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is ibuprofen contraindicated in kidney disease

by Desmond Little Published 7 months ago Updated 6 months ago

People with chronic kidney disease are generally advised not to take NSAIDs, with the exception of aspirin (for cardiovascular indications). NSAIDs have been associated with acute kidney injury in the general population and with progression of disease in those with chronic kidney disease.

Is ibuprofen OK for kidney disease?

Check with your doctor to be sure you can use these medicines safely, particularly if you have kidney disease. Heavy or long-term use of some of these medicines, such as ibuprofen, naproxen, and higher dose aspirin, can cause chronic kidney disease known as chronic interstitial nephritis.

Which NSAID is safest for kidneys?

Ibuprofen was the safest NSAID, conferring a significant 12% increased risk of incident eGFR less than 60, 32% increased risk of an eGFR decline of 30% or greater, and 34% increased risk of the composite outcome. Etoricoxib had the largest negative effect on kidney function.

Is Tylenol or ibuprofen worse for your kidneys?

TYLENOL® does not affect kidney function the way that non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin (Bayer®), naproxen sodium (Aleve®), and ibuprofen (Advil®, MOTRIN® IB) can.

What can I take instead of ibuprofen for inflammation?

Naproxen and aspirin are two other common over-the-counter pain relievers. Reeder describes the uses, benefits and potential problems with these as well: Naproxen. Another anti-inflammatory drug, which works much like ibuprofen.

Can Stage 3 kidney disease patients take ibuprofen?

People with chronic kidney disease are generally advised not to take NSAIDs, with the exception of aspirin (for cardiovascular indications). NSAIDs have been associated with acute kidney injury in the general population and with progression of disease in those with chronic kidney disease.

What pain reliever is hard on kidneys?

And although many people assume that over-the-counter pain relievers are safe because they're easily accessible, abusing these medications can cause serious health problems down the line. Some common medications like ibuprofen and naproxen are known to even cause kidney problems.

What pain meds are hard on kidneys?

NSAIDS, or nonsteroidal anti-inflammatory drugs like ibuprofen (Advil, Motrin) and naproxen (Aleve), lead the list for drugs that cause kidney damage because of their widespread use.

What pain reliever is not a NSAID?

Acetaminophen (Tylenol) is known as a non-aspirin pain reliever. It is NOT an NSAID, which is described below. Acetaminophen relieves fever and headaches, and other common aches and pains. It does not relieve inflammation.

Which pain reliever is least harmful to the kidneys?

Over-the-counter Tylenol (generic acetaminophen) is often the best choice for people with high blood pressure, heart failure, or kidney problems.

Is kidney damage caused by NSAIDs reversible?

Generally, the renal failure with NSAIDs is acute and reversible, though analgesic nephropathy with papillary necrosis and chronic renal failure are reported.

What pain reliever is hard on kidneys?

And although many people assume that over-the-counter pain relievers are safe because they're easily accessible, abusing these medications can cause serious health problems down the line. Some common medications like ibuprofen and naproxen are known to even cause kidney problems.

Can kidneys recover from NSAID damage?

Renal function will recover in most patients after withdrawal of NSAID therapy. Steroids may aid recovery in patients with interstitial nephritis who do not improve after stopping NSAID therapy.

What Pain Relievers Are Safe for Kidneys?

Stick to medications like Tylenol, Midol, and Excedrin, which use acetaminophen as their active ingredient to play it safe.

What is the function of the kidneys?

Your kidneys function as your body’s filter, ridding the body of toxins and waste while returning nutrients, vitamins, hormones, and other vital substances to the bloodstream. And because the kidneys receive such heavy volumes of your bloodstream, they are susceptible to damage caused by diabetes and high blood pressure. However, inappropriate medication use can also cause kidney damage.

Is It Bad to Take Ibuprofen Every Day?

If you are suffering from an injury or illness, it’s perfectly acceptable to take Ibuprofen as directed for a few days in a row. However, regardless of whether or not you are pro ne to kidney problems, you should not take the medication every day indefinitely unless prescribed by your doctor. Not only can it cause kidney damage, but excessive Ibuprofen intake can also cause mild nausea, stomach ulcers, and more.

