Precautions
How is iron dextran given?
What happens if I overdose?
What should I avoid while using iron dextran?
What other drugs will affect iron dextran?
What is iron dextran used for?
What are the side effects of a syringe?
What to do if you feel light headed?
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About this website
What is side effect of iron dextran?
Tell your doctor right away if you have the following symptoms after receiving this medicine: chills, backache, dizziness, headache, moderate to high fever, joint or muscle pain, nausea, or vomiting. Tell any doctor or dentist who treats you that you are using this medicine.
Does iron dextran have a black box warning?
Iron dextran carries a black box warning because of this risk of severe, sometimes fatal anaphylactic reactions (loss of consciousness, collapse, difficulty breathing associated with the high molecular weight product. 3,4 High molecular weight iron dextran (Dexferrum) has been removed from the U.S. market.
Is getting an iron infusion safe?
While most iron infusions are safe and well tolerated, hypophosphatemia following parenteral iron infusion presents a new complication that appears to be growing in frequency. Clinicians should encourage patients to seek follow-up care if they experience new musculoskeletal symptoms or unusual tiredness.
What is iron dextran made from?
Iron Dextran, Iron Sucrose Iron dextran injection contains either 100 mg elemental iron per mL or 200 mg per mL. Ferric hydroxide is complexed with a low-molecular-weight dextran in this formulation. Iron dextran is a dark brown, slightly viscous liquid complex of ferric oxide and hydrolyzed dextran.
Which iron infusion has the least side effects?
Injectafer has fewer common side effects: Nausea. High blood pressure....Triferic AVNU also tends to cause more side effects:Low blood pressure during infusion.Muscle spasms.Headache.Swelling or pain in the arms or legs.Fever.
What is a safe iron supplement?
Ferrous sulfate is an iron supplement you may use to treat iron-deficiency anemia. You may need ferrous sulfate if you don't get enough iron through the foods you eat. Ferrous sulfate comes in tablet and liquid form.
Why do I feel worse after iron infusion?
Iron infusion side effects However, some people may feel worse after an iron IV infusion due to the side effects of the medication. The most common side effects include headache, dizziness, nausea, and vomiting. These symptoms typically go away on their own within a day.
Why do I feel sick after iron infusion?
Headache, feeling sick or vomiting, muscle or joint pain. Changes in taste (e.g. metallic) Changes to blood pressure or pulse. Mild fever, skin staining (brown discolouration) may occur due to leakage of iron into the tissues around the needle site.
How many iron infusions are safe?
Most doctors will not recommend giving an individual more than 600 mg of iron in one week. If a person receives too much iron too quickly, they may be at greater risk for adverse side effects from the infusion.
How often can iron dextran be given?
Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute.
How often can you get iron dextran?
If no reaction is seen after one hour, the full dose may be given. You will be checked carefully for reactions by a health care worker each time you are getting the iron. Iron injections may be given once daily in small doses or as directed by your doctor.
Is it good to take iron injection?
An iron infusion is a way to increase the body's iron levels quickly. It's a more immediate treatment than supplements or dietary changes. This can be very helpful in situations where anemia is severe. The physical benefits of an iron infusion include increased energy and easier breathing.
Which patient is contraindicated for therapy with iron dextran?
Iron dextran is contraindicated in patients with iron dextran hypersensitivity. Fatal anaphylactoid reactions have occurred during the parenteral administration of iron dextran. These reactions have been characterized by sudden onset of respiratory difficulty and/or cardiovascular collapse.
What is the black box warning for Epogen?
The warning states: Avoid serious cardiovascular and arterial and venous thromboembolic events by using the lowest dose of Aranesp, Epogen, or Procrit that will gradually raise the hemoglobin concentration to the lowest level sufficient to avoid the need for blood transfusion.
What is the function of iron dextran injection?
Iron dextran injection is used to treat iron-deficiency anemia (a lower than normal number of red blood cells due to too little iron) in people who cannot be treated with iron supplements taken by mouth.
