is monopril an ace inhibitor

Precautions

Monopril Description. Monopril® (fosinopril sodium tablets) is the sodium salt of fosinopril, the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, fosinoprilat. It contains a phosphinate group capable of specific binding to the active site of angiotensin-converting enzyme.

What type of drug is Monopril?

Monopril (fosinopril) is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Monopril is used to treat high blood pressure (hypertension) or heart failure.

Is fosinopril an ACE inhibitor?

MONOPRIL (fosinopril sodium) (fosinopril sodium tablets) is contraindicated in patients who are hypersensitive to this product or to any other angiotensin-converting enzyme inhibitor (e.g., a patient who has experienced angioedema with any other ACE inhibitor therapy).

What is the contraindication for Monopril?

Monopril may be used alone or in combination with other agents. Effectiveness in severe hypertension has not been established. Monopril is also useful as an adjunct (eg: with diuretics) in the treatment of heart failure. Fosinopril is an angiotensin-converting enzyme (ACE) inhibitor.

What is the difference between Monopril and fosinopril?

What does ACE stand for in a syringe?

What are the side effects of monopril?

What does it mean when you have a light headed feeling?

Is Monopril discontinued?

Does monopril cause rash?

How to know if you have a syringe?

Can you take monopril while pregnant?

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What drug class is Monopril?

Monopril (fosinopril sodium) Tablets is a prescription medicine used to treat the symptoms of High Blood Pressure (Hypertension) and Congestive Heart Failure. Monopril may be used alone or with other medications. Monopril belongs to a class of drugs called ACE Inhibitors.

What brand names are ACE inhibitors?

Angiotensin-converting enzyme inhibitor (ACE inhibitors) drugs include Benazepril (Lotensin), Captopril (Capoten), Enalapril/Enalaprilat (Vasotec oral and injectable), Fosinopril (Monopril), Lisinopril (Zestril and Prinivil), Moexipril (Univasc), Perindopril (Aceon), Quinapril (Accupril), Ramipril (Altace), and ...

What is Monopril used for?

Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to treat heart failure. Fosinopril is an ACE inhibitor and works by relaxing blood vessels so that blood can flow more easily.

What kind of drug is fosinopril?

Fosinopril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.

What is the most popular ACE inhibitor?

However, there are many different ACE inhibitors, and you may wonder what the difference is between all of them. Three of the most popular are lisinopril, enalapril, and benazepril.

What are the top ACE inhibitors?

The best ACE inhibitors for hypertension include Trandolapril, Enalapril, and Ramipril....Drugs that come under the group angiotensin-converting enzyme (ACE) inhibitors include:Enalapril.Benazepril.Trandolapril.Fosinopril.Ramipril.Moexipril.Quinapril.Captopril.More items...•

Is metoprolol an ACE or ARB?

Is metoprolol a beta-blocker, ACE inhibitor, or diuretic? Metoprolol belongs to the group of drugs called beta-blockers. Like metoprolol, other drugs called angiotensin-converting enzyme (ACE) inhibitors and diuretics can be used to treat certain heart conditions.

Are bisoprolol beta blockers?

Bisoprolol is a type of medicine called a beta blocker. Like other beta blockers, bisoprolol works by changing the way your body responds to some nerve impulses, especially in the heart. It slows down your heart rate and makes it easier for your heart to pump blood around your body.

What class drug is nortriptyline?

Nortriptyline is used to treat depression. Nortriptyline is in a group of medications called tricyclic antidepressants.

Is fosinopril a good blood pressure medication?

Fosinopril is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to treat heart failure. Fosinopril is an ACE inhibitor and works by relaxing blood vessels so that blood can flow more easily.

What is the difference between lisinopril and fosinopril?

Lisinopril, like enalapril, contains pyrrolidone ring of proline, whereas fosinopril contains a bicyclic ring that accounts for its higher lipophilicity. Fosinopril which is more lipophilic exhibits a plasma protein binding of more than 90% whereas lisinopril which is least lipophilic exhibits minimal protein binding.

What time of day should I take fosinopril?

Fosinopril is taken once a day. If you have high blood pressure, your doctor will advise you take your very first dose at bedtime. This is because you can feel quite dizzy when you first start taking it. After the first dose, you can generally take fosinopril at a time of day you find easy to remember.

What is the best ACE inhibitor for blood pressure?