Is Tylenol or Ibuprofen Worse for Your Kidneys?

Unlike Ibuprofen and other NSAIDs, the active ingredient in Tylenol (acetaminophen) does not cause damage to the kidneys. In fact, the National Kidney Foundation recommends acetaminophen as the pain reliever of choice for occasional use in patients who have underlying kidney disease.

How Is Analgesic Nephropathy Diagnosed

Your healthcare provider will review your medical history and do a physical exam. Other tests may include:

How Do I Know If Analgesics Have Affected My Kidneys

Your doctor can check your kidneys by doing a simple blood test called a serum creatinine level. This test measures the amount of a waste product in your blood that is normally removed by your kidneys. If your kidneys are not working as well as they should, the creatinine level will be increased in your blood.

What Form Does This Medication Come In

Each brown, sugar-coated tablet/caplet contains 200 mg of ibuprofen.

What Side Effects Are Possible With This Medication

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

Risks For Distance Runners

Acute kidney injury is common in these athletes due to the high rates of dehydration that cause reduced blood flow and rhabdomyolsis a breakdown of muscle tissue that leads to the release of muscle fiber contents into the blood, which is harmful to the kidney and often causes kidney damage, Lipman said.

Pain Reliever Linked To Kidney Injury In Endurance Runners

The common practice of taking ibuprofen for pain relief while competing in ultramarathons causes an increased risk of acute kidney injury, a Stanford study says.

What Is The Connection Between Ibuprofen And Kidney Disease

The connection between ibuprofen and kidney damage might appear suddenly or after long-term use, depending on several risk factors. People with kidney disease might suffer acute kidney failure when using this nonsteroidal, anti-inflammatory drug .

What are the liver enzymes that are elevated with NSAIDs?

Borderline elevations of serum transaminases, LDH, and alkaline phosphatase have been reported in up to 15% of patients treated with nonsteroidal anti-inflammatory drugs (NSAIDs). These abnormalities may progress, remain unchanged, or regress with continuing therapy. Notable liver enzyme elevations exceeding 3 times the upper limit of normal have been reported in approximately 1% of patients in clinical trials. In addition, rare cases of severe hepatotoxicity, including liver necrosis, hepatic failure, jaundice and fatal fulminant hepatitis, have been reported. Therapy with NSAIDs should be administered cautiously in patients with preexisting liver disease. Periodic monitoring of liver function is recommended during prolonged therapy. NSAIDs are also highly protein-bound and some are extensively metabolized by the liver. Metabolic activity and/or plasma protein binding may be altered in patients with hepatic impairment. A dosage reduction may be required in some cases.

Can COX-2 inhibitors cause gastric ulcers?

In addition, there is evidence that COX-2 inhibitors may delay healing of gastric ulcers, and likely to the same extent as traditional NSAIDs. Thus, therapy with all NSAIDs, including COX-2 inhibitors, should be prescribed cautiously in patients with a history of peptic ulcer disease and/or gastrointestinal bleeding.

Can NSAIDs cause fluid retention?

Fluid retention and edema have been reported in association with the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Therapy with NSAIDs should be administered cautiously in patients with preexisting fluid retention, hypertension, or a history of heart failure. Blood pressure and cardiovascular status should be monitored closely during the initiation of NSAID treatment and throughout the course of therapy.

Can NSAIDs cause renal failure?

Chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with renal toxicities, including elevations in serum creatinine and BUN, tubular necrosis, glomerulitis, renal papillary necrosis, acute interstitial nephritis, nephrotic syndrome, and renal failure. In patients with pre-renal conditions whose renal perfusion may be dependent on the function of prostaglandins, NSAIDs may precipitate overt renal decompensation via a dose-related inhibition of prostaglandin synthesis. Patients at greatest risk for this reaction include geriatric patients and those with impaired renal function, heart failure, liver dysfunction, or substantial volume and/or sodium depletion (e.g., due to diuretics). Therapy with NSAIDs should be administered cautiously in such patients, and hypovolemia and hyponatremia should be corrected prior to initiating treatment. Clinical monitoring of renal function is recommended during therapy, particularly in the presence of manifestations associated with mild azotemia (e.g., malaise, fatigue, loss of appetite). If renal function declines or renal failure occurs, prompt discontinuation of NSAID therapy will usually lead to recovery to the pretreatment state. NSAIDs are generally not recommended for patients with advanced renal disease due to the lack of information from controlled clinical studies regarding their use in such patients.

