How much does LCIS diagnosis increase risk of breast cancer?
Studies suggest that women who are found to have LCIS have an increased risk of breast cancer development of about 1%/year, so a 10% risk in 10 years, 20% risk in 20 years, etc. LCIS is typically found incidentally on a biopsy that is done for calcifications or another abnormality found on breast imaging.
What does diagnosis of DCIS or LCIs breast cancer mean?
With DCIS and LCIS, cancerous or precancerous cells are confined to the ducts or lobules of the breast. They typically don’t cause any obvious signs or symptoms.
What does LCIs stand for in breast?
Lobular carcinoma in situ (LCIS) may be present in one or both breasts, but it usually isn't visible on a mammogram. The condition is most often diagnosed as an incidental finding when you have a biopsy done to evaluate some other area of concern in your breast.
Is breast leakage a sign of cancer?
The most common symptom of breast cancer is the presence of a new breast lump or mass, but there are other signs like a nipple discharge other than breast milk. A nipple discharge is considered the leakage of any fluid from the nipple.
Why is LCIS not cancer?
LCIS is not considered cancer, and it typically does not spread beyond the lobule (that is, it doesn't become invasive breast cancer) if it isn't treated. But having LCIS does increase your risk of later developing an invasive breast cancer in either breast. (See "How does LCIS affect breast cancer risk?")
How long does it take for LCIS to become invasive?
That risk increases over time. For example, one study showed that 8% of women with LCIS developed invasive breast cancer five years after diagnosis. That percentage increased to 20% 15 years after diagnosis.
Should I worry about LCIS?
Although LCIS is not cancer, it can make you worry about your increased risk of a future breast cancer. Coping with your diagnosis means finding a long-term way to manage your fear and uncertainty.
Does LCIS need to be removed?
In some cases where LCIS is found on needle biopsy, the doctor might recommend that it be removed completely (with an excisional biopsy or some other type of breast-conserving surgery). This may occur if the LCIS is pleomorphic or has necrosis (discussed in a later question).
Should I take tamoxifen for LCIS?
It's strongly recommended women with LCIS take a risk-lowering drug (such as tamoxifen) to lower their risk of breast cancer [193]. Tamoxifen and raloxifene are the only drugs FDA-approved for lowering the risk of breast cancer (for women who do not have breast cancer), but are at higher risk of breast cancer.
How do you get LCIS?
Breast anatomy It's not clear what causes LCIS . LCIS begins when cells in a milk-producing gland (lobule) of a breast develop genetic mutations that cause the cells to appear abnormal. The abnormal cells remain in the lobule and don't extend into, or invade, nearby breast tissue.
Is LCIS hereditary?
There are no known genes that confer susceptibility to LCIS.
Which is worse DCIS or LCIS?
In summary, LCIS is considered a risk factor for invasive cancer while DCIS is considered a precursor to invasive cancer.
How serious is lobular carcinoma?
The five-year survival rate for invasive lobular carcinoma is high compared to other types of cancer — nearly 100% when treated early. If the cancer has spread to nearby tissues, the five-year survival rate is about 93%. If it has metastasized to other areas of your body, the five-year survival rate is 22%.
Can LCIS turn into DCIS?
Nevertheless, it is of interest that 15–25% of cases of DCIS are associated with invasive lobular carcinoma and that an equal proportion of patients diagnosed with LCIS will develop an invasive carcinoma of the ductal subtype over the next 15–20 years.
What stage is invasive lobular carcinoma?
Stage 1: The tumor is up to 2 centimeters (cm) across and may have spread to nearby lymph nodes. Stage 2: At this stage, the tumor may be about 2 cm across and the cancer has spread to nearby lymph nodes. Or, the tumor has grown up to 5 cm across and the cancer hasn't spread to nearby lymph nodes.
Can LCIS turn into DCIS?
Nevertheless, it is of interest that 15–25% of cases of DCIS are associated with invasive lobular carcinoma and that an equal proportion of patients diagnosed with LCIS will develop an invasive carcinoma of the ductal subtype over the next 15–20 years.
Which is worse LCIS or DCIS?
This is in contrast to LCIS which has risk for the development of invasive breast cancer in either breast over time. In summary, LCIS is considered a risk factor for invasive cancer while DCIS is considered a precursor to invasive cancer.
Is LCIS estrogen receptor positive?
Most LCIS is hormone-receptor-positive, meaning that estrogen and/or progesterone fuel the growth of the abnormal cells.
What is the risk of breast cancer in women diagnosed with LCIS?
