is lantus an analog insulin

Is the Lantus insulin no longer covered by health insurance?

My understanding is soon Lantus will no longer be produced and everyone needs to be switched to the biosimilar insulin Basalar. Insurances are not covering Lantus because they want you switched before Lantus goes out of production. It is a 1:1 conversion. You will use the same dose of Basalar as you use with Lantus.

What does Lantus do for diabetes?

Like other types of insulin, Lantus is used to normalize blood sugar levels. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual dysfunction. Proper control of diabetes has also been shown to reduce your risk of a heart attack or stroke.

Is Toujeo and Lantus the same?

Toujeo has the same active ingredient as Lantus, called insulin glargine, but at three times the concentration and with a design to release the insulin more gradually. Lantus is the world’s most prescribed insulin. Full Prescribing Information for Toujeo® Continue reading >>

What is Lantus prescribed for?

What is Lantus ® (insulin glargine injection) 100 Units/mL? Prescription Lantus is a long-acting insulin used to treat adults with type 2 diabetes and adults and pediatric patients (children 6 years and older) with type 1 diabetes for the control of high blood sugar. Do not use Lantus to treat diabetic ketoacidosis.

Which insulins are analog insulins?

Currently, there are three commercially-available rapid-acting insulin analogs: insulin aspart, insulin lispro, and insulin glulisine (table 1 ▶). For each analog, the specific modifications made to the insulin molecule are relatively minor, involving only one or two amino acid alterations.

What type of insulin is Lantus?

Lantus is classified as a long-acting insulin. It contains the active drug insulin glargine, which is a biologic drug. Biologic drugs are made from parts of living cells. Lantus is available in a biosimilar form called insulin glargine-yfgn (Semglee).

Is insulin glargine analog?

Background: Insulin glargine is the first long-acting basal insulin analogue indicated for subcutaneous administration once daily at bedtime in adults with type 1 or type 2 diabetes mellitus and pediatric patients aged > or = 6 years with type 1 diabetes.

Is Lantus ultra long acting analogue insulin?

Glargine: Insulin glargin is also known as Lantus. It is a long-acting basal insulin analog. It is given once daily to control the blood sugar level.

How is Lantus different from other insulins?

Glargine (Lantus) is an insulin analog recently available in the U.S. It is a long-acting insulin but differs from other long-acting insulins (such as NPH, Lente, and ultralente) because it is clear as opposed to cloudy. It also has an acidic pH and should not be mixed with other insulins.

What is the difference between regular insulin and Lantus?

Insulin is one of the most effective blood sugar-lowering medication and can lower your A1c (average blood sugar over time) by up to 2-3%. Lantus (insulin glargine) is a long-lasting insulin that provides consistent, all-day sugar control with just once or twice daily dosing.

What is the difference between insulin and insulin analogues?

Insulin analogs are made in the same way as human insulin but are genetically altered to change the way they act in your body. Insulin analogs have a different chemical structure and lower your blood sugar more quickly once insulin is injected into your body.

What are long acting analogue insulin?

Long acting insulin analogs (Insulin Glargine, Insulin Detemir) which have an onset of insulin effect in 1 1/2-2 hours. The insulin effect plateaus over the next few hours and is followed by a relatively flat duration of action that lasts 12-24 hours for insulin detemir and 24 hours for insulin glargine.

Is NovoLog and analog insulin?

ReliOn™ NovoLog® is a rapid-acting insulin analog used to control high blood sugar in adults and children with diabetes.

When should you not take Lantus?

Who should not take Lantus Vial?low blood sugar.low amount of potassium in the blood.liver problems.decreased kidney function.

Which insulins are ultra long acting?

This includes insulin ultralente, detemir and glargine (Lepore 2000; Porcellati 2007). Ultra‐long acting insulin is defined as insulin showing the clinically significant biological action of a glucose lowering effect beyond 24 hours after subcutaneous injection in individuals with diabetes mellitus.

What is meant by insulin analogue?

An insulin analog (also called an insulin analogue) is any of several types of medical insulin that are altered forms of the hormone insulin, different from any occurring in nature, but still available to the human body for performing the same action as human insulin in terms of controlling blood glucose levels in ...

What blood sugar should you hold Lantus?

Once insulin therapy is started, a target glucose range of 140–180 mg/dL is recommended for the majority of critically ill and noncritically ill patients. More stringent goals, such as 140 mg/dL, may be appropriate for selected patients, as long as this can be achieved without significant hypoglycemia.

Is it better to take Lantus at night or in the morning?

Lantus can be used any time of day but at the same time every day. You should pick a time of the day that will be convenient and when it will be easiest to remember.

When should you not give Lantus?

You should not use Lantus if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar) or diabetic ketoacidosis (call your doctor for treatment). Lantus is not approved for use by anyone younger than 6 years old, and some brands are for use only in adults.

What are the 5 types of insulin?