Can NSAIDs cause thrombocytopenia?

With the exception of aspirin, the platelet effects seen with most NSAIDs at usual recommended dosages are generally slight and of relatively short duration but may be more pronounced in patients with underlying hemostatic abnormalities. Thrombocytopenia has also been reported rarely during NSAID use.

Do NSAIDs affect liver function?

Periodic monitoring of liver function is recommended during prolonged therapy. NSAIDs are also highly protein-bound and some are extensively metabolized by the liver. Metabolic activity and/or plasma protein binding may be altered in patients with hepatic impairment. A dosage reduction may be required in some cases.

Does Motrin contain aspartame?

Chewable products frequently may contain aspartame, which is metabolized in the gastrointestinal tract to phenylalanine. Motrin (brand of ibuprofen) chewable 50 mg and 100 mg tablets provide the equivalent of 3 mg and 6 mg of phenylalanine each, respectively. The aspartame/phenylalanine content should be considered when these and similar products are used in patients who must restrict their intake of phenylalanine (i.e. phenylketonurics).

Why should Ibuprofen be avoided during pregnancy?

In late pregnancy, as with other NSAIDs, Ibuprofen tablets should be avoided because it may cause premature closure of the ductus arteriosus.

What is the most common adverse reaction to ibuprofen?

The most frequent type of adverse reaction occurring with Ibuprofen tablets is gastrointestinal. In controlled clinical trials the percentage of patients reporting one or more gastrointestinal complaints ranged from 4% to 16%.

How long after ibuprofen infusion did a 19-month-old have apn?

Approximately 1½ hours after the reported ingestion of from 7 to 10 Ibuprofen tablets (400 mg), a 19-month old child weighing 12 kg was seen in the hospital emergency room, apneic and cyanotic, responding only to painful stimuli. This type of stimulus, however, was sufficient to induce respiration. Oxygen and parenteral fluids were given; a greenish-yellow fluid was aspirated from the stomach with no evidence to indicate the presence of Ibuprofen. Two hours after ingestion the child's condition seemed stable; she still responded only to painful stimuli and continued to have periods of apnea lasting from 5 to 10 seconds. She was admitted to intensive care and sodium bicarbonate was administered as well as infusions of dextrose and normal saline. By four hours post-ingestion she could be aroused easily, sit by herself and respond to spoken commands. Blood level of Ibuprofen was 102.9 mcg/mL approximately 8½ hours after accidental ingestion. At 12 hours she appeared to be completely recovered.

What is the melting point of ibuprofen?

Ibuprofen is a white powder with a melting point of 74° to 77° C and is very slightly soluble in water (<1 mg/mL) and readily soluble in organic solvents such as ethanol and acetone.

Can Ibuprofen be given to asthma patients?

Ibuprofen tablets should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients (see WARNINGS, Anaphylactoid Reactions, and PRECAUTIONS, Preexisting Asthma ).

Does food affect ibuprofen bioavailability?

The bioavailability of the drug is minimally altered by the presence of food. A bioavailability study has shown that there was no interference with the absorption of Ibuprofen when Ibuprofen tablets were given in conjunction with an antacid containing both aluminum hydroxide and magnesium hydroxide.

Is ibuprofen better than aspirin?

