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is it bad to have high folate levels

by Alberto Thompson Published 3 years ago Updated 2 years ago
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High levels of folate in the blood may mean that you eat a diet rich in folate or folic acid, take vitamins, or take folic acid pills. Consuming more folate than the body needs does not cause problems. High folate levels can also mean a vitamin B12 deficiency. Body cells need vitamin B12 to use folate.

Which foods is highest in folate?

The 20 Best Folate-Rich Foods

  • Banana. Who doesn't love a banana? ...
  • Papaya. This sweet, tropical fruit is sure to become a summer favorite once you learn about its many benefits.
  • Peanuts. ...
  • Turnip Greens. ...
  • Orange. ...
  • Crab (Dungeness) Good news for crab-lovers! ...
  • Tomato Juice. ...
  • Orange Juice. ...
  • Kidney Beans. ...
  • Brussels Sprouts. ...

More items...

What are the consequences of taking too much folate?

UMFA can cause a variety of problems within the body including (9,11):

  • Impairment of the immune system
  • Cancer grows more easily
  • Lowers iron
  • Slows cognition
  • Impairs memory

How to lower high folate levels?

To help lower ALT levels, consider adding more folate-rich foods to your diet, such as:

  • leafy greens, including kale and spinach
  • asparagus
  • legumes
  • Brussels sprouts
  • beets
  • bananas
  • papaya

What food group is high in folate?

Legumes, which include beans, peas, and lentils, are an excellent source of plant protein, as well as fiber, iron, magnesium, and antioxidants. They’re also high in folate, with different varieties providing different amounts. A half-cup of kidney beans has 46mcg and black-eyed peas have 105mcg.

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What happens if folate is too high?

Excess folic acid is excreted in urine. A high folate intake can mask vitamin B-12 deficiency until its neurological effects become irreversible. This can typically be remedied by taking a supplement containing 100 percent of the daily value of both folic acid and vitamin B-12.

Is high folate a concern?

"We found no evidence that folate could worsen their health problems. Consuming higher amounts of folate does not seem to interfere with the body's use of vitamin B12 in otherwise healthy individuals." Folate is the naturally occurring form of folic acid.

What is considered a high folate level?

Adults: 140-628 ng/mL or 317-1422 nmol/L. Children: Over 160 ng/mL or over 362 nmol/L.

How can I lower my folate levels?

The best way to prevent folate deficiency is to eat a healthy diet that includes foods that contain folate or folic acid. Folate can be found naturally in: Peas, beans and legumes. Citrus fruits.

What causes high levels of B12 and folate?

An abnormally high vitamin B-12 status can be an early sign of liver disease, diabetes, or certain types of leukemia. A doctor may use the results of a vitamin B-12 test to help form their diagnosis.

Can high folate cause neuropathy?

However, previous studies have found evidence that excess folate intake could potentially worsen associated neurological deficits, including peripheral neuropathy, in older adults.

What does folate mean in a blood test?

This test is done to check for folic acid deficiency. Folic acid helps form red blood cells and produce DNA that stores genetic codes. Taking the right amount of folic acid before and during pregnancy helps prevent neural tube defects, such as spina bifida.

What is a normal folate level for a woman?

For adults, normal serum folate levels range from 3–10 ng/mL. Normal red blood cell folate levels are typically between 140–630 ng/mL.

How much is too much folate?

We don't know of an amount that is dangerous. Yet, for most women, consuming more than 1,000 mcg of folic acid daily is of no benefit. Unless their doctor advises them to take more, most women should limit the amount they take to 1,000 mcg a day.

Can high folate cause neuropathy?

However, previous studies have found evidence that excess folate intake could potentially worsen associated neurological deficits, including peripheral neuropathy, in older adults.

What is a normal folate level for a woman?

The normal range is 2.7 to 17.0 nanograms per milliliter (ng/mL) or 6.12 to 38.52 nanomoles per liter (nmol/L).