When considering factors such as increased ejection fraction, stroke volume, and decreasing mean arterial pressure, our results suggest that enalapril was the most effective ACE inhibitor.

Is metoprolol an ACE inhibitors?

Is metoprolol a beta-blocker, ACE inhibitor, or diuretic? Metoprolol belongs to the group of drugs called beta-blockers. Like metoprolol, other drugs called angiotensin-converting enzyme (ACE) inhibitors and diuretics can be used to treat certain heart conditions.

Are statins ACE inhibitors?

Medications classified as statins were atorvastatin, cerivastatin, fluvastatin, lovastatin, pravastatin and simvastatin. Medications classified as ACE inhibitors were benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, quinapril and ramipril.

Is amlodipine an ACE inhibitors?

Amlodipine relaxes (widens) blood vessels and improves blood flow. Benazepril is an ACE inhibitor. ACE stands for angiotensin converting enzyme....Similar Drugs.Generic ExamplesSupplied AsStrengthAmlodipine Besylate-Benazepril HydrochlorideCapsule5 Mg-20 Mg5 Mg-40 Mg2.5Mg-10Mg10 Mg-20Mg5 Mg-10 Mg10 Mg-40Mg

Before Taking This Medicine

You should not use Monopril if you are allergic to fosinopril or similar medications, such as benazepril, captopril, enalapril, lisinopril, moexipr...

How Should I Take Monopril?

Take Monopril exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose...

Monopril Dosing Information

Usual Adult Dose for Hypertension:Initial dose: 10 mg orally once a day alone or in combination with a diureticMaintenance dose: 20 to 40 mg orally...

What Happens If I Miss A Dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...

What Should I Avoid While Taking Monopril?

Avoid drinking alcohol. It can further lower your blood pressure and may increase some of the side effects of Monopril.Avoid taking an antacid with...

What Other Drugs Will Affect Monopril?

Tell your doctor about all your current medicines and any you start or stop using, especially: 1. gold injections to treat arthritis; 2. lithium (L...

Monopril Oral: Uses, Side Effects, Interactions, Pictures ... - WebMD

Find patient medical information for Monopril oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

Compare Monopril vs Lisinopril - Iodine.com

Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough. Requires a yearly blood test to see how the medicine is affecting your body.

Side Effects of Monopril (Fosinopril Sodium), Warnings, Uses

SIDE EFFECTS. MONOPRIL (fosinopril sodium) has been evaluated for safety in more than 2100 individuals in hypertension and heart failure trials, including approximately 530 patients treated for a year or more. Generally adverse events were mild and transient, and their frequency was not prominently related to dose within the recommended daily dosage range.

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What is monopril sodium?

Monopril Description. Monopril ® (fosinopril sodium tablets) is the sodium salt of fosinopril, the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, fosinoprilat. It contains a phosphinate group capable of specific binding to the active site of angiotensin-converting enzyme. Fosinopril sodium is designated chemically as: L-proline, ...

How is fosinopril eliminated?

After oral administration of radiolabeled fosinopril, approximately half of the absorbed dose is excreted in the urine and the remainder is excreted in the feces.

How much does fosinopril absorb?

Following oral administration, fosinopril (the prodrug) is absorbed slowly. The absolute absorption of fosinopril averaged 36% of an oral dose. The primary site of absorption is the proximal small intestine (duodenum/jejunum). While the rate of absorption may be slowed by the presence of food in the gastrointestinal tract, the extent of absorption of fosinopril is essentially unaffected.

Is fosinopril toxic to humans?

Oral doses of fosinopril at 2600 mg/kg in rats were associated with significant lethality. Human overdoses of fosinopril have not been reported, but the most common manifestation of human fosinopril overdosage is likely to be hypotension.

Is fosinopril carcinogenic?

No evidence of a carcinogenic effect was found when fosinopril was given in the diet to mice and rats for up to 24 months at doses up to 400 mg/kg/day. On a body weight basis, the highest dose in mice and rats is about 250 times the maximum human dose of 80 mg, assuming a 50 kg subject. On a body surface area basis, in mice, this dose is 20 times the maximum human dose; in rats, this dose is 40 times the maximum human dose. Male rats given the highest dose level had a slightly higher incidence of mesentery/omentum lipomas.

Does Monopril cause hypotension?