In clinical studies in patients with rheumatoid arthritis and osteoarthritis, Ibuprofen tablets have been shown to be comparable to aspirin in controlling pain and inflammation and to be associated with a statistically significant reduction in the milder gastrointestinal side effects (see ADVERSE REACTIONS ). Ibuprofen may be well tolerated in some patients who have had gastrointestinal side effects with aspirin, but these patients when treated with Ibuprofen tablets should be carefully followed for signs and symptoms of gastrointestinal ulceration and bleeding. Although it is not definitely known whether Ibuprofen causes less peptic ulceration than aspirin, in one study involving 885 patients with rheumatoid arthritis treated for up to one year, there were no reports of gastric ulceration with Ibuprofen whereas frank ulceration was reported in 13 patients in the aspirin group (statistically significant p<.001).

What percentage of participants reported taking ibuprofen during an ultramarathon?

Lipman explains that one of his driving points to conduct the study was to examine the effect of taking ibuprofen during an ultramarathon after noticing that over 75 percent of participants reported doing so. They then found a link between the ibuprofen and acute kidney injury.

What percentage of runners came back with kidney injury?

Burns explained that they observed that around 44 percent of the whole group came back with acute kidney injury.

Does ibuprofen affect kidneys?

Study reveals harmful effects on kidney of Ibuprofen. The use and effect of ibuprofen, a common ingredient in many pain-relieving medications, among ultramarathon runners was studied by Stanford researchers in the department of emergency medicine, whose findings suggested high consumption increased risk of acute kidney disease ...

Is ibuprofen safe for ultramarathons?

Lipman explains the recent findings about the long-term risks of ibuprofen pose much concern for the ultramarathon community because of the high rate of people taking ibuprofen to alleviate symptoms. The particular runners in the study were competing in 150-mile weeklong races, often over rugged terrain, according to an interview with Lipman in ...

When to include ibuprofen in consideration of a toxic agent?

Include ibuprofen in consideration of a toxic agent when treating patients who have overdosed on an unknown substance.

Is ibuprofen an over the counter medication?

Ibuprofen, an over-the-counter drug in most countries, is available in forms convenient for consumer consumption. Typical dosage formulations include oral capsule, oral suspension, oral tablet, chewable tablet, intravenous solution, topical gel, and combination kit. The recommendation with oral administration is usually to consume the drug with food or milk in both adults and children. IV administration is often an option in inpatient settings for convenience of delivery or when oral delivery is unavailable,[15][4]and infusion should be over at least 30 minutes for adults and 10 minutes in pediatric patients. Ibuprofen with lysine is a commonly used IV formulation. Ibuprofen should not be administered simultaneously with total parenteral nutrition but may still use the same line, pausing total parenteral nutrition for 15 minutes before and after ibuprofen dosing. Burgeoning research hopes to explore further the possibility of simultaneous delivery of ibuprofen with other IV medications or nutrition. A recent study exploring the chemical compatibility of continuous ibuprofen lysine infusion with total parenteral nutrition was conducted in 2018, which showed both physical and chemical compatibility of IV ibuprofen infusion with two different total parenteral nutrition formulations in neonates with PDA.[28]  The topical application of ibuprofen is also currently under research as a more efficient means of treating diseases known to be susceptible to ibuprofen, such as osteoarthritis and dysmenorrhea. [9][29]

Is ibuprofen an antipyretic?

Ibuprofen is also an FDA-approved antipyretic used for fever reduction in both adults and children. The use of NSAIDs in treating fever is much more commonplace in pediatric patients, and much contemporary research centers around creating more efficacy in the usage of ibuprofen in treating pediatric fever. A literature review in 2017 showed little evidence to suggest superior efficacy between either ibuprofen or acetaminophen (paracetamol) in the treatment of fever. Six studies evaluated in the review showed a marginal difference with ibuprofen, but data remained insufficient to state ibuprofen as producing better outcomes.[5] In a related study, refractory fevers responded more favorably to alternating acetaminophen and ibuprofen dosing compared with monotherapy of either, but only in those patients who respond positively after the first cycle. [6]

Is ibuprofen FDA approved?

