
Is methadone a controlled substance?
Methadone is also regulated internationally as a Schedule I controlled substance under the United Nations Single Convention on Narcotic Drugs of 1961.
Is methadone an analgesic?
An analgesic is a drug that is used to relieve pain. However, methadone is more commonly used in the treatment of opioid addiction. Methadone is a schedule II controlled substance. 2. Upsides
What are the different schedules of Narcotic Drugs?
Schedule 2 – narcotic drugs that have medical uses but carry a high abuse potential. Schedule 3 – narcotic and non-narcotic drug combinations, such as codeine and aspirin which have a moderate abuse potential. Schedule 4 – narcotic and non-narcotic drug combinations, which have a low abuse potential.
Is methadone treatment right for You?
Methadone is a medication approved by the Food and Drug Administration (FDA) to treat opioid use disorder (OUD) as a medication-assisted treatment (MAT), as well as for pain management. When taken as prescribed, methadone is safe and effective. Methadone helps individuals achieve and sustain recovery and to reclaim active and meaningful lives.

How many schedules are there for drugs?
Drugs and other substances that are considered controlled substances under the Controlled Substances Act (CSA) are divided into five schedules. An updated and complete list of the schedules is published annually in Title 21 Code of Federal Regulations (C.F.R.) §§1308.11 through 1308.15. Substances are placed in their respective schedules based on whether they have a currently accepted medical use in treatment in the United States, their relative abuse potential, and likelihood of causing dependence when abused. Some examples of the drugs in each schedule are listed below.
What are some examples of Schedule I drugs?
Some examples of substances listed in Schedule I are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), peyote, methaqualone, and 3,4-methylenedioxymethamphetamine ("Ecstasy").
What are the other Schedule II substances?
Other Schedule II substances include: amobarbital, glutethimide, and pentobarbital.
What is a controlled substance analogue?
A controlled substance analogue is a substance which is intended for human consumption, is structurally substantially similar to a schedule I or schedule II substance, is pharmacologically substantially similar to a schedule I or schedule II substance, or is represented as being similar to a schedule I or schedule II substance and is not an approved medication in the United States. See 21 U.S.C. §802 (32) (A) for the definition of a controlled substance analogue and 21 U.S.C. §813 for the schedule.
What is methadone used for?
Opioid addiction. Methadone is used for the treatment of opioid use disorder. It may be used as maintenance therapy or in shorter periods for detoxification to manage opioid withdrawal symptoms. Its use for the treatment of addiction is usually strictly regulated.
When was methadone first used?
Methadone was developed in Germany around 1937 to 1939 by Gustav Ehrhart and Max Bockmühl. It was approved for use in the United States in 1947. It is on the World Health Organization's List of Essential Medicines. In 2013, about 41,400 kilograms were manufactured globally. It is regulated similarly to other narcotic drugs. It is not particularly expensive in the United States.
What is the goal of methadone maintenance?
The principal goals of methadone maintenance are to relieve opioid cravings, suppress the abstinence syndrome, and block the euphoric effects associated with opioids. Chronic methadone dosing will eventually lead to neuroadaptation, characterised by a syndrome of tolerance and withdrawal (dependence).
How much does methadone cost?
In the US, generic methadone tablets are inexpensive, with retail prices ranging from $0.25 to $2.50 per defined daily dose. Brand-name methadone tablets may cost much more.
How many deaths from methadone in 2004?
National Center for Health Statistics, as well as a 2006 series in the Charleston Gazette (West Virginia), medical examiners listed methadone as contributing to 3,849 deaths in 2004. That number was up from 790 in 1999.
How long does methadone take to work?
While a single dose has a rapid effect, maximum effect can take up to five days of use. The pain-relieving effects last about six hours after a single dose.
Where was methadone made?
In the 1930s, pethidine (meperidine) went into production in Germany; however, production of methadone, then being developed under the designation Hoechst 10820, was not carried forward because of side effects discovered in the early research. After the war, all German patents, trade names and research records were requisitioned and expropriated by the Allies. The records on the research work of the I.G. Farbenkonzern at the Farbwerke Hoechst were confiscated by the U.S. Department of Commerce Intelligence, investigated by a Technical Industrial Committee of the U.S. Department of State and then brought to the US. The report published by the committee noted that while methadone was potentially addictive, it produced less sedation and respiratory depression than morphine and was thus interesting as a commercial drug.