How long does it take iron dextran to work?
[2][3] Hematologic responses of iron dextran may be observed within 3 to 10 days.
Before Taking This Medicine
You should not receive iron dextran if you are allergic to it, or if you have a type of anemia that is not caused by iron deficiency.To make sure i...
How Is Iron Dextran given?
Iron dextran is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not under...
What Happens If I Overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include joint pain, chills, dizziness, fever,...
Iron Dextran Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue,...
What Other Drugs Will Affect Iron dextran?
Other drugs may interact with iron dextran, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your...
Iron Dextran Intravenous: Uses, Side Effects, Interactions ... - WebMD
Find patient medical information for iron dextran intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Iron Dextran Injection: Uses, Side Effects, Interactions ... - WebMD
Find patient medical information for iron dextran injection on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Iron Dextran Dosage Guide + Max Dose, Adjustments - Drugs.com
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 1 Nov 2022), Cerner Multum™ (updated 25 Oct 2022), ASHP (updated 12 Oct 2022 ...
iron dextran (Dexferrum, INFeD) - MedicineNet
Iron dextran is an injectable form of iron used to treat iron-deficiency anemia, a condition in which the blood doesn't have enough healthy red blood cells because of a deficiency of available iron. It is only used to treat patients who cannot be adequately treated with oral iron supplements.Iron is an important mineral and is a necessary component of red blood cells and their ability to carry ...
INTRAVENOUS IRON THERAPY (Venofer or Feraheme or Iron Dextran ...
Sunnybrook Health Sciences Centre November 4, 2014 INTRAVENOUS IRON THERAPY (Venofer© or Feraheme© or Iron Dextran) INDICATIONS & CRITERIA FOR USE Intravenous iron may be used to treat iron deficiency defined as: 1. Hb < 110 AND either of 2 or 3 below
Dexferrum (iron dextran) dose, indications, adverse effects ... - PDR
PDR Drug Summaries are concise point-of-care prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their practice PDR's drug summaries are available free of charge and serve as a great resource for US based MDs, DOs, NPs and PAs in patient practice
What is the rarest anaphylactoid reaction?
Very rare (less than 0.01%): Acute severe anaphylactoid reactions (sudden onset of respiratory difficulty and/or cardiovascular collapse)
What does it mean when you feel lightheaded?
lightheadedness, dizziness, or fainting. muscle pain or stiffness. nausea. nervousness. no blood pressure or pulse. pain in the joints. pounding in the ears. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. redness of the face, neck, arms, and occasionally, upper chest.
What are the side effects of iron dextran?
Check with your doctor or nurse immediately if any of the following side effects occur while taking iron dextran: Incidence not known. Backache. blood in the urine. bluish color of the fingernails, lips, skin, palms, or nail beds. blurred vision. chest pain or discomfort. chills. cold, clammy skin.
Can you administer iron dextran with anaphylactic reaction?
Have resuscitation equipment and personnel readily available during administration. Administer a test dose, and only administer full dose in the absence of signs or symptoms of anaphylactic-type reaction. Observe patients during administration for anaphylactic-type reaction. Use iron dextran only in patients no amenable to oral iron therapy. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic reactions.
Does iron dextran need medical attention?
Side effects not requiring immediate medical attention. Some side effects of iron dextran may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
How is iron dextran ingested?
Iron dextran is ingested via endocytosis by the macrophages of the reticuloendothelial system. The fusion of the newly formed endosome with acidic lysosome results in the cleavage of the carbohydrate shell and the release of ferrous iron (Fe[2+]). Following release from its complex, Fe(2+) is shuttled across the endolysosomal membrane into the cytoplasm via divalent metal transporter 1 (DMT1), where it can be stored as a Fe-ferritin complex or get shuttled into the blood via ferroportin, a transmembrane protein. Once in the blood, Fe(2+) is immediately oxidized to ferric iron (Fe[3+]) by ceruloplasmin and subsequently bound by transferrin for transport to various sites throughout the body for utilization (i.e.,, to bone marrow for hemoglobin synthesis or to the liver for storage). [2][3] Hematologic responses of iron dextran may be observed within 3 to 10 days.
