What is the use of hextend?
Indications and Usage for Hextend. Hextend (6% Hetastarch in Lactated Electrolyte Injection) is indicated in the treatment of hypovolemia when plasma volume expansion is desired. It is not a substitute for blood or plasma.
Can hextend be used as a substitute for blood?
Hextend (6% Hetastarch in Lactated Electrolyte Injection) is indicated in the treatment of hypovolemia when plasma volume expansion is desired in settings where adequate alternative treatment is unavailable. It is not a substitute for blood or plasma. Do not use HES products, including Hextend, unless adequate alternative treatment is unavailable.
Is hextend safe to use for lactated electrolyte injection?
DO NOT use HES products, including Hextend, unless adequate alternative treatment is unavailable. Hextend ® (6% Hetastarch in Lactated Electrolyte Injection) is a sterile, nonpyrogenic solution for intravenous administration. The composition, pH, and osmolarity are given in Table 1 and the electrolyte composition in Table 2.
What are HES colloids?
In common with all of the synthetic colloids, HES are polydisperse systems containing particles with a wide range of molecular mass. In polydisperse systems, the determination of particle mass or relative molecular mass gives averages, which depend on the method used as mentioned earlier (Mw and Mn).
Is hetastarch a colloid or crystalloid?
Hetastarch or Vetstarch, 2 to 10 mL/kg per hour, are a synthetic colloid solutions that has a high and low molecular weight respectively.
Is hetastarch a colloid solution?
Hydroxyethyl starch (hetastarch) is a synthetic colloid solution with adverse effects on blood coagulation.
Is hespan a colloid?
HESPAN® (6% hetastarch in 0.9% sodium chloride injection) is a sterile, nonpyrogenic solution for intravenous administration. Hetastarch is a synthetic colloid derived from a waxy starch composed almost entirely of amylopectin.
What is hetastarch colloid?
A synthetic, nonionic hydroxyethyl derivative of starch used as a plasma expander when prepared in an isotonic solution. Upon intravenous administration, hydroxyethyl starch colloid increases blood volume and thus improves circulation.
What are examples of colloids?
Examples of ColloidsColloids refer to dispersions of small particles usually with linear dimensions from around 1 nm to 10 micrometres. ... Examples: fog, smog, and sprays.Examples: smoke and dust in the air.Examples: milk and mayonnaise.Examples: pigmented plastics.Examples: silver iodide sol, toothpaste, and Au sol.More items...
What is colloid solution example?
According to colloidal solution definition, it is defined as a solution in which a material is evenly suspended in a liquid. Some of the Examples of Colloidal Solution are gelatin; muddy water, Butter, blood, Colored Glass.
What are the 5 types of colloid?
Based on the physical state of the dispersion medium and of the dispersed phase, colloids can be classified into:Foam.Solid Foam.Aerosol.Emulsion.Gel.Solid Aerosol.Sols.Solid sols.
What are the 4 types of colloids?
The types of colloids includes sol, emulsion, foam, and aerosol.Sol is a colloidal suspension with solid particles in a liquid.Emulsion is between two liquids.Foam is formed when many gas particles are trapped in a liquid or solid.Aerosol contains small particles of liquid or solid dispersed in a gas.
What are colloid drugs?
Colloids are used to provide oncotic expansion of plasma volume. They expand plasma volume to a greater degree than isotonic crystalloids and reduce the tendency of pulmonary and cerebral edema. About 50% of the administered colloid stays intravascular.
How does hextend work?
Hextend (hydroxyethyl starch) is made from natural sources of starch. This medicine increases the volume of blood plasma that can be lost from bleeding or severe injury. Plasma is needed to circulate red blood cells that deliver oxygen throughout the body.
What type of fluid is hetastarch?
HEXTEND (6% Hetastarch in Lactated Electrolyte Injection) is an artificial colloidal solution, pharmacologically classified as a plasma volume expander, and is intended to support oncotic pressure as well as provide electrolytes.
What are the 3 types of crystalloid solutions?
These solutions were designed to sustain a normal physiologic plasma pH. The three commonly used molecules are lactate, acetate, and gluconate.
What type of fluid is hetastarch?
HEXTEND (6% Hetastarch in Lactated Electrolyte Injection) is an artificial colloidal solution, pharmacologically classified as a plasma volume expander, and is intended to support oncotic pressure as well as provide electrolytes.
Is hetastarch a hypertonic solution?
Hypertonic saline solution-hetastarch for fluid resuscitation in experimental septic shock. Anesth Analg.
What are the 4 types of colloids?
The types of colloids includes sol, emulsion, foam, and aerosol.Sol is a colloidal suspension with solid particles in a liquid.Emulsion is between two liquids.Foam is formed when many gas particles are trapped in a liquid or solid.Aerosol contains small particles of liquid or solid dispersed in a gas.
What are colloid IV solutions?
Colloids and crystalloids are types of fluids that are used for fluid replacement, often intravenously (via a tube straight into the blood). Crystalloids are low-cost salt solutions (e.g. saline) with small molecules, which can move around easily when injected into the body.
How long does dextran stay in the body?
