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Disease Entity. Disease. Papilledema refers to swelling of the optic disc from increased intracranial pressure (ICP)]. It must be distinguished from optic disc swelling from other causes which is simply termed "optic disc edema". Papilledema must also be distinguished from pseudo-papilledema such as optic disc drusen.
What is the disease entity of papilledema?
Headache With Papilledema Papilledema is bilateral optic disc swelling due to increased intracranial pressure. It is considered an emergency because intracranial pressure may rise in an exponential fashion with the potential for acute neurologic decompensation.
Why is a headache with papilledema an emergency?
Papilledema: Point-of-Care Ultrasound Diagnosis in the Emergency Department Point-of-care ultrasound (POCUS) has the potential to diagnose papilledema, a sign of increased intracranial pressure, through optic disc elevation as well as optic nerve sheath diameter measurements.
How is papilledema diagnosed in the ER?
A mild case of papilledema with symptoms that don’t disrupt your life is nothing to worry about. But papilledema can be a sign of an underlying condition or injury that needs to be treated as soon as possible. This is especially true if you notice the symptoms after major trauma to your head. What are the symptoms of papilledema?
Should I worry about papilledema?

Should I go to the ER for papilledema?
On the contrary, if there is suspicion of papilledema, the patient must be sent immediately to the hospital for further evaluation and neuroimaging, preferably magnetic resonance imaging (MRI) of the brain with and without contrast to rule out intracranial mass and magnetic resonance venogram (MRV) to assess for venous ...
Is papilledema life threatening?
Swelling or injury to your brain can be serious and life-threatening. If papilledema is caused by an underlying condition, get treated right away to prevent any long-term complications.
How quickly does papilledema progress?
Papilledema that develops in patients after head trauma is usually described as mild (but is quite variable) and may develop immediately, occur several days after the injury, or up to 2 weeks later.
What happens if papilledema goes untreated?
Untreated papilledema can lead to serious eye problems, starting with the loss of your peripheral, or side, vision. In later stages, your vision can become completely blurred. Some people go blind in one or both eyes.
What can be mistaken for papilledema?
The term papilledema refers to optic disc swelling due to increased intracranial pressure, and the two conditions most commonly mistaken for it are disc swelling due to optic neuropathy and pseudopapilledema (disc elevation without nerve fiber layer edema).
What is the most common cause of papilledema?
While many cases of bilateral papilledema are caused by idiopathic intracranial hypertension (IIH), some will be caused by other etiologies, such as obstructive hydrocephalus, cerebral venous sinus thrombosis, and intracranial masses, among others.
What are the stages of papilledema?
Disc edema in papilledema results from blockage of axoplasmic flow in nerve fibers, increasing the volume of axoplasm in the optic disc (Hayreh, 1977). On the basis of the chronicity and fundus appearance, papilledema can be divided into four stages: early, fully developed (acute), chronic, and atrophic.
Can you reverse papilledema?
Most visual defects associated with papilledema are reversible if intracranial pressure is lowered before there is optic nerve damage.
Can an eye doctor see papilledema?
The conditions that cause papilledema can cause serious damage to the optic nerve or to the brain, resulting in vision loss or brain damage if not treated. Often, papilledema is detected as part of the routine eye examination that you would have if you see an optometrist, an ophthalmologist, or a neurologist.
Can papilledema be benign?
Although papilledema results from benign intracranial hypertension, it may not be so benign for your vision.
Can you recover from papilledema?
In case the patient has undergone surgery, the proper recovery time can range from 2 weeks to even a month or more depending upon the physical health and the extent of surgery. For patients who simply use diuretics or antibiotics to treat papilledema, the recovery time is almost instant.
Can papilledema be cured?
Papilledema that occurs as a result of idiopathic intracranial hypertension can be treated with weight loss and a diuretic. If unsuccessful, surgical procedures can be done. An infection, if bacterial, can be treated with antibiotics. A brain abscess is drained, and antibiotics are given.
What happens if you have papilledema?
Symptoms associated with papilledema can include: Blurred vision or loss of vision: This occurs due to physical pressure on the optic nerve, which controls your vision. Some people with optic nerve compression experience blurred vision or loss of vision from one or both eyes.
What are the stages of papilledema?
Disc edema in papilledema results from blockage of axoplasmic flow in nerve fibers, increasing the volume of axoplasm in the optic disc (Hayreh, 1977). On the basis of the chronicity and fundus appearance, papilledema can be divided into four stages: early, fully developed (acute), chronic, and atrophic.
What does it mean when your eye is blurry?
Your doctor may diagnose you with papilledema if your optic disc, which is at the end of the optic nerve, looks abnormally blurry or high up. Your doctor might also see spots of blood in your eye if you have this condition. If your doctor believes a brain condition is causing papilledema, they’ll do additional tests.
What is the condition where the optic nerve swells?
Papilledema is an eye condition that happens when pressure in your brain makes your optic nerve swell.
How long does it take for papilledema to go away?