How long should you monitor for anaphylaxis?
Patients should be monitored for anaphylaxis and hypersensitivity reactions for 1 hour following the administration of a 25 mg (0.5 mL) test dose. Test doses should be administered over 1 to 2 minutes. Other adverse reactions must also require monitoring throughout dose administration. Patients who do not experience an anaphylactoid reaction during the test dose may still be at risk for developing adverse drug reactions during the administration of the remainder of the calculated required dose. Anemia-related parameters including hematocrit, reticulocyte count, serum ferritin, serum iron, total iron-binding capacity (TIBC), and hemoglobin should be monitored following administration. TIBC, serum iron, transferrin saturation, and ferritin require monitoring for cancer or chemotherapy-related anemia.[11] Patients with chronic renal failure need more frequent monitoring as compared to patients without renal failure.
Is iron dextran safe for anemia?
Additionally, iron dextran is contraindicated in any form of anemia, which is not the result of iron deficiency. Co-administration with dimercaprol should be avoided as iron-dimercaprol chelates are especially toxic to renal tissue. Patients taking angiotensin-converting enzyme inhibitors may be at an elevated risk of developing adverse reactions. Additionally, caution is necessary when administering iron dextran to patients with any disease states that mimic known major adverse effects; disease states of concern include atopy, asthma, rheumatoid arthritis, and cardiovascular disease.
Can you take iron dextran during pregnancy?
There is limited data regarding the safety of iron dextran during early pregnancy; therefore, Pavord et al. have suggested refraining from using intravenous iron dextran until the second or third trimesters.[8] Iron dextran may be found in trace amounts within breast milk; however, the World Health Organization (WHO) has indicated that iron dextran is compatible with breastfeeding.
Is iron dextran effective for chemotherapy?
Auerbach's multicenter randomized clinical trial demonstrated that iron dextran (INFeD) administration is useful in optimizing the effects of recombinant human erythropoietin in patients with chemotherapy-associated anemia .[4] The researchers found two different administration approaches to be effective; 1) a 25 mg test dose followed by a 75 mg bolus once weekly for the first three weeks and 100 mg over 5 minutes once weekly thereafter until achieving the total calculated required dose, and 2) a total dose infusion diluted in 500 mL of normal saline and infused at a rate of 175 mL per hour.
How much ml is 100 mg?
More than 10 kg: 100 mg (2 mL) / day
Is iron dextran a medicine?
Iron dextran is an injectable medication used in the management of iron deficiency anemia, particularly in patients who are unable to tolerate iron by mouth. It is in the class of medications referred to as iron replacement products. This activity outlines the indications, actions, and contraindications for iron dextran as a valuable agent in the treatment of iron deficiency anemia. Additionally, it will highlight the mechanism of action, adverse event profile, and other vital factors pertinent to members of the healthcare team.
What to do if you miss a dose of a med?
Missed Dose. For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule. Do not double the dose to catch up.
How long does it take for a syringe to go away?
Some people may experience a delayed reaction 1-2 days after their treatment. These side effects usually lessen within 3 to 4 days if the medication was injected into a vein or within 3 to 7 days if the medication was injected into a muscle.
What are the symptoms of an allergic reaction to a sulfate based sulfate solution?
Get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching / swelling (especially of the face/ tongue /throat), severe dizziness, trouble breathing . This is not a complete list of possible side effects.
Where to inject a syringe?
This medication is usually injected deep into the muscle of the buttock or slowly into a vein as directed by your doctor. When injecting into the buttock, the next injection is given on the opposite side from the last injection. Before the first full dose, a smaller test dose is given slowly to check for possible allergic effects.
Why is iron low?