Ibuprofen is indicated and FDA-approved for use in the treatment of inflammatory diseases and rheumatoid disorders. The discovery of ibuprofen was spurred by finding an alternative non-corticosteroid treatment for rheumatoid arthritis. The disease was the initial impetus for creating what would eventually become known as ibuprofen; Dr. Stewart Adams OBE was the researcher whose work would lead to the discovery of the drug. Initially patented as 2-(4-isobutylphenyl) propionic acid in 1961 by Dr. Adams and John Nicholson, ibuprofen became and remains one of the most widely used NSAIDs worldwide.[1] Today, ibuprofen remains a monotherapy for managing pain in rheumatoid disorders and inflammatory diseases, with a portion of research centered around creating novel treatments or drugs. One such study involves creating NSAID and carbonic anhydrase inhibitor hybrid drugs to manage pain in rheumatoid arthritis. [2]

Does ibuprofen affect renal function?

Diminished renal function is also a concern with ibuprofen usage, with a recent surveillance study showing NSAIDs having nephrotoxic properties even in patients with no deficit in kidney function.[32] Dehydration is a common risk factor in ibuprofen-induced renal injury, and as such much research has taken place regarding NSAIDs and kidney function in populations more vulnerable to dehydration, such as children with renal comorbidities or endurance athletes. A double-blind placebo-controlled trial in a population of ultramarathon participants showed an increased rate of acute kidney injury in those who took ibuprofen, with a number needed to harm of 5.5.[33] Consideration of a patient’s renal function is necessary when weighing treatment with ibuprofen or other NSAIDs.

Is ibuprofen a NSAID?

It is in the non-steroidal anti-inflammatory drug (NSAID) class of medication s. This activity will highlight the mechanism of action, adverse event profile, pharmacology, and other vital factors pertinent for members of the interprofessional team in the treatment of patients with inflammatory diseases and related conditions.

Can ibuprofen be used for gout?

The use of ibuprofen for the treatment of gout attacks or flares has been long-researched, with Schweitz et al. in 1978 demonstrating the rapid improvement and symptom resolution in 10 patients with acute gouty arthritis after being treated with 2400 mg of ibuprofen .[12] NSAIDs are commonly used as monotherapy for mild flares and with colchicine as dual therapy for moderate or severe flares. Treatment of acute gout flares is an off-label use for ibuprofen.

Why are NSAIDs dangerous for kidney disease?

Nonsteroidal anti-inflammatory drugs (NSAIDs) have long been regarded as dangerous for use in patients with CKD because of their risk for nephrotoxicity and thus alternative classes of analgesics, including opioids, have become more commonly used for pain control in this population. Given the well-established risks that opioids and other analgesics pose, further characterization of the risk posed by NSAIDs in patients with CKD is warranted. NSAID use has been associated with acute kidney injury, progressive loss of glomerular filtration rate in CKD, electrolyte derangements, and hypervolemia with worsening of heart failure and hypertension. The risk for these nephrotoxicity syndromes is modified by many comorbid conditions, risk factors, and characteristics of use, and in patients with CKD, the risk differs between levels of glomerular filtration rate. In this review, we offer recommendations for the cautious use of NSAIDs in the CKD population after careful consideration of these risk factors on an individualized basis.

Why are CKD medications prescribed more frequently?

Medications that have adverse side effects specifically associated with their use in CKD are prescribed more frequently as patients progress to more severe stages of CKD.

What is the major concern associated with NSAID use?

The major concern associated with NSAID use is acute kidney injury (AKI). Despite this, AKI and other adverse effects such as fluid and electrolyte derangements rarely develop in patients with few or no risk factors for injury ( Box 2) with regular NSAID use.

What is the risk of proton pump inhibitors?

Proton pump inhibitors and traditional nonsteroidal anti-inflammatory drugs and the risk of acute interstitial nephritis and acute kidney injury.

Can NSAIDs cause kidney damage?

NSAIDs also cause kidney injury through idiosyncratic reactions, including acute interstitial nephritis (AIN). In this setting, AIN may occur in part due to shunting of arachidonic acid into the lipo-oxygenase pathway, leading to increased production of proinflammatory leukotrienes.

Does aspirin cause kidney failure?

Risk of kidney failure associated with the use of acetaminophen, aspirin, and nonsteroidal antiinflammatory drugs.

Can proteinuria be caused by NSAIDs?