Does folate build up in your system?

Folic acid does not cause harm when used at recommended levels. Folic acid dissolves in water. This means that it is regularly removed from the body through urine, so excess amounts do not build up in the body. You should not get more than 1000 mcg per day of folic acid.

How to get high folate levels?

The participants with high blood folate levels achieved them through high intake of folic acid in the form of fortified foods and supplements, not through eating naturally folate-rich foods.

How much folate should I take a day?

The RDI for folate is 400 mcg per day for most adults, 600 mcg per day during pregnancy , and 500 mcg per day while breastfeeding. Supplement dosages usually range from 400–800 mcg ( 1 ).

Why do people take folic acid supplements?

In certain countries, some foods are also fortified in this vitamin. Folic acid supplements are typically used to prevent or treat low blood folate levels. Moreover, pregnant women or those planning to become pregnant often take them to reduce the risk of birth defects ( 1. Trusted Source. ).

Why do pregnant women take folic acid?

Moreover, pregnant women or those planning to become pregnant often take them to reduce the risk of birth defects ( 1 ).

Why is folate important during pregnancy?

Adequate folate intake during pregnancy is necessary for your baby’s brain development and reduces the risk of malformations ( 21, 22, 23, 24 ).

Where does folate go before it is absorbed?

For instance, almost all of the folate you ingest from foods gets broken down and converted into its active form in your gut before being absorbed into your bloodstream ( 7 ).

Does folic acid cause mental decline?

Furthermore, other research ties excessive use of folic acid supplements to mental decline ( 20 ).

What causes high folic acid levels?

Possible Causes of High Folic Acid Level. 1. Pernicious Anemia. Pernicious anemia occurs when the your body doesn't make enough healthy red blood cells resulting from a vitamin B-12 deficiency, and a high folic acid level might hide the damaging effects of the deficiency by correcting the anemia caused by a vitamin B-12 deficiency, ...

Why is my folic acid level low?

A low folic acid level may indicate an anemia, folic acid deficiency, or malabsorption problems.

How much folic acid is in blood?

Medical experts agree that the normal range of folic acid in the blood is between 2.7 and 17.0 nanogram/milliliter. So how much folate acid can you take?

What does a bandage mean on a folic acid test?

A bandage is used to cover the puncture site, and the blood sample is sent to a laboratory for analysis. Review the results with you in a follow up appointment. What do the Results of a Folic Acid Test Mean? A high folic acid level is usually not a problem; however, it could indicate a vitamin B-12 deficiency.

What is the role of folic acid in the brain?

Folic acid (folate) also works closely with vitamin B-12 to help produce red blood cells, and is an essential vitamin critical to normal brain function, especially when tissue and cells are rapidly growing, such as during pregnancy, infancy, and adolescence.

Where to draw folic acid?

A folic acid test involves drawing a small sample of blood, usually from a vein on the inside of your elbow. A healthcare professional who performs the test will do the following: Swab the area with an antiseptic. Wrap an elastic band around the top of your arm, causing the veins below the band to swell.

Does folic acid raise serum folate?

Increased food containing folic acid may elevate your serum folate levels, but any high folic acid level associated with the food is likely to be short lived, and temporary. Folate consumption and temporary elevated serum folate levels generally do not cause any health risk, and the risk of toxicity from supplemented folic acid consumption is very ...

What is the natural form of folic acid?

Folate is the naturally occurring form of folic acid. Leafy green vegetables, citrus fruits, and beans all are sources of the vitamin.

What percentage of students are B12 deficient?

They also provided blood samples. The researchers found that about 5 percent of the students were B12 deficient. The researchers further divided the students with low B12 into two groups: those ...

Why do people with low B12 levels need to take a supplement?

People with low B12 levels can develop anemia, a condition in which the body does not make enough red blood cells to carry oxygen throughout the body.

What is the problem with the absorption of B12?