It can typically be treated by draining extra CSF fluid, which reduces swelling. Symptoms then disappear in a few weeks. Swelling or injury to your brain can be serious and life-threatening.
Why does my brain swell?
When pressure pushes on the nerve and vein, blood and fluid can’t leave the eye at a normal rate, causing papilledema. Brain swelling can be caused by a number of injuries and conditions, including: traumatic injury to your head. not having enough red blood cells or hemoglobin ( anemia)
What is the fluid that is in the brain called?
The fluid bathing your brain and spinal cord is known as cerebrospinal fluid , or CSF. Optic nerve swelling can happen when CSF builds up where your optic nerve and the central retinal vein travel between your brain and your eye nerve. This area is known as the subarachnoid space. When pressure pushes on the nerve and vein, blood and fluid can’t leave the eye at a normal rate, causing papilledema.
What are the complications of papilledema?
Other complications of untreated papilledema related to the conditions that can cause it include: 1 brain damage 2 stroke 3 seizures 4 constant headaches 5 death
How long does papilledema last?
If brain pressure continues, these changes may last for minutes at a time or longer. In some cases, they may become permanent.
Tumors, head injury, or infection
Certain underlying conditions will require more intensive treatment. For example, a brain tumor, bleeding within the brain, or a blood clot may require surgery. The recommended types of surgical procedures will depend on the conditions that need addressing.
High blood pressure
In rare cases, papilledema can be due to extremely high blood pressure, which doctors refer to as a hypertensive crisis. In these cases, it is essential to reduce blood pressure to avoid more serious harm, so emergency medical care will be necessary. A person will need to receive medical treatment in the emergency room and intensive care unit.
Other causes
A wide variety of other medical problems and conditions can lead to increased pressure inside the brain.
How to treat papilledema?
Treatment. If tests reveal a medical problem, treating it should cure papilledema as well. For instance, you might need antibiotics for a brain infection, surgery to drain an abscess or remove a tumor, or medicine to dissolve a blood clot. Your doctor may be able to switch a problem medication.
What is a brain bleed?
Bleeding in the brain. A blood clot or a problem within certain veins. Pus collecting from a brain infection. Problems with the flow or amount of fluid that runs through the brain and spinal cord. You can also get papilledema as a side effect of taking -- or stopping -- some medications, including: Corticosteroids.
What is a spinal tap?
Your doctor may want you to have a lumbar puncture , also known as a spinal tap. This test measures the pressure of the cerebrospinal fluid that runs through your brain and spinal cord. Further tests on a sample of this fluid can help diagnose an infection or tumor. Treatment.
Why does my brain have papilledema?
Your brain 's network of nerves, blood, and fluid all fit snugly inside your skull. Because there's a limited amount of space, when tissues swell, something grows, or there's more liquid than normal, the pressure inside goes up and, in turn, can cause papilledema. That may happen because of: A head injury.
Why does my brain swell?
This swelling is a reaction to a buildup of pressure in or around your brain that may have many causes. Often, it's a warning sign of a serious medical condition that needs attention, such as a brain tumor or hemorrhage. But sometimes the pressure and swelling can't be traced to a specific problem. In that case, there are other ways to ease ...
What is the best way to diagnose papilledema?
Diagnosis. Eye doctors use a tool called an ophthalmoscope to look inside the back of the eyes and diagnose papilledema. An imaging test, such as an MRI, can provide more details and possibly show what's causing the pressure in your brain. Later on, MRIs can measure how well treatment is working.
What is it called when you have high pressure in your skull?
Tetracycline. When there's no apparent reason for high pressure inside your skull, the condition is called idiopathic intracranial hypertension (IIH). It happens to about 1 out of 100,000 people, but it's 20 times more likely among obese women in their childbearing years. As obesity rates rise, so does the IIH rate.
What are the early funduscopic changes of papilledema?
The early funduscopic changes of papilledema include opacification or “splaying” of the peripapillary nerve fiber layer; obscuration of the retinal vessels as they cross the optic disc margin; optic disc hyperemia; optic disc telangiectasias or hemorrhages; retinal venous dilation; and loss of venous pulsations, especially if they were previously present ( Figure 6a and 6b ).
Why does papilledema cause headaches?
Headache With Papilledema. Papilledema is bilateral optic disc swelling due to increased intracranial pressure. It is considered an emergency because intracranial pressure may rise in an exponential fashion with the potential for acute neurologic decompensation. The increased CSF pressure is transmitted to the optic nerve, ...
What are the symptoms of increased intracranial pressure?
The symptoms of increased intracranial pressure include daily headache that is often worse after being supine or with Valsalva maneuver, nausea and vomiting, transient visual obscurations (TVOs), binocular diplopia due to sixth nerve palsy, and pulse-synchronous intracranial noises.
Can hypertension cause optic nerve swelling?
Although most patients with severe hypertension will show retinal hemorrhages and retinal arteriolar narrowing, there may be exceptions where bilateral optic nerve swelling is the only manifestation. The detection of papilledema warrants emergent neuroimaging, preferably MRI.
How long does it take for papilledema to develop?