What are the side effects of methadone?
Downsides. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Sedation, drowsiness, or dizziness that may affect a person's ability to drive or operate machinery.
What is methadone used for?
Methadone is a man-made substance that may be used to reduce withdrawal symptoms in people addicted to heroin or other narcotic drugs as part of a drug addiction detoxification and maintenance program. It may also be used as a pain reliever.
Why is methadone used in patients?
Because of the high risk of addiction and potential for abuse, methadone should only be used in patients intolerant or unresponsive to other analgesics (either opioid or nonopioid analgesics). Methadone is considered a drug of abuse and legitimate supplies may be sought out by drug users.
What to do if methadone is making you have breakthrough pain?
If you are taking methadone for severe pain, tell your doctor if you begin to have breakthrough pain.
How long does methadone stay in your system?
Methadone accumulates within the liver and repeated and overdosing may enhance its toxic effects. Although it only lasts for 4 to 8 hours, it can take up to 59 hours for 50% of a dose to be eliminated from the body.
How long after taking methadone can you stop breathing?
Tell your doctor if you experience any difficulty with breathing or shortness of breath after taking methadone, especially within the first 24 to 72 hours of initiating therapy. Avoid sudden discontinuation of methadone.
Is methadone toxic or ineffective?
Methadone has a narrow therapeutic window which means there is a fine line between too much methadone (and toxic effects) and too little (meaning it is ineffective). There is a wide variation in the way individuals absorb, metabolize, and respond to methadone, which increases the risk of a person receiving a toxic or ineffective dose. This means opioid equivalency charts should not be used when changing from an opioid to methadone and vice versa.
How Does Methadone Work?
Methadone has analgesic and pain relieving properties similar to morphine because it is also a narcotic. But the difference is that methadone is much less likely to produce a high. It means it is also less likely to be abused by recreational users. It takes a lot of this drug to get high.
What is a Narcotic?
There’s a bit of a stigma associated with the word “narcotic”. This is perhaps due to the fact that the term is used in law enforcement to refer to any illegal drug, no matter what kind of substance it is.
Why are opioids prescribed?
Both types of substances are prescribed to relieve pain because they attach to the opioid receptors in the brain , blocking our ability to feel pain.
Why are narcotics beneficial?
Narcotics, for example, are beneficial because they help patients who are struggling with moderate to severe pain. But they are also known for their addictive properties. So if narcotics are actually prescribed for a medical purpose. Only recreational users experience the consequences of abusing these drugs.
Does methadone make you high?
This tricks the brain into thinking that the person has already taken their usual drug. The brain is “satisfied” but methadone doesn’t actually produce a high.
Is methadone good for addiction?
But just like many other drugs out there, methadone is helpful if used correctly. Look for an addiction treatment facility near you today and get started on the road to recovery.
Is opium a narcotic?
But in the medical industry, only opiates and opioids are technically classified as narcotics. Opiates are natural derivatives of the opium poppy plant while opioids are the synthetic and semi-synthetic derivatives.
Who abuses Methadone?
It is difficult to gauge the extent of methadone abuse in the United States because most data sources that quantify drug abuse combine methadone with other narcotics. This lack of statistical information renders it impossible to describe a typical methadone abuser. Information provided by the Treatment Episode Data Set does reveal that the number of individuals who were treated for abuse of "other opiates" (a category that includes methadone) increased dramatically from 28,235 in 2000 to 36,265 in 2001. These individuals were predominantly Caucasian; they were nearly evenly split between males and females and represented various age groups.
How long does methadone last?
When used to treat narcotic addiction, methadone suppresses withdrawal symptoms for 24 to 36 hours.
What does methadone look like?
Methadone is available as a tablet, oral solution, or injectable liquid.
How long does methadone help with withdrawal?
When used to treat narcotic addiction, methadone suppresses withdrawal symptoms for 24 to 36 hours. Individuals who are prescribed methadone for treatment of heroin addiction experience neither the cravings for heroin nor the euphoric rush that are typically associated with use of that drug. To Top.
How many high schoolers abuse methadone?