One such potential problem is pernicious anemia, a condition in which the body does not make enough of the protein needed to absorb B12 from the intestines. Other disorders or a history of intestinal surgery also could hinder the absorption of B12.

Does fortified food affect B12?

Increased folic acid from supplements, fortified foods not likely to affect B12 deficiency. Taking folic acid supplements or eating fortified grain products is unlikely to worsen problems related to low levels of vitamin B12, according to researchers at the National Institutes of Health and five other institutions in the United States, ...

Is bread a folate?

In the United States, bread, cereal and other enriched flour products have been fortified with folic acid (the synthetic form of the vitamin folate) since 1998. Women with low levels of folate are at increased risk for conceiving a child with birth defects of the brain and spinal cord known as neural tube defects.

Can older people absorb B12?

However, many of these studies were conducted in older people, a group more likely to have difficulty absorbing B12. Researchers were uncertain whether these blood abnormalities were due to the high folate levels or to medical conditions common to older people. For this reason, the NIH researchers conducted the current study in otherwise healthy younger people to determine if high folate levels alone had an influence on B12 metabolism.

What Is Folate?

Folate is one of a group of eight B vitamins, also including thiamin, riboflavin, biotin, pantothenic acid, niacin and vitamins B6 and B12. As a group, these vitamins play a role in metabolism and the formation of red blood cells. Individually, folate is involved in DNA and RNA synthesis and cell division. Folate also plays a role in lowering levels of an amino acid called homocysteine, high levels of which are associated with increased risk of heart disease, impaired cognitive function and depression.

What is the role of folate in the body?

As a group, these vitamins play a role in metabolism and the formation of red blood cells. Individually, folate is involved in DNA and RNA synthesis and cell division.

Can B12 cause cancer?

Untreated B12 deficiency can cause severe neurological problems. According to a 2018 review in Blood Journal, this only happens in the presence of large amounts of excess folic acid. Advertisement. Increases risk of cancer: Normal folate intake can be cancer-preventive.

Can folate deficiency cause anemia?

Exacerbates B12 deficiency: Folate deficiency and B12 deficiency both cause anemias, conditions in which the body is unable to make enough healthy red blood cells. Taking a folic acid supplement for folate deficiency can temporarily alleviate the symptoms of a B12 deficiency, allowing it to go untreated.

Is folic acid bad for you?

High Folate Levels Symptoms. When used at the appropriate dose, folic acid is safe for most adults. But it can still cause side effects, including: Advertisement. Bad taste in your mouth. Nausea. Loss of appetite. Confusion. Irritability.

Do pregnant women need folic acid?

Folate deficiency is uncommon in healthy adults. When you eat a balanced diet and have no health conditions impairing absorption of folate — also called folic acid — you don't need a supplement. But pregnant women, those planning a pregnancy and individuals with a gene mutation referred to as MTHFR do.

Can folate cause rash?

These side effects may occur at any dose, but large doses could be more likely to cause or worsen side effects. People with allergies may have allergic reactions to folate, symptoms of which include: Skin rash. Itching.

Why is folate high?

Pernicious anemia may cause high serum folate levels, due to impaired utilization of folate. According to a 2006 article by Florence Aslinia, M.D., and colleagues, published in the journal "Clinical Medicine & Research," if you are a person with a vitamin B12 deficiency caused by pernicious anemia, your serum folate levels will tend ...

What causes high folate levels in the body?

Intestinal blind loop syndrome can cause elevated serum folate levels. The University of Maryland Medical Center states that intestinal blind loop syndrome -- also known as stasis syndrome or stagnant loop syndrome -- occurs when a segment of your small intestine becomes bypassed and cut off from the usual flow of food and digestive juices. The bypassed segment of your small intestine, called a blind loop, creates numerous health problems. Food is unable to pass through the loop, and digestive juices stagnate. Decreased gut motility, meaning decreased movement of food through your gut, causes food to ferment, which encourages bacteria to flourish and interferes with your body's absorption of essential nutrients. Common signs and symptoms associated with blind loop syndrome include increased serum folate levels, loss of appetite, abdominal pain, nausea, fatty stools, bloating, diarrhea and unintentional weight loss.