Proteinuria and nephrotic syndrome due to either membranous nephropathy or minimal change disease are other well-established but more infrequent complications of NSAIDs, which may occur alone or with AIN.

Can you take Tylenol with heart failure?

Be sure to tell your doctor about any prescription drugs, over-the-counter drugs, or herbal medicines you take. Over-the-counter Tylenol (generic acetaminophen) is often the best choice for people with high blood pressure, heart failure, or kidney problems. However, high doses of Tylenol can damage the liver, so take the lowest dose you can ...

Does Tylenol hurt the liver?

However, high doses of Tylenol can damage the liver, so take the lowest dose you can to get enough pain relief.

Can NSAIDs cause shortness of breath?

Long-term use of NSAIDs can make your body hold onto fluid. This can make the symptoms of heart failure, such as shortness of breath, swollen ankles, and a rapid or irregular heartbeat, worse. NSAIDs can also keep the kidneys from working well. This makes taking NSAIDs risky for people who already have kidney disease.

Can NSAIDs cause high blood pressure?

NSAIDs are bad for your blood pressure. NSAIDs can cause high blood pressure. And if you have high blood pressure, they can make it worse. This increases your chances of having a heart attack or a stroke. NSAIDs can also keep some blood pressure drugs from working right. NSAIDs can interfere with:

Can you take ibuprofen with kidney disease?

NSAIDs help ease pain and inflammation. But if you have high blood pressure, heart failure, or kidney disease, you should not take an NSAID. And you should not take any drugs that have ibuprofen or another NSAID in them. Here’s why:



  • The following is a comprehensive ibuprofen dosage chart for adults to help explain the correct dosage in which the drug can treat specific conditions:
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  • Nonprescription cough and cold combination products, including products that contain ibuprofen, can cause serious side effects or death in young children. Do not give these products to children younger than 4 years of age. If you give these products to children 4 to 11 years of age, use caution and follow the package directions carefully. If you are giving ibuprofen or a combination …
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  • Sadly, some cases of toxicity occur because pet owners give human medication to their pet without being instructed to do so by a veterinarian. Ibuprofen and naproxen are intended for human use and should not be given to pets.
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  • Because it can cause life threatening complications when taken improperly you should take ibuprofen under the supervision of your health care provider, particularly if you will be using this medication for long-term treatment. You should monitor your condition carefully when on a long-term ibuprofen regimen and report any side affects you experience to your physician immediatel…
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Side Effects

  • Possible warning signs of some serious side effects that can occur during treatment with this medicine may include swelling of the face, fingers, feet, and/or lower legs; severe stomach pain, black, tarry stools, and/or vomiting of blood or material that looks like coffee grounds; unusual weight gain; yellow skin or eyes; decreased urination; bleeding or bruising; and/or skin rash. Also…
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  • Ibuprofen and other NSAIDS seldom affect the liver. Unlike acetaminophen (Tylenol) most NSAIDs are absorbed entirely and have minimal first-pass hepatic (liver) metabolism. To puts it simply, the way NSAIDS are metabolized makes liver toxicity (hepatotoxicity) really rare. Quotes are that 1 in 100,000 NSAID prescriptions result in severe liver injury. Normally NSAIDs are extremely liver-sa…
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  • It is a known fact that there is no specific ibuprofen toxicity. This is the reason why veterinary care is required for treating bleeding stomach ulcers and kidney failure.
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  • The most common side effects of ibuprofen (4) include ringing in your ears, rash or mild itching, constipation, diarrhea, gas, bloating, edema, headaches, nervousness, dizziness, mild heartburn, nausea, vomiting, and an upset stomach. Other ibuprofen side effects may include rapid weight gain, vision changes, severe skin reactions, ulcers, stomach inflammation, kidney problems, live…
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  • Ibuprofen may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).
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  • Both aspirin and ibuprofen may also cause hearing problems. You may notice ringing in your ears or a decrease in your hearing. If you do, you should contact your doctor.
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  • While NSAIDs rarely affect the liver, they have important adverse effects on the kidney that you should know about. Here is the science behind the problem. Ibuprofen and other NSAIDs block prostaglandins, natural body chemicals that normally dilate blood vessels leading to the kidneys. Blocking prostaglandins may lead to decreased blood flow to the kidneys, which means a lack o…
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  • This medicine may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk . This medicine may cause bleeding in your stomach or intestines. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if …
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Medical Uses

