What conditions does octreotide acetate vial treat?
What Conditions does OCTREOTIDE ACETATE Treat?
- diarrhea with HIV
- diarrhea associated with vasoactive intestinal peptide (VIP)-secreting tumor
- diarrhea caused by chemotherapy
- insulinoma
- increased growth of islet cells of pancreas
- acromegaly
- carcinoid syndrome
- carcinoid crisis
- bleeding from varicose veins or varices in the esophagus
- inadequate absorption of nutrients due to a short bowel
Is Herceptin a form of chemotherapy?
Herceptin is not a form of chemotherapy; it is a type of biological therapy and is considered less "toxic" than chemotherapy. What Is Herceptin Used For? Herceptin ® ( trastuzumab ) is a prescription medication used to treat breast cancer and gastric cancer ( stomach cancer ).
What are the side effects of chemotherapy?
With chemotherapy, you can have fatigue, lowering of blood counts, increased risk of infection, and GI effects such as nausea or change in bowels.For many of these symptoms, we have tools to help prevent or treat them. Fatigue is one symptom that is still hard to treat.
Is interferon like chemo?
There are several websites that say "yes" Interferon IS a chemotherapy drug. But I think it refers more to the "class" of the drug as it is not at all like traditional chemotherapy for cancer patients. Methotrexate for rheumatoid arthritis is a chemotherapy drug.
What type of drug is octreotide?
PeptideOctreotide / ClassificationPeptides are short chains of amino acids linked by peptide bonds. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. A polypeptide is a longer, continuous, unbranched peptide chain. Wikipedia
What is octreotide used for cancer?
Octreotide is a synthetic version of somatostatin (a somatostatin analogue) and slows down the production of hormones. This helps to control the symptoms of carcinoid syndrome and slow down the growth of the cancer.
What is the drug octreotide used for?
Octreotide injection is used to treat severe diarrhea and other symptoms that occur with certain intestinal tumors (eg, vasoactive intestinal peptide tumors or VIPomas) or metastatic carcinoid tumors (tumors that has already spread in the body).
Does octreotide shrink tumors?
Octreotide is helpful in treating the symptoms of carcinoid syndrome. Sometimes octreotide can temporarily shrink carcinoid tumors, but it does not cure them. The original version of octreotide (Sandostatin®) is injected under the skin (subcutaneously) at least twice daily.
Is Sandostatin a form of chemo?
Official answer. Sandostatin is not a chemotherapy drug, it is a man-made hormone that has similar effects to somatostatin, a hormone produced naturally in our bodies by our hypothalamus and some other tissues such as the pancreas and the gastrointestinal tract.
How long do you take octreotide?
You will be treated with the immediate-release injection for 2 weeks, and your doctor may gradually increase your dose during that time. If the medication works for you and does not cause severe side effects, your doctor may give you the long-acting injection after 2 weeks.
What is another name for octreotide?
Octreotide is available under the following different brand names: Sandostatin, and Sandostatin LAR.
What is octreotide used for in palliative care?
RATIONALE: Palliative therapy with octreotide may help patients who have bowel obstruction that cannot be removed by surgery to live longer and more comfortably.
Which major side effect is associated with octreotide?
Commonly reported side effects of octreotide include: cardiac conduction disorder, gallbladder sludge, and hyperglycemia. Other side effects include: cardiac arrhythmia, and hypoglycemia.
Does Chemo help neuroendocrine tumors?
Chemotherapy uses anti cancer (cytotoxic) drugs to destroy neuroendocrine tumour (NET) cells. The drugs circulate throughout your body in the bloodstream.
Can a neuroendocrine tumor be cured?
Many neuroendocrine tumors can be successfully treated with surgery and chemotherapy, especially if the tumor is localized and has not spread to the lymph nodes or other organs in the body.
What is the best treatment for neuroendocrine tumors?
Targeted drug therapy is usually combined with chemotherapy for advanced neuroendocrine tumors. Peptide receptor radionuclide therapy (PRRT). PRRT combines a drug that targets cancer cells with a small amount of a radioactive substance. It allows radiation to be delivered directly to the cancer cells.
What is octreotide used for in palliative care?
RATIONALE: Palliative therapy with octreotide may help patients who have bowel obstruction that cannot be removed by surgery to live longer and more comfortably.
Which major side effect is associated with octreotide?
Commonly reported side effects of octreotide include: cardiac conduction disorder, gallbladder sludge, and hyperglycemia. Other side effects include: cardiac arrhythmia, and hypoglycemia.
How does octreotide treat esophageal varices?
Variceal bleeding: Octreotide decreases the inflow of blood to portal system by constricting the splanchnic arterioles and significantly reduces intravariceal pressure.
Is octreotide a hormone therapy?
Drug type: Octreotide is hormone drug that is used to treat some types of cancer. This medication is classified as a somatostatin analog.
What is octreotide injection?