Monopril can cause symptomatic hypotension. Like other ACE inhibitors, fosinopril has been only rarely associated with hypotension in uncomplicated hypertensive patients. Symptomatic hypotension is most likely to occur in patients who have been volume- and/or salt-depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. Volume and/or salt depletion should be corrected before initiating therapy with Monopril.

How long does it take for ACE to be suppressed?

Serum ACE activity was inhibited by ≥90% at 2 to 12 hours after single doses of 10 to 40 mg of fosinopril. At 24 hours, serum ACE activity remained suppressed by 85%, 93%, and 93% in the 10, 20, and 40 mg dose groups, respectively.

How long should you take Monopril?

The usual starting dose of MONOPRIL (fosinopril sodium) should be 10 mg once daily. Following the initial dose of MONOPRIL (fosinopril sodium) , the patient should be observed under medical supervision for at least 2 hours for the presence of hypotension or orthostasis, and if present, until blood pressure stabilizes.

How much does fosinopril absorb?

Following oral administration, fosinopril (the prodrug) is absorbed slowly. The absolute absorption of fosinopril averaged 36% of an oral dose. The primary site of absorption is the proximal small intestine ( duodenum / jejunum ). While the rate of absorption may be slowed by the presence of food in the gastrointestinal tract, the extent of absorption of fosinopril is essentially unaffected.

What is a monopril?

DESCRIPTION. MONOPRIL® (fosinopril sodium tablets) is the sodium salt of fosinopril, the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, fos inoprilat. It contains a phosphinate group capable of specific binding to the active site of angiotensin-converting enzyme. Fosinopril sodium is designated chemically as: L- proline, ...

Is digitalis required for monopril?

Digitalis is not required for MONOPRIL (fosinopril sodium) to manifest improvements in exercise tolerance and symptoms. Most placebo-controlled clinical trial experience has been with both digitalis and diuretics present as background therapy.

How long does it take for ACE to be inhibited?

Serum ACE activity was inhibited by ≥ 90% at 2 to 12 hours after single doses of 10 to 40 mg of fosinopril. At 24 hours, serum ACE activity remained suppressed by 85%, 93%, and 93% in the 10, 20, and 40 mg dose groups, respectively.

Does Monopril increase potassium levels?

Since concomitant administration of MONOPRIL (fosinopril sodium) with potassium supplements, or potassium-containing salt substitutes or potassium-sparing diuretics may lead to increases in serum potassium, they should be used with caution (see PRECAUTIONS ). Pediatrics.

Can you use Monopril with thiazide?

It may be used alone or in combination with thiazide diure tics. MONOPRIL (fosinopril sodium) is indicated in the management of heart failure as adjunctive therapy when added to conventional therapy including diuretics with or without digitalis (see DOSAGE AND ADMINISTRATION ).

What is Fosinopril used for?

Uses. Fosinopril is used to treat high blood pressure ( hypertension ). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to treat heart failure .Fosinopril is an ACE inhibitor and works by relaxing blood vessels so that blood can flow more easily.

How to take monopril?

How to use Monopril Tablet. Take this medication by mouth with or without food as directed by your doctor, usually once or twice daily. The dosage is based on your medical condition and response to treatment. Antacids containing aluminum or magnesium can decrease the absorption of fosinopril. If you are taking an antacid ...

How long does it take to get the full benefit of a blood pressure medicine?

Most people with high blood pressure do not feel sick. For the treatment of high blood pressure, it may take several weeks before you get the full benefit of this medication.

What are the side effects of a syringe?

Tell your doctor right away if you notice any of the following rare but serious side effects: yellowing eyes / skin, dark urine, severe stomach / abdominal pain, persistent nausea / vomiting. A very serious allergic reaction to this drug is rare.

Can you take fosinopril if you are allergic to it?

Precautions. Before taking fosinopril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (such as benazepril ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.

How long does it take for a heart med to work?

For the treatment of heart failure, it may take weeks to months before you get the full benefit of this medication. Tell your doctor if your condition does not improve or if it worsens (such as your blood pressure readings remain high or increase). Side Effects.

Can you take potassium supplements while pregnant?

Older adults may be more sensitive to the side effects of this drug, including dizziness and increases in potassium level. This medication is not recommended for use during pregnancy.

Indication

Monopril is used in the treatment of mild to moderate hypertension. Monopril may be used alone or in combination with other agents. Effectiveness in severe hypertension has not been established.