What is the best source of folate?

Folate is a water-soluble B-complex vitamin. Common dietary sources of folate include cereals, leafy green vegetables, asparagus, legumes and organ meat. Certain medical conditions and other factors may cause you to have an increase in serum -- or blood -- folate levels.

Why does food ferment in the gut?

Decreased gut motility, meaning decreased movement of food through your gut, causes food to ferment, which encourages bacteria to flourish and interferes with your body's absorption of essential nutrients.

Does eating high folate increase your folate levels?

Any increase in serum folate associated with feeding is likely to be transient, or temporary. Folate intake, and therefore increased serum folate levels, is not associated with any health risk , and the risk of toxicity from supplement-related folic acid intake is extremely low. However, speculation is present that high levels of folic acid may provoke seizures if you are taking anti-convulsant medication. Consult a medical doctor before consuming a folic acid supplement if you are taking anti-convulsant medication.

Does folic acid cause seizures?

However, speculation is present that high levels of folic acid may provoke seizures if you are taking anti-convulsant medication.

What is the recommended daily amount of folate for adults?

The recommended daily amount of folate for adults is 400 micrograms (mcg).

What are the symptoms of folic acid?

Nausea. Loss of appetite. Confusion. Irritability. Sleep pattern disturbance. People with allergies might have a reaction to folic acid supplements. Warning signs of an allergic reaction include: Skin rash. Itching.

What drugs interact with folic acid?

Possible interactions include: Anticonvulsants. Taking folic acid with fosphenytoin (Cerebyx), phenytoin (Dilantin, Phenytek) or primidone (Mysoline) might decrease the drug's concentration in your blood. Barbiturates.

What fruits are rich in folate?

Fruits rich in folate include oranges, lemons, bananas, melons and strawberries. The synthetic form of folate is folic acid. It's in an essential component of prenatal vitamins and is in many fortified foods such as cereals and pastas. A diet lacking foods rich in folate or folic acid can lead to a folate deficiency.

Why is folic acid important for pregnancy?

The nutrient is crucial during early pregnancy to reduce the risk of birth defects of the brain and spine.

Is it safe to take folate?

Generally safe. For most people, it's best to get folate from food. A balanced diet usually provides all you need. However, folic acid supplements are recommended for women who are planning to become pregnant, could become pregnant, are pregnant or are breast-feeding.

Does folic acid decrease effectiveness?

Barbiturates. Taking folic acid with a drug that acts as a central nervous system depressant (barbiturate) might decrease the drug's effectiveness.

Why is my folate level high?

Causes Of High Folate Levels In The Blood. A high reflection of folate levels in the blood may not be a good sign. The causes of high folate levels in the blood may be the result of a recent high intake of folate and folic acid in the food. Folate is highly present in foods like; Citrus fruits. Liver. Dark green, leafy vegetables such as spinach.

How to maintain folate levels?

The best way to maintain normal folate levels in the blood is to take the required amount of folate either through foods or supplements. However, remember that it is also not advisable to take it in high quantities. Every now and then go for a folate blood test to know if you have this important vitamin in enough level. Sudheendra Reddy.

What causes folate to be less absorbed?

Few diseases such as celiac disease, Crohn’s disease in the gastrointestinal tract lead to less absorption of folate. Besides some cancers and kidney problems that ask for dialysis may also cause this condition.

What is the human-made type of folate?

Folic acid is the human-made type of folate which is present in fortified foods (fortified breakfast cereals) and vitamin pills (folic acid tablets).

How is folic acid blood drawn?

The blood is usually drawn using a needle. The result may come in hours, however, one may need other follow-up tests (if the doctor feels).