Octreotide immediate-release injection is also used to control diarrhea and flushing caused by carcinoid tumors (slow-growing tumors that release natural substances that can cause symptoms) and vasoactive intestinal peptide secreting adenomas (VIP- omas; tumors that form in the pancreas and release natural substances that can cause symptoms). ...
How long does it take for octreotide to work?
You will be treated with the immediate-release injection for 2 weeks, and your doctor may gradually increase your dose during that time. If the medication works for you and does not cause severe side effects, your doctor may give you the long-acting injection after 2 weeks. In order to control your condition, you may need to continue to receive the immediate-release injection for 2 weeks or longer after you receive your first dose of the long-acting injection. Your doctor may increase or decrease your dose of the long-acting injection 2 or 3 months after you first receive it.
Why is this medicine prescribed?
Octreotide immediate-release injection is used to decrease the amount of growth hormone (a natural substance) produced by people with acromegaly (condition in which the body produces too much growth hormone , causing enlargement of the hands, feet, and facial features; joint pain; and other symptoms) who cannot be treated with surgery, radiation, or another medication. Octreotide immediate-release injection is also used to control diarrhea and flushing caused by carcinoid tumors (slow-growing tumors that release natural substances that can cause symptoms) and vasoactive intestinal peptide secreting adenomas (VIP-omas; tumors that form in the pancreas and release natural substances that can cause symptoms). Octreotide long-acting injection is used to control acromegaly, carcinoid tumors, and VIP-omas in people who have been successfully treated with octreotide injection but prefer to receive injections less often. Octreotide injection is in a class of medications called octapeptides. It works by decreasing the amounts of certain natural substances produced by the body.
What should I do in case of overdose?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at [WEB]. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Does octreotide affect blood sugar?
This medication may cause changes in your blood sugar. You should know the symptoms of high and low blood sugar and what to do if you have these symptoms. Octreotide injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: Some side effects can be serious.
Can octreotide be used to treat a symtom?
Octreotide injection may control your symptoms, but it will not cure your condition. Continue to use octreotide injection even if you feel well. Do not stop using octreotide injection without talking to your doctor. If you stop using octreotide injection, your symptoms may return.
Are there other uses for this medicine?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What is octreotide used for?
Octreotide is now widely used in the treatment of hormonal syndromes that result from a variety of neuroendocrine and endocrine neoplasms. Its dramatic effect in controlling malignant carcinoid syndrome and hormone-induced diarrhea (for example, from gastrinoma and VIPoma) has been well documented. However, the chronic use ...
What is octreotide somatostatin?
Octreotide (Sandostatin), a somatostatin analog, has a wide range of uses in the management of cancer patients. It is a unique molecule that specifically binds to somatostatin receptor subtype 2. This property of activating the receptor can result in a multitude of physiologic actions (for example, inhibition of synthesis and release ...
Is radiolabeled octreotide used for prostate cancer?
Radiolabeled octreotide has been used successfully for imaging (neuroendocrine,endocrine, breast, small-cell lung, and prostate cancers) and more recently fortargeted radiotherapy. It is also an effective agent for the control oftherapy-induced diarrhea refractory to oral therapy.
Who explains the antiangiogenic properties of octreotide?
Finally, Eugene Woltering explains the antiangiogenic propertiesof octreotide and discusses methods to exploit these properties in futureprojects.
Does octreotide cause steatorrhea?
However, the chronic use of octreotide can result in steatorrhea and gallstone formation. Octreotide (Sandostatin), a somatostatin analog, has a wide range of uses inthe management of cancer patients. It is a unique molecule that specifically binds to somatostatin receptor subtype 2. This property of activating thereceptor can result in ...
How long does octreotide last?
Although the half-life of octreotide is 1.7 to 2 hours, the duration of action is 6 to 12 hours. Octreotide has a longer half-life than native somatostatin. It is largely hepatically metabolized, with some renal excretion of unchanged drug.
What is chemo induced diarrhea?
Chemotherapy-induced diarrhea (CID) can cause a wide range of complications, including dehydration, electrolyte and metabolic disturbances, and renal insufficiency. If poorly controlled, CID can lead to increased costs of care and treatment delays, as well as suffering of the patient.
What is the best treatment for diarrhea after irinotecan?
For patients with symptoms unresponsive to loperamide, octreotide and opium tincture can be used.
What is the name of the drug that regulates the release of a somatostatin?
Octreotide (Sandostatin, Novartis) is a synthetic analog of somatostatin. It regulates the release of many gastrointestinal hormones such as vasoactive intestinal polypeptide, gastrin, insulin, glucagon, secretin, motilin and pancreatic polypeptide. This results in increases in gastrointestinal absorption of intestinal fluids and electrolytes and decreases in smooth muscle contractility and small bowel motility.
Is 40 mg intramuscular depot octreotide more effective than 30 mg?
