteristics, penetrate certain organs or parts of the body better than others. These qualities in antibiotics are often a major factor in our choice of medication from the thousands of antibiotics available.
Why did we know we were on the right track with cephalosporin?
We knew we were on the right track with the cephalosporin because both lick granuloma lesions were looking better.
How long does Convenia stay in your system?
It exerts its antibacterial effects for approximately 1-2 weeks but stays in the body for over 2 months. This is in contrast to antibiotics that are rapidly cleared from the body ...
Why is Pfizer called "convenia"?
There is no doubt that Pfizer (now Zoetis) originally named this long-acting antibiotic “Convenia” because of the convenience for the pet owner. Unfortunately, because of this ‘convenience’, Convenia is being used within the veterinary profession with increasing frequency.
Why is it important to match the correct antibiotic with the target infection?
Antibiotics vary significantly in their ability to kill various species of bacteria so it is important to match the correct antibiotic with the target infection.
Can a dog have a convenia reaction?
Therefore, if your cat or dog has experienced a possible adverse reaction to Convenia, please do not let that reaction go unreported.
What is Convenia used for?
Convenia is licensed to treat infections caused by particular bacteria. Therefore, it can be used to treat infected wounds and abscesses caused by Pasteurella, Fusobacterium, Bacteroides, Prevotella, Beta hemolytic Streptococci, or Staphylococcus. In addition, it is licensed for the treatment of urinary tract infections caused by E. Coli.
How does Convenia work?
This reflects how much their structure has been altered compared to their original form, which was derived from mold. First-generation Cephalosporins are the original structure, whereas subsequent generations have been modified. These modifications can make them more effective or help them work against a larger spectrum of bacteria.
How is Convenia given to cats?
Before the first use, Convenia needs to be reconstituted. The package contains a vial of powder and a vial of liquid. The entire vial of liquid should be added to the vial containing the powder to prepare the solution. Once added, the vial should be gently shaken to dissolve the powder thoroughly. Before and after reconstitution, Convenia must be stored in a refrigerator. Once the Convenia solution has been prepared, it must be discarded after 28 days.
What are the side effects of Convenia?
One concern regarding penicillin or Cephalosporin-based medications is the risk of allergy in either the patient or anyone handling the drug. Thankfully, because Convenia is injectable, it is not a risk to the pet parent, whereas tablets could be. As with any medication, there is a risk of an allergic or anaphylactic reaction, but this risk is very minimal.
When shouldn’t Convenia be given?
Convenia isn’t licensed to be given to kittens under eight weeks of age , and studies haven’t yet been performed to prove it is safe for pregnant or lactating cats. Similarly, it should be avoided, where possible, in cats with severe kidney failure because its safety has not been established.
How much Cefovecin is in Convenia?
Convenia contains 80mg/ml of Cefovecin when it is prepared.
How long does Convenia last?
Convenia lasts for 14 days, which is sufficient time to resolve most infections. However, the dose can safely be repeated on day 14 if further treatment is required.
How long does it take for convenica to work on dogs?
At an exaggerated dose of 180 mg/kg (22.5X) in dogs, CONVENIA caused some injection site irritation, vocalization and edema. Edema resolved within 8-24 hours.
What drugs compete with cefovecin?
Concurrent use of these or other drugs that have a high degree of protein-binding (e.g. NSAIDs, propofol, cardiac, anticonvulsant, and behavioral medications) may compete with cefovecin binding and cause adverse reactions.
How many milligrams of cefovecin are in a vial?
CONVENIA is available as a 10 mL multi-use vial containing 800 milligrams of cefovecin as a lyophilized cake.
How is cefovecin absorbed?
Cefovecin is rapidly and completely absorbed following subcutaneous administration. Non-linear kinetics is exhibited (plasma concentrations do not increase proportionally with dose). Cefovecin does not undergo hepatic metabolism and the majority of a dose is excreted unchanged in the urine. Elimination also occurs from excretion of unchanged drug in the bile. Cefovecin is a highly protein bound molecule in dog plasma (98.5%) and cat plasma (99.8%) and may compete with other highly protein bound drugs for plasma protein binding sites that could result in transient, higher free drug concentrations of either compound. Pharmacokinetic parameters following subcutaneous dosing at 8 mg/kg in the dog and cat are summarized in Table 4.
What is the synergistic activity of cephalosporins plus fluoroquinolones against?
2 Fish DN, Choi MK, and Jung R: Synergic activity of cephalosporins plus fluoroquinolones against Pseudomonas aeruginosa with resistance to one or both drugs. Journal of Antimicrobial Chemotherapy (2002) 50, 1045-1049.
