is metolazone a thiazide

Precautions

Thiazide diuretics, though usually not metolazone, are very often used alone as first-line treatment for mild hypertension. They are also used in combination with other drugs for difficult-to-treat or more severe hypertension.

Is metolazone a thiazide diuretic?

Such drugs are called benzothiadiazides, or thiazides for short; however, in terms of chemistry, metolazone is not a substituted benzothiadiazine, and therefore is not technically a thiazide.

Is metolazone a benzothiadiazide?

Structure and classification. Metolazone is a quinazoline, a derivative of the similar diuretic quinethazone, as well as a sulfonamide. It is related to analogs of 1,2,4-benzothiadizine-1,1-dioxide ( benzothiadiazine ).

What is the classification of metolazone?

Hospital length of stay was shorter in the metolazone cohort (median 7 days) compared to chlorothiazide (median 15 days), suggesting the chlorothiazide cohort was likely sicker.

Are patients with metolazone sicker than those with chlorothiazide?

What class of drug is metolazone?

Metolazone, is used to reduce the swelling and fluid retention caused by heart failure or kidney disease. It also is used alone or with other medications to treat high blood pressure. Metolazone is in a class of medications called diuretics ('water pills').

What class of diuretics is metolazone?

Metolazone is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps to lower blood pressure . This medicine is available only with your doctor's prescription .

What is the difference between hydrochlorothiazide and metolazone?

Metolazone is more potent than hydrochlorothiazide and retains its effectiveness even when there is severe glomerular filtration rate (GFR) reduction. Diuretics are used to achieve and maintain euvolaemia (the patient's 'dry weight') with the lowest possible dose.

Which drug comes in Class of thiazides?

Low-dose thiazides are tolerated as well as the other classes of medications for hypertension, including ACE inhibitors, beta blockers and calcium channel blockers....Hypertension.Drug TypeGeneric Drug NameLow Dose Threshold (mg/day)Thiazide-like DiureticIndapamide56 more rows

Why is metolazone thiazide like?

Since metolazone (as well as other drugs like indapamide) acts on the same target as thiazides and behave in a similar pharmacologic fashion, it is, however, considered a "thiazide-like diuretic." Therefore, metolazone and similar drugs are often categorized with thiazide diuretics despite not being thiazides ...

What's the difference between Lasix and metolazone?

Lasix (furosemide) and Zaroxolyn (metolazone) are diuretics (water pills) used treat excess accumulation of fluid or swelling of the body (edema) and high blood pressure (hypertension). Lasix is a brand name for furosemide. Zaroxolyn is a brand name for metolazone.

Can you take metolazone with hydrochlorothiazide?

Studies have shown that metolazone and hydrochlorothiazide have demonstrated a synergistic response when used in combination with furosemide in congestive heart failure patients. The current guidelines for treating diuretic resistance in congestive heart failure patients recommend the metolazone-furosemide combination.

Why do you give metolazone 30 minutes before furosemide?

Many physicians dose metolazone 30 minutes prior to dosing the loop diuretic to ensure the distal Na-Cl channel is already blocked when the increased sodium reaches the DCT.

Is there an alternative to metolazone?

Metolazone belongs to a group of diuretics known as thiazide diuretics. There are other drugs that are thiazide diuretics including chlorthalidone, chlorthiazide, hydrochlorthiazide, indapamide, and methyclothiazide.

What is an example of a thiazide diuretic?

Three thiazide diuretics are the most commonly used: hydrochlorothiazide (HCTZ), chlorthalidone, and indapamide. HCTZ and chlorthalidone are FDA-approved for clinical use in the management of primary hypertension.

What brands are thiazide diuretics?

Thiazide diureticsGeneric NameBrand Namechlorthalidone and chlorthalidone combinationsClorpres, Tenoretic, Thalitonehydrochlorothiazide and hydrochlorothiazide combinationsCapozide, Dyazide, Hyzaar, Lopressor HCT, Maxzide, Prinzide

Is Lasix a thiazide?