The 5 types of insulin are:rapid-acting insulin.short-acting insulin.intermediate-acting insulin.mixed insulin.long-acting insulin.

What happens when you use Lantus?

By constantly releasing small amount of insulin into our bloodstream all day long, which is what happens when using basal doses of Lantus, all we will accomplish is suppression of our natural production (because the body doesn’t need to make as much anymore). Basically, we will be trading our natural insulin for synthetic insulin. What’s the point in that? While natural production will never be completely suppressed in the presence of basal dosages of insulin, we will still receive some benefit, but the results won’t be nearly as good as they could be.

How long does Lantus last?

Taking the above information into consideration, I believe Lantus is best used at large dosages for no more than 2-3 weeks at a time, max. The term “large” is subjective, as what might be large for one person might not be large for another and vice versa. Diabetics use Lantus as a “base” insulin in combination with shorter-acting insulins at meals times. The short-acting insulins are used to control the large rises in blood sugar that take place after meals, while Lantus is typically used to manage the minor fluctuations in blood glucose that occur between meals and when at rest. Obviously, if our goal is to maximize muscle growth, then we want to do more than just manage minor fluctuations in BG. After all, in non-diabetics the body does this well enough on its own.

How to get muscle growth while on Lantus?

During the time Lantus is active, you will need to eat at least 6-7 meals daily , including a meal right before bed. This will keep glucose and aminos pumping throughout your system, which will not only help prevent hypoglycemia, but will optimize muscle growth. I suggest following a traditional clean (lower-fat) diet during this time, as doing so will help minimize fat gain in those who are prone. Growth hormone makes a great addition as well, due to its significant and sustained lipolytic effect. Lastly, I always recommend insulin sensitizers be used with these kinds of programs, as they prevent/minimize the decrease in insulin sensitivity that normally accompanies their use. Metformin and berberine are two of the best and can be purchased at a low cost, although metformin will require a prescription. 500 mg of each, 2-3X per day, will suffice.

Why is insulin high?

In order to maximize results, insulin levels need to be high enough to facilitate the optimal transport of nutrients into the muscle cell every time we eat a meal , in spite of this suppression. However, the dose should never be so high that blood sugar drops dangerously low in-between feedings.

Does Lantus affect IGF-1?

Perhaps the most fascinating characteristic of Lantus is its affect on IGF-1/IGF-1 receptors. In multiple university studies, Lantus has demonstrated a much greater binding affinity for the IGF-1 receptor than regular human insulin or any of the other analogs. It is interesting to note that Levemir, the only other long-acting insulin on the market, exhibits reduced IGF-1 binding affinity compared to human insulin. This puts Lantus and Levemir at the opposite ends of the spectrum in terms of binding affinity. While increased IGF-1 binding is generally viewed as a positive thing for muscle growth, it has been the focal point of ongoing debate in the medical community for the last several years, as some studies have shown an increased cancer risk when using Lantus. Since then, other studies have refuted that notion, but the debate continues, with the medical community reluctant to take a stand one way or the other.

Is Lantus good for short periods?

The main downside to Lantus is that it can only be used for short-periods of time, as continuous exposure to elevated exogenous insulin levels will lead to reduced insulin sensitivity, subsequent Glut-4 down-regulation, and impaired endogenous insulin output, none of which are desirable from either a health or muscle growth standpoint. So, while Lantus may be superior for initiating muscle growth over the short-term, we find that things begin to even out in the long-run, as the more commonly employed pre-workout only programs can be used indefinitely without damaging insulin sensitivity to any meaningful degree. This makes Lantus ideal for short blasts, in which the athlete wants to pack on as much muscle as quickly as possible, but it is not suitable for extended use.

Is Lantus a good insulin?

Since maximum growth is the goal, this statement could easily be interpreted to mean that I think Lantus is the better drug, but this is not necessarily the case. Before a claim like this can be made, we need to take into consideration the bigger picture, as BB’ing is not about what we can accomplish in a few weeks, but over several years.

What is lantus insulin?

Lantus is a brand name for a type of long-acting insulin called insulin glargine. Insulin glargine is a biosynthetic human insulin analog of rDNA origin that has been made using genetic engineering technology.

How to give lantus?

Lantus must be given by subcutaneous (under the skin) injection. It should not be given by IV or IM injection or in an infusion pump.

How often is Lantus injected?

Lantus is a long-acting insulin that only needs to be injected once a day, subcutaneously. It is available as a prefilled pen (Lantus Solostar) or a 10mL vial. Hypoglycemia is the most common side effect and it cannot be given IV, IM, or by an infusion pump.

How many units of Lantus are in a pen?

Lantus is available as Lantus Solostar U-100 prefilled pen which is for single patient-use. This 3mL pen contains 300 units of insulin. Units can be increased by 1 unit at a time by moving the dial on the pen. The maximum dosage each use is 80 units. Lantus is also available in a 10mL vial. The vial contains 1000 units of Lantus.