Can you use cefovecin on dogs?
WARNINGS: Not for use in humans. Keep this and all drugs out of reach of children. Consult a physician in case of accidental human exposure. For subcutaneous use in dogs and cats only. Antimicrobial drugs, including penicillins and cephalosporins, can cause allergic reactions in sensitized individuals. To minimize the possibility of allergic reactions, those handling such antimicrobials, including cefovecin, are advised to avoid direct contact of the product with the skin and mucous membranes.
Can cephalosporin cause neutropenia?
Occasionally, cephalosporins and NSAIDs have been associated with myelotoxicity, thereby creating a toxic neutropenia 4. Other hematological reactions seen with cephalosporins include neutropenia, anemia, hypoprothrombinemia, thrombocytopenia, prolonged prothrombin time (PT) and partial thromboplastin time (PTT), platelet dysfunction and transient increases in serum aminotransferases.
Dogs
Cats
- CONVENIA is indicated for the treatment of skin infections (wounds and abscesses) in cats caused by susceptible strains of Pasteurella multocida.
General Dosing Information
- A sample of the lesion should be obtained for culture and susceptibility testing prior to beginning antimicrobial therapy. Once results become available, continue with appropriate therapy. If acceptable response to treatment is not observed, or if no improvement is seen within 3 to 4 days, then the diagnosis should be re-evaluated and appropriate alternative therapy considered. CONV…
Contraindications
- CONVENIA is contraindicated in dogs and cats with known allergy to cefovecin or to β-lactam (penicillins and cephalosporins) group antimicrobials. Anaphylaxis has been reported with the use of this product in foreign market experience. If an allergic reaction or anaphylaxis occurs, CONVENIA should not be administered again and appropriate therapy s...
Precautions
- Prescribing antibacterial drugs in the absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to treated animals and may increase the risk of the development of drug-resistant animal pathogens. The safe use of CONVENIA in dogs or cats less than 4 months of age (see Animal Safety) and in breeding or lactating animals has not been det…
Pharmacokinetics
- Cefovecin is rapidly and completely absorbed following subcutaneous administration. Non-linear kinetics is exhibited (plasma concentrations do not increase proportionally with dose). Cefovecin does not undergo hepatic metabolism and the majority of a dose is excreted unchanged in the urine. Elimination also occurs from excretion of unchanged drug in the bile. Cefovecin is a highl…
What Is Convenia?
Convenia Is Too Convenient
- There are two good reasons why cefovecin is usually not the best antibiotic, but no others are so easy to administer. This leads are some of the following thoughts a vet might have: 1. I bet this cat is hard to give tablets to 2. I doubt this owner can give the medication any other way 3. If I use it I’m more confident that my treatment won’t fail 4. Owners prefer it when I give their animal a s…
Convenia’S Side Effects
- When Convenia came on the market, vets were understandably excited. It opened up a whole new way of treating difficult cases. But fairly soon we started to hear stories of adverse reactions. Cefovecin contains the same base structure as penicillin, and so allergies can occur. When they happen with other antibiotics, we just stop them. With Convenia, blood levels are known to persi…
Convenia’S Wider Effects
- Nobody has ever come to me with what I am about to say. I have learnt this only by finding the information myself. It’s the silence of a guilty status quo that needs to change. It turns out that cefovecin is a “highest priority critically important antimicrobial”. It’s supposed to be a third lineantibiotic, only used after the first and second choices fail, or after culture and sensitivity tes…
Why Does It Matter?
- Antimicrobial resistance affects us all. We tend to blame doctors for overprescribing, or the agricultural industries, but people in glasshouses shouldn’t throw stones. The rate of antibiotic resistance in dogs and cats is comparable to that in humans and certainly higher than farm animals. The use of third-generation cephalosporins like cefovecinis known to lead to the develo…
So What Should We All do?
- The path out of this mess is actually quite simple. Here are some suggestions for cat owners: 1. Proactively tell your vet if you think you can give oral medications. We are often time-pressured so you might find you don’t get a choice otherwise. 2. Even if you think you can’t, you mostly can. Common diseases like hyperthyroidism and chronic kidney diseasetell us that every cat owner c…
Sources
- Hardefeldt, L., Hur, B., Verspoor, K., Baldwin, T., Bailey, K. E., Scarborough, R., … & Gilkerson, J. (2020). Use of cefovecin in dogs and cats attending first‐opinion veterinary practices in Australia. Veterinary Record, 187(11), e95-e95 Norris, J. M., Zhuo, A., Govendir, M., Rowbotham, S. J., Labbate, M., Degeling, C., … & Ward, M. P. (2019). Factors influencing the behaviour and percepti…