  • Prescription ibuprofen is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). It is also used to relieve mild to moderate pain, including menstrual pain (pain that happens before or during a menstrual period). Nonpres…
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  • Ginger is well known as an effective substitute for ibuprofen. In a double-blind comparative study published in the Journal of Alternative and Complementary Medicine in 2009, ginger was as effective as ibuprofen in relieving menstrual pain in women (10). In the study, 150 women with menstrual pain were divided into groups. One group took 250 mg capsules of ginger rhizome po…
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  • Ibuprofen is a type of non-steroidal anti-inflammatory drug, or NSAID, which is effective for reducing pain, fever and inflammation, as stated by PetPlace. Veterinarians commonly prescribe ibuprofen to treat dogs suffering from arthritis or musculoskeletal pain.
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  • Ibuprofen is the active ingredient in medications like Advil and Nuprin. Naproxen is similar to ibuprofen but is longer-acting; it is the active ingredient in medications like Aleve and Naprosyn. Ibuprofen and naproxen are widely used to treat pain, fever, and inflammation in people. Unfortunately, these drugs can be extremely toxic (poisonous) to cats and dogs. Toxicity occurs …
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  • Both aspirin and ibuprofen belong to a drug class called nonsteroidal anti-inflammatory drugs (NSAIDs). They have similar side effects, and taking them together increases your risk of these side effects.
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  • A number of medications are thought to interact with ibuprofen, such as anti-inflammatory painkillers (19), antihypertensive medications, aspirin, digoxin, lithium, methotrexate, tacrolimus, warfarin, selective serotonin reuptake inhibitors, and antidepressants. So its important to remember that ibuprofen alternatives include ginger, Panax ginseng, omega-3 fatty acids, and h…
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  • There are no known interactions between calcium and ibuprofen, according to the medication information site, but your specific condition and treatment regimen could cause side effects. Always check with your doctor before adding calcium supplements or prescription or over-the-counter ibuprofen to your care regimen.
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  • Take this medication by mouth, usually every 4 to 6 hours with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking this drug. If you have stomach upset while taking this medication, take it with food, milk, or an antacid. The dosage is based on your medical condition and response to treatment. To reduc…
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  • Ibuprofen comes alone and in combination with other medications. Some of these combination products are available by prescription only, and some of these combination products are available without a prescription and are used to treat cough and cold symptoms and other conditions. If your doctor has prescribed a medication that contains ibuprofen, you should be careful not to ta…
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  • For the treatment of mild to moderate pain, minor fever, and acute or chronic inflammatory conditions 200 mg to 400 mg of ibuprofen will work, and is similar to 650 mg of acetaminophen (Tylenol) or aspirin. Typically taken every 6 to 8 hours, the optimum dose of NSAIDs per day is 2400 mg which is 12 over-the-counter pills.
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  • If you do take ibuprofen, what is the proper dosage (3)? Ibuprofen can be used by adults and children that are at least six months of age. Its best to take ibuprofen as directed on the label, or as prescribed by your doctor. Ibuprofen should also not be taken in large amounts, or for longer than the recommended time period or dose. The maximum amount of ibuprofen for adults is 80…
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  • In other words, the way NSAIDs are metabolized makes liver toxicity (aka. hepatotoxicity) very rare. Estimates are that one in 100,000 NSAID prescriptions result in acute liver injury. Generally, NSAIDs are very liver-safe.
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  • Results published in the journal Drug and Chemical Toxicology in 2012 indicate that ibuprofen is capable from inducing genotoxicity in bone marrow cells of mice (5). Genotoxicity is a term that describes genetic mutations, or DNA damage, which can possibly lead to cancer. In the study, ibuprofen was given orally to mice at doses of 10, 20, 40, and 60 mg per kg of body weight.
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  • The damaging effects of ibuprofen or naproxen in pets include inhibiting blood flow to the kidneys and interfering with the production of compounds that help protect the inner lining of the stomach. Therefore, toxic effects of ibuprofen and naproxen in dogs and cats include kidney damage that can lead to kidney failure and severe stomach irritation that can progress to stoma…
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  • Ibuprofen is also sometimes used to treat ankylosing spondylitis (arthritis that mainly affects the spine), gouty arthritis (joint pain caused by a build-up of certain substances in the joints), and psoriatic arthritis (arthritis that occurs with a long-lasting skin disease that causes scaling and swelling). Talk to your doctor about the risks of using this drug for your condition.
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Aspirin and ibuprofen are both used to treat minor pains. Aspirin can also help prevent heart attacks or strokes, and ibuprofen can lower fever. As you may have guessed, its possible to have conditions or symptoms that both drugs can treat or prevent. So can you take these drugs together? In short, most people shouldnt. H…
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Its logical to wonder if a medication you often take for pain is safe. There are some concerns about the popular over-the-counter pain relievers known as NSAIDs (non-steroidal anti-inflammatory drugs), which include ibuprofen (a.k.a. Motrin or Advil). Every week, Im asked: How much can I take, and is it bad for my liver or kidneys? …
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  • If you are diagnosing ibuprofen toxicity in a dog, it is recommended to hospitalize the dog with constant intravenous fluids. In case of recent ingestion, activated charcoal can be used for treating the toxicity. If your dog is in severe anemic conditions because of the bleeding ulcers, the best solution is blood transfusions. The normal medications for stomach ulcer including sucralf…
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Adverse Effects