Low iron levels can occur when the body can't get enough iron from food (poor nutrition, poor absorption) or when there is a large or long- term blood loss (for example, due to hemophilia, stomach bleeding). It is also used by people who have anemia due to long-term kidney disease .Iron is an important part of your red blood cells and is needed to carry oxygen in the body.
What should be done periodically to monitor your progress?
Notes. Laboratory and/or medical tests (e.g., complete blood count, iron) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details. It is important to maintain a well- balanced diet to ensure adequate intake of iron, vitamins, and minerals.
What is the best way to get iron?
It is important to maintain a well- balanced diet to ensure adequate intake of iron, vitamins, and minerals. Good sources of iron include meats ( especially liver ), eggs, raisins, figs, broccoli, Brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. Follow any diet recommendations given to you by your doctor.
INFeD (Iron dextran) - Dose, Indications, Side effects
INFeD is a formulation of Iron Dextran that contains 50 mg per ml of elemental iron. It is used in the treatment of iron deficiency anemia.
Infed (Iron Sucrose) for Iron replacement therapy in patients with blood loss
IM (INFeD, DexIron [Canadian product]), IV (INFeD, DexIron [Canadian product]): Replacement iron (mg) = blood loss (mL) x Hct Maximum daily dosage (manufacturer's labeling): Replacement of larger estimated iron deficits (total dose) may be obtained by serial administration of smaller incremental doses daily. Daily dosages should usually be limited to 100 mg iron i.e 2 mL..
Iron Dextran (Infed) in Cancer or chemotherapy-associated anemia: IV
Use the iron-deficiency anemia equation for determining a calculated dose, whenever applicable.
Infed (Iron Dextran) Dose in patients with Iron deficiency anemia
Infants ≥4 months, Children, and Adolescents: IM, IV: Test dose: Usual reported range: of 10 to 25 mg (0.2 to 0.5 mL) administered 1 hour before starting iron dextran therapy. The manufacturer suggests a fixed test dose of 25 mg i.e 0.5 mL); however, lower doses and a weight-based approach may be preferable and some centers have used the following: Infants ≥4 months and <10 kg: 10 mg (0.2 mL). Children 10 to 20 kg: 15 mg (0.3 mL). Children >20 kg and Adolescents: 25 mg (0.5 mL)..
Infed (Iron dextran) Dose in patients with anemia of chronic renal failure
Initiation of iron therapy, determination of dose, and duration of therapy should be on the basis of results of iron status tests combined with the Hb level and the dose of the erythropoietin stimulating agent.
Infed (Iron Dextran) Dose in Kidney Disease
There are no dosage adjustments provided in the drug manufacturer's labeling.
Monitoring parameters
Monitor iron, total iron-binding capacity, transferrin saturation, or ferritin levels at baseline and period of time.
How to calculate iron dextran dose?
I find it much simpler to do the following dose calculation: simply multiply the deficit for the hemoglobin (in grams) by 250mg (amount needed to form a pint of blood), and add an additional 1000 mg to replace the normal reserve amount.
How much iron dextran is in a drip chamber?
For an iron dextran dose of 3000 mg, the resulting concentration of iron dextran in the drip chamber would now be <0.008mg/cc, but as yet no iron dextran will have reached the patient.
How much iron dextran should I take for anaphylaxis?
The obvious benefit for this “ test dose/rapid desensitization ” method is to allow the patient to begin with a miniscule dose of iron dextran, rather than the package insert recommended 25mg, dose, which is sufficient to precipitate full-blown anaphylaxis if the patient is indeed sensitive. The tiny dose gives an opportunity for the patient to have a smaller reaction and for the medical personnel to stop the infusion quickly, before the adverse reaction can fully develop. On occasion, I have needed to slow an infusion, but none of my patients was unable to complete the full infusion, and no “medical resuscitation” beyond diphenhydramine and prednisone or dexamethasone has ever been required.
How much saline is allowed into the drip chamber?