Methadone abuse among high school students is a concern. Nearly 1 percent of high school seniors in the United States abused the drug at least once in their lifetime, according to the University of Michigan's Monitoring the Future Survey.
What happens if you stop taking methadone?
When these individuals stop using the drug they may experience withdrawal symptoms including muscle tremors, nausea, diarrhea, vomiting, and abdominal cramps. Overdosing on methadone poses an additional risk.
Is methadone a synthetic drug?
Methadone is a synthetic (man-made) narcotic. It is used legally to treat addiction to narcotics and to relieve severe pain, often in individuals who have cancer or terminal illnesses. Although methadone has been legally available in the United States since 1947, more recently it has emerged as a drug of abuse.
What is Methadone?
Methadone is a full opioid agonist medication approved by the Food and Drug Administration (FDA) for the treatment of opioid dependence and addiction. Methadone is typically combined with therapy in a practice known as medication-assisted treatment (MAT). 1
What is the most common name for methadone?
Brand Names. The most common name used is Methadone which is the actual brand name of the drug as well as the name of the drug itself. Methadone products are also sold under the following brand names: Westadone. Methadose.
What is methadone maintenance?
Methadone maintenance treatment (MMT) involves taking methadone, in wafer, pill, or liquid form, once a day for an extended period of time, with the goal of maintaining abstinence from opioid use. This medication can only be dispensed through specialized opioid treatment programs. 3,6
What is methadone juice called?
Various street names for methadone exist to describe the drug itself or the manner in which the drug is taken. Methadone is often sold in 40mg or 80mg tablets that are very large in size (about the size of a quarter) and called “biscuits.” These orange colored pills dissolve in juice or water and are often mixed with orange juice and then taken as a drink which is why some people call methadone juice or drink on the streets.
Why do you have to take methadone daily?
Because methadone can be addictive, usually the doses are dispensed daily at a methadone clinic under the supervision of a physician— this is done to minimize the risk of patients diverting from the treatment regimen by misusing methadone . Doses are established and adjusted based on your individual needs. 3
Is methadone a non-addictive drug?
Methadone was once believed to be a non-addictive medication and was widely used for pain relief until doctors realized the addictive nature of the drug and the vast ability for users to become physically dependent on it in a short period of time.
Is methadone safe for opioid addiction?
It is also occasionally prescribed for pain. Methadone relieves opioid withdrawal symptoms, mitigates cravings, and reduces the risk of relapse. While it is a safe and effective medication, there are some potential risks and side effects.
What is a Schedule 1 Narcotic?
The Department of Justice classifies certain drugs as schedule 1 narcotics.
Why are there no narcotics on the Schedule 1 list?
Part of the reason why drugs on the Schedule 1 narcotics list have no medical use is because of their potential to incite out-of-control behaviors. Laws involving Schedule 1 narcotics list specifically prohibit the possession, manufacture, distribution and dispensing of these drugs under any circumstances.
How does heroin affect people?
3 Heroin influences the way a person’s central nervous system and brain function. The pleasure and pain relief associated with heroin use can increase a person’s desire to misuse this substance. When physically dependent on or addicted to heroin, people may continue to misuse heroin despite knowledge of the risks and of developing or existing health problems.
What is the color of heroin?
Heroin may appear as a brown or white powder. Others may consume a type of heroin known as “ black tar heroin ,” which is a sticky black version of this Schedule 1 narcotic.
How to take fentanyl?
People can take fentanyl in several ways. 1 It can be taken by mouth in lozenge or tablet forms. Or a person may inject a fentanyl analog in its powder form. Snorting and smoking fentanyl also serve as methods of ingestion and misuse.
What are the different types of narcotics?
Types of Narcotics. Excluding prescription drug narcotics, the Schedule 1 narcotics list includes the following types of drugs: Stimulants. Cannabinoids. Hallucinogens. Stimulant drugs, such as cocaine, ecstasy and methamphetamine speed up the body’s central nervous system.
What is withdrawal management?
6 Withdrawal management constitutes a set of treatment protocols that helps a person safely remove substances from their system.
What is Schedule 4 drug?
Drugs that are classified as schedule 4 are often prescribed medications, and when a person uses schedule 4 drugs, they are at a very low risk for developing a substance use disorder . Some familiar drugs in the schedule 4 class include:
What drugs are Schedule 1?