The risk of breast cancer in women diagnosed with LCIS is thought to be approximately 20 percent. Put another way, for every 100 women diagnosed with LCIS, 20 will be diagnosed with breast cancer and 80 won't be diagnosed with breast cancer. The risk of developing breast cancer for women in general is thought to be 12 percent.
What causes LCIS in breast?
It's not clear what causes LCIS. LCIS begins when cells in a milk-producing gland (lobule) of a breast develop genetic mutations that cause the cells to appear abnormal. The abnormal cells remain in the lobule and don't extend into, or invade, nearby breast tissue. If LCIS is detected in a breast biopsy, it doesn't mean that you have cancer.
What is lobular carcinoma in situ?
Lobular carcinoma in situ (LCIS) is an uncommon condition in which abnormal cells form in the milk glands (lobules) in the breast. LCIS isn't cancer. But being diagnosed with LCIS indicates that you have an increased risk of developing breast cancer. LCIS usually doesn't show up on mammograms.
What to do if you have LCIS?
If you're diagnosed with LCIS, your doctor may recommend increased breast cancer screening and may ask you to consider medical treatments to reduce your risk of developing invasive breast cancer .
Can LCIS cause symptoms?
LCIS doesn't cause signs or symptoms. Rather, your doctor might discover incidentally that you have LCIS — for instance, after a biopsy to assess a breast lump or an abnormal area found on a mammogram.
Does LCIS mean you have cancer?
If LCIS is detected in a breast biopsy, it doesn't mean that you have cancer. But having LCIS increases your risk of breast cancer and makes it more likely that you may develop invasive breast cancer. The risk of breast cancer in women diagnosed with LCIS is thought to be approximately 20 percent.
Can LCIS show up on a mammogram?
LCIS usually doesn't show up on mammograms. The condition is most often discovered as a result of a breast biopsy done for another reason, such as a suspicious breast lump or an abnormal mammogram. Women with LCIS have an increased risk of developing invasive breast cancer in either breast. If you're diagnosed with LCIS, your doctor may recommend ...
Overview
Lobular carcinoma in situ (LCIS) is a rare condition that happens when you have abnormal cells in your lobules — the glands that produce breast milk. These abnormal cells are in situ, meaning they haven’t spread to surrounding breast tissue.
Symptoms and Causes
Lobular carcinoma in situ doesn’t have symptoms. It can’t be felt during breast examinations or detected by mammograms. Instead, LCIS is often discovered during tests for other conditions. For example, your healthcare provider might find LCIS while performing a biopsy to evaluate a lump in your breast.
Diagnosis and Tests
Many times lobular carcinoma in situ is discovered during tests for other conditions. If providers find suspected abnormal cells while doing a biopsy, they will remove the abnormal cells for additional examination.
Management and Treatment
Your treatment depends on the kind of LCIS you have, your personal health and medical history and your personal choice. Treatments include:
Prevention
Unfortunately, researchers don’t have enough information about LCIS to recommend ways to prevent it. But there are steps you can take to reduce their risk for developing breast cancer:
What is the risk of breast cancer in women with LCIS?
Women with LCIS have an increased risk of invasive breast cancer [ 259-260 ]. Compared to women without LCIS, those with LCIS are 7-11 times more likely to develop invasive cancer in either breast (the breast with LCIS or the opposite breast) [ 259-260 ]. Women diagnosed with LCIS have [ 261-262 ]:
Can LCIS develop into breast cancer?
However, some studies show LCIS may develop into invasive lobular cancer (invasive breast cancer that begins in the lobules) [ 260,263-265 ]. Learn about invasive lobular cancer and other types of tumors.
Needle biopsy
Doctors are uncertain of the best way to treat LCIS found in a needle biopsy. One option involves removing the entire area of abnormal cells with an excision biopsy. This is similar to a lumpectomy, a surgery that removes cancerous breast tissue along with a rim of healthy surrounding tissue.
Excisional biopsy
An LCIS found with an excision biopsy does not need further treatment. However, if the LCIS looks pleomorphic, some doctors may recommend another surgery to ensure the removal of all the abnormal cells. This step is a precaution because pleomorphic LCIS has a higher likelihood of developing into cancer.
Seeing a doctor more frequently
In addition to a yearly mammogram, a doctor may recommend a breast exam every 6–12 months.
Medications
Doctors sometimes recommend taking medications to lower the risk of developing breast cancer. The goal of these drugs is to reduce a person’s exposure to estrogen, which fuels cancer growth.
Prophylactic surgery
Prophylactic refers to a measure that prevents rather than treats disease. A prophylactic bilateral mastectomy is the removal of both breasts to decrease breast cancer risk. Doctors are more likely to recommend this if a person has additional risk factors for breast cancer, such as a certain gene mutation.