  • Aspirin or ibuprofen may also cause allergic reactions, with symptoms such as hives, rash, blisters, facial swelling, and wheezing. Taking them together increases this risk as well. If you experience any redness or swelling from aspirin or ibuprofen, contact your doctor.
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  • Ibuprofen and other NSAIDS rarely affect the liver. Unlike acetaminophen (Tylenol), most NSAIDs are absorbed completely and undergo negligible liver metabolism.
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  • In a study published in the journal The Lancet in 2013, researchers found that long-term side effects of ibuprofen and other NSAIDs include an increased risk of heart attacks. Ibuprofen is also thought to increase the risk of stroke, especially when you have heart disease, or if its used long-term and in high doses. Its best to ask a doctor whether ibuprofen is safe for you, especially if y…
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1.Ibuprofen Contraindications & Interactions - Get Relief …


27 hours ago  · People with kidney disease might suffer acute kidney failure when using this nonsteroidal, anti-inflammatory drug . The link between ibuprofen and kidney disease might …

2.Is Ibuprofen Bad for Kidneys | Village Emergency Centers


9 hours ago NSAIDs (applies to ibuprofen) renal toxicities Major Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction, Dehydration, Congestive Heart Failure, Hyponatremia, Liver …

3.Can Ibuprofen Cause Kidney Issues


16 hours ago  · “It was seen that there was an 18 percent higher chance of somebody who was taking ibuprofen as opposed to the placebo to have acute kidney injury,” Burns said.

4.Ibuprofen Disease Interactions -


6 hours ago If you're over 65, ibuprofen can make you more likely to get stomach ulcers. Your doctor will prescribe you a medicine to protect your stomach if you're taking ibuprofen for a long-term …

5.Ibuprofen: Package Insert / Prescribing Information


14 hours ago Using a controlled multivariable analysis, a retrospective cohort study of nearly 2,000 patients using ibuprofen and 4,000 using acetaminophen found that age of 65 years and older and …

6.Study reveals harmful effects on kidney of Ibuprofen


30 hours ago if you have high blood pressure, heart failure or kidney disease, you should not take an NSAID or any drugs that have ibuprofen or another NSAID in them. When people have pain, they often …

7.Who can and cannot take or use ibuprofen - NHS


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8.Ibuprofen - StatPearls - NCBI Bookshelf


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9.NSAIDs in CKD: Are They Safe? - American Journal of …


10 hours ago

10.Painkiller Choices with Kidney or Heart Problems


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