Some familiar drugs assigned a schedule 1 class include: Ecstasy. Heroin. LSD.
How many classifications of drugs are there?
While the list of drugs is continually being updated (and each state can have its own list), there are five basic classifications, or schedules, of drugs: Since 1970 the United States has maintained the Controlled Substance Act in an effort to protect the general public from potentially dangerous and addictive drugs.
Why do we use Schedule 3?
Using schedule 3 drugs puts a person at a lower risk for developing a substance use disorder than schedule 1 and 2 drugs but at a higher risk than schedule 4 and 5 drugs. Medical providers often prescribe schedule 3 drugs for illnesses, injuries, and other health-related reasons.
What is Schedule I drug?
Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are:
How are drugs classified?
Drugs, substances, and certain chemicals used to make drugs are classified into five (5) distinct categories or schedules depending upon the drug’s acceptable medical use and the drug’s abuse or dependency potential. The abuse rate is a determinate factor in the scheduling of the drug; for example, Schedule I drugs have a high potential for abuse and the potential to create severe psychological and/or physical dependence. As the drug schedule changes-- Schedule II, Schedule III, etc., so does the abuse potential-- Schedule V drugs represents the least potential for abuse. A Listing of drugs and their schedule are located at Controlled Substance Act (CSA) Scheduling or CSA Scheduling by Alphabetical Order. These lists describes the basic or parent chemical and do not necessarily describe the salts, isomers and salts of isomers, esters, ethers and derivatives which may also be classified as controlled substances. These lists are intended as general references and are not comprehensive listings of all controlled substances.
What is abuse rate in drug scheduling?
The abuse rate is a determinate factor in the scheduling of the drug; for example, Schedule I drugs have a high potential for abuse and the potential to create severe psychological and/or physical dependence. As the drug schedule changes-- Schedule II, Schedule III, etc., so does the abuse potential-- Schedule V drugs represents ...
What are some examples of Schedule IV drugs?
Some examples of Schedule IV drugs are: Xanax, Soma, Darvon, Darvocet, Valium, Ativan, Talwin, Ambien, Tramadol.
Is a controlled substance analogue a Schedule I substance?
Please note that a substance need not be listed as a controlled substance to be treated as a Schedule I substance for criminal prosecution. A controlled substance analogue is a substance which is intended for human consumption and is structurally or pharmacologically substantially similar to or is represented as being similar to a Schedule I or Schedule II substance and is not an approved medication in the United States. (See 21 U.S.C. §802 (32) (A) for the definition of a controlled substance analogue and 21 U.S.C. §813 for the schedule.)

Overview
Regulation
Methadone is a Schedule I controlled substance in Canada and Schedule II in the United States, with an ACSCN of 9250 and a 2014 annual aggregate manufacturing quota of 31,875 kilos for sale. Methadone intermediate is also controlled, under ACSCN 9226 also under Schedule II, with a quota of 38,875 kilos. In most countries of the world, methadone is similarly restricted. The salts of methadone in use are the hydrobromide (free base conversion ratio 0.793), hydrochloride (0.8…
Medical uses
Methadone is used for the treatment of opioid use disorder. It may be used as maintenance therapy or in shorter periods for detoxification to manage opioid withdrawal symptoms. Its use for the treatment of addiction is usually strictly regulated. In the US, outpatient treatment programs must be certified by the federal Substance Abuse and Mental Health Services Administration (SAMHSA) and registered by the Drug Enforcement Administration (DEA) in order to prescribe m…
Adverse effects
Adverse effects of methadone include:
• Sedation
• Constipation
• Flushing
• Perspiration
Pharmacology
Methadone acts by binding to the µ-opioid receptor, but also has some affinity for the NMDA receptor, an ionotropic glutamate receptor. Methadone is metabolized by CYP3A4, CYP2B6, CYP2D6, and is a substrate, or in this case target, for the P-glycoprotein efflux protein, a protein which helps pump foreign substances out of cells, in the intestines and brain. The bioavailability and elimination half-life of methadone are subject to substantial interindividual variability. Its main route of admin…
Chemistry
Methadone and its major metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), are often measured in urine as part of a drug abuse testing program, in plasma or serum to confirm a diagnosis of poisoning in hospitalized victims, or in whole blood to assist in a forensic investigation of a traffic or other criminal violation or a case of sudden death. Methadone usage history is considered in interpreting the results as a chronic user can develop tolerance to dose…
History
Methadone was developed in 1937 in Germany by scientists working for I.G. Farbenindustrie AG at the Farbwerke Hoechst who were looking for a synthetic opioid that could be created with readily available precursors, to solve Germany's opium and morphine shortage problem. On 11 September 1941 Bockmühl and Ehrhart filed an application for a patent for a synthetic substance they called Hoechst 10820 or Polamidon (a name still in regular use in Germany) and whose structure had li…
Society and culture
Brand names include Dolophine, Symoron, Amidone, Methadose, Physeptone, Metadon, Metadol, Metadol-D, Heptanon and Heptadon among others.