What is LCIS in breast?
Lobular Carcinoma In Situ (LCIS) is a condition where abnormal cells are found in the lobules of the breast. The atypical cells have not spread outside of the lobules into the surrounding breast tissue.
Is LCIS the same as DCIS?
LCIS is very similar to DCIS. LCIS is cancer that’s in the lobules; DCIS is cancer that’s in the milk ducts. Materials on this page courtesy of National Cancer Institute.
Why do people with LCIS need breast exams?
Because of the increased breast cancer risk, people with LCIS should have regular breast exams and breast imaging. You and your healthcare provider will decide what type of breast imaging is best for you, based on your personal history.
What is lobular carcinoma in situ?
Lobular Carcinoma in Situ (LCIS) This information will help you understand what lobular carcinoma in situ (LCIS) is, and how it can affect your risk of getting breast cancer. It also explains what you can do to prevent breast cancer.
What does it mean when LCIS is touching the ink?
The pathologist looks at slides of the LCIS under the microscope to see how close the LCIS cells get to the ink (the edges or margins of the specimen). If LCIS is touching the ink (called positive margins ), it can mean that some LCIS cells were left behind.
What is lobular carcinoma in situ?
Lobular carcinoma in situ (LCIS) is a type of in-situ carcinoma of the breast. While DCIS is considered a pre-cancer, it is unclear ...
What is it called when a tumor breaks out?
Once the carcinoma cells have grown and broken out of the ducts or lobules, it is called invasive or infiltrating carcinoma. In an invasive carcinoma, the tumor cells can spread (metastasize) to other parts of your body.
Can a LCIS be removed?
In some cases where LCIS is found on needle biopsy, the doctor might recommend that it be removed completely (with an excisional biopsy or some other type of breast-conserving surgery). This may occur if the LCIS is pleomorphic or has necrosis (discussed in a later question).
Can LCIS be found in excision biopsy?
Because it isn't clear if LCIS is a pre-cancer, many doctors prefer to use the term lobular neoplasia instead of lobular carcinoma in situ. If LCIS is found in an excision biopsy, it does not need ...
Is lobular carcinoma in situ a pre-cancer?
Lobular carcinoma in situ (LCIS) is a type of in-situ carcinoma of the breast. While DCIS is considered a pre-cancer, it is unclear whether LCIS is definitely a pre-cancer or if it is just a general risk factor for developing breast cancer. This is because LCIS rarely seems to turn into invasive cancer if it is left untreated.
Is lobular neoplasia the same as LCIS?
LCIS and a condition called atypical lobular hyperplasia (ALH) are both considered lobular neoplasia. In-situ carcinoma with duct and lobular features means that the in-situ carcinoma looks like DCIS in some ways ...
What is LCIS in breast cancer?
LCIS (lobular carcinoma in situ) is a collection of abnormal cells growing in the lobules, the milk-producing glands at the end of breast ducts.
Why is LCIS diagnosed?
It tends to be diagnosed because a breast biopsy was performed for another reason. We know that LCIS increases the risk of being diagnosed with breast cancer in the future. Still, doctors haven’t been sure how much LCIS increases breast cancer risk.
How many women were diagnosed with LCIS in 1990?
More than 98% of the women (1,043) were diagnosed with LCIS after 1990. Age at LCIS diagnosis ranged from 27 to 83 years. Most of the women opted for careful observation as treatment. This means that the women followed a schedule of breast exams and screening to detect any signs of breast cancer as soon as possible:
How much does breast cancer go up after LCIS?
A study suggests that breast cancer risk goes up about 2% per year in the first 6 years after a LCIS diagnosis. The study also found that women who took preventive hormonal therapy after an LCIS diagnosis were less likely to be diagnosed with breast cancer. The study was published online on Sept. 14, 2015 by the Journal of Clinical Oncology.
How many women develop breast cancer in the first 6 years?
About 2% of the women developed breast cancer each year in the first 6 years after being diagnosed with LCIS. Among the women diagnosed with breast cancer: 109 (65%) of the cancers were invasive -- 85% of these cancers were hormone-receptor-positive.
How many women have cancer in the opposite breast?
38 women developed cancer in the opposite breast. 18 developed cancer in both breasts. 109 (65%) of the cancers were invasive -- 85% of these cancers were hormone-receptor-positive. 59 (35%) of the cancers were DCIS. Compared to the women who were only carefully monitored, women who were carefully monitored and took preventive hormonal therapy were ...
Is lobular neoplasia a mammogram?
LCIS is considered uncommon, but it’s not clear how many people are affected. That’s because LCIS doesn’t cause symptoms and usually doesn’t show up on a mammogram.