How long does Lantus last?

Lantus is a long-acting insulin that lasts 24 to 36 hours depending on its concentration. Only needs to be given once a day.

What causes insulin to change?

Your insulin requirements may change if you become unwell, develop an infection, or other medical conditions . Surgery, injury, mental stress, your diet, and how much exercise you do can also affect how much insulin you need. Puberty, pregnancy, and menopause can also affect insulin requirements.

What are the side effects of Lantus?

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Low blood sugar levels (hypoglycemia) is the most common side effect of Lantus.

What is Lantus ® (insulin glargine injection) 100 Units/mL?

Prescription Lantus is a long-acting insulin used to treat adults with type 2 diabetes and adults and pediatric patients (children 6 years and older) with type 1 diabetes for the control of high blood sugar.

What is a Lantus Solostar?

Lantus SoloSTAR is a disposable single-patient-use prefilled insulin pen. Please talk to your healthcare provider about proper injection technique and follow instructions in the Instruction Leaflet that accompanies the pen.

What is a 100 unit lantus?

What is Lantus ® (insulin glargine injection) 100 Units/mL? Prescription Lantus is a long-acting insulin used to treat adults with type 2 diabetes and adults and pediatric patients (children 6 years and older) with type 1 diabetes for the control of high blood sugar. Do not use Lantus to treat diabetic ketoacidosis.

Can you use Lantus for ketoacidosis?

Do not use Lantus to treat diabetic ketoacidosis.

Can you take lixisenatide with pancreatitis?

It has not been studied in people with a history of pancreatitis. It is not recommended for people who also take lixisenatide or other medicines called GLP-1 receptor agonists . It is not for use in people with type 1 diabetes, or people with diabetic ketoacidosis.

Does Lantus cause blood sugar to go down?

The most common side effect of insulin, including Lantus, is low blood sugar (hypoglycemia), which may be serious and life threatening. It may cause harm to your heart or brain. Symptoms of serious low blood sugar may include shaking, sweating, fast heartbeat, and blurred vision.

Can you reuse a needle in Lantus?

Do not share needles, insulin pens, or syringes with others. Do NOT reuse needles. Before starting Lantus, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant or if you are breast-feeding or planning to breast-feed.

How should I use Lantus?

Use Lantus exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

What are the side effects of Lantus?

Common Lantus side effects may include: low blood sugar; itching, mild skin rash; or. thickening or hollowing of the skin where you injected the medicine. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I avoid while using Lantus?

Do not change the brand of insulin glargine or syringe you are using without first talking to your doctor or pharmacist.

What is the name of the hormone that lowers glucose levels in the blood?

Lantus (insulin glargine) is a man-made form of a hormone (insulin) that is produced in the body. Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin glargine is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours.

How often is lantus injected?

Lantus is usually injected once per day at the same time each day. You will be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and syringes.

How old do you have to be to take Lantus?

Lantus is not approved for use by anyone younger than 6 years old, and should not be used to treat type 2 diabetes in a child of any age.

Where is insulin injected?

Insulin is injected under the skin. You will be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and syringes.

How much does Lantus cost?

Lantus costs approximately $135 for a 10ml vial containing 100 units/ml of Insulin glargine ($13.54 per ml); however, cost can vary up to $27 per mL. Neither Levemir nor Lantus has a generic version. Both require refrigeration until opened. Once opened, pens and vials may be stored out of the fridge.

Why is insulin glargine absorbed so slowly?

Insulin glargine (Lantus) tends to be absorbed more slowly and for longer than detemir ( Levemir) because it is not as soluble once injected just under the skin. This means it has a longer duration of action and an insignificant peak effect - instead, it delivers consistent blood levels of insulin.

Is Levemir as effective as Lantus?

Some studies dosed Levemir twice daily; however, at least one study has found this makes no difference to HbA1c control and concluded that Levemir was just as effective if dosed once daily like Lantus is.

Is Levemir a long acting insulin?

Official Answer. Levemir (detemir) and Lantus (glargine) are both long acting insulins and no difference has been found in their efficacy however, weight gain and night-time hypoglycemia appear to be less with Levemir.

Does insulin increase risk of malignancy?

Although some studies have suggested insulin analogs increase the risk of certain types of malignancies, these studies were poorly conducted so it is still unknown how much of a risk insulin poses. Both the American Diabetes Association and the American Cancer Society have acknowledged that people with diabetes who use insulin do appear to be at increased risk. More trials are needed.

Does Levemir mimic insulin?

However, neither Levemir or Lantus perfectly mimic normal basal insulin release. Studies that have compared Levemir and Lantus to NPH have reported almost identical effectiveness in long-term HbA1C control. The rates of symptomatic hypoglycemia were lower with glargine; however, overall hypoglycemia was lower with detemir.

How It Works

Upsides

Downsides

Bottom Line

Tips

Response and Effectiveness

Interactions

References

Further Information