Action

Fosinopril is an angiotensin-converting enzyme (ACE) inhibitor. ACE is an enzyme that converts angiotensin I to angiotensin II. Angiotensin II is a powerful modulator of vasoconstriction (narrowing of blood vessels) and it also stimulates secretion aldosterone, which promotes sodium and water retention.

Does monopril cause dizziness?

dizziness or lightheadedness as your body adjusts to the medication. Other side effects of Monopril include: dry cough. muscle or joint pain, headache, tired feeling, runny or stuffy nose, nausea, vomiting,

What are the side effects of a syringe?

Common side effects may include: cough, runny or stuffy nose; muscle or joint pain; dizziness, headache, tired feeling; nausea, vomiting, diarrhea; or. mild skin itching or rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

How to know if you have a syringe?

Call your doctor at once if you have: 1 a light-headed feeling, like you might pass out; 2 sudden weakness or ill feeling, fever, chills, sore throat, painful mouth sores, cough, trouble breathing; 3 little or no urinating; or 4 high potassium --nausea, slow or unusual heart rate, weakness, loss of movement.

Does Monopril affect growth?

The adverse experience profile for pediatric patients is similar to that seen in adult patients with hypertension. The long-term effects of MONOPRIL (fosinopril sodium) on growth and development have not been studied.

Monopril Tablet, Oral Tablet

Monopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Monoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).

Uses

Monopril is an ACE inhibitor used to treat mild to moderate hypertension, congestive heart failure, and to slow the progression of renal disease in hypertensive diabetics.

Food Interaction

Avoid hypertensive herbs (e.g. bayberry, blue cohosh, cayenne, ephedra, and licorice).

What is fosinopril used for?

What are the uses for fosinopril sodium? Fosinopril sodium is an ACE inhibitor drug prescribed for treatment of high blood pressure and congestive heart failure, and for treatment after a heart attack.

How far apart should I take antacids and fosinopril?

Patients should take antacids and fosinopril at least two hours apart. Fosinopril can cause an increase in the amount of lithium (Eskalith, Lithobid) in the body in patients taking lithium, sometimes causing lithium-associated side effects. Aspirin and other nonsteroidal anti-inflammatory drugs ( NSAIDs) such as ibuprofen ( Advil, Motrin, Medipren, ...

What drugs interact with fosinopril?

Which drugs or supplements interact with fosinopril sodium? Combining fosinopril with potassium supplements, potassium containing salt substitutes, or potassium-conserving diuretics such as amiloride (Moduretic), spironolactone ( Aldactone ), and triamterene (Dyazide, Maxzide), can lead to dangerously high blood levels of potassium ( hyperkalemia) ...

What is the role of ACE inhibitors in blood pressure?

Constriction of arteries and veins elevates blood pressure. ACE inhibitors inhibit ACE and block the formation of angiotensin II. By blocking the formation of angiotensin II, ...

Is Fosinopril an ACE inhibitor?

Fosinopril sodium (Monopril) is an ACE inhibitor drug prescribed for the treatment of high blood pressure and congestive heart failure, as well as for post-heart attack treatment. Review side effects, drug interactions, warnings and precautions, and patient safety information prior to taking any medication.

What are the side effects of a syringe?

Other important and serious side effects, although rare, include: 1 liver failure, 2 low white blood cell counts ( neutropenia) and 3 angioedema (swelling of lips and throat that can obstruct breathing ).

Can you take fosinopril with aluminum?

Fosinopril should not be taken at the same time as aluminum or magnesium-based antacids, such as simethicone ( Mylanta, Gas-X, etc.) or Maalox since these antacids bind fosinopril and decrease the amount of fosinopril that is absorbed from the intestine.

What is angiotensin II?

Angiotensin II is formed from angiotensin I in the blood by the enzyme angiotensin converting enzyme (ACE). (Angiotensin I in the blood is itself formed from angiotensinogen, a protein produced by the liver and released into the blood.) Angiotensin converting enzyme inhibitors (ACE inhibitors) are medications that slow (inhibit) ...

Why are ACE inhibitors important?

ACE inhibitors are an important group of drugs because they prevent early death resulting from hypertension, heart failure or heart attacks. Some individuals with hypertension do not respond sufficiently to ACE inhibitors alone. In these cases, other drugs often are used in combination with ACE inhibitors.