In the US, generic methadone tablets are inexpensive, with retail prices ranging from $0.25 to $2.50 per defined daily dose. Brand-name methadone tablets may cost much more.
Methadone maintenance clinics in the US may be covered by private insurances, Medicaid, or Me…
How It Works
- Methadone is a man-made substance that may be used to reduce withdrawal symptoms in people addicted to heroin or other narcotic drugs as part of a drug addiction detoxification and maintenance prog...
- Methadone acts on muopioid receptors in a similar way to morphine to provide pain relief. It inhibits ascending pain pathways, altering the perception of and response to pain. It has also …
- Methadone is a man-made substance that may be used to reduce withdrawal symptoms in people addicted to heroin or other narcotic drugs as part of a drug addiction detoxification and maintenance prog...
- Methadone acts on muopioid receptors in a similar way to morphine to provide pain relief. It inhibits ascending pain pathways, altering the perception of and response to pain. It has also been show...
- Methadone belongs to the class of medicines known as narcotic analgesics. It may also be called an opioid analgesic. An analgesic is a drug that is used to relieve pain. However, methadone is more...
- Methadone is a schedule II controlled substance.
Upsides
- Used for the treatment of pain severe enough to require continuous, round-the-clock treatment in patients unresponsive or intolerant of other opioid and nonopioid analgesics.
- May be used under strict conditions for the treatment of opioid addiction disorders.
- Withdrawal symptoms associated with methadone generally are less severe than with morphine and have a slower onset.
- Used for the treatment of pain severe enough to require continuous, round-the-clock treatment in patients unresponsive or intolerant of other opioid and nonopioid analgesics.
- May be used under strict conditions for the treatment of opioid addiction disorders.
- Withdrawal symptoms associated with methadone generally are less severe than with morphine and have a slower onset.
- Generic methadone is available.
Downsides
- If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: 1. Sedation, drowsiness, or dizziness that may affect a person's ability to drive or operate machinery. Alcohol should be avoided as it can contribute to the sedative effect of methadone. 2. Methadone tablets may cau…
Bottom Line
- Methadone is a potent opioid analgesic that may be used to relieve severe pain unresponsive to other strong pain relievers; however, it is more commonly used to treat opioid addiction. There is a w...
Tips
- Take strictly as directed by your doctor. Do not use on an "as needed" basis or increase or decrease the dosage without your doctor's advice. There is a fine line between an effective dose of metha...
- If you are taking methadone for severe pain, tell your doctor if you begin to have breakthrough pain.
- Take strictly as directed by your doctor. Do not use on an "as needed" basis or increase or decrease the dosage without your doctor's advice. There is a fine line between an effective dose of metha...
- If you are taking methadone for severe pain, tell your doctor if you begin to have breakthrough pain.
- When used to treat drug addiction, it is important that you take advantage of any social support and counseling services offered to you as withdrawal from opioids is a long and often difficult proc...
- All other around-the-clock opioid drugs should be discontinued when starting methadone. Deaths have occurred in people who continue to take these.
Response and Effectiveness
- The analgesic effect of methadone lasts between four and eight hours; however, it takes anywhere from eight to 59 hours for a dose to be eliminated from the body. With prolonged dosing, methadone i...
- The peak respiratory depressant effect of methadone occurs later and persists for longer than its peak analgesic effect.
Interactions
- Medicines that interact with methadone may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with methadone. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions sh…
Further Information
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use methadone only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Copyright 1996-2022 Drugs.com. Revision date: February 14, 2022. Medical Disc…