In the 124 evaluable patients, 62% of the patients treated with 30 mg experienced grade-3 or -4 CID; whereas 48% of the 40-mg treated patients had grade-3 or -4 symptoms. There were small but not statistically significant decreases in health care utilization in patients treated with 40 mg intramuscular depot octreotide. The researchers concluded that 40 mg intramuscular depot octreotide was more effective than 30 mg in the secondary prophylaxis of patients with CID.
Can irinotecan cause diarrhoea?
Patients receiving chemotherapy that contains fluorouracil, capecitabine or irinotecan are especially prone to CID. In these patients, the incidence of CID can approach 70% to 80%, with about one-third suffering severe symptoms. Diarrhea after irinotecan therapy follows two scenarios: early onset symptoms (within minutes to hours of dose, cholinergically mediated, treated with atropine) and late-onset symptoms (onset from days to a week; multifactorial).
Is 40 mg octreotide effective?
The researchers concluded that 40 mg intramuscular depot octreotide was more effective than 30 mg in the secondary prophylaxis of patients with CID. Other uses. Octreotide is also indicated in the treatment of acromegaly, metastatic carcinoid syndrome and vasoactive intestinal polypeptide-secreting tumors.
How often is sandostatin given?
Sandostatin LAR is given by intramuscular injection (into the muscle) under a doctor's supervision. Sandostatin is generally given once every 4 weeks. The preferred site for injection is the hip, because it is painful given into the arm. Sandostatin LAR should NOT be given by S.C. or IV routes.
What is somatostatin used for?
Drug Type: Sandostatin is a hormone drug that is used to treat some types of cancer. Sandostatin is classified as a somatostatin analog. (For more detail, see "How Sandostatin Works" section below).
What is short acting sandostatin?
Short acting Sandostatin may also be used to control breakthrough symptoms in carcinoid. The amount of Sandostatin that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated.
Is there a relationship between the presence or severity of side effects and the effectiveness of the medication?
There is no relationship between the presence or severity of side effects and the effectiveness of the medication.
What is targeted drug?
Targeted drugs. Anti-cancer drugs that work differently from standard chemotherapy drugs have been developed for some types of cancer. These drugs target specific parts of cancer cells. They are sometimes helpful when chemotherapy is not. They often have different side effects.
How long does chemo last?
Chemo cycles generally last about 3 to 4 weeks, and initial treatment is typically 4 to 6 cycles.
What is a telotristat?
Telotristat (Xermelo™): This drug is used along with a somatostatin analog (octreotide or lanreotide) to help control carcinoid syndrome diarrhea. It is given by mouth as a pill and common side effects can include fever, poor appetite, headache, nausea, and swelling of the hands or feet
What is the drug that slows down the growth of neuroendocrine cells?
These drugs are related to somatostatin, a natural hormone that seems to help slow the growth of neuroendocrine cells. They are especially useful in people who have carcinoid syndrome (facial flushing, diarrhea, wheezing, rapid heart rate) and in people whose tumors show up on a somatostatin receptor scintigraphy (SRS) scan or gallium-68 Dotatate scans .
What is the best treatment for GI carcinoid tumors?
For these, combinations of 5-FU plus streptozocin, 5-FU plus doxorubicin or oxaliplatin plus capecitabine may be used.
What are the side effects of chemo?
The side effects of chemo depend on the type and dose of drugs given and the length of time they are taken. Common side effects can include: 1 Nausea and vomiting 2 Loss of appetite 3 Hair loss 4 Mouth sores 5 Diarrhea or constipation 6 Increased chance of infections (from having too few white blood cells) 7 Easy bruising or bleeding (from having too few blood platelets 8 Fatigue (from having too few red blood cells)
Does chemo help with cancer?
These drugs enter the blood and reach almost all areas of the body, making this treatment useful for some types of cancers that have spread. Unfortunately, gastrointestinal (GI) carcinoid tumors often do not respond well to chemo. Because of this, chemo generally is used only for tumors that have spread to other organs, are causing severe symptoms, ...
What is octreotide used for?
This helps to control the symptoms of carcinoid syndrome and slow down the growth of the cancer. Some of the symptoms you may have with carcinoid syndrome include flushing of the skin, diarrhoea and tummy (abdominal) pain.
How often do you have octreotide?
When you have octreotide depends on your individual needs. Ask your doctor or nurse when are you going to have it and for how long.
What are the side effects of octreotide?
They also depend on what other treatment you are having. For example, your side effects could be worse if you are also having other drugs or radiotherapy.
What is octreotide somatostatin?
Octreotide (also known as Sandostatin) is a man made (synthetic) version of the natural hormone somatostatin. Carcinoid syndrome is a group of symptoms that some people get when they have a neuroendocrine tumour (NET) . The symptoms happen when the NET makes large amounts of hormones.
How often do you get octreotide injections?
You usually have short acting octreotide as injections under the skin once or twice a day.
Where to inject octreotide?
You might have octreotide as an injection under the skin (subcutaneous) or into the muscle (intramuscular).