What does a folate blood test show?

What Does A Folate Blood Test Mean? The folate blood test is highly useful in measuring the levels of vitamin in the liquid portion of the blood (plasma or serum) to trace deficiencies. The test is also useful in knowing the quantity of folate inside red blood cells. Vitamin B12 and folate blood test can easily determine the level ...

Why is folic acid important for a fetus?

Folic acid is even key for the standard development of a fetus. It also aids with tissue and cell growth in addition to the making of DNA, which contains genetic information.

What would cause a slightly elevated b12 and folate (folic acid) level on complete blood count?

Dietary supplents: The most likely cause of elevated B12 and folate (folic acid) is dietary or parenteral supplements. Other sources of B12 and folate (folic acid) are t... Read More

What causes elevated B12 levels?

Dietary supplents: The most likely cause of elevated B12 and folate (folic acid) is dietary or parenteral supplements. Other sources of B12 and folate (folic acid) are t... Read More

Does folate mask anemia?

Masks anemia only: High folate (folic acid) can mask megaloblastic anemia caused by B12 deficiency but does not affect B12 levels. The high B12 levels you have are proof... Read More

Are elevated b12 and folate (folic acid) levels a problem? my most recent blood work showed these both to be high...any danger?

How high?: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that.... Read More

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1.High Folate Levels: What Do They Mean? - Health Guide

Url:https://ro.co/health-guide/high-folate-levels/

11 hours ago  · High folate might have other harmful effects relating to low B12. A study of elderly Americans in 2007 found that high folate blood levels for patients with normal B12 indicated …

2.Videos of Is It Bad To Have High Folate Levels

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7 hours ago "Today, it's concerning that consuming excess folate over the long run may lead to greater DNA methylation, which may then lead to other disorders, including maybe an increased risk of …

3.High Folic Acid Level | New Health Advisor

Url:https://www.newhealthadvisor.org/High-Folic-Acid-Level.html

36 hours ago  · Folate consumption and temporary elevated serum folate levels generally do not cause any health risk, and the risk of toxicity from supplemented folic acid consumption is very …

4.NIH study addresses concerns about high folate levels

Url:https://www.nih.gov/news-events/news-releases/nih-study-addresses-concerns-about-high-folate-levels

17 hours ago "We found no evidence that folate could worsen their health problems. Consuming higher amounts of folate does not seem to interfere with the body’s use of vitamin B12 in otherwise …

5.Signs and Symptoms of Too Much Folic Acid in Your Body

Url:https://www.livestrong.com/article/408171-signs-symptoms-of-having-too-much-folic-acid-in-your-body/

7 hours ago Folate intake, and therefore increased serum folate levels, is not associated with any health risk, and the risk of toxicity from supplement-related folic acid intake is extremely low. However, …

6.What Causes High Folate Serum Levels? | livestrong

Url:https://www.livestrong.com/article/284723-what-causes-high-folate-serum-levels/

9 hours ago  · Itching Redness Difficulty breathing Excess folic acid is excreted in urine. A high folate intake can mask vitamin B-12 deficiency until its neurological effects become …

7.Folate (folic acid) - Mayo Clinic

Url:https://www.mayoclinic.org/drugs-supplements-folate/art-20364625

16 hours ago  · A high reflection of folate levels in the blood may not be a good sign. The causes of high folate levels in the blood may be the result of a recent high intake of folate and folic …

8.Folate Blood Test- Normal Range, Low And High - Health …

Url:https://www.healthcheckup.com/tests/folate-blood-test-normal-range-low-and-high/

32 hours ago Masks anemia only: High folate (folic acid) can mask megaloblastic anemia caused by B12 deficiency but does not affect B12 levels. The high B12 levels you have are proof... Read More. …

9.High b12 and folate levels in blood - HealthTap

Url:https://www.healthtap.com/q/high-b12-and-folate-levels-in-blood/

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