Lasix (thiazides) is an anthranilic acid derivative that is used as a strong diuretic in adults and children to treat excessive fluid accumulation (edema) caused by congestive heart failure, liver failure, renal failure, and nephritic syndrome.

What Should I Discuss With My Doctor Before Taking Metolazone?

You should not use metolazone if you are allergic to it, or if you have: 1. severe liver disease; or 2. if you are unable to urinate.To make sure m...

How Should I Take Metolazone?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use t...

What Happens If I Miss A Dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...

What Happens If I Overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include severe dizziness or drowsiness, dry m...

What Should I Avoid While Taking Metolazone?

Drinking alcohol with this medicine can cause side effects.Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drink...

Metolazone Dosing Information

Usual Adult Dose for Hypertension:Initial dose: 2.5 mg orally once a day (Zaroxolyn) or0.5 mg orally once a day (Mykrox).Usual Adult Dose for Edema...

What Other Drugs Will Affect Metolazone?

Taking this medicine with other drugs that make you make you light-headed can worsen this effect. Ask your doctor before taking metolazone with a n...

Medical uses

One of the primary uses of metolazone is for treating edema (fluid retention) associated with congestive heart failure (CHF). In mild heart failure, metolazone or another diuretic may be used alone, or combined with other diuretics for moderate or severe heart failure.

Toxicity

Since thiazide diuretics affect the transport of electrolytes and water in the kidney, they can be responsible for abnormalities of water balance and electrolyte levels. Removal of too much fluid can cause volume depletion and hypotension.

Mechanism of action

Schematic of a nephron. The distal convoluted tubule and proximal convoluted tubule are labeled in Latin ("tubulus contortus proximalis" and "tubulus contortus distalis") in this illustration.

Pharmacokinetics

Metolazone is only available in oral preparations. Approximately 65% of the amount ingested becomes available in the bloodstream. Its half-life is approximately fourteen hours, similar to indapamide but considerably longer than hydrochlorothiazide. Metolazone is around ten times as potent as hydrochlorothiazide.

Chemistry

The use of activated anthranilic acid derivatives facilitates the preparation of the amides in those cases where the amines are either unreactive or difficult to obtain.

History

Metolazone was developed in the 1970s. Its creator, Indian born chemist Dr. Bola Vithal Shetty has been active in helping the U.S. Food and Drug Administration review drug applications, and in the development of new medicines.

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Picture of Hypertension

High blood pressure, defined as a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140...

Picture of Pitting Edema

Observable swelling of body tissues due to fluid accumulation that may be demonstrated by applying pressure to the swollen area...

How long can you take Metolazone?

It may take up to 3-6 weeks to see a lowering of your blood pressure. Cholestyramine and colestipol can decrease the absorption of metolazone. If you are taking either of these drugs, separate metolazone from cholestyramine by at least 4 hours and from colestipol by at least 2 hours.

How quickly does Metolazone work?

It usually takes 3 to 4 days for metolazone to start reducing edema, and 3 to 6 weeks to start reducing blood pressure. Your doctor may have suggested this medication for conditions other than those listed in these drug information articles.

What is Metolazone 5 mg used for?

Metolazone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Metolazone is used to treat fluid retention (edema) in people with congestive heart failure, or a kidney disorder such as nephrotic syndrome.

How often can you take Metolazone?

Adults—At first, 5 to 20 milligrams (mg) once a day. Your doctor may adjust your dose if needed.

What is another name for Metolazone?

Metolazone is a thiazide-like diuretic marketed under the brand names Zytanix, Metoz, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure.

When should I take Metolazone?

A reasonable strategy in patients who are refractory to loop diuretics is to give 5 mg of metolazone one hour before the morning dose of the loop diuretic. 6 Patients may require only one dose every seven to 10 days to maintain their target weight.

Is Metolazone bad for kidneys?

This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled . Metolazone is a thiazide diuretic (water pill).

Overview

Medical uses

Toxicity

Mechanism of action

Pharmacokinetics

Metolazone is a thiazide-like diuretic marketed under the brand names Zytanix, Metoz, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess fluid accumulation in heart failure. Metolazone is sometimes used togethe…

Chemistry

History