Kidneys primarily excrete dextran solutions. Smaller molecules (14000–18000 kDa) are excreted in 15minutes, whereas larger molecules stay in circulation for several days. Up to 40% of dextran-40 and 70% of dextran-70 remain in circulation at 12 h.2,16,17
How is polygeline produced?
Polygeline (‘Haemaccel’, Hoechst) is produced by the action of alkali and then boiling water (thermal degradation) on collagen from cattle bones. The resultant polypeptides (MW 12,000–15,000) are urea-crosslinked using hexamethyl di-isocyanate. The branching of the molecules lowers the gel melting point.
How many types of colloids are there?
Colloids are of two types:1–4
What is colloids in medicine?
Abstract. Summary. The administration of intravenous fluids is one of the most common and universal interventions in medicine. Colloids are an alternative to the frequently used crystalloids, with highly variable use depending on a myriad of clinical variables.
How much does a dextran solution weigh?
Two dextran solutions are now most widely used, a 6% solution with an average molecular weight of 70,000 (dextran 70) and a 10% solution with an average weight of 40,000 (dextran 40, low-molecular-weight dextran).17
Which colloids have the shortest duration of volume expansion?
The duration of volume expansion varies, however, among the different colloids. Gelatins have the shortest duration of volume expansion.
What is colloid in biology?
A colloid is defined as a high molecular weight (MW) substance that largely remains in the intravascular compartment, thereby generating an oncotic pressure. Colloids are considered to have a greater intravascular persistence when compared to crystalloids. This property is lost, however, when capillary membranes are altered in a diseased state.
CLINICAL PHARMACOLOGY
The plasma volume expansion produced by HEXTEND approximates that produced by 6% Hetastarch in 0.9% Sodium Chloride Injection and the plasma volume expansion of 6% Hetastarch in 0.9% Sodium Chloride Injection in turn approximates that of 5% Albumin (Human).
INDICATIONS AND USAGE
HEXTEND (6% Hetastarch in Lactated Electrolyte Injection) is indicated in the treatment of hypovolemia when plasma volume expansion is desired. It is not a substitute for blood or plasma.
DOSAGE AND ADMINISTRATION
HEXTEND is administered by intravenous infusion only. Total dosage and rate of infusion depend upon the amount of blood or plasma lost and the resultant hemoconcentration as well as age, weight, and clinical condition of the patient.
HOW SUPPLIED
HEXTEND (6% Hetastarch in Lactated Electrolyte Injection) is supplied sterile and nonpyrogenic in 500 mL single-dose flexible plastic infusion containers.
What is hextend 6%?
HEXTEND ® (6% Hetastarch in Lactated Electrolyte Injection) is a sterile, nonpyrogenic solution for intravenous administration. The composition, pH, and osmolarity are given in Table 1 and the electrolyte composition in Table 2.
What is hexend in lactic acid?
HEXTEND (6% Hetastarch in Lactated Electrolyte Injection) is an artificial colloidal solution, pharmacologically classified as a plasma volume expander, and is intended to support oncotic pressure as well as provide electrolytes.
What is the chemical name for hetastarch?
The chemical name for hetastarch is hydroxyethyl starch.
What is the alkaline effect of lactate?
Lactate is provided at 28 mEq/L. Sodium lactate in water dissociates to provide sodium (Na +) and lactate (C 3 H 5 O 3 –) ions. The lactate anion provides an alkaline effect resulting from simultaneous removal of lactate and hydrogen ions by the liver. In the liver, the lactate is metabolized to glycogen, which is ultimately converted to carbon dioxide and water by oxidative metabolism.
What is a flexible plastic container?
The flexible plastic container is fabricated from a specially formulated polyvinylchloride. Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials. The container solution unit is a closed system and is not dependent upon entry of external air during administration. The container is overwrapped to provide protection from the physical environment and to provide an additional moisture barrier when necessary.
What is a hexene solution?
HEXTEND is a clear, pale yellow to amber solution. Exposure to prolonged adverse storage conditions may result in a change to a turbid deep brown or the formation of a crystalline precipitate. Do not use the solution if these conditions are evident.
How many ports does the closure system have?
The closure system has two ports; the one for the administration set has a tamper evident plastic protector.
What is Hextend?
Hextend (hydroxyethyl starch) is made from natural sources of starch. This medicine increases the volume of blood plasma that can be lost from bleeding or severe injury. Plasma is needed to circulate red blood cells that deliver oxygen throughout the body.
How is Hextend given?
Hextend is injected into a vein through an IV. A healthcare provider will give you this injection.
What happens if I overdose?
Since Hextend is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What does it mean to be allergic to corn?
If possible before you receive Hextend, tell your doctor if you have: liver disease; a history of heart disease; or. if you are allergic to corn.
What are the side effects of hextend?
Hextend side effects. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. easy bruising, unusual bleeding, or any bleeding that will not stop.
Can you take a blood clotting medication if you have a kidney disease?
You should not receive this medication if you have a bleeding or blood clotting disorder, congestive heart failure, kidney disease, or urination problems not caused by hypovolemia (decreased blood plasma volume).
Can hetastarch be used with other drugs?
Other drugs may interact with hetastarch, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