2. A large drip chamber (Buretrol brand) is connected to the IV bag and 100cc of saline is allowed into the drip chamber and the IV flow is begun, at 125 cc/hr.
What is the intravenous solution to be used?
The intravenous solution to be used is normal saline.
How long does it take for hemoglobin to rise after iron deficiency?
The rate of red cell production and hemoglobin rise is generally proportionate to the severity of the patient’s anemia: most patients with severe iron deficiency will show a hemoglobin rise of approximately ½ gram/day for a week (i.e. 3 to 4 gram rise in hemoglobin in one week) if there are no other complicating medical problems. Patients with a lesser deficit, or with complicating illnesses will have a slower rate of rise.
Does iron dextran stain tissue?
Care should be taken to avoid extravasation of the iron solution since it does stain tissue, although not permanently . To decrease the risk of tissue staining, I request that the IV line be flushed with 20 cc of normal saline at the end of the infusion in order to minimize the presence of any residual iron dextran in the iv catheter.
How much iron dextran is in a ml?
Total iron dextran dose in mL = blood loss (mL) x hematocrit (expressed as a decimal fraction) x 0.02. NOTE: Iron dextran injection contains 50 mg of elemental iron per mL. If test dose uneventful, give the remainder of the total dose as 100 mg of elemental iron per day IM or slow IV until the total calculated dose is given. The maximum IV/IM dose of undiluted iron dextran is 100 mg (2 mL) per day.
How long after iron dextran is administered?
Observe patient for at least 1 hour after test dose administration. Because anaphylactic reactions are known to occur after uneventful test doses, subsequent test doses should be considered.
How long should you wait to give iron dextran?
Give DexFerrum test doses gradually over at least 5 minutes. Observe the patient for at least 1 hour after test dose administration. Because anaphylactic reactions are known to occur after uneventful test doses, test doses before subsequent doses should be considered. DO NOT mix iron dextran with other medications.
How long after a dexferrum test should you observe?
Observe the patient for at least 1 hour after test dose administration. Because anaphylactic reactions are known to occur after uneventful test doses, test doses before subsequent doses should be considered. DexFerrum: DexFerrum is administered by intravenous injection only.
What is SLE in iron dextran?
Ankylosing spondylitis, asthma, atopy, rheumatoid arthritis, systemic lupus erythematosus (SLE) Patients with a significant history of allergies (e.g., atopy), asthma, or other inflammatory conditions appear to be susceptible to experiencing adverse effects from iron dextran treatment.
How long does it take to infuse NS?
If test dose is uneventful after 1 hour of observation, then infuse the remaining dose over 4 to 6 hours (usually no faster than 2 to 6 mg/min). Once the infusion is completed, flush vein with NS injection.
Can iron dextran cause anaphylactoid reactions?
Fatal anaphylactoid reactions have occurred during the parenteral administration of iron dextran. These reactions have been characterized by sudden onset of respiratory difficulty and/or cardiovascular collapse. A test dose should be given prior to administration of the initial therapeutic dose.
How is iron dextran given?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using iron dextran?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
What other drugs will affect iron dextran?
Other drugs may affect iron dextran, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
What is iron dextran used for?
Iron dextran is used to treat iron deficiencies and iron deficiency anemia (low red blood cells). Iron dextran may also be used for purposes not listed in this medication guide.
What are the side effects of a syringe?
Common side effects may include: 1 mild itching or rash; 2 body aches, numbness or tingly feeling; 3 nausea, vomiting, stomach pain, diarrhea; 4 mild dizziness or weakness, low fever; or 5 brown discoloration of your skin.
What to do if you feel light headed?
Call your doctor or seek medical help right away if you feel light-headed or if you suddenly have trouble breathing. Also all your doctor at once if you have: fast or slow heartbeats. chest pain, wheezing, trouble breathing ; a light-headed feeling, like you might pass out; flushing (warmth, redness, or tingly feeling);