Reduced absorption of CSF (e.g. meningitis, cerebral venous thrombosis) The time course for development of papilledema may be weeks if there is only a slow and mild rise in intracranial pressure, but severe and rapid changes in pressure can cause papilledema to present within a few hours to a day.
What is the term for a swelling of the optic disc?
Disease Entity. Papilledema is a term that is exclusively used when a disc swelling is secondary to increased intracranial pressure (ICP). It must be distinguished from optic disc swelling from other causes which is simply termed "optic disc edema". Papilledema must also be distinguished from pseudo-papilledema such as optic disc drusen.
What is probable IIH?
Probable IIH: if criteria 1–4 are met with bilateral papilledema present, and the measured CSF pressure is lower than the specified for a definite diagnosis.
What is the Dandy criteria for IIH?
The diagnosis of IIH as a cause of papilledema is one of exclusion, the modified Dandy criteria helps in diagnosing patients with IIH in order to safely exclude other causes and initiate the treatment in a timely manner to prevent visual function loss. The modified Dandy Criteria to Diagnose IIH. papilledema.
What is the scale used for papilledema?
Chronic papilledema may show all the aforementioned signs in addition to optic disc pallor along with decreasing swelling due to loss of axons, gliosis ( greying of the retinal fibers due to scarring), optociliary shunts, and refractile bodies. Frisen scale is a grading system that is used for papilledema.
How much water is normal for ICP?
Normal ICP is typically less than 250 mm of water in adults when measured with a manometer and is less than 280 mm of water in children. Papilledema results from orthograde axoplasmic flow stasis at the optic nerve head leading to edema of the nerve from the increased intracranial pressure pressing on the nerve behind the eye.
What are the risk factors for papilledema?
This includes space occupying lesions such as tumor or subarachnoid hemorrhage, decreased absorption of cerebrospinal fluid, change in the dynamics of cerebrospinal flow through the ventricles (for example by obstruction of the 4th ventricle), or rarely by increased production of cerebrospinal fluid.
What is the ancillary test for papilledema?
Other ancillary tests to consider on patients with ODD and/or papilledema include ultrasound of the optic nerve and fluorescein angiography (FA). In orbital ultrasonography, the optic nerve sheath width (ONSW) widens with increased ICP. Increased ICP also causes a change in the ONSW in primary gaze vs. upon 30º of abduction. Drusen will present as ovoid hyperreflective structures. 26 With FA, drusen present as bright ovoid structures, staining in early and late stages and papilledema presents as leakage in the peripapillary region.
How to assess papilledema?
Papilledema has certain fundoscopic characteristics that should be carefully assessed for. A stepwise approach to assessing the optic nerve head on dilated exam will help determine if the patient has disc edema. First, assess each quadrant of the optic disc for any elevation. Next, assess the margins of the optic disc, evaluate for any margins that are blurry or indistinct. Further assess the margins for vessel obscuration; look at the small vessels at the edge of the margin and determine if there are segments missing of the vessel. 12
What are the symptoms of papilledema?
First, ask about common symptoms and signs of increased intracranial pressure including headaches, transient visual obscurations, pulsatile tinnitus, nausea, vomiting and diplopia. 1 Headaches are an especially common symptom associated with papilledema. The pain is often described as diffuse, may radiate down the posterior portion of the neck, and is characteristically more severe upon wakening in the morning and when laying down.
Why do patients have spontaneous venous pulsations?
SVPs are caused by variations in the pressure gradient along the retinal vein as it emerges through the lamina cribrosa. It has been found that when a patient’s cerebral spinal fluid (CSF) pressure is higher than 190mm H 2 O, the CSF pulse pressure rises to equal the intraocular pressure causing the SVP to cease. 15 Therefore, the presence of an SVP does suggest normalized ICP. However, approximately 10% of the normal population does not exhibit a physiologic SVP.
Does decreasing RNFL mean improving papilledema?
While decreasing RNFL values may signify improving papilledema, this change must be differentiated from papilledema-related atrophy. Analysis of the ganglion cell complex is often a helpful discriminator, as thinning can be an early sign of papilledema related optic atrophy. 29 The presence of GCC thinning may be associated with a visual field defect, and as more aggressive treatment is often warranted in patients with visual field defects and loss, providers must continually monitor for these changes.
Does papilledema cause anterior displacement?
It has been theorized that the force of increased subarachnoid pressure in patients with papilledema may result in an anterior displacement of structures in the peripapillary region. Specifically, Bruch’s membrane (BM) and the retinal pigmented epithelium (RPE) have been shown to have an increased angle toward the vitreous in these patients, while BM and RPE in patients with disc swelling unrelated to intracranial hypertension was angled away from the vitreous. 19
How big is a blind spot?
The blind spot size averages 5.5º horizontal and 7.5º vertical. 10 In cases of chronic papilledema, abnormal afferent functions may further manifest and are extremely important to identify as treatment may need to be modified. The long-term pressure on the optic nerves causes retinal nerve fiber layer (RNFL) damage resulting in findings such as reduced visual acuity, color vision and visual field defects. 11
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