What is ACE inhibitor used for?

ACE inhibitors are used for: Controlling acute and chronic high blood pressure. Treat ing left ventricular dysfunction and heart failure. Preventing strokes. Preventing and treating kidney disease (nephropathy) in people with hypertension or diabetes. ACE inhibitors also improve survival after heart attacks.

What are the side effects of ACE inhibitors?

There are serious side effects of this drug like kidney failure, severe allergic reactions, and liver dysfunction, or failure. ACE inhibitors all are similar in the way they work; however, they differ in how the body eliminates doses of the drug.

How do ACE inhibitors work?

What are ACE inhibitors, and how do they work (mechanism of action)? Angiotensin II is a very potent chemical produced by the body that primarily circulates in the blood. It causes the muscles surrounding blood vessels to contract, thereby narrowing the vessels.

What are some examples of ACE inhibitors?

Examples of ACE inhibitors include benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), and ramipril (Altace). Examples of the most common side effects of this class of drugs are dizziness, headache, cough, rash, chest pain, and rash. There are serious side effects of this drug like kidney failure, ...

How long does it take for a cough to subside after taking ACE?

Sun sensitivity. Increased BUN and creatinine levels. It may take up to a month for coughing to subside, and if one ACE inhibitor causes cough it is likely that the others will too. The most serious, but rare, side effects of ACE inhibitors are: Kidney failure. Allergic reactions.

How does this medication work? What will it do for me?

Fosinopril belongs to the class of medications called angiotensin converting enzyme inhibitors (ACE inhibitors). It is used to treat high blood pressure. It works by relaxing blood vessels and by helping the heart to pump blood that carries oxygen to the different parts of the body more efficiently.

What form (s) does this medication come in?

Monopril is no longer being manufactured for sale in Canada. For brands that may still be available, search under fosinopril. This article is being kept available for reference purposes only. If you are using this medication, speak with your doctor or pharmacist for information about your treatment options.

How should I use this medication?

The recommended adult dose of fosinopril ranges from 10 mg to 40 mg daily in a single daily dose, with or without meals. The dose of the medication usually begins at 10 mg daily, with dosing increases as directed by your doctor occurring approximately every 2 weeks as needed. It may take up to 2 weeks to see the full effects of the medication.

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

Are there any other precautions or warnings for this medication?

Health Canada has issued new restrictions concerning the use of fosinopril. To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.

What other drugs could interact with this medication?

There may be an interaction between fosinopril and any of the following:

What does ACE stand for in a syringe?

ACE stands for angiotensin converting enzyme. Monopril is used to treat high blood pressure (hypertension) or heart failure. Monopril may also be used for purposes not listed in this medication guide.

What are the side effects of monopril?

Get emergency medical help if you have signs of an allergic reaction to Monopril: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. sudden weakness or ill feeling, fever, chills, sore throat, painful mouth sores, cough, trouble breathing;

What does it mean when you have a light headed feeling?

Call your doctor at once if you have: a light-headed feeling, like you might pass out; sudden weakness or ill feeling, fever, chills, sore throat, painful mouth sores, cough, trouble breathing; little or no urinating; or. high potassium - nausea, slow or unusual heart rate, weakness, loss of movement.

Is Monopril discontinued?

Medically reviewed by Drugs.com. Last updated on March 24, 2021. The Monopril brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.

Does monopril cause rash?

Common Monopril side effects may include: cough, runny or stuffy nose; muscle or joint pain; dizziness, headache, tired feeling; nausea, vomiting, diarrhea; or. mild skin itching or rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

How to know if you have a syringe?

Call your doctor at once if you have: 1 a light-headed feeling, like you might pass out; 2 sudden weakness or ill feeling, fever, chills, sore throat, painful mouth sores, cough, trouble breathing; 3 little or no urinating; or 4 high potassium - nausea, slow or unusual heart rate, weakness, loss of movement.

Can you take monopril while pregnant?

Do not use Monopril if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Fosinopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Fosinopril can pass into breast milk and may harm a nursing baby.

Monopril Description

Monopril - Clinical Pharmacology

Indications and Usage For Monopril

Contraindications

Warnings

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Precautions

Adverse Reactions

Overdosage

Monopril Dosage and Administration

How Is Monopril Supplied

Indication

Action

Common Side Effects

Uncommon Side Effects

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